AutismKB 2.0

Annotation Detail for MTTP


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MTTP ( ABL,MGC149819,MGC149820,MTP )
Gene Full Name: microsomal triglyceride transfer protein
Band: 4q23
Quick LinksEntrez ID:4547; OMIM: 157147; Uniprot ID:MTP_HUMAN; ENSEMBL ID: ENSG00000138823; HGNC ID: 7467
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of lipid/glycolipid metabolism
H00160Abetalipoproteinemia
Genetic disorders
Desease IDDesease Name
1856Obesity
1904Diabetes mellitus
1918Atherosclerosis
1936Hypercholesterolemia
2007Liver tumor
2022Liver cancer
2126Encephalopathies
Desease Name
apoB
lipid metabolism disorders
atherosclerosis, coronary
blood pressure, arterial
CARDIOVASCULAR
cholesterol, LDL
ApoB-48
lipids
body mass
lipoprotein
plasma cholesterol levels and body mass index
METABOLIC
blood pressure, arterial diabetes, type 2 glucose insulin
insulin
cholesterol, total
steatohepatitis, non-alcoholic
diabetes, type 2
Hepatitis C, Chronic
Fatty Liver
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MTTP mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MTTP mRNAincreases expression 18648102
C041594 4-nonylphenol 4-nonylphenol results in decreased expression of MTTP mRNAdecreases expression 17912697
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MTTP proteinaffects expression 20106945
C103303 alitretinoin alitretinoin results in increased expression of MTTP mRNAincreases expression 15537571
C006780 bisphenol A bisphenol A results in decreased expression of MTTP mRNAdecreases expression 17912697
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased activity of MTTP proteindecreases activity 17405876
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased degradation of MTTP proteinincreases degradation 17405876
D002331 Carnitine Carnitine inhibits the reaction [Stavudine results in decreased expression of MTTP mRNA]decreases expression|decreases reaction 18299183
D002791 Cholesterol, Dietary [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of MTTP mRNAaffects cotreatment|decreases expression 19509184
D016572 Cyclosporine Cyclosporine results in decreased expression of MTTP mRNAdecreases expression 20106945
D018119 Stavudine Carnitine inhibits the reaction [Stavudine results in decreased expression of MTTP mRNA]decreases expression|decreases reaction 18299183
D018119 Stavudine Stavudine results in decreased expression of MTTP mRNAdecreases expression 18299183
D003609 Dactinomycin Dactinomycin inhibits the reaction [pirinixic acid results in increased expression of MTTP mRNA]decreases reaction|increases expression 15537571
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of MTTP mRNAdecreases expression 16835292
D004041 Dietary Fats [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of MTTP mRNAaffects cotreatment|decreases expression 19509184
D004041 Dietary Fats Dietary Fats results in increased expression of MTTP mRNAincreases expression 16357043
D004958 Estradiol Estradiol results in decreased expression of MTTP mRNAdecreases expression 20106945
D005231 Fatty Acids, Unsaturated Fatty Acids, Unsaturated results in increased expression of MTTP mRNAincreases expression 18356535
D005632 Fructose [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of MTTP mRNAaffects cotreatment|decreases expression 19509184
D018684 Glycine Agents Glycine Agents results in decreased expression of MTTP mRNAdecreases expression 16532367
C067713 lactacystin lactacystin results in increased ubiquitination of MTTP proteinincreases ubiquitination 17405876
D010126 Ozone Ozone results in decreased expression of MTTP mRNAdecreases expression 16183385
C023036 perfluorooctanoic acid perfluorooctanoic acid affects the expression of MTTP mRNAaffects expression 18281256
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of MTTP mRNAincreases expression 17681415
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MTTP mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased activity of MTTP proteinincreases activity 15537571
C006253 pirinixic acid pirinixic acid results in increased expression of MTTP mRNAincreases expression 16357043
18301758
15375163
15537571
C006253 pirinixic acid pirinixic acid results in increased expression of MTTP proteinincreases expression 15537571
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in increased expression of MTTP mRNA]affects reaction|increases expression 15537571
C006253 pirinixic acid Dactinomycin inhibits the reaction [pirinixic acid results in increased expression of MTTP mRNA]decreases reaction|increases expression 15537571
C006253 pirinixic acid pirinixic acid results in increased activity of MTTP proteinincreases activity 15537571
C006253 pirinixic acid pirinixic acid results in increased expression of MTTP mRNAincreases expression 15537571
C006253 pirinixic acid pirinixic acid results in increased expression of MTTP proteinincreases expression 15537571
C003377 taxifolin taxifolin results in decreased activity of MTTP proteindecreases activity 15380446
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MTTP mRNAincreases expression 20106945
C009564 trilinolein trilinolein results in increased expression of MTTP mRNAincreases expression 18356535
C101314 trilinolenin trilinolenin results in increased expression of MTTP mRNAincreases expression 18356535
D014304 Triolein Triolein results in increased expression of MTTP mRNAincreases expression 18356535
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:C535554 Abdominal obesity metabolic syndrome marker/mechanism
MESH:D000012 Abetalipoproteinemia marker/mechanism
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6215322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 2.9118653653
MESH:D000230 Adenocarcinoma Estradiol 2.0411473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.623712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.1416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.1416835633
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 4.6720157255
MESH:D000544 Alzheimer Disease Ozone 4.6715513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 9.9415552841
MESH:D001161 Arteriosclerosis Dietary Fats 9.9415238619
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5115570426
MESH:D001249 Asthma Ozone 2.5716373670 17854713
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.791440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.0919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 5.3114601052
MESH:D001862 Bone Resorption bisphenol A 3.6611985600
MESH:D001943 Breast Neoplasms alitretinoin 2.2716344269
MESH:D001943 Breast Neoplasms bisphenol A 2.2717123778
MESH:D001943 Breast Neoplasms Dietary Fats 2.2720435547
MESH:D001943 Breast Neoplasms Estradiol 2.2717261762 17289903 19861407 12948864 14630087 16675129 17018787 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2720435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5015516495 17626835 18417511 16777450 18315731 14754758 19059883
MESH:D002100 Cachexia Ozone 4.5116183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5615700767 16097048 15673190 18705752 3786805 16192424 10355542 16050911 15721981 16011737 16227642 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.4516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.457296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.4512907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.4518788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.4516924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.7617123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.577296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2418850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.247505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.2412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.2418566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.419022650 19486331
MESH:D002779 Cholestasis Cyclosporine 12.4119486331
MESH:D002779 Cholestasis pirinixic acid 12.4119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0112621046 8697196 16354765 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8714669216 17141729
MESH:D003327 Coronary Disease Fructose 4.3318504504
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2415322242 10048152 20055451
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.2316037377
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7918551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5911298694 18759878 12868966 8156756 14531868 2524372 11906362 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.283621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.3118603373
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 4.4618603373
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.3821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.386482804 1440618 18289764 9328219 9022650 16192314 11289319 6679447 18692083 7440962 18648102 8291058 9653073
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.386884620 19085960 3786805 16177239 11566570 17522070 6623471 15968718 10915739 7440962 15027814 4309450 10092053 21278145 7179309 9327722 19336974 3732212 7120509 2869522 15998439 16227642
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.3820420201
MESH:D004362 Drug Toxicity Stavudine 8.0315040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2918367378
MESH:D004487 Edema perfluorooctanoic acid 10.2812083418 17259670
MESH:D004487 Edema pirinixic acid 10.2812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.2812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6716714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 2.8311473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8210568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.053581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.0612795759 16239168 12631006 16045604 15959796 19224547 17595544 61145
MESH:D005234 Fatty Liver Cyclosporine 28.0619224547
MESH:D005234 Fatty Liver Dietary Fats 28.0617967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Fructose 28.0618395287 18641190 19196556
MESH:D005234 Fatty Liver pirinixic acid 28.0620131406 19236843
MESH:D005234 Fatty Liver Stavudine 28.0618299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.796705139
MESH:D005355 Fibrosis Carbon Tetrachloride 25.3518705752
MESH:D005355 Fibrosis Cyclosporine 25.3512639820 12168785
MESH:D005355 Fibrosis Dietary Fats 25.3518296743
MESH:D005355 Fibrosis Fructose 25.3518504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.3520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D018149 Glucose Intolerance Fructose 5.1119165636
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.827505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.506705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.5019900420 19110552
MESH:D006529 Hepatomegaly perfluorooctanoic acid 13.163609246
MESH:D006529 Hepatomegaly pirinixic acid 13.1619772884 19176532 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.1615340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8015709030
MESH:D015658 HIV Infections Stavudine 4.3311141242
MESH:D019584 Hot Flashes Estradiol 3.5217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8116354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia perfluorooctanoic acid 3.6712083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3016899240
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 9.0110876104
MESH:D006937 Hypercholesterolemia Dietary Fats 9.0121332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D006946 Hyperinsulinism Fructose 4.7115752949 14757778 19008412 18360027 18563319
MESH:D006949 Hyperlipidemias Dietary Fats 8.8521332399
MESH:D006949 Hyperlipidemias Fructose 8.8515752949
MESH:D006951 Hyperlipoproteinemias Fatty Acids, Unsaturated 6.0018435438
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7115034207
MESH:D006973 Hypertension Cyclosporine 8.1710903974
MESH:D006973 Hypertension Fructose 8.1714633139 19008412 14568997 14573337 16843071
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1718850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8615338365
MESH:D015228 Hypertriglyceridemia Fructose 4.8819799862 19342510
MESH:D007249 Inflammation Dietary Fats 7.6820412841
MESH:D007249 Inflammation perfluorooctanoic acid 7.6812083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6812878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 21.6316393666
MESH:D007333 Insulin Resistance Dietary Fats 21.6311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 21.6316393666 16627594
MESH:D007333 Insulin Resistance Fructose 21.6319586609 14573337 18057795 14757778 18563319 17133782 14633139 19008412 18981581 19342510 19799862
MESH:D007333 Insulin Resistance pirinixic acid 21.6316306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.798074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.4116144296
MESH:D007674 Kidney Diseases Cyclosporine 5.508314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.5015618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.2216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.226582329
MESH:D007680 Kidney Neoplasms Cyclosporine 16.2212371664
MESH:D007680 Kidney Neoplasms Estradiol 16.2215610895
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.008812269
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.2116239168 17157831 16943688 17174718 11408273 21278145 17334410 16221502 11903743
MESH:D008103 Liver Cirrhosis Dietary Fats 6.2118296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.4416033810 12898905 10355542 17714472 12958196 12389079 17721639 17922224 18187930 17944888 18205269 18210741 16116963 14512876 18279442 15338365 12632512 16015684 17766677 17823541 17708605 14716496 18317297 18705752 15052691 12546737 15362042 18006644 17761835 18166357 13678700 18251166 18339082 15673190 17900296 18412020 16011737 17869086 17976157 18395914 16097048 16136751 17640975 18420326 15959796 12632514 12445421 11481614 15876570 17805973 12586293 18277467 15996030 18054572 18263696 15730626 15818738 17698563 18418968 12445418 17525996 16248980 15650968 12609069 17631135 14724832 15123356 20821823 12667390 17481882 18429990 18376398 18156304 18472332 16192424 15925388 17565644 18472094 12741479 17557913 16027843 12649538 15893842 12666154 14716833 18395095 18481824 14620537 14748882 15931870 16638106 15057751 15370692
MESH:D008106 Liver Cirrhosis, Experimental Carnitine 6.4414748882
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4412878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0316246199 15720792 17285989 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 11.0915123358
MESH:D017093 Liver Failure Stavudine 11.0918299183
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4916899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 16.869163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.8619294768
MESH:D008113 Liver Neoplasms Carnitine 16.8619294768
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 16.8614757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 16.8616377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.8616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 12.94598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.948603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.9415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.9412151625
MESH:D008171 Lung Diseases Ozone 3.2319066396 8266340
MESH:D055370 Lung Injury Ozone 3.6320417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.6614755239
MESH:D008175 Lung Neoplasms alitretinoin 4.6616413115
MESH:D008175 Lung Neoplasms Ozone 4.668597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6611884234 19555203
MESH:D008228 Lymphoma, Non-Hodgkin Carnitine 5.3916283381
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.4216891317 11807958 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.2519453300
MESH:D024821 Metabolic Syndrome X Fructose 4.6317261469 18497449 17098227 16815490 19165636
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D008679 Metaplasia Ozone 4.8710496685
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.6716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.6716411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6318551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.383581430
MESH:D009369 Neoplasms alitretinoin 4.8516946489
MESH:D009369 Neoplasms pirinixic acid 4.8517405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5017289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0918481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 15.0916427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 15.0916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.0914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.776679447
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.739802331
MESH:D009765 Obesity Dietary Fats 7.1818457598 21332399 16723640 18674790 19632207 17217161 20518802 20132043 11836018
MESH:D009765 Obesity Fructose 7.1818585860 17707055
MESH:D009765 Obesity pirinixic acid 7.1820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.2216049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.224026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.793988306
MESH:D010049 Ovarian Diseases bisphenol A 4.7611985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.1519401270
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.267296757
MESH:D010300 Parkinson Disease Cholesterol, Dietary 4.0919014385
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010538 Peritonitis Ozone 3.9116369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.246228378
MESH:D011014 Pneumonia Ozone 4.1718929643 18381685 18007984
MESH:D017499 Porokeratosis alitretinoin 5.7716144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0312371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.9910548101
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 14.9917132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.9911896295 11118676 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.8720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.8720887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3516740699
MESH:D011471 Prostatic Neoplasms Estradiol 3.3516740699
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D011629 Puberty, Precocious bisphenol A 4.5610548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.213692021
MESH:D012512 Sarcoma, Ewing's Dactinomycin 4.8614601052
MESH:D012640 Seizures 2,4-dinitrotoluene 2.3818551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9416192470
MESH:D019966 Substance-Related Disorders bisphenol A 3.7616684133 16045194
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.727505956 3712494 6587162 6582329 1399818
MESH:D013978 Tibial Fractures Estradiol 4.4519048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.7116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.718074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0910091137
MESH:D014591 Uterine Diseases bisphenol A 4.7814652134
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D015430 Weight Gain Dietary Fats 3.5516723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
KEGG:04975 Fat digestion and absorption
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA164742099
    • No data
    No data
    Releated drug ID Related drug Name
    PA133950441hmg coa reductase inhibitors
    PA450952phospholipids
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01094 antagonist Hesperetin Anticholesteremic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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