AutismKB 2.0

Annotation Detail for MTNR1A


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Basic Information Top
Gene Symbol:MTNR1A ( MEL-1A-R,MT1 )
Gene Full Name: melatonin receptor 1A
Band: 4q35.2
Quick LinksEntrez ID:4543; OMIM: 600665; Uniprot ID:MTR1A_HUMAN; ENSEMBL ID: ENSG00000168412; HGNC ID: 7463
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1907Depression
2251Osteosarcoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MTNR1A mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MTNR1A mRNAaffects expression 16483693
D002713 Chlorine Chlorine results in decreased expression of MTNR1A mRNAdecreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of MTNR1A mRNAaffects cotreatment|increases expression 18636392
D008550 Melatonin Melatonin binds to MTNR1A proteinaffects binding 17762829
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of MTNR1A mRNAaffects cotreatment|increases expression 18636392
D010634 Phenobarbital Phenobarbital results in decreased expression of MTNR1A mRNAdecreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MTNR1A mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of MTNR1A mRNAincreases expression 18301758
D018038 Sodium Selenite Sodium Selenite results in decreased expression of MTNR1A mRNAdecreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.786195326
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury Chlorine 10.0320601635
MESH:D055371 Acute Lung Injury pirinixic acid 10.0318653653
MESH:D000236 Adenoma Melatonin 4.4917195641
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2716434500
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6015570426
MESH:D001249 Asthma Ozone 2.7017854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 2.3718445737
MESH:D001321 Autistic Disorder Melatonin 2.3716919138 16897403
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8718417511 19059883 15516495 16777450 18315731 14754758 17626835
MESH:D002100 Cachexia Ozone 5.0816183385
MESH:D002252 Carbon Tetrachloride Poisoning Melatonin 5.6215700767
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.9720007298 17173139 6705139 20935162 1701930
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 20657642
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0310915739 11739529 19085960 11529661 14986274 14725611 11287661 11743745 11834606 16485898 10774834 15619225 16227642 19420014 16177239 2444490 15968718 16781746 16109766 19739265 17906064 12392966 17522070 19923254 11461765 19164858 11421492 19370779 19416960 10663392 12705907 16393943 16081117 17562736 18071297 12153990 12958197 12540782 18713872 14550746 12594235
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.0315131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004417 Dyspnea Chlorine 5.0020016425
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.253922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D005234 Fatty Liver pirinixic acid 3.0120131406 19236843
MESH:D005739 Gas Poisoning Chlorine 5.3920016425
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly Phenobarbital 9.5216109766
MESH:D006529 Hepatomegaly pirinixic acid 9.5219176532 16221962 18467677 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D007333 Insulin Resistance pirinixic acid 7.8116306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.8114714311
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0121047994
MESH:D008106 Liver Cirrhosis, Experimental Melatonin 2.9515298665 15925388 16703270
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.9515474484
MESH:D008107 Liver Diseases Acetaminophen 4.1016611625 12969438 12587719 19784758 16610002 19014921 11587558 19460945
MESH:D008107 Liver Diseases Phenobarbital 4.1019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 4.7219812893 19073162 15975961 21047994 8742319 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 4.7216377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.846150874 17172636 18308698 1399818 2563599
MESH:D008171 Lung Diseases Ozone 3.538266340 19066396
MESH:D055370 Lung Injury Ozone 4.1520417186
MESH:D008175 Lung Neoplasms Melatonin 3.1917195641
MESH:D008175 Lung Neoplasms Ozone 3.197614698 8597069
MESH:D008180 Lupus Erythematosus, Systemic Melatonin 3.9616373423
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008679 Metaplasia Ozone 5.4810496685
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009336 Necrosis Melatonin 5.8012195237
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5616965848
MESH:D020734 Parkinsonian Disorders Melatonin 5.2615574749
MESH:D010538 Peritonitis Melatonin 11.6115707874
MESH:D010538 Peritonitis Ozone 11.6116369182
MESH:D011014 Pneumonia Ozone 4.7318007984 18381685 18929643
MESH:D011230 Precancerous Conditions Phenobarbital 3.842563599
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3518760546
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012120 Respiration Disorders Chlorine 5.5918579056
MESH:D012640 Seizures Phenobarbital 2.8411442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012893 Sleep Disorders Melatonin 5.8016919138 18182647 16897403
MESH:D020178 Sleep Disorders, Circadian Rhythm Melatonin 7.0118078449 19452292
MESH:D007319 Sleep Initiation and Maintenance Disorders Melatonin 5.6318078449
MESH:D013276 Stomach Ulcer Melatonin 4.7412500499 16150113 11523592
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.231399818
MESH:D014581 Urticaria Acetaminophen 3.2410982225
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00980 multitarget Ramelteon Hypnotics and Sedatives
DB01065 agonist Plenovit Melatonina Antioxidants;Free Radical Scavengers;Anticonvulsants;Adjuvants, Immunologic;Central Nervous System Depressants
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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