AutismKB 2.0

Annotation Detail for MST1R


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Basic Information Top
Gene Symbol:MST1R ( CD136,CDw136,PTK8,RON )
Gene Full Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Band: 3p21.31
Quick LinksEntrez ID:4486; OMIM: 600168; Uniprot ID:RON_HUMAN; ENSEMBL ID: ENSG00000164078; HGNC ID: 7381
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200162a6b1 and a6b4 Integrin signaling
200108amb2 Integrin signaling
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Related Diseases/Disorders Top
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Desease IDDesease Name
1877Multiple sclerosis
1901Endometriosis
1934Cancer
1998Enteritis
2094Ulcerative colitis
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MST1R mRNAaffects expression 17562736
D003474 Curcumin Curcumin inhibits the reaction [RELA protein binds to MST1R promoter]affects binding|decreases reaction 18593918
D003474 Curcumin Curcumin inhibits the reaction [RELA protein results in increased expression of MST1R mRNA]decreases reaction|increases expression 18593918
D003474 Curcumin Curcumin results in decreased expression of MST1R mRNAdecreases expression 18593918
D003474 Curcumin Curcumin results in decreased expression of MST1R proteindecreases expression 18593918
C029938 nickel sulfate nickel sulfate results in decreased expression of MST1R mRNAdecreases expression 16780908
C029938 nickel sulfate nickel sulfate results in increased expression of MST1R mRNAincreases expression 16780908
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MST1R mRNAaffects binding|decreases expression|increases activity 19710929
C020972 pyrrolidine dithiocarbamic acid pyrrolidine dithiocarbamic acid results in decreased expression of MST1R mRNAdecreases expression 18593918
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury nickel sulfate 10.5211954676 12718980 16100012 19131640
MESH:D055371 Acute Lung Injury pirinixic acid 10.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D019973 Alcohol-Related Disorders Curcumin 5.6917887948
MESH:D000544 Alzheimer Disease Curcumin 2.6715590663
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.8016807698
MESH:D050197 Atherosclerosis Curcumin 3.5118704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Curcumin 4.9819761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D002545 Brain Ischemia Curcumin 4.8716770732
MESH:D001932 Brain Neoplasms Curcumin 4.2817596214
MESH:D001943 Breast Neoplasms Curcumin 2.7118593918 18462866 19250217 16243823
MESH:D002277 Carcinoma Curcumin 4.1218593918
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0718414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8418462866
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003092 Colitis Curcumin 4.6616782535 16804969 18200517
MESH:D003103 Coloboma Curcumin 4.9218809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5519359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.3818497527
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 4.1516780908 11298694 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7718403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.3318204486
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6612540782 12958197 11287661 12705907 16485898 11834606 17562736 10774834 19739265 14725611 11529661 19416960 10915739 18071297 12153990 11461765 19923254 16177239 2444490 16081117 11743745 16227642 19164858 16109766 11739529 11421492 10663392 17522070 16393943 12392966 12594235 14986274 18713872 17906064 14550746 15968718 19370779 16781746 19420014 19085960 15619225
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004381 Duodenal Ulcer Curcumin 4.4917351913
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D005234 Fatty Liver Curcumin 9.1319297423
MESH:D005234 Fatty Liver pirinixic acid 9.1319236843 20131406
MESH:D005355 Fibrosis Curcumin 4.4718705752
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.1818462866
MESH:D005909 Glioblastoma Curcumin 3.6917596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8818829502 18462866
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4819176532 16221962 19772884 18467677
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.5217701891
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006937 Hypercholesterolemia Curcumin 4.4318704882
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007249 Inflammation Curcumin 3.0518403477 16956363 17151092
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3218200517 18596194
MESH:D007251 Influenza, Human pyrrolidine dithiocarbamic acid 6.1718473937
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007414 Intestinal Neoplasms Curcumin 4.5710783313
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D007889 Leiomyoma Curcumin 4.9818555241
MESH:D007938 Leukemia Curcumin 3.3918462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.5816106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.2016106398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.9017355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.9015474484
MESH:D008106 Liver Cirrhosis, Experimental pyrrolidine dithiocarbamic acid 3.9015078482
MESH:D008107 Liver Diseases Acetaminophen 4.3416611625 12969438 11587558 19460945 12587719 19014921 16610002 19784758
MESH:D008107 Liver Diseases Curcumin 4.3416956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.9216377806 20007298 15890375
MESH:D055370 Lung Injury pyrrolidine dithiocarbamic acid 5.4716129981
MESH:D008175 Lung Neoplasms Curcumin 2.2816243823 19359593 18462866
MESH:D008223 Lymphoma Curcumin 3.8318462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.1816173963
MESH:D008545 Melanoma Curcumin 2.4518462866 17885582
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008569 Memory Disorders Curcumin 4.5917263510
MESH:D009101 Multiple Myeloma Curcumin 3.7619372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.4617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.8118495463
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 5.1412497104
MESH:D009423 Nervous System Neoplasms Curcumin 6.2418462866
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity Curcumin 4.8419297423
MESH:D009765 Obesity pirinixic acid 4.8420558911
MESH:D010024 Osteoporosis Curcumin 3.6718719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.9018462866 19020741
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0317440100 19401701 19196508
MESH:D011471 Prostatic Neoplasms Curcumin 3.8711398177 18769126 10851300 18156803 12497104 18226269 15129424
MESH:D011471 Prostatic Neoplasms pyrrolidine dithiocarbamic acid 3.8716139439
MESH:D011656 Pulmonary Emphysema Curcumin 4.8819168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 11.0410666014 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult pyrrolidine dithiocarbamic acid 11.0416129981
MESH:D012509 Sarcoma Curcumin 4.4618462866
MESH:D018805 Sepsis Curcumin 4.3818389075
MESH:D013276 Stomach Ulcer Curcumin 3.8619188055 16631530
MESH:D001749 Urinary Bladder Neoplasms Curcumin 3.0018593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.8018462866
MESH:D014581 Urticaria Acetaminophen 3.3810982225
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018