AutismKB 2.0

Annotation Detail for MPG


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Basic Information Top
Gene Symbol:MPG ( AAG,ADPG,APNG,CRA36.1,MDG,Mid1,PIG11,PIG16,anpg )
Gene Full Name: N-methylpurine-DNA glycosylase
Band: 16p13.3
Quick LinksEntrez ID:4350; OMIM: 156565; Uniprot ID:3MG_HUMAN; ENSEMBL ID: ENSG00000103152; HGNC ID: 7211
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03410Base excision repair
Pathway IDPathway Name
DNA Repair
No data
No data
Pathway IDPathway Name
500910Cleavage of the damaged purine
500030Recognition and association of DNA glycosylase with site containing an affected purine
501000Displacement of DNA glycosylase by APE1
500029Depurination
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2053Colon cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MPG mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MPG mRNAaffects expression 21346803
C031278 2-chloroethyl ethyl sulfide MPG protein results in increased susceptibility to 2-chloroethyl ethyl sulfideincreases response to substance 17292678
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MPG mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of MPG mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of MPG mRNAincreases expression 16751229
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MPG mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MPG mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of MPG mRNAincreases expression 20504355
D001629 Bezafibrate Bezafibrate results in increased expression of MPG mRNAincreases expression 15447978
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MPG mRNAdecreases expression 15336504
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MPG mRNA]decreases reaction|increases expression 11007951
D003520 Cyclophosphamide Cyclophosphamide affects the expression of MPG mRNAaffects expression 11906922
D002945 Cisplatin Cisplatin analog binds to and affects the activity of MPG proteinaffects activity|affects binding 10891085
C007482 dimethyl sulfate MPG protein results in increased susceptibility to dimethyl sulfateincreases response to substance 15299078
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MPG mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MPG mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MPG mRNAaffects cotreatment|increases expression 17942748
D005027 Ethylene Oxide Ethylene Oxide results in increased expression of MPG proteinincreases expression 16051529
D006918 Hydroxyurea Hydroxyurea results in increased expression of MPG mRNAincreases expression 12929121
C005214 methoxyamine methoxyamine promotes the reaction [MPG protein results in increased susceptibility to Methyl Methanesulfonate]increases reaction|increases response to substance 15299078
C005214 methoxyamine methoxyamine promotes the reaction [MPG protein results in increased susceptibility to temozolomide]increases reaction|increases response to substance 15299078
D008741 Methyl Methanesulfonate methoxyamine promotes the reaction [MPG protein results in increased susceptibility to Methyl Methanesulfonate]increases reaction|increases response to substance 15299078
D008741 Methyl Methanesulfonate MPG protein results in increased susceptibility to Methyl Methanesulfonateincreases response to substance 15299078
D008769 Methylnitronitrosoguanidine MPG protein results in increased susceptibility to Methylnitronitrosoguanidineincreases response to substance 15299078
D008770 Methylnitrosourea MPG protein results in increased susceptibility to Methylnitrosoureaincreases response to substance 15299078
17674369
D009151 Mustard Gas MPG protein results in increased susceptibility to Mustard Gasincreases response to substance 17292678
D010100 Oxygen Oxygen deficiency results in increased expression of MPG mRNAincreases expression 17914565
C047246 temozolomide methoxyamine promotes the reaction [MPG protein results in increased susceptibility to temozolomide]increases reaction|increases response to substance 15299078
C047246 temozolomide MPG protein results in increased susceptibility to temozolomideincreases response to substance 15299078
16024643
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MPG mRNA]decreases reaction|increases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MPG mRNAincreases expression 11007951
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MPG mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MPG mRNAincreases expression 19465110
D014752 Vinyl Chloride Vinyl Chloride analog results in increased expression of MPG mRNAincreases expression 10882851
C016829 vinyl fluoride vinyl fluoride results in increased expression of MPG mRNAincreases expression 10882851
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6415322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.7715814532 12690470 17670903
MESH:D055371 Acute Lung Injury Oxygen 4.3416759491
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.7720464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 9.7711798837 17638652
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.7714692618
MESH:D000230 Adenocarcinoma Methylnitrosourea 9.7715688392 15113128
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.193712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.196695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000799 Angioedema Acetaminophen 3.6310982225
MESH:D000860 Anoxia Oxygen 4.8420872349
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8719183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 9.4815014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5415885639
MESH:D001249 Asthma Mustard Gas 2.6510378619
MESH:D001254 Astrocytoma temozolomide 6.2615865885
MESH:D050197 Atherosclerosis Oxygen 3.6816391483
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8111289319 1440618
MESH:D001661 Biliary Tract Neoplasms Vinyl Chloride 6.6511024202
MESH:D001768 Blister Mustard Gas 4.9519167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.6714601052
MESH:D001932 Brain Neoplasms Ethylene Oxide 9.4512562636
MESH:D001932 Brain Neoplasms Vinyl Chloride 9.4512562636
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6417474063 20146248
MESH:D001943 Breast Neoplasms Cisplatin 3.6418382427 19526202
MESH:D001943 Breast Neoplasms Cyclophosphamide 3.6418234424 12006526 11325840 15093573 17388661 15136595 18323546 16978400 17020986
MESH:D001943 Breast Neoplasms Ethylene Oxide 3.6417162533 11921183
MESH:D001943 Breast Neoplasms Methylnitrosourea 3.6411306469 16253758 14633655
MESH:D001943 Breast Neoplasms Oxygen 3.6417263869
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6420435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7617687719 10378619
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.5516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.5516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.557296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.553084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 13.5517982673
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 13.5519701751
MESH:D006528 Carcinoma, Hepatocellular Vinyl Chloride 13.5510699891 12958735 15289165 12828392
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.6816152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9616685392 12023789
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.367296757
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 6.3616201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5520419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 4.5518337622 17066447 6189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2516120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 7.1510977129
MESH:D002386 Cataract Methylnitrosourea 7.1512484553
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.956135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.957505956
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 14.952727394
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 14.957505956 2727394
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.359022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3511677210 17681005 15861022 16105132 17110522 17333356 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0216354765 15340226 12621046 8697196 15668235
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3215273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 10048152 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.2018551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.2018551238
MESH:D003556 Cystitis Cyclophosphamide 4.7717010015 18093676 16651033 10498854 12161096 12913760 11948286 18483878 18710439 18295254 17979934 18433785 10700343 15643279 16989017 18372110 15276878 16614059 12388444 16413132
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6111298694 12868966 8970840 8156756 2524372 18759878 14531868 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.303621924 2952479
MESH:D009783 Dermatitis, Occupational Vinyl Chloride 5.5010870345
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.9010990075 15331540 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1618772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.3121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.3121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.319328219 6482804 18692083 6679447 7440962 1440618 18289764 8291058 11289319 9022650 16192314 9653073 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.3111739529 16109766 2444490 16781746 11743745 19416960 19923254 11461765 12392966 10915739 12540782 11287661 11529661 12958197 19739265 11834606 12153990 16485898 10774834 16177239 15619225 15968718 19420014 16227642 14550746 19085960 10663392 18071297 18713872 14725611 12594235 16393943 19164858 14986274 16081117 17906064 12705907 17522070 19370779 11421492 17562736
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.3120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8919426721
MESH:D004362 Drug Toxicity Cisplatin 7.6715033597 12649298 19839026 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.6711462148
MESH:D004417 Dyspnea Oxygen 4.6220016425
MESH:D004487 Edema Mustard Gas 6.2211428647 9260866 11428631 11402378
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6916714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9912538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.849294722 10568697
MESH:D004802 Eosinophilia Cyclophosphamide 4.0111006010
MESH:D004890 Erythema Mustard Gas 4.959357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.953581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.9516530937
MESH:D004938 Esophageal Neoplasms Cisplatin 6.9516785472 15464296 16481741 15173087 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8611564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.7215345470
MESH:D005234 Fatty Liver Vinyl Chloride 7.7212197357
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.816705139
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.0211555667
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.7420067830
MESH:D005739 Gas Poisoning Oxygen 5.0120016425
MESH:D005756 Gastritis Acetaminophen 3.4616983495
MESH:D005909 Glioblastoma temozolomide 4.7715865885
MESH:D005910 Glioma Methylnitrosourea 6.729825942
MESH:D005910 Glioma temozolomide 6.7216327979 10871815
MESH:D018316 Gliosarcoma Cyclophosphamide 5.3011389073
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.847505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.8316376943 15172196 11014644
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.5815102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.1219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2515464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.0820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0810048152 11294989
MESH:D006390 Hemangioendothelioma Vinyl Chloride 5.9615380572
MESH:D006393 Hemangiopericytoma Vinyl Chloride 6.6510964802
MESH:D006394 Hemangiosarcoma Vinyl Chloride 5.0712828392 12762079 12958735 11217710 12211074 15999577 15989139
MESH:D006467 Hemophilia A Cyclophosphamide 5.0811918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.3214986274
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.316705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6916120746 15340226 12621046
MESH:D006689 Hodgkin Disease Cisplatin 7.2016200630 16170182
MESH:D006689 Hodgkin Disease Cyclophosphamide 7.2017606976 16135485
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.838697196 18606429 16959395 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.5416870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7315034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016945680 16569931
MESH:D007154 Immune System Diseases Cyclophosphamide 5.1216076520
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male Cyclophosphamide 10.5916517039 7193160
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.5917937319
MESH:D007248 Infertility, Male Methylnitrosourea 10.597193160
MESH:D007249 Inflammation Mustard Gas 4.698975870 11428647 9260866 16001271 11428620 9357497 17524151 11428631 11402378
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.6912200463 12878042
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.818074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1516580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.9315464296
MESH:D007674 Kidney Diseases Acetaminophen 5.7315629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 5.7312649298 12231392 18289764 15190930 19839026
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.4416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.4416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.446582329
MESH:D007680 Kidney Neoplasms Vinyl Chloride 16.4412562636
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.5811231351
MESH:D007938 Leukemia Cyclophosphamide 6.9410602166
MESH:D007938 Leukemia temozolomide 6.9417500047
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4117802794 17008537 17296974 18172266 18587576 17658394
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.9310373061
MESH:D007951 Leukemia, Myeloid Hydroxyurea 4.8216532439
MESH:D007970 Leukopenia Cyclophosphamide 4.7510052129 11830472
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.0515526292
MESH:D008103 Liver Cirrhosis Vinyl Chloride 4.4611679801 15354062 15289165 12499459 12958735
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2312878042
MESH:D008107 Liver Diseases Acetaminophen 4.3619460945 11587558 19784758 12587719 19014921 16611625 12969438 16610002
MESH:D008107 Liver Diseases Vinyl Chloride 4.3616270392 15211785
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0517185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.107678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.1020195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.1016984957
MESH:D008113 Liver Neoplasms Vinyl Chloride 10.1010964802 11024202 10629081 11679801 12762079 15999577 12211074
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 17.342876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.34598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.3412151625
MESH:D008114 Liver Neoplasms, Experimental Vinyl Chloride 17.3412562636
MESH:D008114 Liver Neoplasms, Experimental vinyl fluoride 17.3412562636
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.2616080182
MESH:D008171 Lung Diseases 2-chloroethyl ethyl sulfide 7.6218675330 12815614 16252256
MESH:D008171 Lung Diseases Mustard Gas 7.6218702808 18161513
MESH:D055370 Lung Injury Oxygen 4.3018339021
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.5418816296 20064080 18520028 17053015 20464547 20869020 18569708 6695378 20135361
MESH:D008175 Lung Neoplasms Cisplatin 12.5417225452 11798837 6189445
MESH:D008175 Lung Neoplasms Ethylene Oxide 12.5417325976 12562636
MESH:D008175 Lung Neoplasms Methylnitrosourea 12.5418062963
MESH:D008175 Lung Neoplasms Mustard Gas 12.548781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.5419555203 11884234
MESH:D008175 Lung Neoplasms Vinyl Chloride 12.5412958735 12562636
MESH:D008175 Lung Neoplasms vinyl fluoride 12.5412562636
MESH:D008223 Lymphoma Cyclophosphamide 7.5912854902
MESH:D008223 Lymphoma Methylnitrosourea 7.5911418001 16257854
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 10.0016675587
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 10.0014633661
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.0011911406
MESH:D015674 Mammary Neoplasms, Animal Ethylene Oxide 16.3412562636
MESH:D015674 Mammary Neoplasms, Animal Vinyl Chloride 16.3412562636
MESH:D015674 Mammary Neoplasms, Animal vinyl fluoride 16.3412562636
MESH:D008325 Mammary Neoplasms, Experimental Ethylene Oxide 6.6911921183
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 6.6910767621 15113128 15688392 11807958 16619500 16051031 16827153 16944150 14999141 15313902 12931682 17131329 14633655 19196723 17020996 11751437 10838139
MESH:D008545 Melanoma Cisplatin 4.0811135225 17761969 16809738 18505091 12883367 17023156 18176117 16432458 12393984 16248763 18332650 15577323 12374674
MESH:D008545 Melanoma temozolomide 4.0816260697 16432458 12374674 16260693 18281670 10623706 17576461 15577323 16225601 16248763 17623835 12829675
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.5615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 10.1419513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 10.1416388313
MESH:D008654 Mesothelioma Cisplatin 3.1617638057
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.6817671175
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0316381670
MESH:D009135 Muscular Diseases Bezafibrate 5.2216239165
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.6418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.6418551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.393581430
MESH:D009369 Neoplasms Benzo(a)pyrene 14.6911141357
MESH:D009369 Neoplasms Cisplatin 14.6916773208
MESH:D009369 Neoplasms Cyclophosphamide 14.6918854779
MESH:D009369 Neoplasms Methylnitrosourea 14.6915533788
MESH:D009369 Neoplasms Vinyl Chloride 14.6911911487
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.2712696579
MESH:D009395 Nephritis, Interstitial Cisplatin 4.2815464296
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.786679447
MESH:D009442 Neurilemmoma Methylnitrosourea 5.2711555667
MESH:D009447 Neuroblastoma Cisplatin 11.148761367
MESH:D009447 Neuroblastoma Cyclophosphamide 11.1416115947 15176712 8761367
MESH:D009447 Neuroblastoma temozolomide 11.1415176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7018514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.828761367
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 10.8212837982 8761367
MESH:D009503 Neutropenia Cyclophosphamide 8.888291058
MESH:D009503 Neutropenia Mustard Gas 8.8816761898 7688884
MESH:D009765 Obesity 2-chloroethyl ethyl sulfide 3.7716289378
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 20.1416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 20.1416049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 20.146482804 4026338
MESH:D009784 Occupational Diseases Vinyl Chloride 20.1412061072
MESH:D009845 Oligospermia Cyclophosphamide 4.5016517039
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.813988306
MESH:D010051 Ovarian Neoplasms Cisplatin 2.8119769630 15464296 17225452 6897625
MESH:D010146 Pain Acetaminophen 6.2916870215
MESH:D010146 Pain Cyclophosphamide 6.2912161096 18093676
MESH:D010190 Pancreatic Neoplasms Cisplatin 8.4619003803
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 8.4611332152
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 8.4616965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.287296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.1115464296
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.266228378
MESH:D010997 Pleural Neoplasms Cisplatin 5.1317638057
MESH:D011041 Poisoning Mustard Gas 3.6015727166
MESH:D017285 Polymyositis Vinyl Chloride 6.6511642524
MESH:D011115 Polyneuropathies Ethylene Oxide 5.968472653
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.6921297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9811118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.8117292933
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.8117136230
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.8115682402 12376480
MESH:D011537 Pruritus Ethinyl Estradiol 8.8216919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.8218058305
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.7416636934
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.7417894541 10334151 17266442 17720292 17620002
MESH:D011928 Raynaud Disease Vinyl Chloride 5.9216977343
MESH:D051437 Renal Insufficiency Cisplatin 4.2015464296
MESH:D012128 Respiratory Distress Syndrome, Adult 2-chloroethyl ethyl sulfide 9.2318257742 12210543 16292752
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 9.2317627322 18339021
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.603692021
MESH:D012162 Retinal Degeneration Methylnitrosourea 8.6018155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 5.2711555667
MESH:D012509 Sarcoma Vinyl Chloride 5.1712828392
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.2314601052
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 11.0816636934
MESH:D012595 Scleroderma, Systemic Vinyl Chloride 11.0814979077
MESH:D012640 Seizures 2,4-dinitrotoluene 5.4018551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.4018551238
MESH:D012871 Skin Diseases Mustard Gas 2.6612880345 15451306 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.8210029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.828532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8216192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.1315464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7316709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.3016517039
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.6820155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 4.6818396642 17522103 15958060
MESH:D013274 Stomach Neoplasms Methylnitrosourea 4.6816257854 15930296 18593901
MESH:D013274 Stomach Neoplasms Vinyl Chloride 4.6812562636
MESH:D013398 Sudden Infant Death Oxygen 5.3312563064
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.8512837982
MESH:D013736 Testicular Neoplasms Cisplatin 4.4315464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.0211418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.946582329 1399818 7505956 6587162 3712494
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 6.947505956 3078959
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 18.8216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 18.8216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 18.828074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 18.8217053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 18.8217225452 15464296 12973940
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 18.8214692829
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.2810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.2810091137
MESH:D014581 Urticaria Acetaminophen 2.7810982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.0216803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.4314692618
MESH:D014594 Uterine Neoplasms Ethylene Oxide 9.4312562636 17325976
MESH:D014625 Vaginal Neoplasms Cisplatin 10.9615577323
MESH:D014625 Vaginal Neoplasms temozolomide 10.9615577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D014839 Vomiting Cisplatin 4.5111897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
Pathway ID Pathway Name
KEGG:03410 Base excision repair
REACT:216 DNA Repair
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30917
    • No data
    No data
    Releated drug ID Related drug Name
    PA448691busulfan
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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