AutismKB 2.0

Annotation Detail for MTF1


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Basic Information Top
Gene Symbol:MTF1 ( MGC23036,MTF-1,ZRF )
Gene Full Name: metal-regulatory transcription factor 1
Band: 1p34.3
Quick LinksEntrez ID:4520; OMIM: 600172; Uniprot ID:MTF1_HUMAN; ENSEMBL ID: ENSG00000188786; HGNC ID: 7428
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MTF1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MTF1 mRNAdecreases expression 18648102
C041524 aluminum sulfate aluminum sulfate results in decreased expression of MTF1 mRNAdecreases expression 15961160
C050510 arsenic trichloride arsenic trichloride promotes the reaction [MTF1 protein binds to MT1 protein]affects binding|increases reaction 19276070
C050510 arsenic trichloride MTF1 protein affects the reaction [arsenic trichloride results in increased expression of MT1 mRNA]affects reaction|increases expression 19276070
C050510 arsenic trichloride MTF1 protein affects the reaction [Cycloheximide promotes the reaction [arsenic trichloride results in increased expression of MT1 mRNA]]affects reaction|increases expression|increases reaction 19276070
C050510 arsenic trichloride MTF1 protein affects the susceptibility to arsenic trichlorideaffects response to substance 19276070
C050510 arsenic trichloride MTF1 protein results in decreased susceptibility to arsenic trichloridedecreases response to substance 19276070
D020122 tert-Butylhydroperoxide MTF1 gene mutant form results in increased susceptibility to tert-Butylhydroperoxideincreases response to substance 15378601
D002104 Cadmium Cadmium affects the localization of and results in increased activity of MTF1 proteinaffects localization|increases activity 17269467
D002104 Cadmium Cadmium affects the localization of MTF1 proteinaffects localization 17269467
D002104 Cadmium Cadmium promotes the reaction [MTF1 protein binds to MT1 promoter]affects binding|increases reaction 17269467
D002104 Cadmium Cadmium results in increased expression of MTF1 mRNAincreases expression 17269467
D002104 Cadmium MTF1 protein results in decreased susceptibility to Cadmiumdecreases response to substance 12716893
C074702 chromium hexavalent ion chromium hexavalent ion inhibits the reaction [MTF1 protein binds to MT1A promoter]affects binding|decreases reaction 12716893
C074702 chromium hexavalent ion chromium hexavalent ion results in decreased activity of MTF1 proteindecreases activity 12716893
C074702 chromium hexavalent ion MTF1 protein results in decreased susceptibility to chromium hexavalent iondecreases response to substance 12716893
D003300 Copper MTF1 protein affects the susceptibility to Copperaffects response to substance 17290228
D003513 Cycloheximide MTF1 protein affects the reaction [Cycloheximide promotes the reaction [arsenic trichloride results in increased expression of MT1 mRNA]]affects reaction|increases expression|increases reaction 19276070
D003513 Cycloheximide MTF1 protein affects the reaction [Cycloheximide results in increased expression of MT1 mRNA]affects reaction|increases expression 19276070
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MTF1 mRNAincreases expression 17606305
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MTF1 mRNAincreases expression 17942748
D007501 Iron Iron affects the localization of MTF1 proteinaffects localization 17269467
D007501 Iron Iron results in increased expression of MTF1 mRNAincreases expression 17269467
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of MTF1 mRNAincreases expression 19339665
D008070 Lipopolysaccharides methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MTF1 mRNA]decreases reaction|increases expression 19339665
D008628 Mercury Mercury results in increased expression of MTF1 mRNAincreases expression 16823088
C008435 methyldithiocarbamate methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MTF1 mRNA]decreases reaction|increases expression 19339665
D009532 Nickel Nickel affects the localization of and results in increased activity of MTF1 proteinaffects localization|increases activity 19097988
C029938 nickel sulfate nickel sulfate results in increased activity of MTF1 proteinincreases activity 19131640
D009599 Nitroprusside Nitroprusside promotes the reaction [Zinc Sulfate results in increased expression of MTF1 mRNA]increases expression|increases reaction 17018880
D009599 Nitroprusside Nitroprusside results in increased expression of MTF1 mRNAincreases expression 17018880
D009599 Nitroprusside N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MTF1 mRNA]decreases reaction|increases expression 17018880
C044387 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MTF1 mRNA]decreases reaction|increases expression 17018880
C029341 oxophenylarsine oxophenylarsine binds to MTF1 proteinaffects binding 19276070
C059514 resveratrol resveratrol results in increased expression of MTF1 mRNAincreases expression 12002526
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of MTF1 mRNAaffects cotreatment|increases expression 19244175
C009277 sodium arsenate sodium arsenate results in increased expression of MTF1 proteinincreases expression 11353140
C017947 sodium arsenite sodium arsenite results in increased expression of MTF1 proteinincreases expression 11353140
D017693 Sodium Bicarbonate Sodium Bicarbonate promotes the reaction [MTF1 protein binds to MT2 promoter]affects binding|increases reaction 15965962
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of MTF1 mRNAaffects cotreatment|increases expression 19244175
D015032 Zinc Zinc affects the localization of and results in increased activity of MTF1 proteinaffects localization|increases activity 17269467
D015032 Zinc Zinc promotes the reaction [MTF1 protein binds to MT1 promoter]affects binding|increases reaction 17269467
D015032 Zinc CEBPA protein promotes the reaction [MTF1 protein promotes the reaction [Zinc results in increased expression of MT2A mRNA]]increases expression|increases reaction 17363595
D015032 Zinc MTF1 protein promotes the reaction [Zinc results in increased expression of MT2A mRNA]increases expression|increases reaction 17363595
D015032 Zinc MTF1 protein results in decreased susceptibility to Zincdecreases response to substance 12716893
D015032 Zinc Zinc promotes the reaction [MTF1 protein binds to HSF1 protein]affects binding|increases reaction 16460681
D015032 Zinc Zinc promotes the reaction [MTF1 protein binds to MT2A enhancer]affects binding|increases reaction 16460681
D015032 Zinc Zinc results in increased activity of MTF1 proteinincreases activity 16460681
D015032 Zinc Zinc results in increased expression of MTF1 proteinincreases expression 16719502
D015032 Zinc MTF1 protein results in increased susceptibility to Zincincreases response to substance 16847313
D015032 Zinc Zinc binds to MTF1 proteinaffects binding 19097988
D019287 Zinc Sulfate Nitroprusside promotes the reaction [Zinc Sulfate results in increased expression of MTF1 mRNA]increases expression|increases reaction 17018880
D019287 Zinc Sulfate Zinc Sulfate promotes the reaction [MTF1 protein binds to HSF1 protein]affects binding|increases reaction 16460681
D019287 Zinc Sulfate Zinc Sulfate promotes the reaction [MTF1 protein binds to MT2A enhancer]affects binding|increases reaction 16460681
D019287 Zinc Sulfate Zinc Sulfate results in increased activity of MTF1 proteinincreases activity 16460681
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of MTF1 mRNAincreases expression 17018880
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Sodium Bicarbonate 10.9320061926
MESH:D000138 Acidosis Zinc Sulfate 10.937265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7117505938
MESH:D000169 Acrodermatitis Zinc 5.1717190629 16889938 17202136
MESH:D058186 Acute Kidney Injury resveratrol 3.6516538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 14.3011850527 18653653
MESH:D055371 Acute Lung Injury Nickel 14.3016166738
MESH:D055371 Acute Lung Injury nickel sulfate 14.3019131640 12718980 11954676 16100012
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.403712494
MESH:D000236 Adenoma resveratrol 6.4015688382
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6717306315 16712894
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.4216640825
MESH:D000544 Alzheimer Disease Copper 9.1116886094 16866297 16962711 16325427 16410023 17119284
MESH:D000544 Alzheimer Disease Iron 9.1116640825 16563566
MESH:D000544 Alzheimer Disease resveratrol 9.1116183991 16162502
MESH:D000544 Alzheimer Disease Zinc 9.1116325427 16580781 17119284 16410023
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 4.1610694572
MESH:D000740 Anemia Iron 4.1716566752 16434484
MESH:D018798 Anemia, Iron-Deficiency Copper 9.8116614410
MESH:D018798 Anemia, Iron-Deficiency Iron 9.8117162259 17375513 16569441 17147795 17163184
MESH:D000755 Anemia, Sickle Cell Zinc 4.6816916123
MESH:D000756 Anemia, Sideroblastic Iron 4.6116910769
MESH:D000860 Anoxia Zinc Sulfate 4.797265320
MESH:D001145 Arrhythmias, Cardiac Iron 4.1716604332
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.9015885639
MESH:D001169 Arthritis, Experimental resveratrol 6.9017115116
MESH:D001249 Asthma Zinc 2.8917085522
MESH:D001260 Ataxia Telangiectasia Iron 5.2215336622
MESH:D050197 Atherosclerosis Cadmium 10.4315687053
MESH:D050197 Atherosclerosis Iron 10.4316640825 16632123
MESH:D050197 Atherosclerosis resveratrol 10.4317967414 16873680
MESH:D001321 Autistic Disorder marker/mechanism 15446388
MESH:D001321 Autistic Disorder Iron 2.6417352947
MESH:D001321 Autistic Disorder Mercury 2.6417497416
MESH:D001327 Autoimmune Diseases Mercury 4.6516634805
MESH:D001424 Bacterial Infections Iron 4.9716640825
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.791440618 11289319
MESH:D001930 Brain Injuries Nitroprusside 10.8214637104
MESH:D001930 Brain Injuries Zinc 10.8217109824
MESH:D002545 Brain Ischemia resveratrol 4.0617600658
MESH:D001932 Brain Neoplasms Copper 4.3617079463
MESH:D001943 Breast Neoplasms Copper 2.2615986119 17079463
MESH:D001943 Breast Neoplasms Nickel 2.2615986119
MESH:D001943 Breast Neoplasms resveratrol 2.2616393696 17534123 17651959
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.7116050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.2816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.283581430 7296757
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.2816227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.2816507464 17306315 15276417
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3616675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.577296757
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.2816227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.2818572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 7.2816543248
MESH:D006332 Cardiomegaly Copper 3.9017327471
MESH:D009202 Cardiomyopathies Iron 3.9016640825
MESH:D002311 Cardiomyopathy, Dilated Iron 6.1116604332
MESH:D002311 Cardiomyopathy, Dilated Mercury 6.1110334427
MESH:D002318 Cardiovascular Diseases resveratrol 7.1315458977
MESH:D002318 Cardiovascular Diseases Zinc 7.1316936243
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.796135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.797505956
MESH:D002471 Cell Transformation, Neoplastic Cadmium 14.7917332340
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.7919524636 20056578
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.319022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3117110522 16105132 11677210 16919318 15861022 17681005 17333356
MESH:D003092 Colitis resveratrol 8.9116474422
MESH:D003092 Colitis Selenium 8.9117936198
MESH:D003110 Colonic Neoplasms Iron 4.0116640825
MESH:D003110 Colonic Neoplasms resveratrol 4.0116338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D003327 Coronary Disease resveratrol 3.6116507316
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.9010525206
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.9019769572
MESH:D019465 Craniofacial Abnormalities Zinc 3.9019302082
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7918551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 14.7811298694 18759878 2524372 8156756 14531868 12868966 8970840 11906362
MESH:D017449 Dermatitis, Allergic Contact Mercury 14.7816823706
MESH:D017449 Dermatitis, Allergic Contact Nickel 14.7817244072 17100760 19470301
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 14.7816780908 11298694 16823706
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 8.832952479 3621924
MESH:D003877 Dermatitis, Contact Nickel 8.832952479
MESH:D003920 Diabetes Mellitus Iron 9.0016604332 16640825
MESH:D003920 Diabetes Mellitus Zinc 9.0016479319
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5916873680
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.2916506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 3.0416506275
MESH:D003928 Diabetic Nephropathies resveratrol 3.7716286809
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.4621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.4618289764 6679447 9022650 16192314 18692083 1440618 11289319 7440962 6482804 18648102 9328219 9653073 8291058
MESH:D056486 Drug-Induced Liver Injury Selenium 8.4615131321
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 8.4618186108
MESH:D004417 Dyspnea Sodium Bicarbonate 6.1320016425
MESH:C538011 Eales disease Vitamin E 4.479068938
MESH:D004487 Edema resveratrol 3.178985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.4012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 8.4017872969
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1715328337 15821434 17637181
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6217923197
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.473581430
MESH:D004938 Esophageal Neoplasms Zinc 4.4716543248
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.3515345470
MESH:D005234 Fatty Liver Iron 7.3516640825
MESH:D005334 Fever Lipopolysaccharides 3.829205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.796705139
MESH:D005621 Friedreich Ataxia Iron 5.2016604332 16640825
MESH:D005739 Gas Poisoning Sodium Bicarbonate 6.5120016425
MESH:D005756 Gastritis Zinc 4.5717241300
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4516452187
MESH:D018149 Glucose Intolerance sodium arsenate 4.8719446573
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.827505956
MESH:D006130 Growth Disorders Zinc 3.8217217573
MESH:D006330 Heart Defects, Congenital Vitamin E 2.8716080930
MESH:D006333 Heart Failure Selenium 6.8817162251
MESH:D006333 Heart Failure Zinc 6.8817162251
MESH:D006335 Heart Injuries Zinc 5.5417074742
MESH:D016481 Helicobacter Infections Zinc 4.3217241300
MESH:D006432 Hemochromatosis Iron 4.3316640825 16574947 17236123 17255318 16604332 17053826
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1916366002
MESH:D006486 Hemosiderosis Iron 4.9816604332
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.306705139
MESH:D006521 Hepatitis, Chronic Copper 5.0517338147
MESH:D006525 Hepatitis, Viral, Human Iron 5.2416640825
MESH:D006527 Hepatolenticular Degeneration Copper 24.5617276780 17182432 19888908 16607473 17109627
MESH:D006527 Hepatolenticular Degeneration Iron 24.5617182432
MESH:D006527 Hepatolenticular Degeneration Zinc 24.5617276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 24.5617063115
MESH:D006529 Hepatomegaly Iron 4.0916890145
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6216863852 16490937
MESH:D006561 Herpes Simplex resveratrol 3.9516876885
MESH:D015658 HIV Infections Iron 6.7516597321
MESH:D015658 HIV Infections Nickel 6.7517263646
MESH:D006689 Hodgkin Disease sodium arsenite 2.9712676792
MESH:D019584 Hot Flashes Vitamin E 3.7414716179
MESH:D006937 Hypercholesterolemia resveratrol 3.8017188708
MESH:D006949 Hyperlipidemias resveratrol 3.8216873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7115034207
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1017488730
MESH:D007006 Hypogonadism Iron 4.2416640825
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5816945680 16569931
MESH:D007022 Hypotension Zinc Sulfate 4.267265320
MESH:D007037 Hypothyroidism Iron 4.8616640825
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.4217600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1417937319
MESH:D007248 Infertility, Male sodium arsenite 6.1412646999 15346721
MESH:D007249 Inflammation Lipopolysaccharides 7.929205823 12878042 17963957 17237260 17255318
MESH:D007249 Inflammation Nickel 7.9216166738
MESH:D007249 Inflammation resveratrol 7.9216366677
MESH:D007251 Influenza, Human resveratrol 17.2816624496
MESH:D007251 Influenza, Human Selenium 17.2816624496
MESH:D007251 Influenza, Human Vitamin E 17.2816624496
MESH:D019189 Iron Metabolism Disorders Iron 10.8917163184
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 10.8917255318
MESH:D007511 Ischemia Zinc 4.4116584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.798074119 9022650
MESH:D007674 Kidney Diseases Cadmium 17.7216322080 16962696 16226777
MESH:D007674 Kidney Diseases Mercury 17.7217934191
MESH:D007674 Kidney Diseases sodium arsenite 17.7220008137
MESH:D007674 Kidney Diseases Vitamin E 17.7212488133
MESH:D007674 Kidney Diseases Zinc 17.7216960431
MESH:D007676 Kidney Failure, Chronic Copper 15.6816518626
MESH:D007676 Kidney Failure, Chronic Selenium 15.6816518626
MESH:D007676 Kidney Failure, Chronic Zinc 15.6816518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 6.7516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.756582329
MESH:D007859 Learning Disorders Copper 4.5717134702
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.0815237267
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4316087638
MESH:D007970 Leukopenia Lipopolysaccharides 4.4715821434
MESH:D020961 Lewy Body Disease Iron 5.2016563566
MESH:D008103 Liver Cirrhosis Iron 3.6016640825
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.069327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.6412878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.6416169303
MESH:D008108 Liver Diseases, Alcoholic Iron 4.7816737972 17207112
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.367678174
MESH:D008113 Liver Neoplasms Copper 13.3620302851
MESH:D008113 Liver Neoplasms Iron 13.3620302851 16640825
MESH:D008113 Liver Neoplasms resveratrol 13.3620405173 19321006 19812893 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 13.3616712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.426135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.423712494 598648 6587162 1399818
MESH:D008171 Lung Diseases chromium hexavalent ion 11.6616775837
MESH:D008171 Lung Diseases sodium arsenite 11.6619095001
MESH:D008171 Lung Diseases Vitamin E 11.6616863852
MESH:D055370 Lung Injury Lipopolysaccharides 3.7921114838
MESH:D008175 Lung Neoplasms chromium hexavalent ion 4.7616570259 16876463
MESH:D008175 Lung Neoplasms Iron 4.7616640825
MESH:D008175 Lung Neoplasms sodium arsenite 4.7617077188 17306315 16712894 15276417 19931552
MESH:D008175 Lung Neoplasms Vitamin E 4.7611062179
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0917088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6914749477
MESH:D008268 Macular Degeneration Iron 3.8616640825
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.0215688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 9.2811606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.2815318939
MESH:D008325 Mammary Neoplasms, Experimental Zinc 9.2812773700
MESH:D008545 Melanoma resveratrol 3.3617992120
MESH:D008545 Melanoma sodium arsenite 3.3619082730 16487513
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.6517268249 17109627
MESH:D008654 Mesothelioma Selenium 2.7015107826
MESH:D008659 Metabolic Diseases resveratrol 4.1717112576
MESH:D009101 Multiple Myeloma resveratrol 3.3117049120 17935668 16490592 17164350 16267019 14749477
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.4417086897
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6417962980
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.6518186108
MESH:D009181 Mycoses Iron 5.2416640825
MESH:D009203 Myocardial Infarction resveratrol 2.9416456233 16525036 16317513 17188708 17015251 17125593
MESH:D017202 Myocardial Ischemia Iron 8.9416604332
MESH:D017202 Myocardial Ischemia resveratrol 8.9417015251 17125593
MESH:D015428 Myocardial Reperfusion Injury Iron 4.0916604332
MESH:D009205 Myocarditis resveratrol 4.5317322642
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.6318551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.383581430
MESH:D009369 Neoplasms sodium arsenite 2.3911559025
MESH:D009374 Neoplasms, Experimental resveratrol 8.488985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.4820056578
MESH:D009389 Neovascularization, Pathologic Copper 4.7217308104
MESH:D009404 Nephrotic Syndrome Iron 4.3217178036
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.406679447
MESH:D009436 Neural Tube Defects sodium arsenate 11.4011749123 18186108 10525206 19446573
MESH:D009436 Neural Tube Defects sodium arsenite 11.4012854658
MESH:D019636 Neurodegenerative Diseases Iron 8.2416604332 17296847
MESH:D019636 Neurodegenerative Diseases resveratrol 8.2417652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.1917929310
MESH:D009669 Nose Neoplasms chromium hexavalent ion 4.8916876463
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.2216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.224026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.793988306
MESH:D010003 Osteoarthritis Iron 3.8316640825
MESH:D010024 Osteoporosis Iron 3.7216640825 16648989
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0417513867
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.3715276417 17306315
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.717296757
MESH:D010212 Papilloma Iron 8.7112065085
MESH:D020447 Parasomnias Iron 5.7917352947
MESH:D010300 Parkinson Disease Iron 3.2416563566 16640825
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.1515687053
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.246228378
MESH:D010900 Pituitary Diseases Iron 5.4416604332
MESH:D010954 Plasmacytoma Selenium 4.6615087411
MESH:D011014 Pneumonia Lipopolysaccharides 4.3312224865 11605937
MESH:D011041 Poisoning Iron 4.0816604332
MESH:D017119 Porphyria Cutanea Tarda Iron 4.7616640825
MESH:D011225 Pre-Eclampsia Iron 8.9616640825
MESH:D011225 Pre-Eclampsia Zinc 8.9617114810
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 3.9516679765
MESH:D011471 Prostatic Neoplasms Cadmium 1.8917075824
MESH:D011471 Prostatic Neoplasms Copper 1.8917079463 17308104
MESH:D011471 Prostatic Neoplasms resveratrol 1.8917804756 17718901 17675339 15767336 17636462 16731767
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8916039940
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8915084515
MESH:D011471 Prostatic Neoplasms Zinc 1.8916606632 16517595 16700911 12429649
MESH:D011528 Protozoan Infections Iron 5.7916640825
MESH:D011537 Pruritus Ethinyl Estradiol 3.0915861022 16919318
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3516325855
MESH:D015427 Reperfusion Injury resveratrol 3.1616314181 17520802 17058453 15827377 16317513
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5810835634
MESH:D012148 Restless Legs Syndrome Iron 4.3816930377
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.453692021
MESH:D012162 Retinal Degeneration Zinc 8.4516584753
MESH:D012559 Schizophrenia Copper 3.0516842975
MESH:D012640 Seizures 2,6-dinitrotoluene 2.3918551238
MESH:D012871 Skin Diseases Vitamin E 2.3818709164
MESH:D012878 Skin Neoplasms Iron 12.7712065085
MESH:D012878 Skin Neoplasms resveratrol 12.7715837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 12.7719524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.778532709
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7116709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6212854658
MESH:D020521 Stroke Vitamin E 3.3416517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2816321402
MESH:D013398 Sudden Infant Death Iron 5.2216640825
MESH:D013610 Tachycardia Nitroprusside 5.3915306635
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9715821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.727505956 6587162 6582329 1399818 3712494
MESH:D014062 Tongue Neoplasms resveratrol 9.4816227395
MESH:D014062 Tongue Neoplasms Zinc 9.4816543248
MESH:D014376 Tuberculosis Iron 3.9516597321
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.3016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.308074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.3016452187 17306315 11723127 16712894
MESH:D001749 Urinary Bladder Neoplasms Sodium Bicarbonate 11.3016896691
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.0910091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.9117473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.9111813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.7714692618
MESH:D014594 Uterine Neoplasms resveratrol 8.7717044934
MESH:D014652 Vascular Diseases sodium arsenite 4.2017056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3315869587 14671159
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0817488730
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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