AutismKB 2.0

Annotation Detail for MSH5


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Basic Information Top
Gene Symbol:MSH5 ( DKFZp434C1615,G7,MGC2939,MUTSH5,NG23 )
Gene Full Name: mutS homolog 5 (E. coli)
Band: 6p21.33
Quick LinksEntrez ID:4439; OMIM: 603382; Uniprot ID:MSH5_HUMAN; ENSEMBL ID: ENSG00000204410; HGNC ID: 7328
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1979Testicular dysfunction
2121Ovarian failure
Desease Name
CANCER
lung cancer
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of MSH5 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of MSH5 mRNAaffects expression 17562736
C004984 apocarotenal apocarotenal results in increased expression of MSH5 mRNAincreases expression 17034753
D019207 beta Carotene beta Carotene results in increased expression of MSH5 mRNAincreases expression 17034753
C029424 hydrazine hydrazine results in increased expression of MSH5 mRNAincreases expression 15282401
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MSH5 mRNAaffects binding|decreases expression|increases activity 19710929
D012643 Selenium Selenium results in decreased expression of MSH5 mRNAdecreases expression 19244175
C017947 sodium arsenite sodium arsenite results in decreased expression of MSH5 mRNAdecreases expression 12377979
D014810 Vitamin E Vitamin E results in decreased expression of MSH5 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.237525203
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2216712894 17306315
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D002545 Brain Ischemia beta Carotene 5.3816157235
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.983084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 2.9817306315 15276417 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4318572023
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.7914694615
MESH:D002386 Cataract Acetaminophen 7.7910977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1220056578 19524636
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.3415095906
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.6021346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6017562736 16109766 10774834 19416960 10663392 14986274 18071297 11421492 11739529 19085960 14550746 15968718 12540782 12594235 18713872 16781746 16485898 14725611 16393943 12958197 12705907 17522070 11743745 19420014 15619225 19739265 2444490 16177239 19923254 19164858 12153990 16081117 12392966 17906064 19370779 11834606 10915739 16227642 11529661 11461765 11287661
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6015131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D005234 Fatty Liver pirinixic acid 2.9719236843 20131406
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9616452187
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0816080930
MESH:D006333 Heart Failure pirinixic acid 7.3520558911
MESH:D006333 Heart Failure Selenium 7.3517162251
MESH:D006529 Hepatomegaly pirinixic acid 3.2518467677 19176532 16221962 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616863852 16490937
MESH:D015658 HIV Infections beta Carotene 4.1416960176
MESH:D006689 Hodgkin Disease sodium arsenite 3.3312676792
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D007248 Infertility, Male sodium arsenite 3.1212646999 15346721
MESH:D007251 Influenza, Human Selenium 12.0416624496
MESH:D007251 Influenza, Human Vitamin E 12.0416624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007674 Kidney Diseases Acetaminophen 10.7112587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 10.7120008137
MESH:D007674 Kidney Diseases Vitamin E 10.7112488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4316169303
MESH:D008107 Liver Diseases Acetaminophen 1.6711587558 19460945 16611625 12969438 16610002 19014921 12587719 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 4.7120007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 4.7116712894 15276417
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 4.0217113696
MESH:D008171 Lung Diseases sodium arsenite 7.8919095001
MESH:D008171 Lung Diseases Vitamin E 7.8916863852
MESH:D008175 Lung Neoplasms beta Carotene 3.7616401635
MESH:D008175 Lung Neoplasms sodium arsenite 3.7616712894 17077188 17306315 15276417 19931552
MESH:D008175 Lung Neoplasms Vitamin E 3.7611062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8815318939
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009369 Neoplasms beta Carotene 8.9417051425
MESH:D009369 Neoplasms pirinixic acid 8.9417405874
MESH:D009369 Neoplasms sodium arsenite 8.9411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9220056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.2712854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.2914694615
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4917306315 15276417
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2616039940
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2615084515
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms sodium arsenite 2.7818572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9512854658
MESH:D013272 Stomach Diseases beta Carotene 5.3817638125
MESH:D013276 Stomach Ulcer beta Carotene 4.4612500499
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5717306315 11723127 16712894 16452187
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9611813266
MESH:D014652 Vascular Diseases sodium arsenite 4.7117056641
Pathway ID Pathway Name
REACT:27271 Meiotic Recombination
REACT:27235 Meiotic Recombination (mouse)
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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