AutismKB 2.0

Annotation Detail for MSH3


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Basic Information Top
Gene Symbol:MSH3 ( DUP,MGC163306,MGC163308,MRP1 )
Gene Full Name: mutS homolog 3 (E. coli)
Band: 5q14.1
Quick LinksEntrez ID:4437; OMIM: 600887; Uniprot ID:MSH3_HUMAN; ENSEMBL ID: ENSG00000113318; HGNC ID: 7326
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03430Mismatch repair
hsa05210Colorectal cancer
hsa05200Pathways in cancer
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Cancers of the digestive system
H00020Colorectal cancer
Desease IDDesease Name
1831Prostate cancer
1859Ovarian cancer
2024Basal cell carcinoma
2053Colon cancer
2125Bladder cancer
2237Neoplasm metastasis
Desease Name
Microsatellite Instability
prostate cancer
CANCER
head and neck cancer lung cancer
No data
Desease Name
Endometrial carcinoma
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MSH3 mRNAdecreases expression 20106945
20064835
D002104 Cadmium Cadmium results in decreased activity of MSH3 proteindecreases activity 16677676
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MSH3 mRNAaffects expression 17484886
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of MSH3 mRNA]decreases expression|decreases reaction 11007951
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of MSH3 mRNAdecreases expression 11906922
D016572 Cyclosporine Cyclosporine results in decreased expression of MSH3 mRNAdecreases expression 20106945
C452423 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in decreased expression of MSH3 mRNAdecreases expression 16052530
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of MSH3 mRNA]decreases expression|decreases reaction 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MSH3 mRNAdecreases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MSH3 mRNAdecreases expression 16962184
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MSH3 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 14514962 11752688
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.9015014928
MESH:D050197 Atherosclerosis Cadmium 3.7715687053
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9020146248 17474063
MESH:D001943 Breast Neoplasms Cyclophosphamide 1.9012006526 11325840 15093573 18234424 17020986 17388661 18323546 15136595 16978400
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9020435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0816192424 15721981 3786805 15700767 16227642 16097048 16050911 18705752 10355542 16124888 16011737 15673190
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.3918788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 3.3919701751
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.2316152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.6316201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic Cadmium 7.4517332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.4512371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.198697196 15668235 15340226 16354765 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003556 Cystitis Cyclophosphamide 5.3615276878 10700343 18093676 16614059 15643279 16651033 12388444 18710439 18295254 17010015 12913760 10498854 18433785 16989017 16413132 11948286 18483878 17979934 12161096 18372110
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.2715331540 11751995 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2818772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.927440962 3732212 2869522 15998439 15968718 19336974 19085960 17522070 21278145 11566570 4309450 3786805 16177239 6623471 9327722 7179309 16227642 15027814 10915739 7120509 6884620 10092053
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004802 Eosinophilia Cyclophosphamide 4.5211006010
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.5312631006 17595544 12795759 61145 16045604 19224547 15959796 16239168
MESH:D005234 Fatty Liver Cyclosporine 8.5319224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Carbon Tetrachloride 16.5818705752
MESH:D005355 Fibrosis Cyclosporine 16.5812168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.5820067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D018316 Gliosarcoma Cyclophosphamide 5.8511389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.3416376943 15172196 11014644
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8210048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.6011918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.9114986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2016120746 15340226 12621046
MESH:D006689 Hodgkin Disease Cyclophosphamide 4.0017606976 16135485
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216959395 16354765 8697196 18606429 15340226
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007154 Immune System Diseases Cyclophosphamide 5.7116076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.777193160 16517039
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cadmium 6.7016322080 16226777 16962696
MESH:D007674 Kidney Diseases Cyclosporine 6.708314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D007938 Leukemia Cyclophosphamide 3.5910602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5817008537 17296974 17658394 18587576 18172266 17802794
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.2610373061
MESH:D007970 Leukopenia Cyclophosphamide 5.3010052129 11830472
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9221278145 16943688 16239168 11408273 17157831 16221502 17174718 17334410 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3412609069 12741479 18339082 14748882 16033810 17805973 15650968 18054572 10355542 12898905 15876570 12632514 17631135 17714472 15893842 17481882 18263696 17708605 15362042 17698563 12632512 17557913 16097048 17869086 17823541 18472332 14716496 14620537 18705752 15996030 14716833 18376398 12445421 15931870 15057751 12546737 15959796 18251166 18481824 18472094 16192424 18277467 17976157 18395914 16015684 16638106 13678700 17761835 18156304 18006644 16011737 15818738 18279442 17922224 17640975 18210741 18420326 15730626 17565644 12649538 18395095 12958196 18187930 16248980 14724832 12389079 17900296 15925388 16027843 12445418 20821823 16136751 17525996 12586293 17944888 14512876 11481614 15673190 15123356 15338365 18166357 15370692 12666154 18412020 18205269 18317297 12667390 17721639 18429990 16116963 18418968 17766677 15052691
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3412878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1315720792 16246199 15830285 16964402 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9216899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8220195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.8219294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8216984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.2312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2312151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2418520028 20464547 20135361 17053015 6695378 18816296 20869020 18569708 20064080
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2411884234 19555203
MESH:D008223 Lymphoma Cyclophosphamide 4.0012854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.8616675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.3711911406
MESH:D008546 Melanoma, Experimental Cyclophosphamide 5.1116388313
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009369 Neoplasms Benzo(a)pyrene 5.6111141357
MESH:D009369 Neoplasms Cyclophosphamide 5.6118854779
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009447 Neuroblastoma Cyclophosphamide 3.758761367 15176712 16115947
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.238761367 12837982
MESH:D009503 Neutropenia Cyclophosphamide 4.588291058
MESH:D009845 Oligospermia Cyclophosphamide 5.0516517039
MESH:D010146 Pain Cyclophosphamide 3.8218093676 12161096
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 3.2511332152
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.7215687053
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.9221297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms marker/mechanism 18355840
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6917292933
MESH:D011471 Prostatic Neoplasms Cadmium 2.6917075824
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.6917136230
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3616636934
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.0816636934
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8016192470
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.8516517039
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.3912837982
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 5.0316940797
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.5517053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 5.5514692829
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
KEGG:05210 Colorectal cancer
KEGG:03430 Mismatch repair
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31134
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    PA444750Leukemia
    PA446166Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449692folic acid
    PA164712913Multivitamins, Plain
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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