AutismKB 2.0

Annotation Detail for MPP1


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Basic Information Top
Gene Symbol:MPP1 ( AAG12,DXS552E,EMP55,MRG1,PEMP )
Gene Full Name: membrane protein, palmitoylated 1, 55kDa
Band: Xq28
Quick LinksEntrez ID:4354; OMIM: 305360; Uniprot ID:EM55_HUMAN; ENSEMBL ID: ENSG00000130830; HGNC ID: 7219
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MPP1 mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of MPP1 mRNAincreases expression 15003993
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of MPP1 mRNAincreases expression 17961207
D002994 Clofibrate PPARA protein affects the reaction [Clofibrate results in increased expression of MPP1 mRNA]affects reaction|increases expression 17585979
D004041 Dietary Fats Dietary Fats results in decreased expression of MPP1 mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MPP1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MPP1 mRNAincreases expression 17942748
C041786 palm oil palm oil results in decreased expression of MPP1 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MPP1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of MPP1 mRNAincreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MPP1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of MPP1 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of MPP1 mRNAincreases expression 18301758
20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of MPP1 mRNA]increases expression|increases reaction 20059764
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.726195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.0917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0916434500
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.7915238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.7911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Clofibrate 9.9019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.9019483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.2620435547
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.963084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.966705139 17173139 20007298 1701930 20935162
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 3.661399818
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2516105132 11677210 17333356 15861022 17681005 17110522 16919318
MESH:D002779 Cholestasis pirinixic acid 8.2519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6310774834 12958197 2444490 19370779 14550746 19739265 19923254 16781746 10663392 19085960 10915739 19416960 12540782 16177239 15619225 11461765 12153990 16227642 11529661 11421492 19420014 18071297 11739529 14986274 11743745 11834606 12392966 16109766 18713872 15968718 12594235 17562736 19164858 16485898 14725611 16081117 11287661 16393943 17906064 17522070 12705907
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D050171 Dyslipidemias Clofibrate 9.3016707586
MESH:D050171 Dyslipidemias Dietary Fats 9.3018367378
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.1911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D005234 Fatty Liver Clofibrate 20.5719224547
MESH:D005234 Fatty Liver Dietary Fats 20.5717967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.5715345470
MESH:D005234 Fatty Liver pirinixic acid 20.5719236843 20131406
MESH:D005355 Fibrosis Dietary Fats 3.7818296743
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006529 Hepatomegaly Phenobarbital 9.3616109766
MESH:D006529 Hepatomegaly pirinixic acid 9.3619772884 16221962 18467677 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Dietary Fats 2.5220412841
MESH:D007333 Insulin Resistance Dietary Fats 7.6718457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.6716306350
MESH:D007674 Kidney Diseases Acetaminophen 6.5715629191 12587719
MESH:D007674 Kidney Diseases Cadmium Chloride 6.5716962696
MESH:D008103 Liver Cirrhosis Dietary Fats 7.0118296743
MESH:D008103 Liver Cirrhosis Phenobarbital 7.0121047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.0812587719 19460945 11587558 12969438 16611625 19784758 16610002 19014921
MESH:D008107 Liver Diseases Phenobarbital 4.0819363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms Phenobarbital 4.6919812893 21047994 8742319 19482888 19073162 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 4.6920007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.826150874 1399818 2563599 17172636 18308698
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 5.209802331
MESH:D009765 Obesity Dietary Fats 4.5811836018 17217161 16723640 21332399 18457598 20518802 20132043 18674790 19632207
MESH:D009765 Obesity pirinixic acid 4.5820558911
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5516965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D011230 Precancerous Conditions Phenobarbital 3.802563599
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012640 Seizures Phenobarbital 2.824039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.778532709
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.211399818
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30924
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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