AutismKB 2.0

Annotation Detail for MSH2


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Basic Information Top
Gene Symbol:MSH2 ( COCA1,FCC1,HNPCC,HNPCC1,LCFS2 )
Gene Full Name: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
Band: 2p21-p16.3
Quick LinksEntrez ID:4436; OMIM: 609309; Uniprot ID:MSH2_HUMAN; ENSEMBL ID: ENSG00000095002; HGNC ID: 7325
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03430Mismatch repair
hsa05210Colorectal cancer
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Cancers of the digestive system
H00020Colorectal cancer
H00027Ovarian cancer
Cancers of the breast and female genital organs
Desease IDDesease Name
1712Yersinia infection
1934Cancer
1979Testicular dysfunction
2038Gastritis
2252Female reproductive cancer
Desease Name
colorectal cancer
CANCER
endometrial cancer
Lymphoma, Non-Hodgkin
leukemia
No data
Desease Name
Mismatch repair cancer syndrome
Colorectal cancer, hereditary nonpolyposis, type 1
Muir-Torre syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MSH2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MSH2 mRNAdecreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MSH2 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MSH2 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MSH2 mRNAdecreases expression 20064835
D002101 Cacodylic Acid Cacodylic Acid results in decreased expression of MSH2 mRNAdecreases expression 17481689
D002104 Cadmium Cadmium results in decreased activity of MSH2 proteindecreases activity 16677676
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MSH2 mRNAaffects cotreatment|decreases expression 12634122
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MSH2 mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MSH2 mRNAaffects cotreatment|decreases expression 12634122
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of MSH2 mRNAdecreases expression 11906922
D016572 Cyclosporine Cyclosporine results in decreased expression of MSH2 mRNAdecreases expression 20106945
C014347 decitabine decitabine results in decreased methylation of MSH2 promoterdecreases methylation 19032668
C014347 decitabine decitabine results in increased expression of MSH2 mRNAincreases expression 19032668
D016190 Carboplatin Carboplatin results in decreased expression of MSH2 mRNAdecreases expression 18172885
D002945 Cisplatin MSH2 protein affects the susceptibility to Cisplatinaffects response to substance 12185594
D002945 Cisplatin Cisplatin results in decreased expression of MSH2 mRNAdecreases expression 18172885
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of MSH2 mRNAincreases expression 17854601
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of MSH2 proteinincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MSH2 mRNA]decreases reaction|increases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MSH2 protein]decreases reaction|increases expression 17854601
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of MSH2 mRNAdecreases expression 12655037
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of MSH2 geneincreases mutagenesis 16495775
D005472 Fluorouracil Fluorouracil results in decreased expression of MSH2 mRNAdecreases expression 16709241
16557594
D005472 Fluorouracil MSH2 protein affects the susceptibility to Fluorouracilaffects response to substance 18949393
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of MSH2 mRNAincreases expression 16849584
C027185 indirubin indirubin results in decreased expression of MSH2 mRNAdecreases expression 15056799
C051890 irinotecan irinotecan metabolite results in decreased expression of MSH2 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of MSH2 mRNAdecreases expression 15956246
C051890 irinotecan MSH2 protein affects the susceptibility to irinotecanaffects response to substance 18949393
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MSH2 mRNAaffects cotreatment|decreases expression 12634122
D001556 Lindane Lindane results in decreased expression of MSH2 mRNAdecreases expression 17785943
C015329 lycopene lycopene results in increased expression of MSH2 mRNAincreases expression 16886892
D008466 Mechlorethamine MSH2 protein affects the susceptibility to Mechlorethamineaffects response to substance 12185594
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of MSH2 mRNAincreases expression 12634122
D008770 Methylnitrosourea Methylnitrosourea promotes the reaction [MSH2 protein binds to MLH1 protein binds to PMS2 protein]affects binding|increases reaction 16204460
D008770 Methylnitrosourea Methylnitrosourea promotes the reaction [MSH2 protein binds to PCNA protein binds to MSH6 protein]affects binding|increases reaction 16204460
D008770 Methylnitrosourea MSH2 protein affects the susceptibility to Methylnitrosoureaaffects response to substance 12185594
C020300 monomethylarsonic acid monomethylarsonic acid results in decreased expression of MSH2 mRNAdecreases expression 17481689
D010126 Ozone Ozone results in increased expression of MSH2 mRNAincreases expression 16716893
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MSH2 mRNAaffects binding|decreases expression|increases activity 19710929
D011743 Pyrimidines MSH2 protein results in increased susceptibility to Pyrimidinesincreases response to substance 15611052
D011743 Pyrimidines MSH2 protein results in increased susceptibility to Pyrimidinesincreases response to substance 15611052
D011794 Quercetin Quercetin results in increased expression of MSH2 mRNAincreases expression 14715546
D011794 Quercetin Quercetin results in increased expression of MSH2 mRNAincreases expression 18095365
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MSH2 mRNAaffects cotreatment|decreases expression 12634122
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MSH2 mRNAincreases expression 19465110
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of MSH2 mRNAdecreases expression 17951470
D014212 Tretinoin Tretinoin results in decreased expression of MSH2 mRNAdecreases expression 18230668
D014501 Uranium Uranium affects the expression of MSH2 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of MSH2 mRNAaffects expression 15672453
C088658 zoledronic acid zoledronic acid results in decreased expression of MSH2 proteindecreases expression 17070308
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.1418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5217505938
MESH:D058186 Acute Kidney Injury Cisplatin 7.8712690470 17670903 15814532
MESH:D058186 Acute Kidney Injury zoledronic acid 7.8719715164
MESH:D055371 Acute Lung Injury pirinixic acid 2.7318653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.0620200999
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.2520127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 12.2511798837 17638652
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.2514692618
MESH:D000230 Adenocarcinoma Fluorouracil 12.2517638652
MESH:D000230 Adenocarcinoma Methylnitrosourea 12.2515113128 15688392
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 13.933712494
MESH:D000236 Adenoma Benzo(a)pyrene 13.936695378
MESH:D000236 Adenoma Diethylnitrosamine 13.936695378 10737359
MESH:D000236 Adenoma Ethylnitrosourea 13.936695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.8517162532 19061943 18056438 19052882 16434500 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.8516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.8516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4716712894 17306315
MESH:D000382 Agricultural Workers' Diseases Lindane 3.9612661182
MESH:D000505 Alopecia Tretinoin 3.2815955085
MESH:D000544 Alzheimer Disease Ozone 2.3415513908
MESH:D000740 Anemia Fluorouracil 7.4817963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.4811748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.8717084956
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6619183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 8.8115014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.8111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.3215885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.3216412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.2915570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.2916292516
MESH:D001249 Asthma Ozone 4.4716373670 17854713
MESH:D001249 Asthma Tretinoin 4.4716456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.5615336622
MESH:D050197 Atherosclerosis Cadmium 3.3915687053
MESH:D001327 Autoimmune Diseases Quercetin 4.0019761891
MESH:D001471 Barrett Esophagus Tretinoin 4.0016935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.5911289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.1119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.1112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.1116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4915746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.4614601052
MESH:D001859 Bone Neoplasms zoledronic acid 4.5711697798 15867366 19442620 16121404 17312309 16778634
MESH:D001862 Bone Resorption zoledronic acid 4.3311869084 18404659 16769263 8053405 15845617 18496637
MESH:D001927 Brain Diseases Ethylnitrosourea 4.5214991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 3.9316357521 16436596 18412241 16651633 15144691
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 10.4117474063 20146248
MESH:D001943 Breast Neoplasms Cacodylic Acid 10.4117474063
MESH:D001943 Breast Neoplasms Cisplatin 10.4118382427 19526202
MESH:D001943 Breast Neoplasms Cyclophosphamide 10.4117388661 12006526 18234424 16978400 11325840 15136595 17020986 15093573 18323546
MESH:D001943 Breast Neoplasms decitabine 10.4118320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 10.4117474063
MESH:D001943 Breast Neoplasms Fluorouracil 10.4119217205 18608205 15136595 18357371 16110121 16557594 16595493
MESH:D001943 Breast Neoplasms Lindane 10.4114688026
MESH:D001943 Breast Neoplasms Methylnitrosourea 10.4116253758 14633655 11306469
MESH:D001943 Breast Neoplasms Quercetin 10.4118628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 10.4120435547
MESH:D001943 Breast Neoplasms Tretinoin 10.4116166294 16873071 16443354
MESH:D001943 Breast Neoplasms zoledronic acid 10.4118695136 16096432
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3516777450 14754758 17626835 15516495 19059883 18417511 18315731
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1716813970
MESH:D002057 Burns, Chemical Mechlorethamine 5.819625245
MESH:D002100 Cachexia Ozone 4.3216183385
MESH:D002105 Cadmium Poisoning Quercetin 5.1216962696
MESH:C537421 Cafe au lait spots, multiple marker/mechanism
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2416051944
MESH:D002277 Carcinoma Fluorouracil 7.0917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.0916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 21.1916705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 21.193581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 21.1912907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 21.1917982673
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 21.1919701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 21.1916540662 20432363 17138121 19519916 20727157 18056438 19383236 18978308 3084413 19394651 18494052 19335982 20101231 3581430 20214788 19418558 18393292 20524982 19107877 20084675 17978847 18785209 20512989 18691550 18788625 16681979 19539802 20007298 10672840 18665156 16878318 18506893 17173139 17428255 17055752 19701751 19052882 18971187 19208518 20935162 19919837 16807293 16288022 21159647 18210153 10737359 16502159 19822196 16569478 16779866 17761372 11831363 17162532 16698587 20514400 16830150 19171122 16328049 16935385
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 21.1916332177 17088986 17971768 18930000 16799960 17045692
MESH:D006528 Carcinoma, Hepatocellular Quercetin 21.1912508355 19519916
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 21.1917306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 21.191917145
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.4716152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung Carboplatin 8.3416685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 8.3412023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 8.3419233551
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.5517234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 13.717296757
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 13.7116201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 13.7118695887
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 13.7118507039
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 16.2720419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 16.2717066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell decitabine 16.2719215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 16.2716757204 16280240 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 16.2718572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 16.2716051514 16096774
MESH:D006332 Cardiomegaly Quercetin 6.0019794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.0018670907 18850075 16120746
MESH:D002386 Cataract Methylnitrosourea 6.9012484553
MESH:D002386 Cataract Tretinoin 6.9017460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 32.267505956
MESH:D002471 Cell Transformation, Neoplastic Cadmium 32.2617332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 32.2612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 32.2617174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 32.2616003739
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 32.262727394
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 32.262727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 32.2619524636 20056578
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.5617160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1716129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.1519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.1516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 16.669022650 19486331
MESH:D002779 Cholestasis Cyclosporine 16.6619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.6616919318 17110522 16105132 11677210 15861022 17333356 17681005
MESH:D002779 Cholestasis pirinixic acid 16.6619176532
MESH:D002822 Choriocarcinoma Tretinoin 4.7316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.1415668235 15340226 12621046 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.149407595
MESH:D003092 Colitis Tretinoin 3.3017035595
MESH:D003110 Colonic Neoplasms decitabine 7.5717616700
MESH:D003110 Colonic Neoplasms Fluorouracil 7.5717725105 16340194 16510598 18772588 15001691 17172411 17287894 17018589 17016597 17169374
MESH:D003110 Colonic Neoplasms irinotecan 7.5717725105 17287894
MESH:D003110 Colonic Neoplasms Quercetin 7.5711134977 17148506 19056647 16640504 19440933 15741050 17191121
MESH:D015179 Colorectal Neoplasms marker/mechanism 18949393
MESH:D015179 Colorectal Neoplasms Cisplatin 5.9615273666
MESH:D015179 Colorectal Neoplasms decitabine 5.9618981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 5.9620501625 18448328 16303861 16391804 18383874 18949393 17454858 18288408 16282729 17094418 16331619 15148649 16524972 14970324 17401013 17594712 18802399 17255274 18509181 17016601 17695437 15289873
MESH:D015179 Colorectal Neoplasms irinotecan 5.9618259882 17454858 17159606 15273666 16391804 16303861 18509181
MESH:D015179 Colorectal Neoplasms Quercetin 5.9618095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7117141729 14669216
MESH:D019465 Craniofacial Abnormalities lead acetate 3.6319769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.639125849 9664655 9211117 16925845 9142499 14991402 8800419 10589399 9224671 17551590
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.6118551238
MESH:D003556 Cystitis Cyclophosphamide 4.5615276878 17010015 12388444 12161096 18372110 18295254 10498854 18710439 15643279 11948286 18433785 18093676 12913760 10700343 16614059 18483878 16413132 16651033 17979934 16989017
MESH:D007644 Darier Disease Fluorouracil 4.3716733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.4212868966 11298694 8156756 14531868 18759878 8970840 2524372 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.112952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 7.5410990075 11751995 15331540
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.5419496084
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.0818772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.8320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.8317107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 7.8021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 7.809653073 18289764 7440962 1440618 11289319 18692083 18648102 6482804 9328219 9022650 16192314 8291058 6679447
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 7.8019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 7.8020420201
MESH:D004362 Drug Toxicity Cisplatin 7.1415033597 12231392 19839026 12649298
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.1411462148
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.5618357618
MESH:D004487 Edema pirinixic acid 5.3212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.3212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.5216714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.5218230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.7912538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.6919294695
MESH:D016889 Endometrial Neoplasms Tretinoin 2.8316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.669294722 10568697
MESH:D004802 Eosinophilia Cyclophosphamide 3.8111006010
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 9.383581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.3816530937
MESH:D004938 Esophageal Neoplasms Cisplatin 9.3817638652 15173087 16785472 16481741 15464296
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.3816337965 17638652 15173087 16785472 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.8011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.809664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 15.6719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 15.6721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.6715345470
MESH:D005234 Fatty Liver pirinixic acid 15.6720131406 19236843
MESH:D005264 Femoral Fractures zoledronic acid 5.4116234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0511858732
MESH:D005317 Fetal Growth Retardation lead acetate 4.9819769572
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.596705139
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.8111555667
MESH:D005355 Fibrosis Cyclosporine 17.8012639820 12168785
MESH:D005355 Fibrosis Quercetin 17.8019474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.8020067830
MESH:D005355 Fibrosis Tretinoin 17.8017994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.808708960
MESH:D005909 Glioblastoma Ethylnitrosourea 10.4016436596
MESH:D005909 Glioblastoma Quercetin 10.4019804834
MESH:D005909 Glioblastoma Tretinoin 10.4017312396
MESH:D005910 Glioma marker/mechanism
MESH:D005910 Glioma Ethylnitrosourea 12.7218412241 16651633 16357521
MESH:D005910 Glioma Fluorouracil 12.7216145905
MESH:D005910 Glioma Methylnitrosourea 12.729825942
MESH:D005910 Glioma Quercetin 12.7217643826
MESH:D018316 Gliosarcoma Cyclophosphamide 5.0911389073
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.657505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1710696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.6316376943 15172196 11014644
MESH:D006258 Head and Neck Neoplasms Cisplatin 16.1215464296 15102660
MESH:D006258 Head and Neck Neoplasms decitabine 16.1219215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 16.1215162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 16.1216096774
MESH:D034381 Hearing Loss Cisplatin 3.9419898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7316084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.0815464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.7520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.7510048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 9.7514991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.2820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0015720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.8811918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9611000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.1114986274
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.126705139
MESH:D006529 Hepatomegaly pirinixic acid 6.9119772884 19176532 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.9115340226 12621046 16120746
MESH:D006689 Hodgkin Disease Cisplatin 10.3716200630 16170182
MESH:D006689 Hodgkin Disease Cyclophosphamide 10.3716135485 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 10.3712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6218606429 8697196 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Tretinoin 7.1016870215
MESH:D006930 Hyperalgesia zoledronic acid 7.1016769263
MESH:D006934 Hypercalcemia zoledronic acid 4.6719622757 18089816
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1616778211
MESH:D006943 Hyperglycemia pirinixic acid 8.0420558911
MESH:D006943 Hyperglycemia Quercetin 8.0411834736 18262572
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5315034207
MESH:D006968 Hypersensitivity, Delayed indirubin 5.5111275354
MESH:D006973 Hypertension Cyclosporine 7.5710903974
MESH:D006973 Hypertension Quercetin 7.5718356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.5718850075 18670907
MESH:D006996 Hypocalcemia zoledronic acid 5.7712669777
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4016569931 16945680
MESH:D007154 Immune System Diseases Cyclophosphamide 4.9016076520
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0812013081
MESH:D007248 Infertility, Male Cyclophosphamide 18.1316517039 7193160
MESH:D007248 Infertility, Male decitabine 18.1317581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 18.1317937319
MESH:D007248 Infertility, Male Methylnitrosourea 18.137193160
MESH:D007248 Infertility, Male sodium arsenite 18.1312646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 4.1518785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.1512200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.0816624496
MESH:D007333 Insulin Resistance pirinixic acid 2.3616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.3617994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.599022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.6916580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.6915992940 17551590
MESH:D007627 Keloid Quercetin 4.5517086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0115604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7115464296
MESH:D007674 Kidney Diseases Cadmium 20.6416962696 16226777 16322080
MESH:D007674 Kidney Diseases Cadmium Chloride 20.6416962696
MESH:D007674 Kidney Diseases Cisplatin 20.6412649298 18289764 19839026 15190930 12231392
MESH:D007674 Kidney Diseases Cyclosporine 20.6418776723 10903974 8314463
MESH:D007674 Kidney Diseases Quercetin 20.6416962696
MESH:D007674 Kidney Diseases sodium arsenite 20.6420008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 19.7516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 19.756582329
MESH:D007680 Kidney Neoplasms Cyclosporine 19.7512371664
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 19.7517379185
MESH:D007680 Kidney Neoplasms Fluorouracil 19.7516985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.3711231351
MESH:D007938 Leukemia Cyclophosphamide 13.2110602166
MESH:D007938 Leukemia decitabine 13.2119235587 18980019
MESH:D007938 Leukemia Quercetin 13.2117468513
MESH:D007938 Leukemia Tretinoin 13.2117143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.3117802794 17296974 18172266 17658394 17008537 18587576
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.3918089816
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.7810373061
MESH:D007951 Leukemia, Myeloid decitabine 8.3219117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 8.3219285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.6718460780 19010910 17679729 18704418 19387464 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.6717596541 16294345 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.0318055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8817712046 19029980 19075265 16766008 9834237 16331271 17339181 15748426 17361223 17649720 17107899 17301526 17368321 19225113 16788101 17217047 16891316 16140955 19642359 12679006 19035177 17506722 16823087 16935935 17294898
MESH:D007970 Leukopenia Cyclophosphamide 4.5510052129 11830472
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 7.4615526292
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.469224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.5918522880 19638242 18407596 18665156 20032147
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.939327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 4.4512741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.4512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.4518397230 16248980
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0417034775
MESH:D008107 Liver Diseases Lindane 4.041715830
MESH:D008113 Liver Neoplasms Aflatoxin B1 22.8915890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 22.8920195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 22.8920101389 10737359 20137499 20492335 12112319 21071580 19294768 20405173 19254457 2862719 18977376 21167192 19690152 16942905 18648771 21047994 20452335 2422723 19850985 19551842 20434301 19642983 18754104 20501860 19812893 19499222 18644402 19833225 15175105 9163691 15885732 19426721 19638242 20118626 12771043 19256749 19255062 18978307 19996281 19073162 20583210 19427195 19090486 21278145
MESH:D008113 Liver Neoplasms Fluorouracil 22.8916603448 18383874 17045692 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 22.8920007298 16377806 15890375
MESH:D008113 Liver Neoplasms Quercetin 22.8918980244
MESH:D008113 Liver Neoplasms sodium arsenite 22.8915276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 22.8916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 15.81598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 15.818603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.8118093689 19539802 9362446 19009564 19126423 18775883 16842330 17854601 17942915 21159647 2563599 16267830 19004024 18079962 18308698 18544905 19519916 18282651 18253720 3124819 17174075 18164116
MESH:D008114 Liver Neoplasms, Experimental Quercetin 15.8119519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.8112151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.0516080182
MESH:D008171 Lung Diseases Ozone 6.5719066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 6.5719095001
MESH:D055370 Lung Injury Ozone 3.4420417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 19.0514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 19.0520869020 18816296 6695378 20464547 18520028 18569708 20135361 20064080 17053015
MESH:D008175 Lung Neoplasms Cisplatin 19.056189445 11798837 17225452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 19.056695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Ethylnitrosourea 19.0517703301 16019985 6695378 16271038
MESH:D008175 Lung Neoplasms Fluorouracil 19.0515246190
MESH:D008175 Lung Neoplasms Methylnitrosourea 19.0518062963
MESH:D008175 Lung Neoplasms Ozone 19.058597069 7614698
MESH:D008175 Lung Neoplasms Quercetin 19.0516280456
MESH:D008175 Lung Neoplasms sodium arsenite 19.0519931552 16712894 17306315 15276417 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 19.0511884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3715086387
MESH:D008223 Lymphoma Cyclophosphamide 15.5112854902
MESH:D008223 Lymphoma decitabine 15.5119470736
MESH:D008223 Lymphoma Ethylnitrosourea 15.5115790496
MESH:D008223 Lymphoma Methylnitrosourea 15.5111418001 16257854
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 9.3616675587
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 9.3614633661
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.8311911406
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.6415375218
MESH:C537261 Lynch syndrome I (site-specific colonic cancer) marker/mechanism
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 8.7610767621 18041768 10838139
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 8.7611751437 15688392 14999141 16051031 16619500 10838139 15113128 17131329 15313902 17020996 11807958 12931682 14633655 16827153 16944150 10767621 19196723
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 8.7617312309
MESH:D008527 Medulloblastoma Tretinoin 2.6117453147
MESH:D008545 Melanoma Carboplatin 8.8711712820 12040289 16225601 16342250
MESH:D008545 Melanoma Cisplatin 8.8717761969 15577323 18505091 18332650 16248763 12393984 16432458 18176117 17023156 11135225 16809738 12374674 12883367
MESH:D008545 Melanoma decitabine 8.8717785578 16505122
MESH:D008545 Melanoma sodium arsenite 8.8716487513 19082730
MESH:D008545 Melanoma Tretinoin 8.8716752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.3615990972
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.3916388313
MESH:D008579 Meningioma Ethylnitrosourea 5.5617943659
MESH:D008591 Meningomyelocele Tretinoin 4.0216940565
MESH:D008654 Mesothelioma Cisplatin 6.1117638057
MESH:D008654 Mesothelioma zoledronic acid 6.1116675582
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3616801185
MESH:D008679 Metaplasia Ozone 4.6810496685
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.4717671175
OMIM:276300 MISMATCH REPAIR CANCER SYNDROME marker/mechanism
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.4616381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.4618986760 16757204
MESH:D052016 Mucositis irinotecan 4.5917159606
MESH:D055653 Muir-Torre Syndrome marker/mechanism
MESH:D009101 Multiple Myeloma decitabine 6.7418172295
MESH:D009101 Multiple Myeloma zoledronic acid 6.7416996129 18089719 19621390
MESH:D009135 Muscular Diseases pirinixic acid 3.1016239165
MESH:D009190 Myelodysplastic Syndromes decitabine 6.6619157545 19010910 18608210 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.6617596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.1019151258
MESH:D009203 Myocardial Infarction Quercetin 5.1019595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6912213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.3716411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.3719207477
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.4418551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 12.153581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 12.153581430 9029167
MESH:D009362 Neoplasm Metastasis irinotecan 12.1518259882
MESH:D009362 Neoplasm Metastasis zoledronic acid 12.1517312309 19139120 15867366
MESH:D009369 Neoplasms Benzo(a)pyrene 46.0011141357
MESH:D009369 Neoplasms Carboplatin 46.0018854779 17925555
MESH:D009369 Neoplasms Cisplatin 46.0016773208
MESH:D009369 Neoplasms Cyclophosphamide 46.0018854779
MESH:D009369 Neoplasms decitabine 46.0017925555 19470736 19116145
MESH:D009369 Neoplasms Fluorouracil 46.0018600527 18239605 16928823
MESH:D009369 Neoplasms Lindane 46.0012807735 16818664
MESH:D009369 Neoplasms lycopene 46.0017051425
MESH:D009369 Neoplasms Methylnitrosourea 46.0015533788
MESH:D009369 Neoplasms pirinixic acid 46.0017405874
MESH:D009369 Neoplasms Quercetin 46.0015185748
MESH:D009369 Neoplasms sodium arsenite 46.0011559025
MESH:D009369 Neoplasms Tretinoin 46.0016946489 16594593
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 13.1016707424
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 13.1012696579
MESH:D009374 Neoplasms, Experimental sodium arsenite 13.1020056578
MESH:D009395 Nephritis, Interstitial Cisplatin 4.0715464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9319348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.1914600291
MESH:D009421 Nervous System Malformations Tretinoin 8.199125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 10.526679447
MESH:D009436 Neural Tube Defects sodium arsenite 10.5212854658
MESH:D009436 Neural Tube Defects Tretinoin 10.529142499
MESH:D009442 Neurilemmoma Ethylnitrosourea 11.8916651423 16003739 17160924
MESH:D009442 Neurilemmoma Methylnitrosourea 11.8911555667
MESH:D009447 Neuroblastoma Cisplatin 10.278761367
MESH:D009447 Neuroblastoma Cyclophosphamide 10.278761367 16115947 15176712
MESH:D009447 Neuroblastoma irinotecan 10.278761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0020387270
MESH:D017599 Neuroectodermal Tumors Carboplatin 23.8112837982
MESH:D017599 Neuroectodermal Tumors Cisplatin 23.818761367
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 23.818761367 12837982
MESH:D017599 Neuroectodermal Tumors irinotecan 23.818761367
MESH:D009456 Neurofibromatosis 1 marker/mechanism
MESH:D020078 Neurogenic Inflammation Quercetin 3.9817929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6920387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1516436463
MESH:D009503 Neutropenia Cyclophosphamide 3.948291058
MESH:D009765 Obesity pirinixic acid 1.7020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.6816049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 7.684026338 6482804
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.5617160924
MESH:D009845 Oligospermia Cyclophosphamide 4.2916517039
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.593988306
MESH:D010014 Osteolysis zoledronic acid 4.9515867366
MESH:D010024 Osteoporosis zoledronic acid 3.7717882678
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.8319495926
MESH:D010051 Ovarian Neoplasms marker/mechanism 19032668
MESH:D010051 Ovarian Neoplasms Cisplatin 13.4219769630 15464296 6897625 17225452
MESH:D010051 Ovarian Neoplasms decitabine 13.4219259094 19331143
MESH:D010051 Ovarian Neoplasms Quercetin 13.4219005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 13.4215276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 13.4216936753
MESH:D010146 Pain Cyclophosphamide 9.5518093676 12161096
MESH:D010146 Pain Tretinoin 9.5516870215
MESH:D010146 Pain zoledronic acid 9.5516475674
MESH:D010190 Pancreatic Neoplasms Cisplatin 26.4819003803
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 26.4811332152
MESH:D010190 Pancreatic Neoplasms decitabine 26.4819294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 26.4816540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 26.4815113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 26.4816965848
MESH:D010190 Pancreatic Neoplasms Quercetin 26.4816965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 26.4815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.087296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8212520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9115464296
MESH:D016491 Peripheral Vascular Diseases Cadmium 4.9615687053
MESH:D010538 Peritonitis Ozone 3.7216369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.046228378
MESH:D010997 Pleural Neoplasms Cisplatin 4.9217638057
MESH:D011014 Pneumonia Ozone 3.9818929643 18381685 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1618163543
MESH:D011230 Precancerous Conditions Cyclosporine 13.2912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 13.292563599
MESH:D011230 Precancerous Conditions Quercetin 13.2919056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.5621297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.7811118676 11222880 11896295 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.3217616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3317292933
MESH:D011471 Prostatic Neoplasms Cadmium 3.3317075824
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 3.3317136230
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3318626508 19082440
MESH:D011471 Prostatic Neoplasms Lindane 3.3314688026 12661182
MESH:D011471 Prostatic Neoplasms lycopene 3.3315084515 17337101
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 3.3312376480 15682402
MESH:D011471 Prostatic Neoplasms Quercetin 3.3317292933 14715546
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3316039940
MESH:D011471 Prostatic Neoplasms zoledronic acid 3.3319103299 12438248
MESH:D011507 Proteinuria Tretinoin 3.2216636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.9015861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.0716882103
MESH:D011625 Pterygium Tretinoin 4.3716723453
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.1116636934
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6618722050 15538739 18286688 16160472
MESH:D051437 Renal Insufficiency Cisplatin 4.0015464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.1719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.073692021
MESH:D012162 Retinal Degeneration Methylnitrosourea 8.0718172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.0711555667
MESH:D012208 Rhabdomyosarcoma decitabine 9.6619155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.6616283617 16116481
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.3814601052
MESH:D012512 Sarcoma, Ewing's zoledronic acid 9.3816121404
MESH:D012554 Schistosomiasis japonica Quercetin 5.1216862918
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.4416636934
MESH:D012640 Seizures 2,4-dinitrotoluene 5.3218551238
MESH:D012640 Seizures Lindane 5.3215475178 12842176 7539098
MESH:D012871 Skin Diseases monomethylarsonic acid 3.8921378128
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 11.8219755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 11.8218572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.8216192470
MESH:D012878 Skin Neoplasms Tretinoin 11.8216467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9215464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5216709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.0916517039
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4712854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 11.7020155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 11.7017522103 15958060 18396642
MESH:D013274 Stomach Neoplasms decitabine 11.7019037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 11.7018456281
MESH:D013274 Stomach Neoplasms Fluorouracil 11.7017172411 16951190 17498489 18396642 16424979 17522103 18567086 15786421 19084572 19015929
MESH:D013274 Stomach Neoplasms irinotecan 11.7015723263
MESH:D013274 Stomach Neoplasms Methylnitrosourea 11.7015930296 16257854 18593901
MESH:D013274 Stomach Neoplasms Tretinoin 11.7017261132
MESH:D015173 Supratentorial Neoplasms Carboplatin 11.0812837982
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 11.0812837982
MESH:D013736 Testicular Neoplasms Cisplatin 4.2417225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8015669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 10.9015790496
MESH:D013953 Thymus Neoplasms Methylnitrosourea 10.9011418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 19.111399818 6582329 7505956 3712494 6587162
MESH:D013964 Thyroid Neoplasms decitabine 19.1117967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 19.117505956
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 19.117505956 3078959
MESH:D013964 Thyroid Neoplasms Tretinoin 19.1116026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 8.6216280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.6216051514
MESH:D014376 Tuberculosis Tretinoin 2.9616040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 29.5416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 29.548074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 29.5417053015
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 29.5415537745
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 29.5415464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 29.5414692829
MESH:D001749 Urinary Bladder Neoplasms decitabine 29.5419087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Quercetin 29.5416720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 29.5411723127 17306315 16452187 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9010091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 19.6616803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 19.6616803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 19.6611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 19.6616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9014692618
MESH:D014604 Uveal Neoplasms decitabine 11.4017785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.4016752155
MESH:D014605 Uveitis Cyclosporine 3.561336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.2015577323
MESH:D014652 Vascular Diseases sodium arsenite 4.0117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1614671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.6616761959
MESH:D014839 Vomiting Cisplatin 4.2911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8215886252
MESH:D009396 Wilms Tumor Tretinoin 3.6116287080
MESH:D014985 Xerophthalmia Cyclosporine 4.0117120751
Pathway ID Pathway Name
KEGG:05210 Colorectal cancer
KEGG:03430 Mismatch repair
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31133
    • No data
    Releated disease ID Related disease Name
    PA444845Lymphoma, Non-Hodgkin
    PA443761Colorectal Neoplasms, Hereditary Nonpolyposis
    PA445204Ovarian Neoplasms
    PA445503Rectal Neoplasms
    Releated drug ID Related drug Name
    PA449197dacarbazine
    PA451609temozolomide
    PA164713220Pyrimidine analogues
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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