AutismKB 2.0

Annotation Detail for MPL


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Basic Information Top
Gene Symbol:MPL ( C-MPL,CD110,MPLV,TPOR )
Gene Full Name: myeloproliferative leukemia virus oncogene
Band: 1p34.2
Quick LinksEntrez ID:4352; OMIM: 159530; Uniprot ID:TPOR_HUMAN; ENSEMBL ID: ENSG00000117400; HGNC ID: 7217
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
Pathway IDPathway Name
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00227Congenital amegakaryocytic thrombocytopenia
Desease IDDesease Name
1809HIV infection
1824Bone disease
1858Hemorrhagic disorder
2114Thrombocytopenia
2173Hematopoietic system disease
2188Bone marrow disease
2201Myeloproliferative disease
2222Polycythemia
2226Thrombocytosis
Desease Name
Thrombocytosis
Myeloproliferative Disorders
No data
Desease Name
Thrombycytosis, susceptibility to
Thrombocythemia, essential
Thrombocytopenia, congenital amegakaryocytic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MPL mRNAdecreases expression 18648102
C006632 arsenic trioxide arsenic trioxide results in decreased expression of MPL mRNAdecreases expression 15761015
D001554 Benzene Benzene results in decreased expression of MPL mRNAdecreases expression 15120971
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3611798837 19825857
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.983712494
MESH:D000741 Anemia, Aplastic Benzene 4.7217661222 14761424 11369114
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.8911289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.1516206674
MESH:D001855 Bone Marrow Diseases Benzene 6.1016183116
MESH:D001943 Breast Neoplasms Benzene 2.8511921183 17162533
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.8611589617
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.187296757 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1816217749 11135700 14691202 15073043 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.7419014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.847296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5712490120
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.057505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.479022650 19486331
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8720501625
MESH:C535982 Congenital amegakaryocytic thrombocytopenia marker/mechanism
MESH:D023903 Coronary Restenosis arsenic trioxide 4.7712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.0010525206
MESH:D019465 Craniofacial Abnormalities Benzene 3.0015643154
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.6315213294
MESH:D003872 Dermatitis Benzene 5.4215902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.442524372 14531868 18759878 11298694 8156756 11906362 12868966 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.022952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0516192314 6482804 18289764 18648102 1440618 11289319 7440962 6679447 9653073 18692083 8291058 9328219 9022650
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.763581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7612903497
MESH:D005234 Fatty Liver arsenic trioxide 3.7715073043
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.896705139
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.8516904648
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.577505956
MESH:D006402 Hematologic Diseases Benzene 5.1816183116
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.106705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5915034207
MESH:D006973 Hypertension Benzene 3.2217940673
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.898074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.356582329
MESH:D007938 Leukemia arsenic trioxide 7.1915070760
MESH:D007938 Leukemia Benzene 7.1914694614 18335105 17119257 15935818
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 5.0516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 11.3619077051
MESH:D007951 Leukemia, Myeloid Benzene 11.3617506065
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.3116968895 20471514 16467208 17050201 19850784
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.3119478238
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4817217047 19642359 11161223 17107899 15622746 11468182 15336539 15213294 16330433 16823087 17869043 9834237 12679006 19035177 15748426 17649720 16331271 19075265 19225113 16112521 12018890 17712046 16966277 16891316 12712474
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.9416882451
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4415034207 9327722
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4714682389
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 11.476587162 598648 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 11.4720377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 11.4712562636
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6915213294
MESH:D017563 Lung Diseases, Interstitial Benzene 5.6714698565
MESH:D008175 Lung Neoplasms arsenic trioxide 2.8311798837 19825857
MESH:D008175 Lung Neoplasms Benzene 2.8312562636
MESH:D008223 Lymphoma Benzene 4.0417119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 5.1812562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.5711921183
MESH:D008527 Medulloblastoma marker/mechanism 19270706
MESH:D009101 Multiple Myeloma arsenic trioxide 8.5319417148 15949261 19549372 14977855 11468182
MESH:D009101 Multiple Myeloma Benzene 8.5317119195
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.5418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3616882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.5416624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.613581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 13.806679447
MESH:D009436 Neural Tube Defects arsenic trioxide 13.8010525206
MESH:D009436 Neural Tube Defects Benzene 13.8015643154
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 10.686482804 4026338
MESH:D009784 Occupational Diseases Benzene 10.6815913788 17119257 16737584 17479406 15612468 15935809 15727169 17178637 15576619
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.893988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.4619769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Benzene 5.4612562636
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6415580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.137296757
MESH:D010235 Paraganglioma arsenic trioxide 4.6919927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.346228378
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2019131511
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.703692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.5416646077
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.7617007042
MESH:D013274 Stomach Neoplasms Benzene 2.7612562636
MESH:D013920 Thrombocythemia, Essential marker/mechanism
MESH:D013953 Thymus Neoplasms Benzene 5.7010850423
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.316587162 7505956 6582329 3712494 1399818
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.3119014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.7015213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.548074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.5412845720 20435036 12973940 11780464
MESH:D014594 Uterine Neoplasms Benzene 4.9112562636
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
REACT:604 Hemostasis
KEGG:04630 Jak-STAT signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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