AutismKB 2.0

Annotation Detail for MYBL2


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Basic Information Top
Gene Symbol:MYBL2 ( B-MYB,BMYB,MGC15600 )
Gene Full Name: v-myb myeloblastosis viral oncogene homolog (avian)-like 2
Band: 20q13.12
Quick LinksEntrez ID:4605; OMIM: 601415; Uniprot ID:MYBB_HUMAN; ENSEMBL ID: ENSG00000101057; HGNC ID: 7548
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200027E2F transcription factor network
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Related Diseases/Disorders Top
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Desease IDDesease Name
1934Cancer
2151Neuroblastoma
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of MYBL2 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of MYBL2 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of MYBL2 mRNAdecreases expression 17942131
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of MYBL2 mRNAincreases expression 17254854
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in increased expression of MYBL2 mRNAaffects cotreatment|increases expression 17639512
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MYBL2 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MYBL2 mRNAdecreases expression 17942131
C006780 bisphenol A bisphenol A results in increased expression of MYBL2 mRNAincreases expression 16474171
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of MYBL2 mRNAdecreases expression 17942131
D016572 Cyclosporine Cyclosporine results in decreased expression of MYBL2 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of MYBL2 mRNAdecreases expression 17942131
D002117 Calcitriol Calcitriol results in decreased expression of MYBL2 mRNAdecreases expression 12875902
D004958 Estradiol Estradiol results in increased expression of MYBL2 mRNAincreases expression 16474171
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MYBL2 mRNAincreases expression 17555576
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYBL2 mRNAaffects cotreatment|increases expression 17942748
C056516 exemestane exemestane results in increased expression of MYBL2 mRNAincreases expression 17254854
D005472 Fluorouracil Fluorouracil results in increased expression of MYBL2 mRNAincreases expression 16557594
D005472 Fluorouracil MYBL2 protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D019833 Genistein Genistein results in increased expression of MYBL2 mRNAincreases expression 16474171
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of MYBL2 mRNAaffects cotreatment|increases expression 17183730
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of MYBL2 mRNAdecreases expression 12419474
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of MYBL2 mRNAincreases expression 12057914
D008713 Methimazole Methimazole results in decreased expression of MYBL2 mRNAdecreases expression 17403546
C008493 methylselenic acid methylselenic acid results in decreased expression of MYBL2 mRNAdecreases expression 12517777
C494474 perchlorate perchlorate results in decreased expression of MYBL2 mRNAdecreases expression 17403546
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of MYBL2 mRNAincreases expression 16474171
D011374 Progesterone Progesterone results in decreased expression of MYBL2 mRNAdecreases expression 16966611
D011441 Propylthiouracil Propylthiouracil results in decreased expression of MYBL2 mRNAdecreases expression 17403546
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in increased expression of MYBL2 mRNAaffects cotreatment|increases expression 17639512
C017947 sodium arsenite sodium arsenite results in increased expression of MYBL2 mRNAincreases expression 12016162
D014284 Triiodothyronine Triiodothyronine results in decreased expression of MYBL2 mRNAdecreases expression 17399805
D013629 Tamoxifen Tamoxifen affects the expression of MYBL2 mRNAaffects expression 17555576
C021751 tanshinone tanshinone results in increased expression of MYBL2 mRNAincreases expression 15849732
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYBL2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MYBL2 mRNAdecreases expression 16611356
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of MYBL2 mRNAdecreases expression 17951470
D014212 Tretinoin Tretinoin results in decreased expression of MYBL2 mRNAdecreases expression 18230668
D014212 Tretinoin Tretinoin results in decreased expression of MYBL2 mRNAdecreases expression 17318229
12875902
D014212 Tretinoin Tretinoin results in decreased expression of MYBL2 mRNAdecreases expression 16604517
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of MYBL2 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2314745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.2815322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6519490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6317505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.7518653653 11850527
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.6320127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 12.6311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.6314692618
MESH:D000230 Adenocarcinoma Fluorouracil 12.6317638652
MESH:D000230 Adenocarcinoma Genistein 12.6311473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.476695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5916712894 17306315
MESH:D000505 Alopecia Tretinoin 3.3715955085
MESH:D000550 Amblyopia Valproic Acid 4.9217688650
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9110965797
MESH:D000740 Anemia Fluorouracil 7.7916511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.7911748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.9617084956
MESH:D000799 Angioedema Acetaminophen 3.5310982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.3317497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7719183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.5715885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.5716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1916292516
MESH:D001249 Asthma Tretinoin 2.2516456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.6715336622
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518316065 18177632 20603192 18940202 18558336 19460635 15238991 18396377 18985861 19232924 17507914 17157402 16609825 17688650 18775368
MESH:D001327 Autoimmune Diseases Quercetin 4.1019761891
MESH:D001471 Barrett Esophagus Tretinoin 4.1116935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.9220046352 17594078
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 13.8219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.8212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.8216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.3615746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.368888407
MESH:D001862 Bone Resorption bisphenol A 3.5911985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0217868700
MESH:D001930 Brain Injuries Progesterone 3.9515665606 15380490 15845082
MESH:D001943 Breast Neoplasms Ascorbic Acid 12.2016443354
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 12.2017474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 12.2017123778
MESH:D001943 Breast Neoplasms Calcitriol 12.2011237771
MESH:D001943 Breast Neoplasms Estradiol 12.2017289903 18497071 17261762 16675129 19861407 17018787 12948864 14630087
MESH:D001943 Breast Neoplasms exemestane 12.2017952589 16002280 17892469
MESH:D001943 Breast Neoplasms Fluorouracil 12.2019217205 16595493 15136595 18608205 16557594 16110121 18357371
MESH:D001943 Breast Neoplasms Genistein 12.2016873071 17200150 16541309
MESH:D001943 Breast Neoplasms Progesterone 12.2016175315 15562024 17614352
MESH:D001943 Breast Neoplasms Quercetin 12.2018628248
MESH:D001943 Breast Neoplasms Tamoxifen 12.2019011961 19059307 20065188 20859285 18855134 19487384 18815881 17049068 18997820 19288272 20135344 21138602 18821012 20390343 18351453 17242785 11161223 17261762 19066611 16873071 16818667 18984771 17893378 19189212 19221464 19189210 15668708 17440819 19142967 19115204 19155303 20544844 19084267 20005174 18629630 19289846 19244106 18425577 16202921 19410462 19200415 21152245 19103187 15565566 16273361
MESH:D001943 Breast Neoplasms tanshinone 12.2015849732 19885617
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 12.2020435547
MESH:D001943 Breast Neoplasms Tretinoin 12.2016443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2816813970
MESH:D002105 Cadmium Poisoning Quercetin 5.2316962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1516111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3516051944
MESH:D002277 Carcinoma Fluorouracil 7.3817121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.3816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8416168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.953084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.9516924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 15.9516799960 16332177 17088986 17971768 18930000 17045692
MESH:D006528 Carcinoma, Hepatocellular Genistein 15.9516924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 15.9519519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 15.9516507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 15.9516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 15.951917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.6817123778
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.6517234771
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8718695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 13.3020419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 13.3011237771
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 13.3016280240 16757204 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.3018572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.3016051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3517572228
MESH:D006332 Cardiomegaly Quercetin 6.2319794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2318670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Genistein 6.8216332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.8216936243
MESH:D002386 Cataract Acetaminophen 6.6210977129
MESH:D002386 Cataract Tretinoin 6.6217460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 9.9412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.9418566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.9419524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2816129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5920734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9016835633
MESH:D002779 Cholestasis Cyclosporine 7.0219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.0216105132 17110522 17681005 15861022 16919318 11677210 17333356
MESH:D002822 Choriocarcinoma Tretinoin 4.8416461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3216354765 15340226 12621046 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 5.329407595
MESH:D003092 Colitis Tretinoin 3.4017035595
MESH:D003110 Colonic Neoplasms Fluorouracil 5.5217172411 17725105 17016597 15001691 17018589 16510598 16340194 18772588 17169374 17287894
MESH:D003110 Colonic Neoplasms Genistein 5.5217182828
MESH:D003110 Colonic Neoplasms Quercetin 5.5215741050 11134977 16640504 17148506 19440933 17191121 19056647
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.4315289873 17695437 17016601 18383874 17255274 15148649 17594712 16282729 17094418 16303861 14970324 18802399 16331619 20501625 16391804 16524972 17401013 18509181 18288408 17454858 18949393 18448328
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 3.4315531428
MESH:D015179 Colorectal Neoplasms Quercetin 3.4318852136 18095365
MESH:D003139 Common Cold Ascorbic Acid 5.1617323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8014669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.559224671 16925845 9125849 9664655 9211117 10589399 8800419 14991402 9142499 17551590
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.5516575769 17688650 8888407
MESH:D007644 Darier Disease Fluorouracil 4.4816733453
MESH:D003704 Dementia Polychlorinated Biphenyls 4.4216140633
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0619031437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.4819496084
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 6.7416506275
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.7416647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7417107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.9819279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.9819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1917187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.5716081117 11529661 11421492 2444490 19085960 18071297 15968718 10663392 19164858 19923254 14725611 18713872 11834606 19420014 16177239 15619225 16227642 11739529 12958197 16485898 14986274 19370779 19416960 12540782 17522070 14550746 11461765 10774834 12594235 11743745 16109766 16393943 19739265 12153990 17906064 12705907 16781746 17562736 10915739 12392966 11287661
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.5720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.5719641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7819426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5311462148
MESH:D004421 Dystonia Valproic Acid 3.761851702
MESH:C538011 Eales disease Ascorbic Acid 5.169068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.8916714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.8918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 19.4915138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 19.4912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 19.4917692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 19.4919031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.2816402032
MESH:D016889 Endometrial Neoplasms Estradiol 16.1211473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 16.1211473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.1219155303 20544844 16202921 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 16.1216569247
MESH:D004715 Endometriosis Progesterone 8.0416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.0410568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.0915328337 15821434 17637181
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.853659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.6016628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.7818234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.337562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.997750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.753659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2016530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.2015173087 17638652 16337965 16481741 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.0811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.0816938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 16.4819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.4815345470
MESH:D005234 Fatty Liver Tamoxifen 16.4819224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 16.4814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5716575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.848888407 18558336
MESH:D005334 Fever Lipopolysaccharides 3.7511852909 9205823
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8719069698
MESH:D005355 Fibrosis Cyclosporine 18.6512168785 12639820
MESH:D005355 Fibrosis Quercetin 18.6519474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.6520067830
MESH:D005355 Fibrosis Tretinoin 18.6517994277
MESH:D005756 Gastritis Acetaminophen 3.3616983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.918708960
MESH:D005909 Glioblastoma Genistein 10.7716598420
MESH:D005909 Glioblastoma Quercetin 10.7719804834
MESH:D005909 Glioblastoma Tretinoin 10.7717312396
MESH:D005910 Glioma Fluorouracil 9.3716145905
MESH:D005910 Glioma Quercetin 9.3717643826
MESH:D005910 Glioma tanshinone 9.3716955220
MESH:D006042 Goiter perchlorate 5.0218801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2810696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.1018337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.1016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8416084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 14.6416080930
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 14.6420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 14.6410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 14.6414991402 9664655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1115720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1216366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5912621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.3616490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.7215709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.9012676792
MESH:D019584 Hot Flashes Estradiol 3.4417088409
MESH:D006849 Hydrocephalus Valproic Acid 4.5617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.738697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.8216870215
MESH:D006930 Hyperalgesia Tretinoin 6.8216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2616778211
MESH:D006943 Hyperglycemia Quercetin 3.7618262572 11834736
MESH:D006973 Hypertension Cyclosporine 7.8610903974
MESH:D006973 Hypertension Quercetin 7.8618356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.8618670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.3216612254
MESH:D006980 Hyperthyroidism Methimazole 5.3214678291
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 4.9719662366
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5116569931 16945680
MESH:D007037 Hypothyroidism Methimazole 10.9418031379
MESH:D007037 Hypothyroidism Propylthiouracil 10.948137927 18031379
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1015869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.9617937319
MESH:D007248 Infertility, Male sodium arsenite 5.9612646999 15346721
MESH:D007249 Inflammation Lipopolysaccharides 10.6212878042 9205823 17255318 17237260 17963957
MESH:D007249 Inflammation Progesterone 10.6215869954
MESH:D007249 Inflammation Tamoxifen 10.6219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.6212200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.1916624496
MESH:D007333 Insulin Resistance bisphenol A 6.7716393666
MESH:D007333 Insulin Resistance Estradiol 6.7716627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.4617994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3417255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.0116580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.0115992940 17551590
MESH:D007627 Keloid Quercetin 4.6517086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1315604871
MESH:D007674 Kidney Diseases Acetaminophen 17.1412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 17.148314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 17.1415618244
MESH:D007674 Kidney Diseases Quercetin 17.1416962696
MESH:D007674 Kidney Diseases sodium arsenite 17.1420008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.0016518626
MESH:D007680 Kidney Neoplasms Cyclosporine 15.7112371664
MESH:D007680 Kidney Neoplasms Estradiol 15.7115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 15.7116985049
MESH:D007680 Kidney Neoplasms Tamoxifen 15.7118625569
MESH:D007938 Leukemia Genistein 9.6318980019 17468513
MESH:D007938 Leukemia Quercetin 9.6317468513
MESH:D007938 Leukemia Tretinoin 9.6317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4219285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.6819850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.6816294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9517217047 19642359 16935935 19035177 16331271 15748426 19029980 17107899 16788101 17361223 19225113 19075265 16140955 17712046 17301526 9834237 17294898 16766008 17506722 16891316 17368321 17339181 12679006 17649720 16823087
MESH:D007970 Leukopenia Lipopolysaccharides 4.3915821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.099224671
MESH:D008064 Lipidoses Tamoxifen 2.9417567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.2614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 10.2617823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 10.2612878042
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 10.2612741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.2618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.2612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.2616248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.5619460945 12587719 19784758 16610002 12969438 16611625 19014921 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9717185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.3821137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 16.3817045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms Quercetin 16.3818980244
MESH:D008113 Liver Neoplasms sodium arsenite 16.3815276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 16.3816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.3816984957
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 12.6218544905
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 12.621423854
MESH:D008114 Liver Neoplasms, Experimental Quercetin 12.6219519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.6212151625
MESH:D008171 Lung Diseases Ascorbic Acid 7.0416863852
MESH:D008171 Lung Diseases sodium arsenite 7.0419095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.9517228818
MESH:D055370 Lung Injury Lipopolysaccharides 3.7121114838
MESH:D008175 Lung Neoplasms Ascorbic Acid 10.0516401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.0520464547 20869020 18520028 17053015 18816296 18569708 20064080 6695378 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 10.0515246190
MESH:D008175 Lung Neoplasms Quercetin 10.0516280456
MESH:D008175 Lung Neoplasms sodium arsenite 10.0516712894 15276417 19931552 17306315 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 10.0518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.0519555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4815086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.6417203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.6414578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.6417203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.6419196722 11731420 16827153 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 11.5919453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.5919453300
MESH:D008527 Medulloblastoma Tretinoin 2.6617453147
MESH:D008545 Melanoma sodium arsenite 4.7419082730 16487513
MESH:D008545 Melanoma Tamoxifen 4.7412393984 19393235
MESH:D008545 Melanoma Tretinoin 4.7416752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2619513568
MESH:D008591 Meningomyelocele Tretinoin 4.1216940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4716801185
MESH:D008881 Migraine Disorders Valproic Acid 2.9718765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.7516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.7518986760 16757204
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.758888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.8017596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.8017596541
MESH:D009203 Myocardial Infarction Genistein 5.5517141266
MESH:D009203 Myocardial Infarction Quercetin 5.5519595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.9216810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.9217141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 12.9219207477
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4119410462
MESH:D009369 Neoplasms Benzo(a)pyrene 14.0711141357
MESH:D009369 Neoplasms Fluorouracil 14.0718600527 16928823 18239605
MESH:D009369 Neoplasms Quercetin 14.0715185748
MESH:D009369 Neoplasms sodium arsenite 14.0711559025
MESH:D009369 Neoplasms Tretinoin 14.0716946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3720056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6819196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0319348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 27.5911399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 27.5916427766 11399458
MESH:D009421 Nervous System Malformations Genistein 27.5916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 27.5914600291
MESH:D009421 Nervous System Malformations Tretinoin 27.599125849
MESH:D009436 Neural Tube Defects sodium arsenite 10.9912854658
MESH:D009436 Neural Tube Defects Tretinoin 10.999142499
MESH:D009436 Neural Tube Defects Valproic Acid 10.9916359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6218514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.0817929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2316436463
MESH:D009765 Obesity Ascorbic Acid 3.0617217161
MESH:D010024 Osteoporosis Genistein 3.0619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.1916169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.1919495926
MESH:D010049 Ovarian Diseases bisphenol A 4.6811985600
MESH:D010051 Ovarian Neoplasms Estradiol 17.5219401270
MESH:D010051 Ovarian Neoplasms Genistein 17.5219005980
MESH:D010051 Ovarian Neoplasms Progesterone 17.5217393432 16525653
MESH:D010051 Ovarian Neoplasms Quercetin 17.5219005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 17.5215276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 17.5216936753
MESH:D010146 Pain Acetaminophen 5.7716870215
MESH:D010146 Pain Tretinoin 5.7716870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.0116500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Quercetin 8.0116965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.0115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4011578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.7912065085
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.2816702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9312520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.1911550810
MESH:D011014 Pneumonia Lipopolysaccharides 4.2411605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2618163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.2412371664
MESH:D011230 Precancerous Conditions Quercetin 8.2419056647
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.4410548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.4411118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 14.4420603192
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.4715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.6320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.6320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 4.0817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 4.0816740699
MESH:D011471 Prostatic Neoplasms Calcitriol 4.0815754350 16289102 12479363 18247401 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 4.0816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 4.0819082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 4.0815378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms methylselenic acid 4.0816205645
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 4.0815721890
MESH:D011471 Prostatic Neoplasms Quercetin 4.0817292933 14715546
MESH:D011471 Prostatic Neoplasms sodium arsenite 4.0816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 4.0815067354
MESH:D011507 Proteinuria Tretinoin 3.3216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0015861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.2311422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D011625 Pterygium Tretinoin 4.4816723453
MESH:D011629 Puberty, Precocious bisphenol A 4.4710548101
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.0214606601
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7516160472 15538739 18286688 18722050
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5310835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5418990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2216849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.9116116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.9119155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7418045962
MESH:D012554 Schistosomiasis japonica Quercetin 5.2316862918
MESH:D012559 Schizophrenia Valproic Acid 2.0319110320 15737665
MESH:D012640 Seizures Valproic Acid 2.543137016 17978042 1511512 16876388 14763951 11738929 11044598 15475178
MESH:D012871 Skin Diseases Ascorbic Acid 3.1318709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 16.3419755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 16.3412065085
MESH:D012878 Skin Neoplasms sodium arsenite 16.3419524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.3416192470
MESH:D012878 Skin Neoplasms Tretinoin 16.3416467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.5116709447
MESH:D013088 Spermatocele Tamoxifen 10.5116709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.8316503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.8319457130
MESH:D016135 Spinal Dysraphism sodium arsenite 8.7612854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.7619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2312833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.182093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 3.1818396642 19084572 16424979 17498489 17522103 15786421 19015929 16951190 17172411 18567086
MESH:D013274 Stomach Neoplasms Tretinoin 3.1817261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 3.6218726076
MESH:D020521 Stroke Ascorbic Acid 4.0516517955 16403987
MESH:D019966 Substance-Related Disorders bisphenol A 3.6716045194 16684133
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9015821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5912697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 6.6515710170
MESH:D013964 Thyroid Neoplasms Tretinoin 6.6516026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.3719048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.9416280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.9416051514
MESH:D014178 Translocation, Genetic Valproic Acid 4.9217262798
MESH:D014376 Tuberculosis Tretinoin 3.0416040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.213119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.9017053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 10.9016720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.9016452187 17306315 11723127 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.908653321 16712894 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.348888407
MESH:D014581 Urticaria Acetaminophen 2.6910982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.3116803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.3111813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.3116129372
MESH:D014591 Uterine Diseases bisphenol A 4.6914652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.2916752155
MESH:D014605 Uveitis Cyclosporine 3.671336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2614671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.7616761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9315886252
MESH:D009396 Wilms Tumor Tretinoin 3.7116287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1317120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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