AutismKB 2.0

Annotation Detail for MTNR1B


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Basic Information Top
Gene Symbol:MTNR1B ( FGQTL2,MEL-1B-R,MT2 )
Gene Full Name: melatonin receptor 1B
Band: 11q14.3
Quick LinksEntrez ID:4544; OMIM: 600804; Uniprot ID:MTR1B_HUMAN; ENSEMBL ID: ENSG00000134640; HGNC ID: 7464
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Metabolic diseases
Diabetes
H00409Type II diabetes mellitus
Desease IDDesease Name
1781Rheumatoid arthritis
Desease Name
impaired fasting glycemia and type 2 diabetes
other metabolic traits
fasting plasma glucose
fasting glucose-related traits
METABOLIC
diabetes, type 2
Insulin Resistance
Desease Name
Fasting plasma glucose
Type 2 diabetes
Other metabolic traits
Fasting glucose-related traits
Glycated hemoglobin levels
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MTNR1B mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MTNR1B mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MTNR1B mRNAaffects expression 12734012
D005419 Flavonoids Flavonoids results in increased expression of MTNR1B mRNAincreases expression 18035473
D008550 Melatonin Melatonin binds to MTNR1B proteinaffects binding 16030176
D008550 Melatonin Melatonin binds to MTNR1B proteinaffects binding 17762829
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.853712494
MESH:D000236 Adenoma Melatonin 7.8517195641
MESH:D001321 Autistic Disorder Melatonin 3.3816897403 16919138
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.631440618 11289319
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 12.1116011737 15700767 16124888 16192424 16097048 16227642 10355542 15673190 3786805 16050911 18705752 15721981
MESH:D002252 Carbon Tetrachloride Poisoning Melatonin 12.1115700767
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.117296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1118788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.997505956
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 20657642
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.419022650 19486331
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2812868966 11906362 18759878 11298694 8156756 14531868 8970840 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.893621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism 19060907 19060909 19060908
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.169328219 18289764 11289319 18692083 18648102 7440962 1440618 8291058 6482804 9022650 16192314 6679447 9653073
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.167120509 17522070 19336974 4309450 7179309 16227642 6884620 15968718 3732212 10915739 3786805 7440962 15027814 11566570 10092053 9327722 6623471 16177239 15998439 2869522 21278145 19085960
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.5416045604 15959796 16239168 12631006 19224547 12795759 17595544 61145
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D005355 Fibrosis Carbon Tetrachloride 3.9418705752
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.736705139
MESH:D006505 Hepatitis Carbon Tetrachloride 10.7319900420 19110552
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007249 Inflammation Flavonoids 2.8017296493
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.639022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9817334410 17174718 21278145 16943688 11408273 17157831 16239168 16221502 11903743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.1215362042 12445418 18339082 16097048 17766677 17708605 16248980 16638106 18210741 17823541 15730626 12666154 15876570 15370692 13678700 15931870 12958196 14512876 15673190 16033810 16027843 14716496 17640975 17481882 15959796 16136751 11481614 17557913 18205269 15925388 12609069 15052691 18395095 14748882 20821823 18006644 18166357 12389079 15650968 14620537 12741479 18472094 17944888 17761835 17525996 17698563 14724832 18472332 18279442 15818738 12667390 18277467 16116963 12898905 16011737 17714472 17565644 18054572 17721639 18412020 15338365 17900296 15057751 18376398 17805973 18251166 18317297 12546737 12586293 17922224 12632512 18395914 14716833 12649538 18481824 16015684 18420326 17869086 16192424 17631135 18156304 10355542 15996030 18263696 15123356 12632514 18429990 18418968 12445421 17976157 18187930 18705752 15893842
MESH:D008106 Liver Cirrhosis, Experimental Melatonin 3.1215925388 15298665 16703270
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1516964402 15830285 16246199 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0414706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.3219294768
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.60598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.6012014681 15583823
MESH:D008175 Lung Neoplasms Melatonin 3.2817195641
MESH:D008180 Lupus Erythematosus, Systemic Melatonin 3.9916373423
MESH:D009336 Necrosis Melatonin 6.0012195237
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.774026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D020734 Parkinsonian Disorders Melatonin 5.3815574749
MESH:D010538 Peritonitis Melatonin 5.8015707874
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012893 Sleep Disorders Melatonin 6.0016919138 18182647 16897403
MESH:D020178 Sleep Disorders, Circadian Rhythm Melatonin 7.2518078449 19452292
MESH:D007319 Sleep Initiation and Maintenance Disorders Melatonin 5.8618078449
MESH:D013276 Stomach Ulcer Melatonin 4.8711523592 16150113 12500499
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.153712494 6582329 1399818 6587162 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.398074119
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31268
    • No data
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00980 multitarget Ramelteon Hypnotics and Sedatives
    DB01065 agonist Plenovit Melatonina Antioxidants;Free Radical Scavengers;Anticonvulsants;Adjuvants, Immunologic;Central Nervous System Depressants
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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