AutismKB 2.0

Annotation Detail for MSN


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Basic Information Top
Gene Symbol:MSN ( - )
Gene Full Name: moesin
Band: Xq12
Quick LinksEntrez ID:4478; OMIM: 309845; Uniprot ID:MOES_HUMAN; ENSEMBL ID: ENSG00000147065; HGNC ID: 7373
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200007RhoA signaling pathway
200029Plasma membrane estrogen receptor signaling
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1809HIV infection
1832Congenital abnormality
1843Metastasis to lymph nodes
1904Diabetes mellitus
1976Squamous cell cancer
2052Infection
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MSN mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of MSN mRNAincreases expression 15336504
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MSN mRNA]decreases reaction|increases expression 18200517
D016572 Cyclosporine Cyclosporine results in increased expression of MSN mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of MSN mRNAincreases expression 18042831
D005419 Flavonoids Flavonoids results in decreased expression of MSN mRNAdecreases expression 18035473
C041786 palm oil palm oil results in increased expression of MSN mRNAincreases expression 18042831
D010656 Phenylephrine Phenylephrine results in increased expression of MSN mRNAincreases expression 18158353
D012643 Selenium Selenium results in increased expression of MSN mRNAincreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of MSN mRNAaffects expression 17440010
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MSN mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of MSN mRNAincreases expression 18200517
C025643 vinclozolin vinclozolin affects the expression of MSN mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of MSN mRNAdecreases expression 18042343
D014810 Vitamin E Vitamin E results in increased expression of MSN mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D019973 Alcohol-Related Disorders Curcumin 5.2217887948
MESH:D000544 Alzheimer Disease Curcumin 2.6315590663
MESH:D001008 Anxiety Disorders vinclozolin 3.7019015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1917460149
MESH:D001161 Arteriosclerosis Dietary Fats 3.9915238619
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7516807698
MESH:D050197 Atherosclerosis Curcumin 3.3618704882
MESH:D001327 Autoimmune Diseases Curcumin 4.6019761891
MESH:D001919 Bradycardia Phenylephrine 4.6615306635
MESH:D002545 Brain Ischemia Curcumin 4.4516770732
MESH:D001932 Brain Neoplasms Curcumin 4.0117596214
MESH:D001943 Breast Neoplasms Curcumin 2.3618462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms Dietary Fats 2.3620435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D002277 Carcinoma Curcumin 3.9018593918
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0018414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.7818462866
MESH:D006332 Cardiomegaly Phenylephrine 3.5716170337 15728586 17287366 17124262 11754973 11179087
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5812371664
MESH:D002779 Cholestasis Cyclosporine 2.9719486331
MESH:D003092 Colitis Curcumin 16.8016782535 16804969 18200517
MESH:D003092 Colitis Selenium 16.8017936198
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 16.8017991707 16804969 18023891 16782535 16867261 16474422 17936198 11698051 18200517
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4717276891
MESH:D003103 Coloboma Curcumin 4.6318809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5116340194 19359593
MESH:D016510 Corneal Neovascularization Curcumin 5.0018497527
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003456 Cryptorchidism vinclozolin 4.4414966744
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7218403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.0818204486
MESH:D056486 Drug-Induced Liver Injury Selenium 2.1915131321
MESH:D004381 Duodenal Ulcer Curcumin 4.1417351913
MESH:D050171 Dyslipidemias Dietary Fats 3.5118367378
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D005234 Fatty Liver Curcumin 13.6719297423
MESH:D005234 Fatty Liver Cyclosporine 13.6719224547
MESH:D005234 Fatty Liver Dietary Fats 13.6717967931 19551842 19004024 18296743
MESH:D005355 Fibrosis Curcumin 22.1518705752
MESH:D005355 Fibrosis Cyclosporine 22.1512168785 12639820
MESH:D005355 Fibrosis Dietary Fats 22.1518296743
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 22.1517994277
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.8018462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4316417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005909 Glioblastoma Curcumin 3.5317596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.7118829502 18462866
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0316080930
MESH:D006333 Heart Failure Selenium 3.1217162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.1417701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8817440010
MESH:D019584 Hot Flashes Vitamin E 4.1114716179
MESH:D006937 Hypercholesterolemia Curcumin 9.5118704882
MESH:D006937 Hypercholesterolemia Dietary Fats 9.5121332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7021332399
MESH:D006973 Hypertension Cyclosporine 5.4710903974
MESH:D006973 Hypertension Phenylephrine 5.478949925 12717712
MESH:D006984 Hypertrophy Phenylephrine 4.6312791704 18502941
MESH:D007248 Infertility, Male vinclozolin 3.0916467254
MESH:D007249 Inflammation Curcumin 8.6918403477 16956363 17151092
MESH:D007249 Inflammation Dietary Fats 8.6920412841
MESH:D007249 Inflammation Flavonoids 8.6917296493
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.7918596194 18200517
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.7918200517
MESH:D007251 Influenza, Human Selenium 11.4116624496
MESH:D007251 Influenza, Human Vitamin E 11.4116624496
MESH:D007333 Insulin Resistance Dietary Fats 3.1518457598 11836018
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.7117994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.2910783313
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Cyclosporine 6.178314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 6.1712488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8012371664
MESH:D007889 Leiomyoma Curcumin 4.6618555241
MESH:D007938 Leukemia Curcumin 3.2818462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.2816106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.8616106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8516417039
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9218296743
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.7417355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.7416169303
MESH:D008107 Liver Diseases Curcumin 2.6316956363
MESH:D008171 Lung Diseases Vitamin E 3.2316863852
MESH:D008175 Lung Neoplasms Curcumin 2.7119359593 16243823 18462866
MESH:D008175 Lung Neoplasms Vitamin E 2.7111062179
MESH:D008223 Lymphoma Curcumin 3.6418462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.8016173963
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8115318939
MESH:D008545 Melanoma Curcumin 2.4217885582 18462866
MESH:D008569 Memory Disorders Curcumin 4.2517263510
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009101 Multiple Myeloma Curcumin 3.5719372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.0317962980
MESH:D009361 Neoplasm Invasiveness Curcumin 4.4618495463
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.6712497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3618481113 19348381
MESH:D009423 Nervous System Neoplasms Curcumin 5.7618462866
MESH:D009765 Obesity Curcumin 4.8419297423
MESH:D009765 Obesity Dietary Fats 4.8417217161 11836018 21332399 19632207 18674790 16723640 18457598 20132043 20518802
MESH:D010024 Osteoporosis Curcumin 3.5218719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8419020741 18462866
MESH:D010190 Pancreatic Neoplasms Curcumin 2.9619196508 17440100 19401701
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.2917698068
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0118220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0518220299
MESH:D011471 Prostatic Neoplasms Curcumin 3.4312497104 11398177 18769126 10851300 18226269 15129424 18156803
MESH:D011471 Prostatic Neoplasms Vitamin E 3.4315084515
MESH:D011472 Prostatitis vinclozolin 5.0518629315
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.6019168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.1118379247 10666014
MESH:D012509 Sarcoma Curcumin 4.1918462866
MESH:D018805 Sepsis Curcumin 4.1418389075
MESH:D012852 Sinusitis Phenylephrine 4.827327846
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.728532709
MESH:D013276 Stomach Ulcer Curcumin 3.5819188055 16631530
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D001749 Urinary Bladder Neoplasms Curcumin 2.9218593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.3818462866
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D015430 Weight Gain Dietary Fats 3.8116723640
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04670 Leukocyte transendothelial migration
KEGG:05162 Measles
KEGG:04810 Regulation of actin cytoskeleton
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31178
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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