AutismKB 2.0

Annotation Detail for MSX1


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Basic Information Top
Gene Symbol:MSX1 ( HOX7,HYD1,STHAG1 )
Gene Full Name: msh homeobox 1
Band: 4p16.2
Quick LinksEntrez ID:4487; OMIM: 142983; Uniprot ID:MSX1_HUMAN; ENSEMBL ID: ENSG00000163132; HGNC ID: 7391
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1745Huntington disease
1755Cleft palate
1832Congenital abnormality
Desease Name
Electrocardiographic conduction measures
limb deficiency
CARDIOVASCULAR
cleft lip with or without cleft palate
DEVELOPMENTAL
cleft lip with cleft palate cleft lip without cleft palate
Desease Name
Electrocardiographic conduction measures
Desease Name
Tooth agenesis, selective, 1, with or without orofacial cleft
Witkop syndrome
Orofacial cleft 5
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MSX1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MSX1 mRNAaffects expression 16483693
C007076 citral citral results in decreased expression of MSX1 mRNAdecreases expression 15581867
D016572 Cyclosporine Cyclosporine results in increased expression of MSX1 mRNAincreases expression 20106945
C014347 decitabine decitabine results in increased expression of MSX1 mRNAincreases expression 16367923
D004040 Dietary Carbohydrates Dietary Carbohydrates results in increased expression of MSX1 mRNAincreases expression 17490981
D005419 Flavonoids Flavonoids results in increased expression of MSX1 mRNAincreases expression 18035473
C091888 monoisoamyl-2,3-dimercaptosuccinate monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of MSX1 mRNA]decreases expression|decreases reaction 19615344
C091888 monoisoamyl-2,3-dimercaptosuccinate monoisoamyl-2,3-dimercaptosuccinate results in decreased expression of MSX1 mRNAdecreases expression 19615344
C009166 retinol acetate retinol acetate results in increased expression of MSX1 mRNAincreases expression 16772331
C115461 SC 560 SC 560 results in decreased expression of MSX1 mRNAdecreases expression 14633654
C115461 SC 560 SC 560 results in decreased expression of MSX1 proteindecreases expression 14633654
C017947 sodium arsenite monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of MSX1 mRNA]decreases expression|decreases reaction 19615344
C017947 sodium arsenite sodium arsenite results in decreased expression of MSX1 mRNAdecreases expression 19615344
C025462 sulindac sulfide sulindac sulfide results in decreased expression of MSX1 mRNAdecreases expression 12734198
C025462 sulindac sulfide sulindac sulfide results in decreased expression of MSX1 proteindecreases expression 12734198
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MSX1 mRNAdecreases expression 17586704
16922920
D014212 Tretinoin Tretinoin results in increased expression of MSX1 mRNAincreases expression 17138961
D014212 Tretinoin Tretinoin results in increased expression of MSX1 mRNAincreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9311752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0017306315 16712894
MESH:D000505 Alopecia Tretinoin 3.6615955085
MESH:D000544 Alzheimer Disease sulindac sulfide 3.1018759972
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D001169 Arthritis, Experimental Tretinoin 3.1116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.1216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms decitabine 1.8819208741 18320071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7621507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular SC 560 6.7616391822
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.7617306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.761917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.4612391285
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.6719215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.6718572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.6716051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 16120746 18670907
MESH:D002386 Cataract Tretinoin 3.1217460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7812371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.7820056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6716129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Cyclosporine 2.9519486331
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D002972 Cleft Palate marker/mechanism 15301380 12701100 12163415
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8315668235 15340226 12621046 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.839407595
MESH:D003092 Colitis Tretinoin 3.7817035595
MESH:D003110 Colonic Neoplasms decitabine 2.3417616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities marker/mechanism 12163415 14654219 14630905 15301380
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4620055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.469142499 14991402 10589399 9664655 16925845 9224671 17551590 9125849 9211117 8800419
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.2716714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.2718230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2119294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.9711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.9716938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 2.9119224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Cyclosporine 15.1612168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.1620067830
MESH:D005355 Fibrosis Tretinoin 15.1617994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D005909 Glioblastoma Tretinoin 3.0417312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.9519215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.9516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.629664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9612621046 15340226 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.2012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.2516870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118670907 18850075
MESH:D007248 Infertility, Male decitabine 7.0217581917
MESH:D007248 Infertility, Male sodium arsenite 7.0215346721 12646999
MESH:D007249 Inflammation Flavonoids 5.0817296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0812200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.8417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.1216580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.1215992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Cyclosporine 6.1118776723 10903974 8314463
MESH:D007674 Kidney Diseases sodium arsenite 6.1120008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7812371664
MESH:D007938 Leukemia decitabine 6.5118980019 19235587
MESH:D007938 Leukemia Tretinoin 6.5117143497
MESH:D007951 Leukemia, Myeloid decitabine 9.7518454857 17236224 19117987
MESH:D007951 Leukemia, Myeloid Tretinoin 9.7519285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0017679729 18206229 18460780 18704418 19387464 19010910
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0016294345 19850784 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5618055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1917649720 17301526 16823087 17217047 17294898 16331271 19642359 17506722 17361223 16766008 17712046 17368321 17339181 19029980 17107899 15748426 19075265 19225113 16788101 19035177 16891316 16935935 9834237 12679006 16140955
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3218397230 16248980
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.542125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms sodium arsenite 7.5415276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.918603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9112151625
MESH:D008171 Lung Diseases sodium arsenite 3.2119095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4414755239
MESH:D008175 Lung Neoplasms sodium arsenite 3.4417306315 17077188 19931552 15276417 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4411884234 19555203
MESH:D008223 Lymphoma decitabine 3.4619470736
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma decitabine 5.2016505122 17785578
MESH:D008545 Melanoma sodium arsenite 5.2016487513 19082730
MESH:D008545 Melanoma Tretinoin 5.2016752155
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009101 Multiple Myeloma decitabine 3.3818172295
MESH:D009190 Myelodysplastic Syndromes decitabine 7.5819010910 16882708 18608210 19157545
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.5817596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D009369 Neoplasms decitabine 8.4917925555 19116145 19470736
MESH:D009369 Neoplasms sodium arsenite 8.4911559025
MESH:D009369 Neoplasms Tretinoin 8.4916946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7420056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3318481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.739125849
MESH:D009436 Neural Tube Defects sodium arsenite 7.4312854658
MESH:D009436 Neural Tube Defects Tretinoin 7.439142499
OMIM:608874 OROFACIAL CLEFT 5 marker/mechanism
MESH:D010051 Ovarian Neoplasms decitabine 8.0319259094 19331143
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.0315276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 8.0316936753
MESH:D010146 Pain Tretinoin 2.9516870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.4419294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4415976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711118676 11222880 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.8017616702
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2916039940
MESH:D011507 Proteinuria Tretinoin 3.6616636307
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012208 Rhabdomyosarcoma decitabine 11.1519155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.1516116481 16283617
MESH:D012878 Skin Neoplasms sodium arsenite 9.5719524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.5716192470
MESH:D012878 Skin Neoplasms Tretinoin 9.5716467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8412854658
MESH:D013274 Stomach Neoplasms marker/mechanism 16367923
MESH:D013274 Stomach Neoplasms decitabine 2.5619037991
MESH:D013274 Stomach Neoplasms Tretinoin 2.5617261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms decitabine 7.4317967635
MESH:D013964 Thyroid Neoplasms Tretinoin 7.4317045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.8416051514
MESH:D014071 Tooth Abnormalities marker/mechanism 14630905
OMIM:106600 TOOTH AGENESIS, SELECTIVE, 1 marker/mechanism
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.3219087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.3211723127 16712894 16452187 17306315
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.5811813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.5816129372
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.7218645019
MESH:D014604 Uveal Neoplasms decitabine 13.1617785578
MESH:D014604 Uveal Neoplasms Tretinoin 13.1616752155
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D014652 Vascular Diseases sodium arsenite 4.5117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
MESH:C536736 Witkop syndrome marker/mechanism
MESH:D054877 Wolf-Hirschhorn Syndrome marker/mechanism 14630905
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31196
    • No data
    Releated disease ID Related disease Name
    PA164924611Partial congenital absence of teeth
    PA443737Cleft Palate
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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