AutismKB 2.0

Annotation Detail for MUC1


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Basic Information Top
Gene Symbol:MUC1 ( CD227,EMA,H23AG,KL-6,MAM6,PEM,PEMT,PUM )
Gene Full Name: mucin 1, cell surface associated
Band: 1q22
Quick LinksEntrez ID:4582; OMIM: 158340; Uniprot ID:MUC1_HUMAN; ENSEMBL ID: ENSG00000185499; HGNC ID: 7508
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1826Cystic fibrosis
1847Alimentary system disease
1894Abortion
1899Eosinophilia
1934Cancer
1999Thalassemia
2087Bacterial infection
2090Hamman-Rich syndrome
Desease Name
Carcinoma
CANCER
Gastritis
Krebs von den Lungen-6 Levels
intestinal metaplasia
Stomach Neoplasms
lung cancer
Desease Name
Serum magnesium levels
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MUC1 mRNAaffects expression 17562736
D019386 Alendronate Alendronate affects the expression of MUC1 mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MUC1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MUC1 mRNAincreases expression 20018196
C095105 bexarotene bexarotene results in increased expression of MUC1 mRNAincreases expression 16648578
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MUC1 mRNAdecreases expression 15336504
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MUC1 mRNAaffects cotreatment|decreases expression 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MUC1 mRNAaffects cotreatment|decreases expression 20360939
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of MUC1 mRNAincreases expression 15289156
15171707
D004958 Estradiol Estradiol affects the expression of MUC1 mRNAaffects expression 15598610
D004958 Estradiol Estradiol results in increased expression of MUC1 mRNAincreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MUC1 mRNAaffects expression 16079270
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MUC1 mRNAincreases expression 17557909
D019304 Ethinyl Estradiol-Norgestrel Combination Ethinyl Estradiol-Norgestrel Combination results in decreased expression of MUC1 proteindecreases expression 11056131
D005419 Flavonoids Flavonoids results in decreased expression of MUC1 mRNAdecreases expression 18035473
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of MUC1 mRNAincreases expression 17187413
D005492 Folic Acid Folic Acid affects the expression of MUC1 mRNAaffects expression 17320366
D019833 Genistein Genistein results in increased expression of MUC1 mRNAincreases expression 15289156
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of MUC1 mRNAaffects cotreatment|increases expression 17183730
C016517 indole-3-carbinol indole-3-carbinol results in decreased expression of MUC1 mRNAdecreases expression 15027113
C016517 indole-3-carbinol indole-3-carbinol results in decreased expression of MUC1 proteindecreases expression 15027113
C452423 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of MUC1 mRNAincreases expression 16052530
D010047 Ovalbumin Ovalbumin results in increased expression of MUC1 mRNAincreases expression 12388339
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MUC1 mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone Progesterone affects the expression of MUC1 proteinaffects expression 15971251
D011374 Progesterone Progesterone results in decreased expression of MUC1decreases expression 17510236
D020849 Raloxifene Raloxifene results in increased expression of MUC1 proteinincreases expression 16012748
D020849 Raloxifene Raloxifene affects the expression of MUC1 mRNAaffects expression 16079270
D012176 Retinoids Retinoids results in increased expression of MUC1 proteinincreases expression 11287445
C025462 sulindac sulfide sulindac sulfide results in decreased expression of MUC1 mRNAdecreases expression 16184548
D013629 Tamoxifen MUC1 protein affects the susceptibility to Tamoxifenaffects response to substance 19289846
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MUC1 mRNAaffects cotreatment|affects expression 16979875
D014212 Tretinoin Tretinoin results in increased expression of MUC1 proteinincreases expression 16473924
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of MUC1 mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin affects the expression of MUC1 mRNAaffects expression 19015723
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MUC1 mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2514745880
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.208875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6619490988
MESH:D000138 Acidosis Ammonium Chloride 3.2618287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6417505938
MESH:D000169 Acrodermatitis Zinc 5.1117202136 17190629 16889938
MESH:D058186 Acute Kidney Injury Folic Acid 4.0716595132 16316344 17003819
MESH:D055371 Acute Lung Injury pirinixic acid 2.8518653653
MESH:D000230 Adenocarcinoma Estradiol 6.6011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6014692618
MESH:D000230 Adenocarcinoma Genistein 6.6011473722
MESH:D000236 Adenoma 2-Acetylaminofluorene 10.4210737359
MESH:D000236 Adenoma Diethylnitrosamine 10.4210737359 6695378
MESH:D000236 Adenoma Folic Acid 10.4216963246
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.716705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.1117620307 16434500 19061943 18056438 17162532 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.1116434500
MESH:D000419 Albuminuria Raloxifene 4.3117451421 17308373
MESH:D000505 Alopecia Tretinoin 3.3815955085
MESH:D000544 Alzheimer Disease Folic Acid 8.9517116317
MESH:D000544 Alzheimer Disease Raloxifene 8.9515800139
MESH:D000544 Alzheimer Disease sulindac sulfide 8.9518759972
MESH:D000544 Alzheimer Disease Zinc 8.9516325427 16580781 17119284 16410023
MESH:D000550 Amblyopia Valproic Acid 4.9317688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2015469931
MESH:D000755 Anemia, Sickle Cell Zinc 4.6216916123
MESH:D000799 Angioedema Acetaminophen 3.5410982225
MESH:D001008 Anxiety Disorders Valproic Acid 8.0917497229
MESH:D001008 Anxiety Disorders vinclozolin 8.0919015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.6015885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.6016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1916292516
MESH:D001249 Asthma Tretinoin 4.7516456186
MESH:D001249 Asthma Zinc 4.7517085522
MESH:D050197 Atherosclerosis Ethinyl Estradiol-Norgestrel Combination 5.1611996209
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Folic Acid 2.1621388746
MESH:D001321 Autistic Disorder Valproic Acid 2.1620603192 17157402 19232924 18775368 15238991 18396377 19460635 18940202 17507914 16609825 18558336 17688650 18316065 18177632 18985861
MESH:D001471 Barrett Esophagus Tretinoin 4.1216935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.9320046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.1019483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.1016197459 16206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.218888407
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0417868700
MESH:D001930 Brain Injuries Progesterone 16.7815665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 16.7816580743
MESH:D001930 Brain Injuries Zinc 16.7817109824
MESH:D001943 Breast Neoplasms bexarotene 9.2816818667 16344269
MESH:D001943 Breast Neoplasms Diethylnitrosamine 9.2817474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 9.2817129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 9.2812948864 16675129 17289903 14630087 17018787 17261762 18497071 19861407
MESH:D001943 Breast Neoplasms Folic Acid 9.2816777985
MESH:D001943 Breast Neoplasms Genistein 9.2816873071 16541309 17200150
MESH:D001943 Breast Neoplasms indole-3-carbinol 9.2816082211
MESH:D001943 Breast Neoplasms Progesterone 9.2815562024 16175315 17614352
MESH:D001943 Breast Neoplasms Raloxifene 9.2815775269 17893378 17049068 15758505 17440819 15572757 17242785 16912660 16837676 17261762 17595753 17952589
MESH:D001943 Breast Neoplasms Retinoids 9.2817491551 19340624 17368321
MESH:D001943 Breast Neoplasms Tamoxifen 9.2821152245 18629630 20859285 19487384 16818667 19011961 16873071 19221464 19103187 18855134 19288272 18815881 19289846 20544844 18821012 19142967 19244106 17440819 19410462 18351453 19059307 15565566 17242785 17893378 11161223 19189210 20135344 17049068 20065188 19189212 20005174 16202921 17261762 19115204 18997820 15668708 19200415 19084267 20390343 16273361 18984771 19155303 21138602 19066611 18425577
MESH:D001943 Breast Neoplasms Tretinoin 9.2816443354 16873071 16166294
MESH:D016535 Bronchial Hyperreactivity Ovalbumin 5.1312794006
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2916813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2219066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8616168501
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 16.0110737359 17761372 3581430 3084413 6705139
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.013084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.0118978308 3084413 20432363 16878318 20512989 20007298 16830150 19052882 11831363 16502159 18691550 19701751 20101231 16328049 16698587 16288022 20524982 18393292 19418558 18788625 17428255 19539802 18494052 17978847 19107877 17761372 17162532 18506893 16807293 16569478 20935162 16935385 17055752 19822196 19519916 16779866 16540662 17138121 19383236 20727157 20084675 19919837 18785209 21159647 18971187 19208518 19394651 19171122 10737359 18210153 10672840 17173139 16681979 20214788 18665156 3581430 20514400 19335982 18056438
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 16.0115948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.0116924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 16.0116924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 16.0116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.011917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.6716247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 5.6712391285
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.1718922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.1716096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Zinc 7.1716543248
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.6517572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.6517572228
MESH:D002318 Cardiovascular Diseases Folic Acid 15.7316755160
MESH:D002318 Cardiovascular Diseases Genistein 15.7316332659
MESH:D002318 Cardiovascular Diseases Raloxifene 15.7315775269
MESH:D002318 Cardiovascular Diseases Zinc 15.7316936243
MESH:D002386 Cataract Acetaminophen 6.6510977129
MESH:D002386 Cataract Tretinoin 6.6517460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.0120889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.012727394 17174075 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.0118566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2916129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6020734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.4419052882
MESH:D002779 Cholestasis Ethinyl Estradiol 7.0216919318 15861022 17681005 11677210 16105132 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 7.0219176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8616461808
MESH:D002971 Cleft Lip Folic Acid 3.8321254359
MESH:D002972 Cleft Palate Folic Acid 5.8821254359 8946559
MESH:D002972 Cleft Palate Tretinoin 5.889407595
MESH:D003072 Cognition Disorders Raloxifene 4.3315800139
MESH:D003092 Colitis Tretinoin 3.4217035595
MESH:D003110 Colonic Neoplasms Genistein 2.2417182828
MESH:D015179 Colorectal Neoplasms Folic Acid 2.6917245555 16985020 17087956 16963246 17116713
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.729142499 10589399 9664655 17551590 9125849 16925845 9211117 8800419 14991402 9224671
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.728888407 16575769 17688650
MESH:D019465 Craniofacial Abnormalities Zinc 3.7219302082
MESH:D003456 Cryptorchidism Diethylstilbestrol 10.4316002989 12952375
MESH:D003456 Cryptorchidism vinclozolin 10.4314966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0719031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9217474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2918249437
MESH:D003920 Diabetes Mellitus Zinc 3.9616479319
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8420387270
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 6.8416886840
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.8416647724
MESH:D003928 Diabetic Nephropathies Estradiol 13.6019279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.6017308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.6019279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2017187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.6814725611 14986274 16177239 11739529 17522070 11529661 11461765 19164858 11421492 10663392 19085960 2444490 15968718 12958197 17906064 11834606 12705907 16227642 18071297 17562736 18713872 10774834 11287661 16485898 19416960 12594235 19739265 19923254 11743745 12392966 10915739 16393943 16781746 14550746 16081117 19370779 15619225 16109766 12153990 19420014 12540782
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.6819107877
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.681733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8019426721
MESH:D004421 Dystonia Valproic Acid 3.781851702
MESH:D004487 Edema pirinixic acid 10.0812083418
MESH:D004487 Edema Raloxifene 10.0815860553
MESH:D004487 Edema Tetradecanoylphorbol Acetate 10.088273558 9599246 16716910 11698051 15177302 7812673 8113982
MESH:D004489 Edema, Cardiac Tretinoin 4.1718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 19.6212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 19.6217692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 19.6215845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 19.6219031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.9116402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.9116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 26.6216804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 26.6219148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Folic Acid 26.6217301261
MESH:D016889 Endometrial Neoplasms Genistein 26.6211473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 26.6220544844 16202921 19155303 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 26.6216569247
MESH:D004715 Endometriosis Progesterone 3.5116134523
MESH:D004802 Eosinophilia Ovalbumin 5.1912689652
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.863659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.6216628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.7818234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.347562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.017750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.773659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3920426865
MESH:D004938 Esophageal Neoplasms Zinc 4.3916543248
MESH:D017889 Exfoliation Syndrome Folic Acid 5.2016504073
MESH:D005124 Eye Abnormalities Tretinoin 3.3616938888 9664655
MESH:D015785 Eye Diseases, Hereditary Retinoids 5.6816968212
MESH:D005234 Fatty Liver Diethylnitrosamine 27.2921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.2915345470
MESH:D005234 Fatty Liver pirinixic acid 27.2919236843 20131406
MESH:D005234 Fatty Liver Raloxifene 27.2917473493
MESH:D005234 Fatty Liver Tamoxifen 27.2919224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 27.2914986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.6215751030 16513791 16534752 16611131 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.6216709447
MESH:D005315 Fetal Diseases Valproic Acid 4.5916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.858888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2314745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8919069698
MESH:D005355 Fibrosis Tretinoin 3.2317994277
MESH:D005756 Gastritis Acetaminophen 17.3716983495
MESH:D005756 Gastritis Folic Acid 17.3717171786
MESH:D005756 Gastritis Zinc 17.3717241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6416973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0016417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.6516452187
MESH:D005901 Glaucoma Folic Acid 4.8116504073
MESH:D005909 Glioblastoma Genistein 6.5716598420
MESH:D005909 Glioblastoma Tretinoin 6.5717312396
MESH:D006130 Growth Disorders Zinc 3.7717217573
MESH:D006258 Head and Neck Neoplasms Retinoids 7.7217368321
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.7216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8616084493
MESH:D006330 Heart Defects, Congenital Folic Acid 6.5517286298 16524890
MESH:D006330 Heart Defects, Congenital Tretinoin 6.559664655 14991402
MESH:D006331 Heart Diseases Raloxifene 3.3311110106
MESH:D006333 Heart Failure pirinixic acid 6.5520558911
MESH:D006333 Heart Failure Zinc 6.5517162251
MESH:D006335 Heart Injuries Zinc 5.4717074742
MESH:D016481 Helicobacter Infections Zinc 4.2617241300
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.026705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.146705139
MESH:D006527 Hepatolenticular Degeneration Zinc 4.4017276780
MESH:D006529 Hepatomegaly pirinixic acid 2.7119176532 16221962 18467677 19772884
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D006679 HIV Seropositivity Folic Acid 5.2017209195
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006849 Hydrocephalus Valproic Acid 4.5717688650
MESH:D006930 Hyperalgesia Acetaminophen 11.8716870215
MESH:D006930 Hyperalgesia Alendronate 11.8716769263
MESH:D006930 Hyperalgesia Tretinoin 11.8716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2816778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9320558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.2516395265 16433478 16865747 16755160 16397167
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1512960047 14722030
MESH:D006973 Hypertension Raloxifene 2.7615787275 17577099
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.3416612254
MESH:D007021 Hypospadias Diethylstilbestrol 10.2816002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.2816569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1115869954
MESH:D007246 Infertility Diethylstilbestrol 4.0715036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.0117937319
MESH:D007248 Infertility, Male vinclozolin 6.0116467254
MESH:D007249 Inflammation Diethylnitrosamine 14.2318785209
MESH:D007249 Inflammation Flavonoids 14.2317296493
MESH:D007249 Inflammation Progesterone 14.2315869954
MESH:D007249 Inflammation Tamoxifen 14.2319457130
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 14.237812673 7562506 8273558 11698051 15177302
MESH:D007333 Insulin Resistance Estradiol 6.5616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.5616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4817994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.3310783313
MESH:D007511 Ischemia Zinc 4.3416584753
MESH:D007569 Jaw Abnormalities Tretinoin 3.6415992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 13.1015629191 12587719
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 13.1015369732
MESH:D007674 Kidney Diseases Estradiol 13.1015618244
MESH:D007674 Kidney Diseases Zinc 13.1016960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.1616518626
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.1014681315 16762066 15003126
MESH:D007680 Kidney Neoplasms Estradiol 11.1015610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.1018625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7717184923
MESH:D007889 Leiomyoma Raloxifene 4.2216973256
MESH:D007938 Leukemia Genistein 5.9217468513 18980019
MESH:D007938 Leukemia Tretinoin 5.9217143497
MESH:D007951 Leukemia, Myeloid Retinoids 9.2316482212
MESH:D007951 Leukemia, Myeloid Tretinoin 9.2316482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.6917596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.6916294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 7.2816766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.2819075265 16140955 17712046 9834237 17361223 17217047 16823087 12679006 17294898 15748426 17649720 17301526 19225113 17368321 16935935 16331271 19029980 16766008 17107899 17506722 16788101 19035177 17339181 16891316 19642359
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4416417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.109224671
MESH:D008064 Lipidoses Tamoxifen 2.9517567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.6618522880 19638242 18665156 18407596 20032147
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.3117823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3115474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.3118564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.3118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 6.1216610002 12969438 19014921 12587719 19784758 16611625 19460945 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 6.1217034775
MESH:D008107 Liver Diseases Folic Acid 6.1216877991
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9817185352 16871587
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 13.0216273603 10737359 14678523 11376686 18001218 10672840
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.0219690152 2862719 18977376 20583210 19499222 20501860 21047994 19833225 19294768 19850985 12771043 19996281 15175105 19551842 16942905 2422723 19812893 19090486 20452335 18978307 19073162 19256749 18648771 15885732 19254457 20118626 12112319 19642983 19426721 21071580 20101389 20405173 18754104 10737359 20137499 20492335 18644402 21167192 19427195 9163691 19638242 19255062 21278145 20434301
MESH:D008113 Liver Neoplasms Diethylstilbestrol 13.0216712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 13.0216377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 13.0216684651
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 5.686150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.689362446 3124819 18282651 18079962 18093689 19009564 19004024 16267830 2563599 19539802 19519916 18775883 21159647 19126423 18164116 18544905 18308698 18253720 17174075 17942915 16842330 17854601
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.9617228818
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 6.2111376686
MESH:D008175 Lung Neoplasms bexarotene 6.2117849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.2121163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 6.2118625569
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 6.2111807781
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.2517718048
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8515166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.2715700306
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.8611161223
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2216002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4719428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 25.6219196723 15591091 19196722
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 25.6216891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 25.6214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 25.6217203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 25.6216827153 11731420 19196723 14580682 19196722
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 25.628985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 25.6212773700
MESH:D020149 Manganese Poisoning Estradiol 11.6519453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.6519453300
MESH:D008415 Mastocytosis Retinoids 6.2916953078
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.4016832597
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma Tamoxifen 3.1112393984 19393235
MESH:D008545 Melanoma Tretinoin 3.1116752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2819513568
MESH:D008591 Meningomyelocele Tretinoin 4.1416940565
MESH:D008654 Mesothelioma marker/mechanism 18454162
MESH:D008881 Migraine Disorders Valproic Acid 2.9818765137 18803445
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2515863610
MESH:D009101 Multiple Myeloma Raloxifene 3.2316497877
MESH:D009135 Muscular Diseases pirinixic acid 3.2216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.768888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.8317596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.8317596541
MESH:D009203 Myocardial Infarction Genistein 5.2617141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.2619151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.8816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.8817141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.8816411023
MESH:D009232 Myxoma Raloxifene 5.2516343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.333581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.3319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4219410462
MESH:D009369 Neoplasms Diethylstilbestrol 7.4115313581
MESH:D009369 Neoplasms pirinixic acid 7.4117405874
MESH:D009369 Neoplasms Tretinoin 7.4116594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 9.9319196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.9319189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4417289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 21.1711399458
MESH:D009421 Nervous System Malformations Estradiol 21.1711399458 16427766
MESH:D009421 Nervous System Malformations Genistein 21.1716427766
MESH:D009421 Nervous System Malformations Tretinoin 21.179125849
MESH:D009436 Neural Tube Defects Folic Acid 11.1617438019
MESH:D009436 Neural Tube Defects Tretinoin 11.169142499
MESH:D009436 Neural Tube Defects Valproic Acid 11.1616359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.3918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.3920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8220387270
MESH:D009503 Neutropenia Folic Acid 4.2316322990
MESH:D009765 Obesity pirinixic acid 1.7420558911
MESH:D010024 Osteoporosis Alendronate 11.0517882678
MESH:D010024 Osteoporosis Genistein 11.0519401787
MESH:D010024 Osteoporosis Raloxifene 11.0517882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.2416169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.2415579764 15758505 17893378 17823083
MESH:D010051 Ovarian Neoplasms Estradiol 10.4919401270
MESH:D010051 Ovarian Neoplasms Genistein 10.4919005980
MESH:D010051 Ovarian Neoplasms Progesterone 10.4916525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 10.4916936753
MESH:D010146 Pain Acetaminophen 5.8116870215
MESH:D010146 Pain Tretinoin 5.8116870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.0516540662
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 8.0515976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.0515976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4111578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.0118404319 8330346 12065085 18922899
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8714722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3815687265 16977796
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.312563599
MESH:D011225 Pre-Eclampsia Zinc 3.9517114810
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 14.6517184923
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 14.6520603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.6518220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.6418220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6220887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0617136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 2.0616740699
MESH:D011471 Prostatic Neoplasms Genistein 2.0616925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0616536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Retinoids 2.0616724957 16166285
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0615067354
MESH:D011471 Prostatic Neoplasms Zinc 2.0612429649 16606632 16700911 16517595
MESH:D011472 Prostatitis vinclozolin 4.6418629315
MESH:D011507 Proteinuria Tretinoin 3.3316636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0215861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.2412752131 11422049
MESH:D011625 Pterygium Tretinoin 4.5016723453
MESH:D011693 Purpura Raloxifene 5.2515770314
MESH:D051437 Renal Insufficiency Folic Acid 4.4915728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.2419058328
MESH:D012162 Retinal Degeneration Zinc 3.9116584753
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.9616283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.9619155313
MESH:D012220 Rhinitis Ovalbumin 5.1512689652 18298128
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7518045962
MESH:D012559 Schizophrenia Folic Acid 3.7316641680
MESH:D012559 Schizophrenia Valproic Acid 3.7315737665 19110320
MESH:D012640 Seizures Valproic Acid 2.5511044598 11738929 3137016 17978042 1511512 15475178 14763951 16876388
MESH:D012871 Skin Diseases Folic Acid 3.1718709164
MESH:D012878 Skin Neoplasms Retinoids 12.5417538947
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.548532709
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 12.548330346 12065085 18404319 11807781 8985016
MESH:D012878 Skin Neoplasms Tretinoin 12.5416467112
MESH:D013088 Spermatocele Diethylstilbestrol 18.3916002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 18.3916709447
MESH:D013088 Spermatocele Tamoxifen 18.3916709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.2016361298
MESH:D013119 Spinal Cord Injuries Progesterone 9.8916503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.8919457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2412833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3118456281
MESH:D013274 Stomach Neoplasms Folic Acid 3.3117171786
MESH:D013274 Stomach Neoplasms Tretinoin 3.3117261132
MESH:D020521 Stroke Folic Acid 8.2416517955
MESH:D020521 Stroke Raloxifene 8.2416837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9115669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.457505956
MESH:D013964 Thyroid Neoplasms N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 15.4516940797
MESH:D013964 Thyroid Neoplasms Retinoids 15.4516940797
MESH:D013964 Thyroid Neoplasms Tretinoin 15.4516026305 17045167
MESH:D013978 Tibial Fractures Estradiol 12.7119048282
MESH:D013978 Tibial Fractures Raloxifene 12.7119048282
MESH:D014062 Tongue Neoplasms Tretinoin 9.1316051514
MESH:D014062 Tongue Neoplasms Zinc 9.1316543248
MESH:D014178 Translocation, Genetic Valproic Acid 4.9317262798
MESH:D014376 Tuberculosis Tretinoin 3.0516040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.233119515
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 11.021399818 15867355 15289314
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.0216452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.0217572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.0216712894 8653321 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.358888407
MESH:D014581 Urticaria Acetaminophen 2.7110982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 14.5716175088
MESH:D002583 Uterine Cervical Neoplasms indole-3-carbinol 14.5716082211
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.5716129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8714652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 14.5115809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 14.5114692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 14.5118645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.3116752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1516002989 16513791
MESH:D054556 Venous Thromboembolism Raloxifene 4.9116837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2814671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.7816761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2516343187
MESH:D009396 Wilms Tumor Tretinoin 3.7216287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31309
    • No data
    Releated disease ID Related disease Name
    PA443265Adenocarcinoma
    PA444635Intestinal Neoplasms
    PA445742Stomach Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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