AutismKB 2.0

Annotation Detail for ASS1


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Basic Information Top
Gene Symbol:ASS1 ( ASS,CTLN1 )
Gene Full Name: argininosuccinate synthase 1
Band: 9q34.11
Quick LinksEntrez ID:445; OMIM: 603470; Uniprot ID:ASSY_HUMAN; ENSEMBL ID: ENSG00000130707; HGNC ID: 758
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-4983citrulline-nitric oxide cycle
ARGININE-SYN4-PWYarginine biosynthesis IV
PWY-4984urea cycle
PWY-5004superpathway of citrulline metabolism
Pathway IDPathway Name
hsa00250Alanine, aspartate and glutamate metabolism
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
Pathway IDPathway Name
P02728Arginine biosynthesis
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of amino acid metabolism
Genetic disorders
H00185Citrullinemia
Desease IDDesease Name
1766Renal Cell cancer
1848Embryoma
2126Encephalopathies
No data
No data
Desease Name
Citrullinemia
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ASS1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen affects the expression of ASS1 mRNAaffects expression 17366322
D000082 Acetaminophen Acetaminophen affects the expression of ASS1 proteinaffects expression 16687475
D000082 Acetaminophen Acetaminophen results in increased expression of ASS1 proteinincreases expression 15800402
16538041
C103505 AM 251 AM 251 results in increased expression of ASS1 mRNAincreases expression 16500647
C018824 ammonium acetate ammonium acetate results in increased activity of ASS1 proteinincreases activity 16009439
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ASS1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ASS1 mRNAdecreases expression 15070760
15761015
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ASS1 mRNAdecreases expression 15336504
C459604 candoxin candoxin results in decreased expression of ASS1 mRNAdecreases expression 16309724
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ASS1 mRNAdecreases expression 17484886
C057862 cyanoginosin LR cyanoginosin LR results in decreased expression of ASS1 mRNAdecreases expression 17383702
D016572 Cyclosporine Cyclosporine results in decreased expression of ASS1 mRNAdecreases expression 20106945
D002945 Cisplatin ASS1 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of ASS1 mRNAaffects cotreatment|increases expression 15784690
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ASS1 proteinincreases expression 20935162
D004052 Diethylnitrosamine [Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of ASS1 proteinaffects cotreatment|decreases expression 20935162
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of ASS1 mRNAincreases expression 15289156
D002117 Calcitriol Calcitriol results in decreased expression of ASS1 mRNAdecreases expression 12875902
D004958 Estradiol Estradiol results in increased expression of ASS1 mRNAincreases expression 15757668
D004958 Estradiol Estradiol results in increased expression of ASS1 mRNAincreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ASS1 mRNAdecreases expression 12655037
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ASS1 mRNAincreases expression 17351261
17557909
D005472 Fluorouracil [Fluorouracil co-treated with irinotecan] results in decreased expression of ASS1 mRNAaffects cotreatment|decreases expression 16391804
C039281 furan furan results in decreased expression of ASS1 mRNAdecreases expression 15120968
D019833 Genistein Genistein results in increased expression of ASS1 mRNAincreases expression 15757668
D019833 Genistein Genistein results in increased expression of ASS1 mRNAincreases expression 15289156
C051890 irinotecan [Fluorouracil co-treated with irinotecan] results in decreased expression of ASS1 mRNAaffects cotreatment|decreases expression 16391804
D008727 Methotrexate Methotrexate results in increased expression of ASS1 mRNAincreases expression 15120968
D008942 Mitoxantrone ASS1 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D010634 Phenobarbital [Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of ASS1 proteinaffects cotreatment|decreases expression 20935162
D010795 Phthalic Acids Phthalic Acids results in decreased expression of ASS1 mRNAdecreases expression 15728792
C006253 pirinixic acid pirinixic acid results in decreased expression of ASS1 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in decreased expression of ASS1 proteindecreases expression 15226431
C006253 pirinixic acid pirinixic acid results in decreased expression of ASS1 mRNAdecreases expression 17164430
D012643 Selenium Selenium results in increased expression of ASS1 mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite affects the expression of ASS1 mRNAaffects expression 19590694
C017947 sodium arsenite sodium arsenite results in decreased expression of ASS1 mRNAdecreases expression 19590694
C021751 tanshinone tanshinone results in decreased expression of ASS1 mRNAdecreases expression 15849732
C004648 testosterone enanthate testosterone enanthate affects the expression of ASS1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ASS1 mRNAincreases expression 16443690
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ASS1 mRNAdecreases expression 18796159
16054898
16497791
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ASS1 proteindecreases expression 16497791
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ASS1 mRNAaffects cotreatment|affects expression 16979875
C052342 topiramate topiramate results in decreased expression of ASS1 mRNAdecreases expression 16979414
D019772 Topotecan ASS1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014212 Tretinoin Tretinoin results in decreased expression of ASS1 mRNAdecreases expression 12875902
16129123
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of ASS1 mRNAaffects cotreatment|increases expression 15784690
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ASS1 mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 12.1012039119
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.106195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.1011752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.1818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5517505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.459612607
MESH:D000169 Acrodermatitis Zinc 5.0217190629 16889938 17202136
MESH:D058186 Acute Kidney Injury Cisplatin 3.6217670903 15814532 12690470
MESH:D055371 Acute Lung Injury pirinixic acid 2.7718653653
MESH:D000230 Adenocarcinoma arsenic trioxide 15.7019825857 11798837
MESH:D000230 Adenocarcinoma Cisplatin 15.7017638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 15.7011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 15.7014692618
MESH:D000230 Adenocarcinoma Fluorouracil 15.7017638652
MESH:D000230 Adenocarcinoma Genistein 15.7011473722
MESH:D000236 Adenoma Diethylnitrosamine 2.6310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 21.7217162532 19052882 18056438 19061943 16434500 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 21.7217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 21.7216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 21.7216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5116712894 17306315
MESH:D000437 Alcoholism topiramate 4.7317925516 19331489 18552399
MESH:D000505 Alopecia Tretinoin 3.3215955085
MESH:D000544 Alzheimer Disease Zinc 2.6717119284 16410023 16325427 16580781
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1215469931
MESH:D000740 Anemia Fluorouracil 7.5916511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.5911748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.5416916123
MESH:D000799 Angioedema Acetaminophen 3.4610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.4115885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.4116412693
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.5317286800
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.5316292516
MESH:D001249 Asthma Tretinoin 4.6416456186
MESH:D001249 Asthma Zinc 4.6417085522
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.1020106747
MESH:D001321 Autistic Disorder Acetaminophen 1.4618445737
MESH:D001471 Barrett Esophagus Tretinoin 4.0416935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 19.1516206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 19.1519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 19.1512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 19.1516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5215746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.5014601052
MESH:D001930 Brain Injuries Zinc 4.3217109824
MESH:D001943 Breast Neoplasms Calcitriol 7.7711237771
MESH:D001943 Breast Neoplasms Cisplatin 7.7718382427 19526202
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.7717474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 7.7715324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 7.7714630087 16675129 18497071 12948864 17018787 17261762 17289903 19861407
MESH:D001943 Breast Neoplasms Fluorouracil 7.7716595493 16110121 16557594 19217205 15136595 18357371 18608205
MESH:D001943 Breast Neoplasms Genistein 7.7716541309 17200150 16873071
MESH:D001943 Breast Neoplasms Methotrexate 7.7716978400
MESH:D001943 Breast Neoplasms tanshinone 7.7719885617 15849732
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.7720435547
MESH:D001943 Breast Neoplasms Tretinoin 7.7716166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2116813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9811589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4116050911 15721981 16097048 15700767 3786805 16227642 10355542 15673190 16124888 18705752 16192424 16011737
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2816051944
MESH:D002277 Carcinoma Fluorouracil 7.1917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.1916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7716168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 27.603084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 27.6015553829 14691202 11135700 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 27.6018788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 27.6017982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 27.6017138121 19519916 20524982 19394651 20935162 19335982 11831363 3581430 17173139 16779866 16288022 18978308 17978847 20084675 19171122 18785209 19539802 20007298 19701751 16807293 17428255 16540662 18506893 21159647 19052882 16830150 3084413 19822196 20432363 16698587 16569478 20514400 18691550 17162532 10737359 19107877 18665156 18210153 19383236 20512989 16681979 18056438 19919837 16935385 16878318 16328049 17055752 18971187 19418558 20727157 10672840 18494052 19208518 17761372 16502159 20101231 18788625 18393292 20214788
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 27.6015948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 27.6016924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 27.6016332177 17971768 17045692 17088986 16799960 18930000
MESH:D006528 Carcinoma, Hepatocellular Genistein 27.6016924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 27.6020935162 1701930 6705139 20007298 17173139
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 27.6017306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 27.601917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9016685392 12023789
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4919014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8318695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7912490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 20.1211237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 20.126189445 17066447 18337622
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 20.1216280240 17066447 18986760 16757204
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 20.1218572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 20.1218922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 20.1216051514 16096774
MESH:D002294 Carcinoma, Squamous Cell Zinc 20.1216543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1516120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 6.7016332659
MESH:D002318 Cardiovascular Diseases Zinc 6.7016936243
MESH:D002386 Cataract Acetaminophen 6.4710977129
MESH:D002386 Cataract Tretinoin 6.4717460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 13.8512371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 13.8521159647 7505956 2727394 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.8518566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 13.8519524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.884080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2116129372
MESH:D002659 Child Development Disorders, Pervasive topiramate 3.9515650499
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.2616835633
MESH:D002779 Cholestasis Cyclosporine 11.7119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.7116919318 17333356 16105132 17681005 17110522 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 11.7119176532
MESH:D002822 Choriocarcinoma Tretinoin 4.7716461808
MESH:D020159 Citrullinemia marker/mechanism
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.2012621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.209407595
MESH:D003092 Colitis Selenium 8.2617936198
MESH:D003092 Colitis Tretinoin 8.2617035595
MESH:D003110 Colonic Neoplasms Fluorouracil 5.4317169374 16510598 17287894 17725105 16340194 15001691 17172411 17018589 18772588 17016597
MESH:D003110 Colonic Neoplasms Genistein 5.4317182828
MESH:D003110 Colonic Neoplasms irinotecan 5.4317287894 17725105
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.4820501625
MESH:D015179 Colorectal Neoplasms Cisplatin 4.4815273666
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.4818288408 17594712 18448328 18383874 18949393 17016601 16391804 16331619 14970324 15148649 15289873 17255274 16282729 17401013 16524972 17094418 18509181 16303861 18802399 17454858 17695437 20501625
MESH:D015179 Colorectal Neoplasms irinotecan 4.4818259882 17159606 18509181 16391804 16303861 15273666 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7414669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 6.8110525206
MESH:D019465 Craniofacial Abnormalities Methotrexate 6.819562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.8120055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.8116925845 14991402 9224671 9664655 9211117 17551590 8800419 9125849 9142499 10589399
MESH:D019465 Craniofacial Abnormalities Zinc 6.8119302082
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.1912952375 16002989
MESH:D003550 Cystic Fibrosis Methotrexate 3.9119747007
MESH:D007644 Darier Disease Fluorouracil 4.4116733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7415213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003882 Dermatomyositis Methotrexate 4.7620191521
MESH:D003920 Diabetes Mellitus Zinc 3.8916479319
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.4220387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.4216647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.4217107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 9.4216979414
MESH:D003928 Diabetic Nephropathies Estradiol 3.0919279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.6215968718 12153990 19420014 10774834 17522070 11461765 11421492 11739529 2444490 18713872 15619225 11743745 19923254 12392966 19164858 16485898 12594235 19416960 16227642 18071297 19739265 12540782 11834606 19370779 11287661 11529661 14986274 16393943 10915739 10663392 12958197 14550746 16109766 14725611 16177239 16781746 19085960 17562736 17906064 12705907 16081117
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 13.6216177239 17522070 7120509 16227642 19085960 10915739 19336974 2869522 15968718 9327722 3732212 4309450 3786805 6884620 7440962 21278145 15998439 10092053 11566570 15027814 6623471 7179309
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 13.6217654400
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 13.6219107877
MESH:D056486 Drug-Induced Liver Injury Selenium 13.6215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.6220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7119426721
MESH:D004362 Drug Toxicity Cisplatin 17.3712649298 19839026 12231392 15033597
MESH:D004362 Drug Toxicity Lamivudine 17.3715040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 17.3711462148
MESH:D004362 Drug Toxicity Zidovudine 17.3715040536
MESH:D004421 Dystonia Phenobarbital 3.651851702
MESH:D004487 Edema pirinixic acid 9.5212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.5211000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 9.5211698051 9599246 15177302 8273558 16716910 7812673 8113982
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.6516714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 10.6518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 7.8915138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.8912538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.6216402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.6216402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 15.7416804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 15.7411473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 15.7411473722
MESH:D016889 Endometrial Neoplasms Tretinoin 15.7416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.699294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.743659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.4911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 6.5020417680
MESH:D004827 Epilepsy topiramate 6.5019148780
MESH:D004832 Epilepsy, Absence Phenobarbital 3.236401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.887750514
MESH:D004833 Epilepsy, Temporal Lobe topiramate 5.8916499746
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.643659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7316302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 9.5512903497
MESH:D004938 Esophageal Neoplasms Cisplatin 9.5516481741 17638652 15173087 16785472 15464296
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.5515173087 16785472 16337965 17638652 16481741
MESH:D004938 Esophageal Neoplasms Zinc 9.5516543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.9011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.9016938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 31.7515073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 31.7512795759 15959796 61145 17595544 19224547 16239168 12631006 16045604
MESH:D005234 Fatty Liver Cyclosporine 31.7519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 31.7521071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 31.7515345470
MESH:D005234 Fatty Liver pirinixic acid 31.7520131406 19236843
MESH:D005234 Fatty Liver Zidovudine 31.7518299183
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.4216002989 16534752 16513791 16611131 15751030
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D005355 Fibrosis Carbon Tetrachloride 18.0718705752
MESH:D005355 Fibrosis Cyclosporine 18.0712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.0720067830
MESH:D005355 Fibrosis Tretinoin 18.0717994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9016904648
MESH:D005756 Gastritis Acetaminophen 9.8716983495
MESH:D005756 Gastritis Zinc 9.8717241300
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.5416452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.5416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.848708960
MESH:D005909 Glioblastoma Genistein 6.3816598420
MESH:D005909 Glioblastoma Tretinoin 6.3817312396
MESH:D005910 Glioma Fluorouracil 6.0116145905
MESH:D005910 Glioma tanshinone 6.0116955220
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006086 Graft vs Host Disease Methotrexate 4.7816518429
MESH:D006130 Growth Disorders Zinc 3.7217217573
MESH:D006258 Head and Neck Neoplasms Cisplatin 11.5115464296 15102660
MESH:D006258 Head and Neck Neoplasms Fluorouracil 11.5115102660 18337622 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 11.5116096774
MESH:D034381 Hearing Loss Cisplatin 3.9819898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7716084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.1115464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.8510048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 5.8514991402 9664655
MESH:D006331 Heart Diseases Mitoxantrone 3.8916019553
MESH:D006333 Heart Failure pirinixic acid 10.4620558911
MESH:D006333 Heart Failure Selenium 10.4617162251
MESH:D006333 Heart Failure Zinc 10.4617162251
MESH:D006335 Heart Injuries Zinc 5.3817074742
MESH:D016481 Helicobacter Infections Zinc 4.1817241300
MESH:D006402 Hematologic Diseases Zidovudine 4.3612579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2419900420 19110552
MESH:D006509 Hepatitis B Lamivudine 4.7617703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.7615274664 15631357 12044531 16476009 15309715
MESH:D006527 Hepatolenticular Degeneration Zinc 4.3217276780
MESH:D006529 Hepatomegaly Phenobarbital 12.2316109766
MESH:D006529 Hepatomegaly pirinixic acid 12.2318467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.2315340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.6415709030
MESH:D015658 HIV Infections Lamivudine 6.3720032539 17530837 9296927 11141242
MESH:D015658 HIV Infections Zidovudine 6.3711363243 11698656 17358032 20032539 11141242
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.3617440010
MESH:D006689 Hodgkin Disease Cisplatin 6.5016170182 16200630
MESH:D006689 Hodgkin Disease sodium arsenite 6.5012676792
MESH:D019584 Hot Flashes Estradiol 3.3717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6615340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 6.6316870215
MESH:D006930 Hyperalgesia Tretinoin 6.6316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1516899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2016778211
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.0614722030 12960047
MESH:D006973 Hypertension Cyclosporine 4.4310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.4318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7215338365
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 4.9119662366
MESH:D007021 Hypospadias Diethylstilbestrol 10.0016002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.0016945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 3.9915036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.7917937319
MESH:D007248 Infertility, Male sodium arsenite 5.7915346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 7.1818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.1812200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 7.1815177302 8273558 7562506 11698051 7812673
MESH:D007251 Influenza, Human Selenium 3.8116624496
MESH:D007333 Insulin Resistance Estradiol 6.3616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.3616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4017994277
MESH:D007511 Ischemia Zinc 4.2616584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.8015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0515604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7515464296
MESH:D007674 Kidney Diseases Acetaminophen 20.9515629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 20.9519839026 18289764 12231392 12649298 15190930
MESH:D007674 Kidney Diseases Cyclosporine 20.958314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 20.9515618244
MESH:D007674 Kidney Diseases sodium arsenite 20.9520008137
MESH:D007674 Kidney Diseases Zinc 20.9516960431
MESH:D007676 Kidney Failure, Chronic Selenium 8.9516518626
MESH:D007676 Kidney Failure, Chronic Zinc 8.9516518626
MESH:D007680 Kidney Neoplasms Cyclosporine 20.0912371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 20.0916762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 20.0915610895
MESH:D007680 Kidney Neoplasms Fluorouracil 20.0916985049
MESH:D007680 Kidney Neoplasms Zidovudine 20.0912579204
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.4111231351
MESH:D007805 Language Development Disorders Methotrexate 4.759562676
MESH:D007859 Learning Disorders Diethylstilbestrol 3.6917184923
MESH:D007938 Leukemia arsenic trioxide 9.3515070760
MESH:D007938 Leukemia Genistein 9.3518980019 17468513
MESH:D007938 Leukemia Tretinoin 9.3517143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.6218172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.7117077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 8.7120370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.3419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.3416482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.6219850784 17050201 16968895 20471514 16467208
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.6216294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.8017107899 9834237 17217047 19035177 16331271 15213294 12018890 16891316 19642359 17649720 15748426 16112521 11161223 12712474 19225113 16823087 15622746 11468182 16330433 17712046 17869043 15336539 12679006 16966277 19075265
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.8019075265 12679006 17339181 19029980 16788101 16891316 17107899 16935935 9834237 19225113 19035177 17361223 16140955 17649720 19642359 17301526 15748426 17294898 16766008 17506722 17712046 16823087 16331271 17217047 17368321
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9916882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.049224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.0211408273 16239168 16943688 16221502 17157831 17334410 11903743 21278145 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.0218407596 19638242 18665156 20032147 18522880
MESH:D008103 Liver Cirrhosis Methotrexate 14.0214986274
MESH:D008103 Liver Cirrhosis Phenobarbital 14.0221047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.0118156304 16638106 12546737 16015684 14620537 18277467 15673190 17976157 17708605 12649538 17823541 18054572 12632514 14748882 10355542 15650968 15338365 17869086 18279442 18263696 17698563 15052691 15925388 18472332 13678700 16136751 17640975 17481882 15370692 15959796 15730626 12445418 18251166 17922224 18205269 18472094 17805973 16011737 14716496 15893842 17721639 15931870 18376398 17944888 12389079 18317297 17761835 17631135 12445421 18395095 14512876 12632512 18412020 16192424 18429990 12609069 12666154 17565644 18006644 14716833 15876570 18420326 18210741 17766677 17714472 15123356 16248980 18187930 18395914 18166357 12667390 18339082 16027843 15362042 15818738 18481824 12898905 17900296 17525996 20821823 17557913 16097048 18418968 11481614 12586293 16033810 12741479 14724832 18705752 15057751 16116963 12958196 15996030
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.0114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.0117823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.0115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.0112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.0118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 8.4419460945 16611625 11587558 12969438 19014921 19784758 16610002 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.4417285989 16246199 16964402 15830285 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 8.4417034775
MESH:D008107 Liver Diseases Phenobarbital 8.4419363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.3117185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.3114706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 27.0714682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 27.0719294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 27.0720405173 19812893 19427195 20501860 19073162 19294768 2862719 18648771 21167192 19551842 21071580 20118626 19642983 15885732 19833225 20101389 21047994 18978307 16942905 19850985 19255062 18977376 19996281 19254457 20583210 20452335 10737359 2422723 20492335 19090486 21278145 15175105 19426721 20434301 19638242 18644402 12771043 20137499 18754104 9163691 12112319 19256749 19690152 19499222
MESH:D008113 Liver Neoplasms Diethylstilbestrol 27.0715890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 27.0717045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms Phenobarbital 27.0719073162 8742319 21047994 15975961 19812893 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 27.0715890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 27.0716712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 27.0716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 16.0820377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.0815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 16.0818253720 17942915 18164116 9362446 18775883 16842330 19009564 18308698 21159647 3124819 18079962 19519916 17174075 18093689 2563599 19126423 19539802 18282651 16267830 19004024 18544905 17854601
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 16.0818308698 1399818 17172636 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.0812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0615213294
MESH:D008171 Lung Diseases sodium arsenite 2.9219095001
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.6318516814
MESH:D008175 Lung Neoplasms arsenic trioxide 12.0119825857 11798837
MESH:D008175 Lung Neoplasms Cisplatin 12.016189445 17225452 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.0120970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Fluorouracil 12.0115246190
MESH:D008175 Lung Neoplasms sodium arsenite 12.0116712894 17077188 17306315 15276417 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.0111884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 12.0111807781
MESH:D008175 Lung Neoplasms Zidovudine 12.0118800350
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4115086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.7715166399
MESH:D008223 Lymphoma Diethylstilbestrol 7.0215700306
MESH:D008223 Lymphoma Methotrexate 7.0217352296
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1316002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 16.2111807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 16.2114578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Selenium 16.2115318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 16.218985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 16.2112773700
MESH:D020149 Manganese Poisoning Estradiol 4.0919453300
MESH:D008527 Medulloblastoma Tretinoin 2.6317453147
MESH:D008545 Melanoma Cisplatin 4.7217023156 18176117 18332650 15577323 12374674 12393984 12883367 11135225 17761969 16809738 18505091 16432458 16248763
MESH:D008545 Melanoma sodium arsenite 4.7219082730 16487513
MESH:D008545 Melanoma Tretinoin 4.7216752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.3915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2019513568
MESH:D008591 Meningomyelocele Tretinoin 4.0516940565
MESH:D008654 Mesothelioma Cisplatin 5.8217638057
MESH:D008654 Mesothelioma Selenium 5.8215107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4016801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.4517358032
MESH:D008881 Migraine Disorders topiramate 4.3118803445 18759728 16942474 18765137
MESH:D009062 Mouth Neoplasms Fluorouracil 3.3416757204 18986760
MESH:D052016 Mucositis irinotecan 11.3317159606
MESH:D052016 Mucositis Methotrexate 11.3317488658
MESH:D009101 Multiple Myeloma arsenic trioxide 2.8415949261 19549372 14977855 11468182 19417148
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.6516105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.6517596541
MESH:D009203 Myocardial Infarction Genistein 5.1217141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.1219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.4916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.4917141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.4916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0917484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6016624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.423581430 9029167
MESH:D009362 Neoplasm Metastasis irinotecan 5.4218259882
MESH:D009369 Neoplasms Cisplatin 21.0316773208
MESH:D009369 Neoplasms Diethylstilbestrol 21.0315313581
MESH:D009369 Neoplasms Fluorouracil 21.0316928823 18600527 18239605
MESH:D009369 Neoplasms Mitoxantrone 21.0316640825
MESH:D009369 Neoplasms pirinixic acid 21.0317405874
MESH:D009369 Neoplasms sodium arsenite 21.0311559025
MESH:D009369 Neoplasms Tretinoin 21.0316594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3020056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3517289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.1115464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9719348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 26.8911399458
MESH:D009421 Nervous System Malformations Estradiol 26.8916427766 11399458
MESH:D009421 Nervous System Malformations Genistein 26.8916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 26.8914600291
MESH:D009421 Nervous System Malformations Tretinoin 26.899125849
MESH:D009436 Neural Tube Defects arsenic trioxide 10.7010525206
MESH:D009436 Neural Tube Defects sodium arsenite 10.7012854658
MESH:D009436 Neural Tube Defects Tretinoin 10.709142499
MESH:D009447 Neuroblastoma Cisplatin 10.438761367
MESH:D009447 Neuroblastoma irinotecan 10.438761367
MESH:D009447 Neuroblastoma Topotecan 10.4315176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.1618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.1620387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.198761367
MESH:D017599 Neuroectodermal Tumors irinotecan 10.198761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7320387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1816436463
MESH:D009765 Obesity pirinixic acid 1.7220558911
MESH:D010018 Osteomalacia Phenobarbital 3.9817016548
MESH:D010024 Osteoporosis Genistein 3.0219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.7416169203
MESH:D010051 Ovarian Neoplasms arsenic trioxide 17.1519769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Cisplatin 17.156897625 19769630 17225452 15464296
MESH:D010051 Ovarian Neoplasms Estradiol 17.1519401270
MESH:D010051 Ovarian Neoplasms Genistein 17.1519005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 17.1517306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 17.1516936753
MESH:D010146 Pain Acetaminophen 9.6116870215
MESH:D010146 Pain AM 251 9.6118987195
MESH:D010146 Pain Tretinoin 9.6116870215
MESH:D010190 Pancreatic Neoplasms AM 251 26.7916500647
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 26.7915580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 26.7919003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 26.7916540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 26.7919003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Phenobarbital 26.7916965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 26.7915976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 26.7915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3411578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.9218922899 12065085 8330346 18404319
MESH:D010235 Paraganglioma arsenic trioxide 3.8119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9515464296
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.7814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3016977796 15687265
MESH:D010954 Plasmacytoma Selenium 4.5015087411
MESH:D010997 Pleural Neoplasms Cisplatin 4.9517638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D011230 Precancerous Conditions Cyclosporine 13.4312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 13.432563599
MESH:D011230 Precancerous Conditions Phenobarbital 13.432563599
MESH:D011225 Pre-Eclampsia Zinc 3.8817114810
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.3017184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.3011222880 11896295 11399792 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.4015572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5420887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.3519131511
MESH:D011471 Prostatic Neoplasms Calcitriol 2.3516644109 16289102 12479363 18247401 15754350
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.3515846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.3516740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.3518626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 2.3515256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.3516039940
MESH:D011471 Prostatic Neoplasms Zinc 2.3516606632 16517595 16700911 12429649
MESH:D011507 Proteinuria Tretinoin 3.2616636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.9316919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.1112752131
MESH:D011565 Psoriasis Cyclosporine 5.4316882103
MESH:D011565 Psoriasis Methotrexate 5.4317410198
MESH:D011625 Pterygium Tretinoin 4.4116723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6915538739 18722050 18286688 16160472
MESH:D051437 Renal Insufficiency Cisplatin 9.3215464296
MESH:D051437 Renal Insufficiency Methotrexate 9.3217352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012162 Retinal Degeneration Zinc 3.8416584753
MESH:D012206 Rhabdomyolysis Lamivudine 5.159296927
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7516116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.1416646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.1414601052
MESH:D012640 Seizures Phenobarbital 5.6616876388 4039156 3137016 11442880
MESH:D012640 Seizures topiramate 5.6616499746
MESH:D003294 Seizures, Febrile Phenobarbital 4.446407741
MESH:D012878 Skin Neoplasms sodium arsenite 15.9418572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 15.948532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.9416192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 15.9418404319 8985016 8330346 12065085 11807781
MESH:D012878 Skin Neoplasms Tretinoin 15.9416467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9515464296
MESH:D013088 Spermatocele Diethylstilbestrol 10.4216002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 10.4216709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5012854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 9.6817007042
MESH:D013274 Stomach Neoplasms Cisplatin 9.6817522103 18396642 15958060
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 9.6818456281
MESH:D013274 Stomach Neoplasms Fluorouracil 9.6819015929 16424979 17172411 19084572 16951190 17498489 18567086 15786421 18396642 17522103
MESH:D013274 Stomach Neoplasms irinotecan 9.6815723263
MESH:D013274 Stomach Neoplasms Tretinoin 9.6817261132
MESH:D013274 Stomach Neoplasms Zidovudine 9.6817696246
MESH:D013576 Syndactyly Methotrexate 4.679562676
MESH:D013736 Testicular Neoplasms Cisplatin 4.2815464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5112697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 14.7319014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 14.737505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 14.731399818
MESH:D013964 Thyroid Neoplasms Tretinoin 14.7316026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.3019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 14.7016280240
MESH:D014062 Tongue Neoplasms Tretinoin 14.7016051514
MESH:D014062 Tongue Neoplasms Zinc 14.7016543248
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5815213294
MESH:D014376 Tuberculosis Tretinoin 2.9916040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 10.6620435036 12973940 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 10.6615464296 17225452 12973940
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 10.6616452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.6617306315 16452187 16712894 11723127
MESH:D014581 Urticaria Acetaminophen 2.6310982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 26.1416803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 26.1416175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 26.1416803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 26.1411813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 26.1416129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.7814652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.2715809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.2714692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.2216752155
MESH:D014605 Uveitis Cyclosporine 3.601336536
MESH:D014625 Vaginal Neoplasms Cisplatin 16.3515577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 16.3516002989 16513791
MESH:D014625 Vaginal Neoplasms Zidovudine 16.3512579204
MESH:D014652 Vascular Diseases sodium arsenite 4.0417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2014671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.6916761959
MESH:D014839 Vomiting Cisplatin 4.3311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D009396 Wilms Tumor Tretinoin 3.6516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.0517120751
Pathway ID Pathway Name
KEGG:00250 Alanine, aspartate and glutamate metabolism
KEGG:00330 Arginine and proline metabolism
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162376926
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA451831urea
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00125 - L-Arginine Dietary supplement;Micronutrient;Conditionally Essential Amino Acids
    DB00128 - L-Aspartic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00155 - L-Citrulline Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00171 - Adenosine triphosphate Dietary supplement;Micronutrient
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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