AutismKB 2.0

Annotation Detail for MRE11A


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Basic Information Top
Gene Symbol:MRE11A ( ATLD,HNGS1,MRE11,MRE11B )
Gene Full Name: MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Band: 11q21
Quick LinksEntrez ID:4361; OMIM: 600814; Uniprot ID:MRE11_HUMAN; ENSEMBL ID: ENSG00000020922; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03450Non-homologous end-joining
hsa03440Homologous recombination
Pathway IDPathway Name
DNA Repair
Pathway IDPathway Name
200174BARD1 signaling events
200072Regulation of Telomerase
No data
Pathway IDPathway Name
500950Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
Related Diseases/Disorders Top
Desease IDDesease Name
H00094DNA repair defect
Immune system diseases
Primary immunodeficiency
Desease IDDesease Name
1740Alzheimer's disease
1944Breast cancer
1841Stomach cancer
2011Leukoencephalopathy
2053Colon cancer
2066Lung cancer
2082Ataxia telangiectasia
2118Adenovirus infection
2154Adenoma
2161Hodgkin's disease
No data
No data
Desease Name
Ataxia-telangiectasia-like disorder
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031903 1-UFT protocol MRE11A protein results in decreased susceptibility to 1-UFT protocoldecreases response to substance 16734730
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MRE11A mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MRE11A mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MRE11A mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of MRE11A mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MRE11A mRNAaffects expression 16483693
C110904 capecitabine MRE11A protein results in decreased susceptibility to capecitabinedecreases response to substance 16734730
C099555 CD 437 CD 437 results in decreased expression of MRE11A proteindecreases expression 15059897
D016572 Cyclosporine Cyclosporine results in decreased expression of MRE11A mRNAdecreases expression 20106945
C014347 decitabine decitabine affects the localization of MRE11A protein modified formaffects localization 17991895
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of MRE11A mRNAincreases expression 17854601
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of MRE11A proteinincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MRE11A mRNA]decreases reaction|increases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MRE11A protein]decreases reaction|increases expression 17854601
C025034 doxifluridine MRE11A protein results in decreased susceptibility to doxifluridinedecreases response to substance 16734730
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of MRE11A mRNAdecreases expression 12057914
C006253 pirinixic acid pirinixic acid results in increased expression of MRE11A mRNAincreases expression 17950772
18301758
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of MRE11A mRNA]increases expression|increases reaction 17950772
D012402 Rotenone Rotenone results in increased expression of MRE11A mRNAincreases expression 18191903
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.1511850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 9.1518653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.723712494
MESH:D000236 Adenoma Diethylnitrosamine 6.7210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.2617162532 17620307 18056438 19061943 16434500 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.2616434500
MESH:D000799 Angioedema Acetaminophen 3.9110982225
OMIM:604391 ATAXIA-TELANGIECTASIA-LIKE DISORDER marker/mechanism
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0811289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1719483382
MESH:D001943 Breast Neoplasms capecitabine 2.1512972520 18473752
MESH:D001943 Breast Neoplasms decitabine 2.1518320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1517474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.9116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.9116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.913581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.913084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.9120935162 16878318 17428255 16540662 17761372 19107877 16328049 20007298 20514400 19919837 17173139 18665156 17055752 21159647 16935385 16681979 11831363 18785209 3084413 3581430 20214788 17162532 19539802 10737359 16569478 18971187 16288022 19394651 19052882 18788625 18393292 19519916 17138121 19383236 19171122 16779866 19208518 18978308 17978847 20432363 20524982 20101231 20727157 20084675 18210153 16698587 19701751 19335982 18506893 19418558 16502159 18494052 10672840 18056438 16830150 19822196 16807293 20512989 18691550
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.697296757
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6019215824
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.176135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.177505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.1712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.1717174075 2727394 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7119052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.5019486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.5019486331
MESH:D002779 Cholestasis pirinixic acid 13.5019176532
MESH:D003110 Colonic Neoplasms decitabine 2.3417616700
MESH:D015179 Colorectal Neoplasms capecitabine 3.1218473752 18448328
MESH:D015179 Colorectal Neoplasms decitabine 3.1218981723
MESH:D003329 Coronary Vasospasm capecitabine 5.8417465463
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.0418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.0418551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8414531868 12868966 2524372 11298694 11906362 18759878 8156756 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.523621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2020387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.1018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.1021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.1018289764 7440962 9653073 6482804 18692083 9328219 8291058 11289319 18648102 1440618 9022650 6679447 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.1011529661 16227642 19370779 16109766 19923254 10915739 14550746 11287661 11421492 11461765 18713872 16781746 17562736 14725611 11739529 12958197 11743745 19739265 12594235 18071297 12540782 19085960 15619225 12705907 2444490 11834606 16393943 14986274 10663392 16081117 17522070 16177239 10774834 17906064 19420014 19416960 12153990 15968718 16485898 12392966 19164858
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.1019107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004487 Edema pirinixic acid 2.5112083418
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1819294695
MESH:D019446 Endotoxemia Lipopolysaccharides 4.4515821434 17637181 15328337
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1816302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.113581430
MESH:D005234 Fatty Liver Cyclosporine 13.2219224547
MESH:D005234 Fatty Liver Diethylnitrosamine 13.2220387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 13.2219236843 20131406
MESH:D005334 Fever Lipopolysaccharides 4.0411852909 9205823
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.086705139
MESH:D005355 Fibrosis Cyclosporine 3.1812639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.077505956
MESH:D006258 Head and Neck Neoplasms decitabine 3.5019215824
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4116366002
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.556705139
MESH:D006529 Hepatomegaly pirinixic acid 3.0416221962 19176532 18467677 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9815034207
MESH:D006973 Hypertension Cyclosporine 2.1110903974
MESH:D007248 Infertility, Male decitabine 3.2217581917
MESH:D007249 Inflammation Diethylnitrosamine 5.3218785209
MESH:D007249 Inflammation Lipopolysaccharides 5.3212878042 9205823 17237260 17963957 17255318
MESH:D007333 Insulin Resistance pirinixic acid 2.6516306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6617255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.088074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.8518776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.9416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.9416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.946582329
MESH:D007680 Kidney Neoplasms Cyclosporine 17.9412371664
MESH:D007938 Leukemia decitabine 3.0819235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.0318454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3819387464 17679729 18460780 19010910 18704418 18206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5218055864
MESH:D007970 Leukopenia Lipopolysaccharides 4.7515821434
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8418522880 19638242 20032147 18665156 18407596
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.5212878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5215474484
MESH:D008107 Liver Diseases Acetaminophen 3.9319460945 16610002 12969438 16611625 19014921 11587558 12587719 19784758
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9317034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.457678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.4519090486 18644402 2422723 19638242 20434301 18977376 16942905 12771043 21047994 20101389 19642983 19254457 19850985 18648771 21167192 20452335 21071580 19812893 2862719 19294768 20118626 15175105 19551842 12112319 20405173 19690152 19073162 19426721 15885732 18754104 20501860 20137499 20492335 21278145 10737359 19499222 19427195 9163691 20583210 19256749 19833225 18978307 19996281 19255062
MESH:D008113 Liver Neoplasms pirinixic acid 7.4520007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.942876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.94598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.943124819 18775883 2563599 18079962 19004024 18544905 17942915 18164116 19009564 18253720 18308698 19539802 16842330 16267830 9362446 21159647 17854601 18282651 17174075 18093689 19126423 19519916
MESH:D055370 Lung Injury Lipopolysaccharides 4.0521114838
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 21163286 20512841 20970405
MESH:D008223 Lymphoma decitabine 3.4419470736
MESH:D008545 Melanoma decitabine 2.2516505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009101 Multiple Myeloma decitabine 3.3618172295
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4019157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.527678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.743581430
MESH:D009362 Neoplasm Metastasis capecitabine 9.7412972520
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.749029167 3581430
MESH:D009369 Neoplasms capecitabine 8.5516374040
MESH:D009369 Neoplasms decitabine 8.5517925555 19116145 19470736
MESH:D009369 Neoplasms pirinixic acid 8.5517405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3119348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.9015790535 17356569 18619942
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.936679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.2618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.2620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1820387270
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.2312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.2316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.236482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.083988306
MESH:D010051 Ovarian Neoplasms CD 437 5.3517474084
MESH:D010051 Ovarian Neoplasms decitabine 5.3519331143 19259094
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.3919294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3916540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.527296757
MESH:D010300 Parkinson Disease Rotenone 2.9916412576 19232380 16140633 18619942 18191903 11535288 19114014 11445065 15451049
MESH:D020734 Parkinsonian Disorders Rotenone 4.1015574749 15927086 18197244 15795934
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.536228378
MESH:D011014 Pneumonia Lipopolysaccharides 4.6011605937 12224865
MESH:D011230 Precancerous Conditions Cyclosporine 9.0312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.032563599
MESH:D055728 Primary Myelofibrosis decitabine 4.7717616702
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7510835634
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.393692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.4319155313
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9318551238
MESH:D013274 Stomach Neoplasms decitabine 2.5419037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.5418456281
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.1915821434
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.126582329 1399818 6587162 3712494 7505956
MESH:D013964 Thyroid Neoplasms decitabine 12.1217967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.127505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.9416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.9416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 15.948074119
MESH:D001749 Urinary Bladder Neoplasms CD 437 15.9416720286
MESH:D001749 Urinary Bladder Neoplasms decitabine 15.9417616700 19087683
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.1610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.1610091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014604 Uveal Neoplasms decitabine 4.9817785578
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
REACT:216 DNA Repair
KEGG:03440 Homologous recombination
REACT:27271 Meiotic Recombination
KEGG:03450 Non-homologous end-joining
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30934
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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