AutismKB 2.0

Annotation Detail for MT1X


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Basic Information Top
Gene Symbol:MT1X ( MT-1l,MT1 )
Gene Full Name: metallothionein 1X
Band: 16q13
Quick LinksEntrez ID:4501; OMIM: 156359; Uniprot ID:MT1X_HUMAN; ENSEMBL ID: ENSG00000187193; HGNC ID: 7405
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MT1X proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in increased expression of MT1X mRNAincreases expression 19774075
D000965 Antimony Antimony results in decreased expression of MT1X mRNAdecreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in decreased expression of MT1X mRNAdecreases expression 17547211
D001151 Arsenic Arsenic results in increased expression of MT1X mRNAincreases expression 17409696
C006632 arsenic trioxide arsenic trioxide results in increased expression of MT1X mRNAincreases expression 19417148
19128835
15725085
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MT1X mRNAdecreases expression 20106945
20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of MT1X mRNAincreases expression 15336504
12414654
D002104 Cadmium Cadmium results in increased expression of MT1X mRNAincreases expression 17409696
16827180
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of MT1X mRNAincreases expression 14555400
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of MT1X mRNAaffects cotreatment|increases expression 12634122
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of MT1X mRNAaffects cotreatment|increases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of MT1X mRNAaffects cotreatment|increases expression 12634122
D003300 Copper Copper results in increased expression of MT1X mRNAincreases expression 17409696
C029892 cupric chloride cupric chloride promotes the reaction [Disulfiram results in increased expression of MT1X mRNA]increases expression|increases reaction 19789329
C014347 decitabine decitabine results in increased expression of MT1X mRNAincreases expression 19151715
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of MT1X mRNAdecreases expression 17547211
D011397 Promegestone methoxyacetic acid promotes the reaction [Promegestone results in increased expression of MT1X mRNA]increases expression|increases reaction 15103026
D011397 Promegestone Promegestone results in increased expression of MT1X mRNAincreases expression 15103026
D004221 Disulfiram cupric chloride promotes the reaction [Disulfiram results in increased expression of MT1X mRNA]increases expression|increases reaction 19789329
D004221 Disulfiram Disulfiram results in increased expression of MT1X mRNAincreases expression 19789329
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MT1X mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of MT1X mRNAincreases expression 19619570
19153601
20106945
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of MT1X mRNAaffects cotreatment|increases expression 17404688
D005472 Fluorouracil Fluorouracil results in decreased expression of MT1X mRNAdecreases expression 17039268
D019833 Genistein Genistein results in increased expression of MT1X mRNAincreases expression 18847459
C040641 genistin genistin analog results in increased expression of MT1X mRNAincreases expression 16719502
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of MT1X mRNAincreases expression 12414654
C475919 hydroxytamoxifen GPR30 protein affects the reaction [hydroxytamoxifen results in increased expression of MT1X mRNA]affects reaction|increases expression 19153601
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of MT1X mRNAincreases expression 19153601
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of MT1X mRNAaffects cotreatment|increases expression 12634122
C013598 methoxyacetic acid methoxyacetic acid promotes the reaction [Promegestone results in increased expression of MT1X mRNA]increases expression|increases reaction 15103026
C437683 motexafin gadolinium motexafin gadolinium results in increased expression of MT1X mRNAincreases expression 15867382
D009599 Nitroprusside Nitroprusside results in increased expression of MT1X mRNAincreases expression 17018880
D009599 Nitroprusside N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MT1X mRNA]decreases reaction|increases expression 17018880
D009599 Nitroprusside Zinc Sulfate promotes the reaction [Nitroprusside results in increased expression of MT1X mRNA]increases expression|increases reaction 17018880
C044387 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MT1X mRNA]decreases reaction|increases expression 17018880
D010100 Oxygen Oxygen deficiency results in increased expression of MT1X mRNAincreases expression 17914565
D019308 Palmitic Acid Palmitic Acid results in decreased expression of MT1X mRNAdecreases expression 17658692
D019800 Phenol Phenol results in decreased expression of MT1X mRNAdecreases expression 17547211
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of MT1X mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of MT1X mRNAincreases expression 18037150
D011374 Progesterone Progesterone results in decreased expression of MT1Xdecreases expression 17510236
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of MT1X mRNAaffects cotreatment|increases expression 12634122
C017947 sodium arsenite sodium arsenite results in increased expression of MT1X mRNAincreases expression 11693492
14555400
12679051
16966095
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MT1X mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MT1X mRNAdecreases expression 19619570
20106945
D024483 Vitamin K 3 Vitamin K 3 results in increased expression of MT1X mRNAincreases expression 12414654
D015032 Zinc Zinc results in increased expression of MT1X mRNAincreases expression 15226459
17409696
11168427
16870260
C016837 zinc chloride zinc chloride results in increased expression of MT1X mRNAincreases expression 16870260
D019287 Zinc Sulfate Zinc Sulfate promotes the reaction [Nitroprusside results in increased expression of MT1X mRNA]increases expression|increases reaction 17018880
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of MT1X mRNAincreases expression 17018880
15226459
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Disulfiram 12.2217676605
MESH:D000014 Abnormalities, Drug-Induced methoxyacetic acid 12.223652986 1761404 1761407 15959878 12805644
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.2211752688 15322242 14514962
MESH:D000138 Acidosis Zinc Sulfate 4.507265320
MESH:D000163 Acquired Immunodeficiency Syndrome Disulfiram 5.169207937
MESH:D000169 Acrodermatitis Zinc 5.0017190629 16889938 17202136
MESH:D055371 Acute Lung Injury Oxygen 4.1616759491
MESH:D000230 Adenocarcinoma arsenic trioxide 15.5819825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 15.5820127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 15.5816033868
MESH:D000230 Adenocarcinoma Estradiol 15.5811473722
MESH:D000230 Adenocarcinoma Fluorouracil 15.5817638652
MESH:D000230 Adenocarcinoma Genistein 15.5811473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.086695378
MESH:D000236 Adenoma Dimethylnitrosamine 6.0819555203
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.9716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2815276417
MESH:D018246 Adrenocortical Adenoma Arsenic 12.4117306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 12.4116712894 17306315
MESH:D000437 Alcoholism Disulfiram 4.6617079463 18968458 10841824
MESH:D000544 Alzheimer Disease Copper 4.3916410023 17119284 16962711 16325427 16866297 16886094
MESH:D000544 Alzheimer Disease Zinc 4.3916325427 16410023 17119284 16580781
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 4.0410694572
MESH:D000740 Anemia Fluorouracil 7.5116511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.5111748828
MESH:D018798 Anemia, Iron-Deficiency Copper 4.5216614410
MESH:D000755 Anemia, Sickle Cell Zinc 4.5116916123
MESH:D000860 Anoxia Oxygen 10.1620872349
MESH:D000860 Anoxia Zinc Sulfate 10.167265320
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6819183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.4520041841 18218290 18057881
MESH:D020261 Arsenic Poisoning Arsenic 2.7516251483 18414634 12569548 16835338
MESH:D001249 Asthma Zinc 2.8317085522
MESH:D050197 Atherosclerosis Arsenic 9.7819371607 12928151
MESH:D050197 Atherosclerosis Cadmium 9.7815687053
MESH:D050197 Atherosclerosis Oxygen 9.7816391483
MESH:D001281 Atrial Fibrillation Amiodarone 3.6019698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 13.2819483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.2816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.2812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5015746008
MESH:D001859 Bone Neoplasms Phenol 4.8310556009
MESH:D001913 Bowen's Disease Phenol 5.3419293009
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9217868700
MESH:D001930 Brain Injuries Nitroprusside 16.3214637104
MESH:D001930 Brain Injuries Progesterone 16.3215665606 15845082 15380490
MESH:D001930 Brain Injuries Zinc 16.3217109824
MESH:D001932 Brain Neoplasms Copper 4.2117079463
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.4817474063 20146248
MESH:D001943 Breast Neoplasms Copper 6.4815986119 17079463
MESH:D001943 Breast Neoplasms decitabine 6.4818320071 19208741
MESH:D001943 Breast Neoplasms Disulfiram 6.4817026967
MESH:D001943 Breast Neoplasms Estradiol 6.4817261762 18497071 19861407 16675129 17289903 14630087 12948864 17018787
MESH:D001943 Breast Neoplasms Fluorouracil 6.4816110121 15136595 19217205 16557594 16595493 18608205 18357371
MESH:D001943 Breast Neoplasms Genistein 6.4816873071 17200150 16541309
MESH:D001943 Breast Neoplasms Oxygen 6.4817263869
MESH:D001943 Breast Neoplasms Progesterone 6.4817614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.4820435547
MESH:D001991 Bronchitis Antimony 5.728768112
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9511589617
MESH:D002177 Candidiasis Disulfiram 5.4515325261
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0616111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2516051944
MESH:D002277 Carcinoma Dimethylnitrosamine 17.3719555203
MESH:D002277 Carcinoma Disulfiram 17.3717026967
MESH:D002277 Carcinoma Fluorouracil 17.3717121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 17.3716835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.3617687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 12.8812907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Arsenic 12.8817306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 12.8811135700 16217749 15073043 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Estradiol 12.8816924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 12.8816799960 16332177 17971768 17045692 18930000 17088986
MESH:D006528 Carcinoma, Hepatocellular Genistein 12.8816924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 12.8815276417 17306315 16507464
MESH:D002289 Carcinoma, Non-Small-Cell Lung Disulfiram 3.7717026967
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4619014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8218695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7612490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 19.9617687452 15504454 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 19.9620419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 19.9619215824
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 19.9616033868
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 19.9616757204 16280240 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 19.9618572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 19.9616543248
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.7318640142
MESH:D006332 Cardiomegaly Copper 6.2917327471
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2918850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.8315710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Antimony 5.8310334427
MESH:D002318 Cardiovascular Diseases Arsenic 15.0417938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases Genistein 15.0416332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 15.0416936243
MESH:D002318 Cardiovascular Diseases Zinc 15.0416936243
MESH:D002340 Carotid Artery Diseases Arsenic 3.9718022660 16973168
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.6818974383
MESH:D002386 Cataract Disulfiram 4.2615003327 17936468
MESH:D002471 Cell Transformation, Neoplastic Cadmium 9.6917332340
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.6918566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.6919524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9316354765 15668235 12621046 15340226 8697196
MESH:D019970 Cocaine-Related Disorders Disulfiram 5.3419462300
MESH:D003110 Colonic Neoplasms decitabine 5.3517616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.3516510598 17169374 15001691 17172411 17725105 18772588 17287894 17016597 17018589 16340194
MESH:D003110 Colonic Neoplasms Genistein 5.3517182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.2320501625
MESH:D015179 Colorectal Neoplasms decitabine 3.2318981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.2318288408 16524972 15148649 18509181 17016601 16331619 17401013 16303861 18949393 20501625 15289873 16282729 17594712 17695437 16391804 17454858 18448328 18802399 17094418 18383874 14970324 17255274
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7217141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.0510525206
MESH:D019465 Craniofacial Abnormalities lead acetate 5.0519769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.0520055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Zinc 5.0519302082
MESH:D007644 Darier Disease Fluorouracil 4.3816733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7215213294
MESH:D003920 Diabetes Mellitus Zinc 3.8616479319
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 3.9516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0719279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.0917187935
MESH:D004283 Dog Diseases Antimony 5.2512019027
MESH:D056486 Drug-Induced Liver Injury Amiodarone 5.5518218290 15265979
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 5.558172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.5520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4611462148
MESH:D004417 Dyspnea Oxygen 4.4220016425
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.0311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4915322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.4017692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.7019294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.1816402032
MESH:D016889 Endometrial Neoplasms Estradiol 6.6111473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 6.6111473722
MESH:D004715 Endometriosis Progesterone 7.7616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.7610568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 12.5612903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.5616530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 12.5617016578
MESH:D004938 Esophageal Neoplasms Fluorouracil 12.5616481741 16337965 16785472 17638652 15173087
MESH:D004938 Esophageal Neoplasms Zinc 12.5616543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7111564622
MESH:D005234 Fatty Liver Amiodarone 6.8014986274
MESH:D005234 Fatty Liver arsenic trioxide 6.8015073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0611858732
MESH:D005317 Fetal Growth Retardation lead acetate 5.0019769572
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.5620067830
MESH:D005532 Foot Deformities, Congenital methoxyacetic acid 5.333652986
MESH:D005534 Foot Diseases Arsenic 5.146392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8816904648
MESH:D005739 Gas Poisoning Oxygen 4.8020016425
MESH:D005756 Gastritis Zinc 4.3817241300
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2716452187
MESH:D005909 Glioblastoma Genistein 2.9916598420
MESH:D005910 Glioma Fluorouracil 2.7016145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1810696789
MESH:D006130 Growth Disorders Zinc 3.7017217573
MESH:D006258 Head and Neck Neoplasms decitabine 6.9819215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.9818337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.7120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7111294989 10048152
MESH:D006333 Heart Failure Zinc 3.3617162251
MESH:D006335 Heart Injuries Zinc 5.3517074742
MESH:D016481 Helicobacter Infections Zinc 4.1617241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9711000095
MESH:D006521 Hepatitis, Chronic Copper 4.8617338147
MESH:D006527 Hepatolenticular Degeneration Copper 16.3516607473 17276780 17182432 17109627 19888908
MESH:D006527 Hepatolenticular Degeneration Zinc 16.3517276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 16.3517063115
MESH:D006529 Hepatomegaly Amiodarone 7.2315265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.2312621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.6215709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.8212676792
MESH:D019584 Hot Flashes Estradiol 3.3417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.638697196 16354765 15340226 18606429 16959395
MESH:D006937 Hypercholesterolemia Amiodarone 3.519751232 8137927
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.1017050553
MESH:D006973 Hypertension Arsenic 4.6811953799 9931084 16076760
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6818670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.1416093927
MESH:D007022 Hypotension Zinc Sulfate 4.107265320
MESH:D007037 Hypothyroidism Amiodarone 4.1218020914 17991464
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0015869954
MESH:D007248 Infertility, Male decitabine 6.0017581917
MESH:D007248 Infertility, Male sodium arsenite 6.0012646999 15346721
MESH:D007249 Inflammation Progesterone 4.2615869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.2612878042 12200463
MESH:D007333 Insulin Resistance Estradiol 2.7016627594 16393666
MESH:D007511 Ischemia Zinc 4.2316584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9716580747
MESH:D007642 Keratosis Arsenic 4.5816930632 12749816
MESH:D055623 Keratosis, Actinic Phenol 6.0319293009
MESH:D007674 Kidney Diseases Cadmium 16.5416322080 16962696 16226777
MESH:D007674 Kidney Diseases Cadmium Chloride 16.5416962696
MESH:D007674 Kidney Diseases Estradiol 16.5415618244
MESH:D007674 Kidney Diseases sodium arsenite 16.5420008137
MESH:D007674 Kidney Diseases Zinc 16.5416960431
MESH:D007676 Kidney Failure, Chronic Copper 14.8216518626
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 14.8216518626
MESH:D007676 Kidney Failure, Chronic Zinc 14.8216518626
MESH:D007680 Kidney Neoplasms Estradiol 6.4015610895
MESH:D007680 Kidney Neoplasms Fluorouracil 6.4016985049
MESH:D007859 Learning Disorders Copper 4.4017134702
MESH:D007896 Leishmaniasis Antimony 4.4721182181 21063981 12019027 10953559 15220340
MESH:D016773 Leishmaniasis, Cutaneous Antimony 7.9919141829 8889330 11475954
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 7.9915237267
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.089643325 7854095 10651420 10881086 11370249
MESH:D007898 Leishmaniasis, Visceral Antimony 7.7111105143 7875148 7854095 20495762 8142506 1899875 7554475
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 7.7112707265
MESH:D007938 Leukemia arsenic trioxide 9.3115070760
MESH:D007938 Leukemia decitabine 9.3118980019 19235587
MESH:D007938 Leukemia Genistein 9.3118980019 17468513
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Disulfiram 4.0017026967
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.3819077051
MESH:D007951 Leukemia, Myeloid decitabine 8.3817236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7016467208 17050201 16968895 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.7018460780 18206229 19010910 18704418 17679729 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.0518055864
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 11.409834237
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 11.4017339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 11.4017217047 16823087 11161223 15213294 12679006 19035177 15336539 17712046 16330433 12712474 15748426 16112521 16331271 19642359 19225113 16891316 12018890 11468182 16966277 17107899 17869043 9834237 15622746 17649720 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9716882451
MESH:D017880 Limb Deformities, Congenital Disulfiram 8.2017676605
MESH:D017880 Limb Deformities, Congenital methoxyacetic acid 8.2012805644 15959878
MESH:D008064 Lipidoses Amiodarone 3.2215342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 4.5114726149 15763062 14643895 17881167 15798949 15942678 17201889 16627068 16570917 12925901 18637143 18095165 15339415 15864749 15369754 18237412 18567088 14709902 15744066 17348192 15504291 17432682 17196135 18672772 17203207 17666798 17198567 17036385 17640959 18210741 16544323 18364076 15842777 15086199 18371158 14659978 15571005 15138612 15366600 15479170 16009107 17465448 15723089 18239293 16270385 15099470 15591649 15081153 16169303 15067225 16603200 17719030 12918455 15492853 15383259 16042886 15793283 15298665 15161499 18629640 17724770 14568256 15577212 17534399 15733078
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.5114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.5117823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.5112878042
MESH:D008107 Liver Diseases Arsenic 2.4411134558
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.0617457977
MESH:D008113 Liver Neoplasms Aflatoxin B1 26.829163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Arsenic 26.8216368122
MESH:D008113 Liver Neoplasms arsenic trioxide 26.8214682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 26.8220195826 21137059
MESH:D008113 Liver Neoplasms Copper 26.8220302851
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 26.8215890375 3113478
MESH:D008113 Liver Neoplasms Fluorouracil 26.8216603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms sodium arsenite 26.8215276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 26.8216984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.028603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 12.0220377131
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 12.026150874 1848544 15603536
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.0212151625
MESH:D008133 Long QT Syndrome Amiodarone 7.1717391786 15350150 11989578
MESH:D008133 Long QT Syndrome arsenic trioxide 7.1715213294
MESH:D008171 Lung Diseases Amiodarone 6.6012587719
MESH:D008171 Lung Diseases sodium arsenite 6.6019095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.0718516814
MESH:D055370 Lung Injury Oxygen 4.1218339021
MESH:D008175 Lung Neoplasms Aflatoxin B1 11.9214755239
MESH:D008175 Lung Neoplasms Arsenic 11.9217306315 19168569 17976673
MESH:D008175 Lung Neoplasms arsenic trioxide 11.9219825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 11.9220135361 18816296 17053015 18569708 20869020 20464547 20064080 18520028 6695378
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 11.9216061637 19555203 11884234
MESH:D008175 Lung Neoplasms Fluorouracil 11.9215246190
MESH:D008175 Lung Neoplasms sodium arsenite 11.9217306315 15276417 16712894 19931552 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.9219555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3815086387
MESH:D008223 Lymphoma decitabine 3.1319470736
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.1317203775 11408345 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.1314578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.1311408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Zinc 12.1312773700
MESH:D020149 Manganese Poisoning Estradiol 4.0719453300
MESH:D008545 Melanoma decitabine 6.7317785578 16505122
MESH:D008545 Melanoma Disulfiram 6.7315367699
MESH:D008545 Melanoma sodium arsenite 6.7319082730 16487513
MESH:D008545 Melanoma Vitamin K 3 6.7319082730
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.4717268249 17109627
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.5016381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.5016757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 6.4119549372 15949261 19417148 14977855 11468182
MESH:D009101 Multiple Myeloma decitabine 6.4118172295
MESH:D009181 Mycoses Amiodarone 4.4912754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.7016882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 6.7018608210 19010910 19157545 16882708
MESH:D009203 Myocardial Infarction Genistein 2.6817141266
MESH:D017202 Myocardial Ischemia Arsenic 7.9315371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.9312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.4816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.4817141266
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 9.3916624393
MESH:D009361 Neoplasm Invasiveness Disulfiram 9.3918047805
MESH:D009362 Neoplasm Metastasis Disulfiram 3.8515367699
MESH:D009369 Neoplasms Benzo(a)pyrene 13.5111141357
MESH:D009369 Neoplasms decitabine 13.5119116145 17925555 19470736
MESH:D009369 Neoplasms Disulfiram 13.5117079463
MESH:D009369 Neoplasms Fluorouracil 13.5118600527 16928823 18239605
MESH:D009369 Neoplasms sodium arsenite 13.5111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.2720056578
MESH:D009389 Neovascularization, Pathologic Copper 14.8717308104
MESH:D009389 Neovascularization, Pathologic Disulfiram 14.8715367699
MESH:D009389 Neovascularization, Pathologic Estradiol 14.8717289903
MESH:D009421 Nervous System Malformations Estradiol 14.1316427766 11399458
MESH:D009421 Nervous System Malformations Genistein 14.1316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.1314600291
MESH:D009436 Neural Tube Defects Arsenic 10.6516620997
MESH:D009436 Neural Tube Defects arsenic trioxide 10.6510525206
MESH:D009436 Neural Tube Defects sodium arsenite 10.6512854658
MESH:D020078 Neurogenic Inflammation Arsenic 4.0017056641
MESH:D020258 Neurotoxicity Syndromes Disulfiram 7.5611005259
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 7.5616436463
MESH:D010024 Osteoporosis Genistein 3.0019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.7116169203
MESH:D012516 Osteosarcoma Disulfiram 4.8518047805
MESH:D010051 Ovarian Neoplasms Arsenic 24.6517306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 24.6512452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms decitabine 24.6519331143 19259094
MESH:D010051 Ovarian Neoplasms Disulfiram 24.6517026967
MESH:D010051 Ovarian Neoplasms Estradiol 24.6519401270
MESH:D010051 Ovarian Neoplasms Genistein 24.6519005980
MESH:D010051 Ovarian Neoplasms Progesterone 24.6517393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 24.6517306315 15276417
MESH:D010146 Pain Phenol 3.8717610455
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 7.7615580305
MESH:D010190 Pancreatic Neoplasms decitabine 7.7619294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 7.7615113037 16929163 16500647 19003803
MESH:D010212 Papilloma Hydrogen Peroxide 3.6912065085
MESH:D010235 Paraganglioma arsenic trioxide 3.7919927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8312520081
MESH:D010392 Pemphigus Phenol 6.0316522979 17163923
MESH:D010409 Penile Diseases Antimony 5.349643325
MESH:D010493 Pericarditis Antimony 5.7120465667
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.7916093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 11.736392382 16905509 15371236
MESH:D016491 Peripheral Vascular Diseases Cadmium 11.7315687053
MESH:D010864 Pilonidal Sinus Phenol 6.0319655223 15622588
MESH:D011041 Poisoning Phenol 4.358825745
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1718163543
MESH:D011225 Pre-Eclampsia Zinc 3.8617114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.7911896295 11118676 11399792 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.3317616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5220887781
MESH:D011471 Prostatic Neoplasms Arsenic 3.9916140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.9919131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.9917292933
MESH:D011471 Prostatic Neoplasms Cadmium 3.9917075824
MESH:D011471 Prostatic Neoplasms Copper 3.9917079463 17308104
MESH:D011471 Prostatic Neoplasms Disulfiram 3.9919789329
MESH:D011471 Prostatic Neoplasms Estradiol 3.9916740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.9919082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 3.9915378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.9916039940
MESH:D011471 Prostatic Neoplasms Zinc 3.9916700911 12429649 16606632 16517595
MESH:D011507 Proteinuria Arsenic 3.6321343184
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.6912832656 11597910 12490602
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6715538739 16160472 18286688 18722050
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.1417627322 18339021
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4518990726
MESH:D012162 Retinal Degeneration Zinc 3.8216584753
MESH:D012208 Rhabdomyosarcoma decitabine 4.0319155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7018045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.5716646077
MESH:D012559 Schizophrenia Copper 3.0316842975
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.6818724381
MESH:D012871 Skin Diseases Arsenic 2.6416353154 19834688 16759981 6392382 15952646 17453740 16702368 17938729 17050553 17548696 18709164
MESH:D012878 Skin Neoplasms Arsenic 19.8517029826 16251483 17976673 19538983 15504454 17050553
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 19.8519755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 19.8512065085
MESH:D012878 Skin Neoplasms sodium arsenite 19.8519524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 19.858532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 19.8516192470
MESH:D013088 Spermatocele Phenol 5.2318646496
MESH:D013119 Spinal Cord Injuries Progesterone 3.8716503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4812854658
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.8512587719
MESH:D013274 Stomach Neoplasms arsenic trioxide 5.8817007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.882093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 5.8819037991
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 5.8816033868
MESH:D013274 Stomach Neoplasms Fluorouracil 5.8817172411 17522103 19084572 18396642 16424979 15786421 19015929 18567086 17498489 16951190
MESH:D013276 Stomach Ulcer Amiodarone 2.9718087811
MESH:D013398 Sudden Infant Death Oxygen 5.1412563064
MESH:D013576 Syndactyly methoxyacetic acid 5.241761404 1761407
MESH:D013610 Tachycardia Amiodarone 9.8911238279
MESH:D013610 Tachycardia Nitroprusside 9.8915306635
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8019225199
MESH:D013733 Testicular Diseases methoxyacetic acid 4.936499806 18486176
MESH:D013959 Thyroid Diseases Amiodarone 10.6719731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.6712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.3019014326
MESH:D013964 Thyroid Neoplasms decitabine 6.3017967635
MESH:D013971 Thyrotoxicosis Amiodarone 4.4619584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.2719048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.8816280240
MESH:D014062 Tongue Neoplasms Zinc 8.8816543248
MESH:D016171 Torsades de Pointes Amiodarone 8.9111989578 17467628
MESH:D016171 Torsades de Pointes arsenic trioxide 8.9115213294
MESH:D014277 Trigeminal Neuralgia Phenol 6.0310223447 16527771
MESH:D014352 Trypanosomiasis Antimony 5.5215220340
MESH:D001749 Urinary Bladder Neoplasms Arsenic 13.9819429237 11144890 17976673 19322015 18640142 15987713 17306315
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 13.9812845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 13.9817053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 13.9819087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 13.9811723127 17306315 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.3216803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.3211813266
MESH:D014604 Uveal Neoplasms decitabine 4.5017785578
MESH:D014652 Vascular Diseases Arsenic 10.4917056641
MESH:D014652 Vascular Diseases sodium arsenite 10.4917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1812125929
MESH:D014860 Warts Phenol 5.6819122958
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8315886252
Pathway ID Pathway Name
KEGG:04978 Mineral absorption
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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