AutismKB 2.0

Annotation Detail for MTR


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Basic Information Top
Gene Symbol:MTR ( FLJ33168,FLJ43216,FLJ45386,MS,cblG )
Gene Full Name: 5-methyltetrahydrofolate-homocysteine methyltransferase
Band: 1q43
Quick LinksEntrez ID:4548; OMIM: 156570; Uniprot ID:METH_HUMAN; ENSEMBL ID: ENSG00000116984; HGNC ID: 7468
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5328superpathway of methionine degradation
ADENOSYLHOMOCYSCAT-PWYmethionine salvage II (mammalia)
PWY-2201folate transformations
Pathway IDPathway Name
hsa00670One carbon pool by folate
hsa01100Metabolic pathways
hsa00270Cysteine and methionine metabolism
Pathway IDPathway Name
Biological oxidations
No data
Pathway IDPathway Name
P02773S-adenosylmethionine biosynthesis
P02743Formyltetrahydroformate biosynthesis
P02753Methionine biosynthesis
Pathway IDPathway Name
500215Methylation
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1755Cleft palate
1848Embryoma
1856Obesity
1860Brain tumor
1918Atherosclerosis
1983Down syndrome
2064Spinal dysraphism
2039Hyperhomocysteinemia
2094Ulcerative colitis
2125Bladder cancer
2146Lupus erythematosus
2191Meningioma
Desease Name
cholesterol, HDL
folate
colorectal cancer
CARDIOVASCULAR
homocysteine
Alzheimer's disease
homocysteine rheumatoid arthritis rheumatoid nodulosis
brain cancer
bipolar disorder schizophrenia
CANCER
PSYCH
PHARMACOGENOMIC
body mass
arsenic metabolism
hypertension
neural tube defects
NEUROLOGICAL
METABOLIC
Infertility, Male
insulin
DEVELOPMENTAL
REPRODUCTION
Down Syndrome
No data
Desease Name
Methylcobalamin deficiency, cblG type
Cleft lip/palate, susceptibility to
Down syndrome, susceptibility to
Neural tube defects, folate-sensitive, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MTR mRNAaffects expression 21346803
C030371 5,6,7,8-tetrahydrofolic acid 5,6,7,8-tetrahydrofolic acid inhibits the reaction [Methotrexate results in decreased expression of MTR protein]decreases expression|decreases reaction 16598758
C030371 5,6,7,8-tetrahydrofolic acid [Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]affects cotreatment|decreases expression|decreases reaction 16598758
C005984 5-methyltetrahydrofolate 5-methyltetrahydrofolate binds to MTR proteinaffects binding 17477549
D012436 S-Adenosylmethionine S-Adenosylmethionine binds to MTR proteinaffects binding 17477549
D006710 Homocysteine Homocysteine binds to MTR proteinaffects binding 17477549
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MTR mRNAaffects expression 16483693
D001562 Benzimidazoles Benzimidazoles results in decreased activity of MTR proteindecreases activity 17222188
C015700 benzo-1,2,3-thiadiazole benzo-1,2,3-thiadiazole analog results in decreased activity of MTR proteindecreases activity 17222188
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MTR mRNAdecreases expression 20064835
D004317 Doxorubicin MTR mRNA results in decreased susceptibility to Doxorubicindecreases response to substance 16322897
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MTR mRNAincreases expression 17606305
D005492 Folic Acid Folic Acid affects the expression of MTR mRNAaffects expression 17311948
D019271 Hypoxanthine [Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]affects cotreatment|decreases expression|decreases reaction 16598758
D019271 Hypoxanthine [Thymidine co-treated with Hypoxanthine] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]affects cotreatment|decreases expression|decreases reaction 16598758
D008727 Methotrexate 5,6,7,8-tetrahydrofolic acid inhibits the reaction [Methotrexate results in decreased expression of MTR protein]decreases expression|decreases reaction 16598758
D008727 Methotrexate Methotrexate results in decreased expression of MTR proteindecreases expression 16598758
D008727 Methotrexate [Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]affects cotreatment|decreases expression|decreases reaction 16598758
D008727 Methotrexate [Thymidine co-treated with Hypoxanthine] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]affects cotreatment|decreases expression|decreases reaction 16598758
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MTR mRNAaffects binding|increases activity|increases expression 19710929
D013311 Streptozocin Streptozocin results in decreased activity of MTR proteindecreases activity 16835399
D013936 Thymidine [Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]affects cotreatment|decreases expression|decreases reaction 16598758
D013936 Thymidine [Thymidine co-treated with Hypoxanthine] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]affects cotreatment|decreases expression|decreases reaction 16598758
D014805 Vitamin B 12 Vitamin B 12 binds to MTR proteinaffects binding 17477549
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.2112039119
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D058186 Acute Kidney Injury Folic Acid 4.2917003819 16316344 16595132
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0020127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 7.0017418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0014692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.896695378
MESH:D000236 Adenoma Folic Acid 6.8916963246
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4416434500
MESH:D000419 Albuminuria Doxorubicin 4.5021441931
MESH:D000544 Alzheimer Disease Folic Acid 5.2017116317
MESH:D000544 Alzheimer Disease Vitamin B 12 5.2017116317
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.0917286800
MESH:D001321 Autistic Disorder 5-methyltetrahydrofolate 3.6718461502
MESH:D001321 Autistic Disorder Folic Acid 3.6721388746
MESH:D001321 Autistic Disorder Homocysteine 3.6720468076 16297937
MESH:D001321 Autistic Disorder S-Adenosylmethionine 3.6719056591 16917939
MESH:D001321 Autistic Disorder Vitamin B 12 3.6716297937
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1119483382
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6714601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.7717150277
MESH:D001943 Breast Neoplasms marker/mechanism 17595805
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0520146248 17474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.0518628466 16826403 16264153 16322301 16096432 17426702 18695136 15567936 15939500 15993339 18234424 11325840 15136595 17983394 19526202 15692762 15668708 16935488 15634643 17369602 15994142 16595493 18382427 16115903
MESH:D001943 Breast Neoplasms Folic Acid 2.0516777985
MESH:D001943 Breast Neoplasms Methotrexate 2.0516978400
MESH:D002276 Carcinoid Tumor Doxorubicin 12.6016051944
MESH:D002276 Carcinoid Tumor Streptozocin 12.6016051944
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1116705839
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.1117876044 18059187 16234567 16023760
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.1416201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6520419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.656189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.5015476868 16651473 16731534 17928571 15505089 17924179 16364871 15792986 16109756 16278810 17131338 17007740 17308081 17351982 17329180 18627295 16269455 16612575 17519947 17382496 16455267 16242529 17974986 15811867 16952015
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9316243910 17334414
MESH:D002318 Cardiovascular Diseases Folic Acid 3.9216755160
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.746135515
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6311677210 16105132 17110522 17681005 17333356 16919318 15861022
MESH:D002779 Cholestasis pirinixic acid 7.6319176532
MESH:D002971 Cleft Lip marker/mechanism 21254359
MESH:D002971 Cleft Lip Folic Acid 3.9621254359
MESH:D002972 Cleft Palate marker/mechanism 21254359
MESH:D002972 Cleft Palate Folic Acid 3.5521254359 8946559
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.9018259882 18802399
MESH:D015179 Colorectal Neoplasms Folic Acid 2.9017116713 17245555 16963246 17087956 16985020
MESH:D003324 Coronary Artery Disease Homocysteine 3.7416379339
MESH:D023903 Coronary Restenosis Vitamin B 12 6.2116489563
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.6512039119 9562676
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9818551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.2019747007
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003882 Dermatomyositis Methotrexate 5.0820191521
MESH:D003920 Diabetes Mellitus Streptozocin 4.6916285004
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 4.4418715473 15862027 12093613 19960420 15831366 12644472 17874149 18603373 12083368 16684804 19586609 12446591 16286809 19496084 11260395 2177838 17442507 6379147 1374869 7637645 11055810 19298542 15298345 8740154
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.6218603373
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 5.1616886840
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 5.1619586609 19647726
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.6916025228
MESH:D003928 Diabetic Nephropathies Streptozocin 4.6319682444 19960420
MESH:D003930 Diabetic Retinopathy Streptozocin 5.3817662242
MESH:D004314 Down Syndrome marker/mechanism
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.9921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 3.9917416283
MESH:D004362 Drug Toxicity Doxorubicin 3.6418602426
MESH:D004487 Edema pirinixic acid 2.4412083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1512538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.8217359293
MESH:D016889 Endometrial Neoplasms Folic Acid 7.8217301261
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1318037988
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0016530937
MESH:D017889 Exfoliation Syndrome Folic Acid 13.2716504073
MESH:D017889 Exfoliation Syndrome Homocysteine 13.2716504073
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.4115345470
MESH:D005234 Fatty Liver pirinixic acid 7.4120131406 19236843
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5519069698
MESH:D005756 Gastritis Folic Acid 5.0617171786
MESH:D005901 Glaucoma Folic Acid 11.7116504073
MESH:D005901 Glaucoma Homocysteine 11.7116504073
MESH:D005909 Glioblastoma Doxorubicin 3.3217150277
MESH:D006086 Graft vs Host Disease Methotrexate 5.1116518429
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.5015692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 16.0020471113
MESH:D006330 Heart Defects, Congenital Folic Acid 16.0016524890 17286298
MESH:D006330 Heart Defects, Congenital Homocysteine 16.0019638421
MESH:D006330 Heart Defects, Congenital Vitamin B 12 16.0017124548
MESH:D006331 Heart Diseases Doxorubicin 8.0116244372 16707910 18006777 16244371 16879835 16144979 17875725 12587719 14766674 16495754 16330681 17888722 18674790
MESH:D006331 Heart Diseases Streptozocin 8.0112093613
MESH:D006333 Heart Failure Doxorubicin 6.9617481944
MESH:D006333 Heart Failure pirinixic acid 6.9620558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8615692506
MESH:D006529 Hepatomegaly pirinixic acid 2.9616221962 19772884 18467677 19176532
MESH:D006679 HIV Seropositivity Folic Acid 5.4617209195
MESH:D006689 Hodgkin Disease Doxorubicin 3.3715147373 18501091 17606976
MESH:D006712 Homocystinuria 5-methyltetrahydrofolate 6.7917413090
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 15.6616395265 16433478 16865747 16755160 16397167
MESH:D020138 Hyperhomocysteinemia Homocysteine 15.6617369066 18234410 17292331
MESH:D020138 Hyperhomocysteinemia Vitamin B 12 15.6616397167
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male marker/mechanism 16861746
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4617937319
MESH:D007333 Insulin Resistance pirinixic acid 2.6016306350
MESH:D007674 Kidney Diseases Doxorubicin 6.5816775033 15369732 15699352
MESH:D007674 Kidney Diseases Streptozocin 6.5812093613
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.1116707910
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.9416705839
MESH:D007805 Language Development Disorders Methotrexate 5.069562676
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1316085563
MESH:D008103 Liver Cirrhosis Methotrexate 3.6814986274
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 5.1216595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1215474484
MESH:D008106 Liver Cirrhosis, Experimental S-Adenosylmethionine 5.1215983038
MESH:D008106 Liver Cirrhosis, Experimental Vitamin B 12 5.1218239293
MESH:D008107 Liver Diseases Folic Acid 3.0316877991
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.277678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.2721137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.2720007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.972876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 5.9716842330 17085340
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.9918516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5020135361 18520028 18569708 18816296 20869020 20464547 6695378 17053015 20064080
MESH:D008175 Lung Neoplasms Doxorubicin 2.506189445 17418594
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 6.2517718048
MESH:D008180 Lupus Erythematosus, Systemic Vitamin B 12 6.2517718048
MESH:D008223 Lymphoma marker/mechanism 16799656
MESH:D008223 Lymphoma Doxorubicin 7.8116098063
MESH:D008223 Lymphoma Methotrexate 7.8117352296
MESH:D008224 Lymphoma, Follicular marker/mechanism 16410450
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7517654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.5315621674
MESH:D044342 Malnutrition marker/mechanism 16709328
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.0015458769
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.6616832597
MESH:D008545 Melanoma Doxorubicin 2.2816827129
MESH:D008591 Meningomyelocele Homocysteine 5.5016602021
MESH:D008654 Mesothelioma Doxorubicin 3.0417638057
OMIM:250940 METHYLCOBALAMIN DEFICIENCY, cblG TYPE marker/mechanism
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4615792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1516381670
MESH:D052016 Mucositis Doxorubicin 12.4017415656
MESH:D052016 Mucositis Methotrexate 12.4017488658
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009203 Myocardial Infarction Doxorubicin 13.5519429709 15857846
MESH:D009203 Myocardial Infarction Homocysteine 13.5517412321
MESH:D009203 Myocardial Infarction pirinixic acid 13.5519151258
MESH:D009203 Myocardial Infarction Vitamin B 12 13.5517412321
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9116411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.837678174 18551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9318259882
MESH:D009369 Neoplasms Benzo(a)pyrene 4.7511141357
MESH:D009369 Neoplasms pirinixic acid 4.7517405874
MESH:D009401 Nephrosis Doxorubicin 4.7316636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.9615640375 16889571
MESH:D009436 Neural Tube Defects 5-methyltetrahydrofolate 8.3317413090
MESH:D009436 Neural Tube Defects Folic Acid 8.3317438019
OMIM:601634 NEURAL TUBE DEFECTS, FOLATE-SENSITIVE marker/mechanism
MESH:D009447 Neuroblastoma Doxorubicin 3.2415555623
MESH:D009503 Neutropenia Folic Acid 4.4616322990
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3916049721
OMIM:119530 OROFACIAL CLEFT 1 marker/mechanism
MESH:D012516 Osteosarcoma Doxorubicin 4.0815930896
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010300 Parkinson Disease Homocysteine 3.5616275827
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1317638057
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3017292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.3016868541 16729912 15749863 15897917 18437689 16888761
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D011565 Psoriasis Methotrexate 3.4217410198
MESH:D051437 Renal Insufficiency Doxorubicin 17.0917922066
MESH:D051437 Renal Insufficiency Folic Acid 17.0915728788
MESH:D051437 Renal Insufficiency Methotrexate 17.0917352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D012509 Sarcoma Doxorubicin 3.9517203757 16767912 17710206 15625365 15675481 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2016326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7517846226
MESH:D012559 Schizophrenia Folic Acid 4.2416641680
MESH:D012559 Schizophrenia Homocysteine 4.2416641680
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5018551238
MESH:D012871 Skin Diseases Folic Acid 3.2418709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7419755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 5.7415692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5317203757 16767912 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D013118 Spinal Cord Diseases Folic Acid 13.6516361298
MESH:D013118 Spinal Cord Diseases Vitamin B 12 13.6516361298
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.6720155912 2093021
MESH:D013274 Stomach Neoplasms Folic Acid 2.6717171786
MESH:D020521 Stroke Folic Acid 9.5316517955
MESH:D020521 Stroke Vitamin B 12 9.5316517955
MESH:D013576 Syndactyly Methotrexate 4.999562676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.3317909728 16010429
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.2316049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.2317053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.2317653716
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2810091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1817334414 17638931 17678736 16364871
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00270 Cysteine and methionine metabolism
KEGG:01100 Metabolic pathways
KEGG:00670 One carbon pool by folate
KEGG:00450 Selenocompound metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31272
    • No data
    Releated disease ID Related disease Name
    PA443937Drug Toxicity
    PA445601Osteosarcoma
    PA443553Brain Diseases
    PA446975Neurotoxicity Syndromes
    PA443359Aneurysm
    PA446509Aortic Aneurysm, Abdominal
    PA445742Stomach Neoplasms
    PA443434Arthritis, Rheumatoid
    PA445062Neoplasms
    PA443269Adenoma
    PA446108Colorectal Neoplasms
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA446892Hyperhomocysteinemia
    PA446974Choroidal Neovascularization
    PA445095Neural Tube Defects
    PA446286Spina Bifida Cystica
    PA445556Rheumatoid Nodule
    PA444367Heart Defects, Congenital
    Releated drug ID Related drug Name
    PA449014cisplatin
    PA449165cyclophosphamide
    PA151917012dactinomycin
    PA449412doxorubicin
    PA451879vincristine
    PA164777036hydroxychloroquine
    PA451547sulfasalazine
    PA448073ethanol
    PA128406956fluorouracil
    PA450198leucovorin
    PA131285527oxaliplatin
    PA448049adenosine
    PA450423l-methionine
    PA451892cyanocobalamin
    PA449692folic acid
    PA451897pyridoxine
    PA450428methotrexate
    PA451871verteporfin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00115 - Liver-Stomach Concentrate with Intrinsic Factor Antianemic Agents;Essential Vitamin;Vitamins (Vitamin B Complex)
    DB00116 - Tetrahydrofolic acid Dietary supplement;Micronutrient
    DB00134 - L-Methionine Dietary supplement;Micronutrient;Essential Amino Acids
    DB00200 cofactor Vege 1 Daily Caplet Nutritional Supplement;Anti-anemic Agents;Vitamin B Complex;Hematinics
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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