AutismKB 2.0

Annotation Detail for MPI


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Basic Information Top
Gene Symbol:MPI ( FLJ39201,PMI,PMI1 )
Gene Full Name: mannose phosphate isomerase
Band: 15q24.1
Quick LinksEntrez ID:4351; OMIM: 154550; Uniprot ID:MPI_HUMAN; ENSEMBL ID: ENSG00000178802; HGNC ID: 7216
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
MANNCAT-PWYD-mannose degradation
PWY-5659GDP-mannose biosynthesis
COLANSYN-PWYcolanic acid building blocks biosynthesis
Pathway IDPathway Name
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
hsa00051Fructose and mannose metabolism
Pathway IDPathway Name
Metabolism of proteins
No data
Pathway IDPathway Name
P02752Mannose metabolism
Pathway IDPathway Name
500553Synthesis of GDP-mannose
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of glycan/glycoprotein metabolism
H00118Congenital disorders of glycosylation (CDG) type I
Genetic disorders
No data
No data
No data
Desease Name
Carbohydrate-deficient glycoprotein syndrome, type Ib
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of MPI mRNAincreases expression 19774075
C006253 pirinixic acid pirinixic acid results in decreased expression of MPI mRNAdecreases expression 17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.7218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.3716434500
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.3118218290 18057881 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 4.2718651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.9719483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.9719483382
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 3.0215710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.9718974383
MESH:D002779 Cholestasis pirinixic acid 3.1919176532
MESH:C535740 Congenital disorder of glycosylation type 1B marker/mechanism
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.6118249437
MESH:D056486 Drug-Induced Liver Injury Amiodarone 2.4915265979 18218290
MESH:D004487 Edema pirinixic acid 3.0212083418
MESH:D005234 Fatty Liver Amiodarone 9.6914986274
MESH:D005234 Fatty Liver pirinixic acid 9.6919236843 20131406
MESH:D006333 Heart Failure pirinixic acid 2.8120558911
MESH:D006529 Hepatomegaly Amiodarone 11.2615265979
MESH:D006529 Hepatomegaly pirinixic acid 11.2618467677 19772884 19176532 16221962
MESH:D006937 Hypercholesterolemia Amiodarone 4.429751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.6920558911
MESH:D007037 Hypothyroidism Amiodarone 5.2817991464 18020914
MESH:D007333 Insulin Resistance pirinixic acid 2.9316306350
MESH:D008064 Lipidoses Amiodarone 3.8517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9520007298 15890375 16377806
MESH:D008133 Long QT Syndrome Amiodarone 3.9611989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.6812587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.5518516814
MESH:D009135 Muscular Diseases pirinixic acid 4.2716239165
MESH:D009181 Mycoses Amiodarone 5.9712754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.3019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.3316411023
MESH:D009369 Neoplasms pirinixic acid 2.1417405874
MESH:D009765 Obesity pirinixic acid 1.9020558911
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9912832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.5819058328
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.9718724381
MESH:D013276 Stomach Ulcer Amiodarone 3.8618087811
MESH:D013610 Tachycardia Amiodarone 4.9611238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.8619225199
MESH:D013959 Thyroid Diseases Amiodarone 5.8319731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.6218020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 5.0811989578 17467628
Pathway ID Pathway Name
KEGG:00520 Amino sugar and nucleotide sugar metabolism
KEGG:00051 Fructose and mannose metabolism
KEGG:01100 Metabolic pathways
REACT:17015 Metabolism of proteins
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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