AutismKB 2.0

Annotation Detail for MUC2


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Basic Information Top
Gene Symbol:MUC2 ( MLP,SMUC )
Gene Full Name: mucin 2, oligomeric mucus/gel-forming
Band: 11p15.5
Quick LinksEntrez ID:4583; OMIM: 158370; Uniprot ID:MUC2_HUMAN; ENSEMBL ID: ENSG00000198788; HGNC ID: 7512
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05146Amoebiasis
hsa05110Vibrio cholerae infection
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1847Alimentary system disease
1934Cancer
2027Connective tissue disease
2032Kidney disease
2164Barrett's esophagus
Desease Name
Asthma
IMMUNE
atopy
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002330 Carmustine Carmustine results in decreased expression of MUC2 mRNAdecreases expression 15980968
D004052 Diethylnitrosamine [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of MUC2 proteinaffects cotreatment|increases expression 20935162
D010047 Ovalbumin Ovalbumin results in increased expression of MUC2 mRNAincreases expression 12388339
D010634 Phenobarbital [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of MUC2 proteinaffects cotreatment|increases expression 20935162
C006253 pirinixic acid pirinixic acid results in increased expression of MUC2 mRNAincreases expression 12832660
D011794 Quercetin Quercetin results in increased expression of MUC2 mRNAincreases expression 15309432
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.906195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma marker/mechanism 12468628
MESH:D000236 Adenoma marker/mechanism 12468628
MESH:D000236 Adenoma Diethylnitrosamine 3.0110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.2518056438 19052882 17162532 19061943 17620307 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.2517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.2516434500
MESH:D000743 Anemia, Hemolytic Quercetin 4.5717084956
MESH:D001260 Ataxia Telangiectasia Quercetin 5.4415336622
MESH:D001327 Autoimmune Diseases Quercetin 4.8219761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001932 Brain Neoplasms Carmustine 4.6916187019
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2917474063
MESH:D001943 Breast Neoplasms Quercetin 2.2918628248
MESH:D016535 Bronchial Hyperreactivity Ovalbumin 5.6212794006
MESH:D002105 Cadmium Poisoning Quercetin 6.0716962696
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.8919171122 10737359 16502159 20084675 17138121 20432363 20727157 11831363 16540662 19107877 17055752 17428255 17761372 21159647 19539802 17162532 17978847 18691550 10672840 19418558 16698587 3581430 16935385 18665156 17173139 19701751 20514400 20524982 19208518 18971187 18788625 16779866 19919837 20007298 16569478 3084413 16878318 20935162 20214788 18978308 18506893 16681979 16288022 16830150 16328049 18056438 20512989 19052882 18210153 20101231 19383236 16807293 19394651 19822196 19519916 18494052 18393292 19335982 18785209
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.8917173139 20935162 6705139 1701930 20007298
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.8919519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.3717234771
MESH:D006332 Cardiomegaly Quercetin 3.4719794523
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0621159647 2727394 7505956 17174075
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9719052882
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003110 Colonic Neoplasms Quercetin 2.4617148506 11134977 17191121 19056647 15741050 16640504 19440933
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 4.0019496084
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2520387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.1219107877
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004802 Eosinophilia Ovalbumin 5.8912689652
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.393922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.6416302075
MESH:D005234 Fatty Liver Diethylnitrosamine 8.7821071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 8.7820131406 19236843
MESH:D005355 Fibrosis Quercetin 4.3219474275
MESH:D005909 Glioblastoma Carmustine 8.2416187019
MESH:D005909 Glioblastoma Quercetin 8.2419804834
MESH:D005910 Glioma Quercetin 3.1517643826
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly Phenobarbital 9.9016109766
MESH:D006529 Hepatomegaly pirinixic acid 9.9018467677 19176532 16221962 19772884
MESH:D006943 Hyperglycemia pirinixic acid 10.2720558911
MESH:D006943 Hyperglycemia Quercetin 10.2711834736 18262572
MESH:D006973 Hypertension Quercetin 2.9518356687
MESH:D007249 Inflammation Diethylnitrosamine 2.5218785209
MESH:D007251 Influenza, Human Quercetin 5.0316624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007414 Intestinal Neoplasms marker/mechanism 12468628
MESH:D007627 Keloid Quercetin 5.3717086741
MESH:D007674 Kidney Diseases Quercetin 3.2616962696
MESH:D007938 Leukemia Quercetin 3.2917468513
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.1619638242 20032147 18407596 18522880 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 7.1621047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5615474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.5612741479
MESH:D008107 Liver Diseases Diethylnitrosamine 4.3217034775
MESH:D008107 Liver Diseases Phenobarbital 4.3219363144
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.5612112319 2422723 19294768 15885732 19255062 19073162 19812893 20492335 20137499 21047994 20101389 20434301 12771043 19642983 15175105 19256749 19499222 20118626 20583210 21167192 18648771 21071580 18977376 19090486 19638242 2862719 19254457 20501860 21278145 18754104 19690152 19833225 20452335 10737359 19426721 18644402 19996281 20405173 19551842 19850985 19427195 18978307 16942905 9163691
MESH:D008113 Liver Neoplasms Phenobarbital 11.5619812893 19482888 8742319 19073162 21047994 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 11.5620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Quercetin 11.5618980244
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 11.0217942915 19009564 18308698 18544905 19126423 18282651 2563599 18079962 3124819 16267830 9362446 18775883 21159647 19539802 19004024 19519916 16842330 17854601 17174075 18164116 18253720 18093689
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 11.0218308698 1399818 2563599 17172636 6150874
MESH:D008114 Liver Neoplasms, Experimental Quercetin 11.0219519916
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.686695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Quercetin 2.6816280456
MESH:D008545 Melanoma Carmustine 2.9012393984
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 6.0919151258
MESH:D009203 Myocardial Infarction Quercetin 6.0919595682
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.2516411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 9.2519207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.679029167 3581430
MESH:D009369 Neoplasms pirinixic acid 5.5117405874
MESH:D009369 Neoplasms Quercetin 5.5115185748
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6120387270
MESH:D020078 Neurogenic Inflammation Quercetin 4.7117929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.6420387270
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.5719495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.8119005980
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 9.2116540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 9.2116965848
MESH:D010190 Pancreatic Neoplasms Quercetin 9.2116965848
MESH:D011230 Precancerous Conditions Diethylnitrosamine 17.092563599
MESH:D011230 Precancerous Conditions Phenobarbital 17.092563599
MESH:D011230 Precancerous Conditions Quercetin 17.0919056647
MESH:D011471 Prostatic Neoplasms Quercetin 3.5514715546 17292933
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D012004 Rectal Neoplasms marker/mechanism 12468628
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012220 Rhinitis Ovalbumin 5.7118298128 12689652
MESH:D012554 Schistosomiasis japonica Quercetin 6.0716862918
MESH:D012640 Seizures Phenobarbital 2.893137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.997505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.991399818
MESH:D001749 Urinary Bladder Neoplasms Quercetin 2.9016720314
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:05110 Vibrio cholerae infection
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31316
    • No data
    Releated disease ID Related disease Name
    PA446108Colorectal Neoplasms
    Releated drug ID Related drug Name
    PA449247dexamethasone
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01411 other/unknown Pranlukast Anti-Asthmatic Agents;Leukotriene Antagonists
    No data
    No data
    No data

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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