AutismKB 2.0

Annotation Detail for MUC4


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Basic Information Top
Gene Symbol:MUC4 ( HSA276359 )
Gene Full Name: mucin 4, cell surface associated
Band: 3q29
Quick LinksEntrez ID:4585; OMIM: 158372; Uniprot ID:MUC4_HUMAN; ENSEMBL ID: ENSG00000145113; HGNC ID: 7514
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1847Alimentary system disease
1934Cancer
2096Otitis media
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MUC4 mRNAaffects expression 16483693
C014347 decitabine [decitabine co-treated with trichostatin A] results in increased expression of MUC4 mRNAaffects cotreatment|increases expression 19127263
C014347 decitabine decitabine results in increased expression of MUC4 mRNAincreases expression 19127263
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of MUC4 mRNAincreases expression 17010207
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of MUC4 mRNAaffects cotreatment|decreases expression 17404688
D004958 Estradiol Estradiol results in increased expression of MUC4 mRNAincreases expression 17010207
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MUC4 mRNAincreases expression 15834898
17557909
D015025 Zearalenone Zearalenone results in increased expression of MUC4 mRNAincreases expression 17557909
C474055 octylphenol octylphenol results in increased expression of MUC4 mRNAincreases expression 17010207
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of MUC4 mRNAaffects cotreatment|decreases expression 17404688
C084904 Ro 41-5253 Ro 41-5253 inhibits the reaction [IFNG protein promotes the reaction [Tretinoin results in increased expression of MUC4 protein]]decreases reaction|increases expression|increases reaction 16007204
C084904 Ro 41-5253 Ro 41-5253 inhibits the reaction [IFNG protein results in increased expression of MUC4 protein]decreases reaction|increases expression 16007204
C084904 Ro 41-5253 Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of MUC4 protein]decreases reaction|increases expression 16007204
D012643 Selenium Selenium results in increased expression of MUC4 mRNAincreases expression 19244175
D014212 Tretinoin IFNG protein inhibits the reaction [Tretinoin results in increased expression of MUC4 mRNA]decreases reaction|increases expression 16007204
D014212 Tretinoin IFNG protein inhibits the reaction [Tretinoin results in increased expression of MUC4 protein]decreases reaction|increases expression 16007204
D014212 Tretinoin Ro 41-5253 inhibits the reaction [IFNG protein promotes the reaction [Tretinoin results in increased expression of MUC4 protein]]decreases reaction|increases expression|increases reaction 16007204
D014212 Tretinoin Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of MUC4 protein]decreases reaction|increases expression 16007204
D014212 Tretinoin Tretinoin results in increased expression of MUC4 mRNAincreases expression 16007204
D014212 Tretinoin Tretinoin results in increased expression of MUC4 proteinincreases expression 16007204
C012589 trichostatin A [decitabine co-treated with trichostatin A] results in increased expression of MUC4 mRNAaffects cotreatment|increases expression 19127263
C012589 trichostatin A trichostatin A results in increased expression of MUC4 mRNAincreases expression 19127263
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Estradiol 4.3011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3014692618
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6115469931
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4215885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3716456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7216197459 16206674
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5117868700
MESH:D001930 Brain Injuries Progesterone 4.4015845082 15380490 15665606
MESH:D001943 Breast Neoplasms decitabine 2.3818320071 19208741
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.3815324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 2.3817261762 12948864 19861407 16675129 14630087 17018787 17289903 18497071
MESH:D001943 Breast Neoplasms Progesterone 2.3817614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tretinoin 2.3816166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7416813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.7316924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.731917145
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.8619215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8616096774 16051514
MESH:D002386 Cataract Tretinoin 3.1517460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8418566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9517333356 11677210 17110522 17681005 15861022 16105132 16919318
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D002972 Cleft Palate Tretinoin 2.719407595
MESH:D003092 Colitis Selenium 9.9717936198
MESH:D003092 Colitis Tretinoin 9.9717035595
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8210589399 9125849 16925845 8800419 17551590 9664655 9224671 9142499 9211117 14991402
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.6816002989 12952375
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6317187935
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2015131321
MESH:D004489 Edema, Cardiac Tretinoin 4.6418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.4617692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 14.6219294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 14.6219294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.8516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 12.8916804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 12.8919148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 12.8916569247
MESH:D004715 Endometriosis Progesterone 3.8716134523
MESH:D005124 Eye Abnormalities Tretinoin 3.6616938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.9215345470
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7216534752 16513791 16002989 15751030 16611131
MESH:D005355 Fibrosis Tretinoin 3.6517994277
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.1016452187
MESH:D005909 Glioblastoma Tretinoin 7.6517312396
MESH:D005909 Glioblastoma trichostatin A 7.6518801729
MESH:D006258 Head and Neck Neoplasms decitabine 8.0719215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.0716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.959664655 14991402
MESH:D006333 Heart Failure Selenium 3.1417162251
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006930 Hyperalgesia Tretinoin 3.3016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006965 Hyperplasia Diethylstilbestrol 4.5712960047 14722030
MESH:D007021 Hypospadias Diethylstilbestrol 11.7116002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.7116945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5415869954
MESH:D007246 Infertility Diethylstilbestrol 4.4815036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male decitabine 6.9617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9617937319
MESH:D007249 Inflammation Progesterone 2.6515869954
MESH:D007251 Influenza, Human Selenium 4.3716624496
MESH:D007333 Insulin Resistance Estradiol 3.0316393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.9017994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0117551590 15992940
MESH:D007674 Kidney Diseases Estradiol 2.6415618244
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.8515003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 7.8515610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2017184923
MESH:D007938 Leukemia decitabine 6.6018980019 19235587
MESH:D007938 Leukemia Tretinoin 6.6017143497
MESH:D007951 Leukemia, Myeloid decitabine 9.9318454857 17236224 19117987
MESH:D007951 Leukemia, Myeloid Tretinoin 9.9319285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.3717679729 18206229 19010910 18704418 18460780 19387464
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.3716294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.3718206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6418055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2219035177 17107899 16766008 17361223 19642359 16823087 19029980 9834237 19225113 17294898 16140955 17339181 17301526 19075265 16935935 12679006 17368321 17712046 15748426 16891316 17217047 17506722 16331271 17649720 16788101
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.389224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5018397230 16248980
MESH:D008113 Liver Neoplasms Diethylstilbestrol 2.6715890375 16712894
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3015166399
MESH:D008223 Lymphoma decitabine 7.9919470736
MESH:D008223 Lymphoma Diethylstilbestrol 7.9915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.6916002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.3917203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.3911408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.3915318939
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma decitabine 5.3516505122 17785578
MESH:D008545 Melanoma Tretinoin 5.3516752155
MESH:D008545 Melanoma trichostatin A 5.3516505122
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D009101 Multiple Myeloma decitabine 7.9218172295
MESH:D009101 Multiple Myeloma trichostatin A 7.9218172295
MESH:D009190 Myelodysplastic Syndromes decitabine 7.6816882708 19010910 19157545 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.6817596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3616810080
MESH:D009369 Neoplasms decitabine 8.6817925555 19116145 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 8.6815313581
MESH:D009369 Neoplasms Tretinoin 8.6816946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 17.2211399458
MESH:D009421 Nervous System Malformations Estradiol 17.2211399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 17.229125849
MESH:D009436 Neural Tube Defects Tretinoin 3.129142499
MESH:D010051 Ovarian Neoplasms decitabine 15.3419259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 15.3419401270
MESH:D010051 Ovarian Neoplasms Progesterone 15.3417393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 15.3416936753
MESH:D010051 Ovarian Neoplasms trichostatin A 15.3419331143
MESH:D010146 Pain Tretinoin 2.9916870215
MESH:D010190 Pancreatic Neoplasms decitabine 8.9719294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.9715976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 8.9719294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8116977796 15687265
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.2717184923
MESH:D055728 Primary Myelofibrosis decitabine 12.9017616702
MESH:D055728 Primary Myelofibrosis trichostatin A 12.9017616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.6815846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.6816740699
MESH:D011471 Prostatic Neoplasms trichostatin A 2.6818798265 19789329
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D012208 Rhabdomyosarcoma decitabine 11.3419155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.3416283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8918045962
MESH:D012878 Skin Neoplasms Tretinoin 2.6516467112
MESH:D013088 Spermatocele Diethylstilbestrol 12.3116709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 12.3116709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.4316503802 15862959
MESH:D013274 Stomach Neoplasms decitabine 2.5719037991
MESH:D013274 Stomach Neoplasms Tretinoin 2.5717261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013964 Thyroid Neoplasms decitabine 7.5817967635
MESH:D013964 Thyroid Neoplasms Tretinoin 7.5817045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.8916051514
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.4819087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.4817306315 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.8616175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.8616129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.3414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.9015809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.9014692618
MESH:D014604 Uveal Neoplasms decitabine 13.4217785578
MESH:D014604 Uveal Neoplasms Tretinoin 13.4216752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.5716513791 16002989
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31319
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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