AutismKB 2.0

Annotation Detail for GADD45B


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GADD45B ( DKFZp566B133,GADD45BETA,MYD118 )
Gene Full Name: growth arrest and DNA-damage-inducible, beta
Band: 19p13.3
Quick LinksEntrez ID:4616; OMIM: 604948; Uniprot ID:GA45B_HUMAN; ENSEMBL ID: ENSG00000099860; HGNC ID: 4096
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04110Cell cycle
hsa04115p53 signaling pathway
No data
Pathway IDPathway Name
200034IL12-mediated signaling events
Pathway IDPathway Name
P00059p53 pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2025Polyarthritis
2022Liver cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of GADD45B mRNAaffects expression 18343893
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of GADD45B mRNAincreases expression 20005886
C029955 2-nitrotoluene 2-nitrotoluene results in increased expression of GADD45B mRNAincreases expression 15618236
D000082 Acetaminophen Acetaminophen affects the expression of GADD45B mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of GADD45B mRNAincreases expression 15618236
C430898 AGN 194204 AGN 194204 results in decreased expression of GADD45B mRNAdecreases expression 16339527
D001151 Arsenic Arsenic results in decreased expression of GADD45B mRNAdecreases expression 16835338
C050510 arsenic trichloride arsenic trichloride results in increased expression of GADD45B mRNAincreases expression 16283526
C050510 arsenic trichloride IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45B mRNA]affects reaction|increases expression 16283526
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of GADD45B mRNAincreases expression 18687144
D001205 Ascorbic Acid [Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GADD45B mRNAaffects cotreatment|decreases expression 18544905
D001374 Azacitidine Azacitidine promotes the reaction [Depsipeptides results in increased expression of GADD45B]increases expression|increases reaction 18225533
D001554 Benzene Benzene results in decreased expression of GADD45B mRNAdecreases expression 15120971
15122651
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GADD45B mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of GADD45B mRNAincreases expression 20106945
20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GADD45B mRNAincreases expression 20382639
19150397
C400082 bortezomib bortezomib inhibits the reaction [lipopolysaccharide A results in increased expression of GADD45B mRNA]decreases reaction|increases expression 15797874
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of GADD45B mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GADD45B mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of GADD45B mRNAincreases expression 15797874
D002251 Carbon Tetrachloride PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of GADD45B mRNA]affects reaction|increases expression 18038451
C099555 CD 437 CD 437 results in increased expression of GADD45B mRNAincreases expression 17474084
C043561 chrysin chrysin results in increased expression of GADD45B mRNAincreases expression 18331776
C043561 chrysin chrysin results in increased expression of GADD45B proteinincreases expression 18331776
D016572 Cyclosporine Cyclosporine results in increased expression of GADD45B mRNAincreases expression 20106945
D047630 Depsipeptides Azacitidine promotes the reaction [Depsipeptides results in increased expression of GADD45B]increases expression|increases reaction 18225533
D047630 Depsipeptides Depsipeptides results in increased expression of GADD45Bincreases expression 18225533
D003907 Dexamethasone Dexamethasone inhibits the reaction [lipopolysaccharide A results in increased expression of GADD45B mRNA]decreases reaction|increases expression 15797874
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of GADD45B mRNAdecreases expression 17942915
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of GADD45B mRNAincreases expression 18691550
19100860
D004052 Diethylnitrosamine IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of GADD45B mRNA]decreases reaction|increases expression 18691550
D004052 Diethylnitrosamine MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of GADD45B mRNA]decreases reaction|increases expression 18691550
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of GADD45B mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine [Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GADD45B mRNAaffects cotreatment|decreases expression 18544905
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GADD45B mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of GADD45B mRNAaffects cotreatment|decreases expression 18253720
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GADD45B mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of GADD45B mRNA]decreases reaction|increases expression 12072388
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GADD45B mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GADD45B mRNAaffects cotreatment|increases expression 17942748
D005038 Ethylnitrosourea Ethylnitrosourea results in increased expression of GADD45B mRNAincreases expression 19100860
D005054 Eugenol Eugenol results in increased expression of GADD45B mRNAincreases expression 15618236
D011345 Fenofibrate [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of GADD45B mRNAaffects cotreatment|decreases expression 18253720
D005472 Fluorouracil GADD45B protein results in decreased susceptibility to Fluorouracildecreases response to substance 17711513
D005472 Fluorouracil IFNG protein inhibits the reaction [GADD45B protein results in decreased susceptibility to Fluorouracil]decreases reaction|decreases response to substance 17711513
D005472 Fluorouracil GADD45B protein affects the susceptibility to Fluorouracilaffects response to substance 16732331
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of GADD45B mRNAaffects cotreatment|increases expression 16996129
C071834 glycidamide glycidamide results in decreased expression of GADD45B mRNAdecreases expression 17822822
D007213 Indomethacin Indomethacin results in increased expression of GADD45B mRNAincreases expression 16984733
C006552 kaempferol kaempferol results in increased expression of GADD45B mRNAincreases expression 18331776
C006552 kaempferol kaempferol results in increased expression of GADD45B proteinincreases expression 18331776
C119620 kenpaullone kenpaullone results in decreased expression of GADD45B mRNAdecreases expression 17993264
C011890 kojic acid [Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GADD45B mRNAaffects cotreatment|decreases expression 18544905
C082161 lipopolysaccharide A bortezomib inhibits the reaction [lipopolysaccharide A results in increased expression of GADD45B mRNA]decreases reaction|increases expression 15797874
C082161 lipopolysaccharide A Dexamethasone inhibits the reaction [lipopolysaccharide A results in increased expression of GADD45B mRNA]decreases reaction|increases expression 15797874
C082161 lipopolysaccharide A lipopolysaccharide A results in increased expression of GADD45B mRNAincreases expression 15797874
C082161 lipopolysaccharide A Thalidomide inhibits the reaction [lipopolysaccharide A results in increased expression of GADD45B mRNA]decreases reaction|increases expression 15797874
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of GADD45B mRNAincreases expression 15860229
D047311 Luteolin Luteolin results in increased expression of GADD45B mRNAincreases expression 18331776
D047311 Luteolin Luteolin results in increased expression of GADD45B proteinincreases expression 18331776
C005223 methyleugenol methyleugenol results in increased expression of GADD45B mRNAincreases expression 15618236
D010076 Oxazepam Oxazepam results in increased expression of GADD45B mRNAincreases expression 17533171
15618236
D010081 Oxazolone Oxazolone results in increased expression of GADD45B mRNAincreases expression 11379042
D010269 Paraquat Paraquat results in increased expression of GADD45B mRNAincreases expression 15246999
12595580
C008776 pelargonic acid pelargonic acid results in increased expression of GADD45B mRNAincreases expression 11379042
D010457 Peptidoglycan Peptidoglycan results in increased expression of GADD45B mRNAincreases expression 15860229
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of GADD45B mRNAincreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of GADD45B mRNA]increases expression|increases reaction 18467677
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GADD45B mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of GADD45B mRNA]increases expression|increases reaction 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of GADD45B mRNAincreases expression 19270015
19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GADD45B mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of GADD45B mRNAincreases expression 18467677
18301758
16985257
17426115
20059764
15618236
18445702
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of GADD45B mRNA]increases expression|increases reaction 20059764
18467677
D011794 Quercetin Quercetin results in increased expression of GADD45B mRNAincreases expression 18331776
D011794 Quercetin Quercetin results in increased expression of GADD45B proteinincreases expression 18331776
C009277 sodium arsenate sodium arsenate results in increased expression of GADD45B mRNAincreases expression 16882884
C017947 sodium arsenite sodium arsenite results in increased expression of GADD45B mRNAincreases expression 12760830
C017947 sodium arsenite sodium arsenite results in increased expression of GADD45B mRNAincreases expression 16014739
15797874
D012460 Sulfasalazine Sulfasalazine results in decreased expression of GADD45B mRNAdecreases expression 15633128
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GADD45B mRNAdecreases expression 16443690
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GADD45B mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of GADD45B mRNAaffects expression 18343893
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GADD45B mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GADD45B mRNAincreases expression 15800033
20005886
16611356
D013792 Thalidomide Thalidomide inhibits the reaction [lipopolysaccharide A results in increased expression of GADD45B mRNA]decreases reaction|increases expression 15797874
D014415 Tunicamycin Tunicamycin results in decreased expression of GADD45B mRNAdecreases expression 17127020
C025643 vinclozolin vinclozolin affects the expression of GADD45B mRNAaffects expression 19015723
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of GADD45B mRNAaffects cotreatment|increases expression 16996129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.046195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.0415322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Thalidomide 11.048333272
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3617505938
MESH:D058186 Acute Kidney Injury zoledronic acid 3.9519715164
MESH:D055371 Acute Lung Injury Lipopolysaccharides 7.2818653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 7.2818653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 4.9120200999
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 8.6520464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 8.6514692618
MESH:D000230 Adenocarcinoma Fluorouracil 8.6517638652
MESH:D000230 Adenocarcinoma Indomethacin 8.6516537180
MESH:D000236 Adenoma Benzo(a)pyrene 17.246695378
MESH:D000236 Adenoma beta-Naphthoflavone 17.2419389873
MESH:D000236 Adenoma Diethylnitrosamine 17.2410737359 6695378
MESH:D000236 Adenoma Ethylnitrosourea 17.246695378
MESH:D000236 Adenoma Indomethacin 17.2411497255
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.1617620307 18056438 19061943 16434500 19052882 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.1617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.1616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.1616835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1115276417
MESH:D018246 Adrenocortical Adenoma Arsenic 11.8417306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 11.8416712894 17306315
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.2011874814
MESH:D016301 Alveolar Bone Loss Indomethacin 4.7817225004
MESH:D000544 Alzheimer Disease Indomethacin 2.5617627676 15579461
MESH:D000690 Amyotrophic Lateral Sclerosis Thalidomide 3.9816510725
MESH:D000740 Anemia Fluorouracil 7.0217963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.0211748828
MESH:D000741 Anemia, Aplastic Benzene 3.9211369114 14761424 17661222
MESH:D000743 Anemia, Hemolytic Quercetin 3.7217084956
MESH:D000799 Angioedema Acetaminophen 3.2610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.1819015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.3010231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 9.8519183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 9.8510388637
MESH:D020261 Arsenic Poisoning marker/mechanism 16835338
MESH:D020261 Arsenic Poisoning Arsenic 2.6812569548 16835338 18414634 16251483
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9111256880
MESH:D018771 Arthralgia Indomethacin 4.582160914
MESH:D001169 Arthritis, Experimental Dexamethasone 10.2517659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.2515885639
MESH:D001169 Arthritis, Experimental Thalidomide 10.259598899
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.9011248219
MESH:D001172 Arthritis, Rheumatoid Sulfasalazine 4.909133974
MESH:D053627 Asthenozoospermia Sulfasalazine 5.7010689203
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4015336622
MESH:D050197 Atherosclerosis Arsenic 2.8912928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.5018445737
MESH:D001327 Autoimmune Diseases Quercetin 3.8519761891
MESH:D001477 Bartter Syndrome Indomethacin 4.4210684365
MESH:D001528 Behcet Syndrome Sulfasalazine 5.6915870978
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.0619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.0612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3815746008
MESH:D001855 Bone Marrow Diseases Benzene 4.6416183116
MESH:D001859 Bone Neoplasms zoledronic acid 4.4315867366 16121404 17312309 19442620 16778634 11697798
MESH:D001862 Bone Resorption zoledronic acid 4.1911869084 18496637 18404659 16769263 15845617 8053405
MESH:D001927 Brain Diseases Ethylnitrosourea 4.3814991843
MESH:D001929 Brain Edema Indomethacin 4.4411481608
MESH:D002545 Brain Ischemia Indomethacin 3.8512524144
MESH:D001932 Brain Neoplasms Ethylnitrosourea 3.7916436596 16651633 18412241 15144691 16357521
MESH:D001943 Breast Neoplasms Ascorbic Acid 8.5716443354
MESH:D001943 Breast Neoplasms Benzene 8.5717162533 11921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 8.5720146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 8.5717474063
MESH:D001943 Breast Neoplasms Fluorouracil 8.5715136595 18608205 19217205 18357371 16110121 16595493 16557594
MESH:D001943 Breast Neoplasms Indomethacin 8.5717401462
MESH:D001943 Breast Neoplasms kaempferol 8.5716756079
MESH:D001943 Breast Neoplasms methyleugenol 8.5711921183
MESH:D001943 Breast Neoplasms Quercetin 8.5718628248
MESH:D001943 Breast Neoplasms Sulfasalazine 8.5717356269
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 8.5720435547
MESH:D001943 Breast Neoplasms zoledronic acid 8.5718695136 16096432
MESH:D002056 Burns Indomethacin 4.1410459503
MESH:D002100 Cachexia Indomethacin 4.4315625704 15141370 16537180 11239499
MESH:D002105 Cadmium Poisoning Quercetin 4.9616962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.2216124888 15673190 16011737 15721981 18705752 16227642 10355542 15700767 16097048 3786805 16192424 16050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.0816051944
MESH:D002277 Carcinoma Fluorouracil 6.6617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.6616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.2417687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 20.173084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 20.1717306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 20.1718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 20.1716698587 16878318 16807293 20214788 17173139 3084413 19519916 16935385 19418558 19052882 20432363 20514400 19822196 18210153 17978847 19171122 21159647 16569478 18665156 16328049 16288022 20727157 19394651 16502159 16540662 18788625 19335982 18506893 20935162 18393292 11831363 17138121 16779866 19701751 20524982 17761372 20512989 20101231 16830150 19208518 18978308 18691550 17428255 17162532 10737359 18056438 18971187 16681979 18494052 19919837 20007298 17055752 3581430 19383236 19539802 10672840 20084675 19107877 18785209
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 20.1717971768 16332177 18930000 17045692 17088986 16799960
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 20.1716391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 20.1717173139 1701930 20935162 6705139 20007298
MESH:D006528 Carcinoma, Hepatocellular Quercetin 20.1719519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 20.1715276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Thalidomide 20.1716313753
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.1511053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.7818791128 14736730 11352223
MESH:D002289 Carcinoma, Non-Small-Cell Lung bortezomib 5.5316052434
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 5.5319233551
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.3917234771
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 9.2118695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 9.2117341418
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 9.2118507039
MESH:D002294 Carcinoma, Squamous Cell Arsenic 12.1215504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.1220419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 12.1216757204 18986760 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 12.1212636206 15482327
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 12.1218572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.5818640142
MESH:D006332 Cardiomegaly Quercetin 5.6519794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.6518670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 6.5415738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases kaempferol 6.5416756079
MESH:D002340 Carotid Artery Diseases Arsenic 3.8216973168 18022660
MESH:D002386 Cataract Acetaminophen 2.2210977129
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 5.1614688030
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.7520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.7512371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.7517174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 16.7516003739
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 16.7520056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.694080065
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.4017160924
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 13.3819052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 13.3816835633
MESH:D018281 Cholangiocarcinoma Thalidomide 13.3818291259
MESH:D002764 Cholecystitis Indomethacin 4.5811181007
MESH:D002779 Cholestasis Cyclosporine 10.8219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 10.8217110522 16105132 11677210 17681005 15861022 16919318 17333356
MESH:D002779 Cholestasis pirinixic acid 10.8219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8412621046 15340226 16354765 8697196 15668235
MESH:D003092 Colitis Thalidomide 4.3016680017
MESH:D003093 Colitis, Ulcerative Sulfasalazine 4.3215955209 17339853
MESH:D003110 Colonic Neoplasms Dexamethasone 7.1615824018
MESH:D003110 Colonic Neoplasms Fluorouracil 7.1617169374 16510598 17287894 17725105 17172411 15001691 18772588 17018589 16340194 17016597
MESH:D003110 Colonic Neoplasms Indomethacin 7.1615936596 11260862 15637740 15963497 15786552 15625704
MESH:D003110 Colonic Neoplasms Quercetin 7.1619056647 11134977 17148506 17191121 19440933 16640504 15741050
MESH:D015179 Colorectal Neoplasms Azacitidine 4.2619934284
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.2616524972 17695437 16282729 18383874 18949393 18802399 18288408 16331619 14970324 15148649 17401013 16303861 17016601 18509181 17255274 20501625 17094418 17454858 16391804 17594712 18448328 15289873
MESH:D015179 Colorectal Neoplasms Indomethacin 4.2611197048 18059344 17054584 12606626
MESH:D015179 Colorectal Neoplasms Quercetin 4.2618095365 18852136
MESH:D003139 Common Cold Ascorbic Acid 4.8917323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5714669216 17141729
MESH:D016510 Corneal Neovascularization Thalidomide 5.019301478
MESH:D003327 Coronary Disease fluvastatin 4.4216142594
MESH:D003328 Coronary Thrombosis methyleugenol 9.4116048847
MESH:D003328 Coronary Thrombosis Oxazepam 9.4116048847
MESH:D018352 Coronavirus Infections Indomethacin 5.1317302372
MESH:D003389 Cranial Nerve Diseases Thalidomide 5.729200351
MESH:D019465 Craniofacial Abnormalities Benzene 6.4315643154
MESH:D019465 Craniofacial Abnormalities Dexamethasone 6.4317728286
MESH:D019465 Craniofacial Abnormalities sodium arsenate 6.4310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.4310048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Thalidomide 6.439200351
MESH:D003424 Crohn Disease Thalidomide 3.8616078585
MESH:D003456 Cryptorchidism vinclozolin 3.7914966744
MESH:D007644 Darier Disease Fluorouracil 4.2216733453
MESH:D003872 Dermatitis Benzene 4.2115902427
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.8812438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1318249437
MESH:D003877 Dermatitis, Contact Oxazolone 4.5715944321 12811023
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.2619496084
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 6.1316506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.1320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.1317107852
MESH:D003967 Diarrhea Dexamethasone 6.487237001
MESH:D003967 Diarrhea Indomethacin 6.487907874 7237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.7719164858 16781746 17522070 18713872 14986274 14725611 11461765 10663392 18071297 2444490 16081117 12540782 19420014 12153990 11287661 11739529 19416960 11743745 19085960 10774834 12705907 12594235 12958197 19923254 15968718 14550746 17906064 15619225 11421492 16485898 19739265 17562736 10915739 11529661 16227642 19370779 11834606 16393943 16109766 12392966 16177239
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.7710092053 15027814 15998439 2869522 6884620 21278145 3786805 10915739 6623471 16227642 3732212 17522070 7120509 7179309 19336974 7440962 15968718 9327722 19085960 4309450 11566570 16177239
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.7719107877
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 9.7718186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.7720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3311462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.5718043480 16326151 18446180 16133044 12774134 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 3.6017151854 16699067 11535926 11595431 17329845 10671773 11991626 11595415 17351913 17045617 17202747
MESH:D050171 Dyslipidemias Fenofibrate 4.0016707586
MESH:D004421 Dystonia Phenobarbital 3.471851702
MESH:C538011 Eales disease Ascorbic Acid 4.899068938
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.4018357618
MESH:D004485 Eczema Dexamethasone 3.9112438553
MESH:D004487 Edema Dexamethasone 16.2719703484
MESH:D004487 Edema Indomethacin 16.278273558 7907874 8985016 16100529 10653021 7990266 19703484
MESH:D004487 Edema perfluorooctanoic acid 16.2717259670 12083418
MESH:D004487 Edema pirinixic acid 16.2712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.2711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.6512538720
MESH:D016889 Endometrial Neoplasms Fenofibrate 3.7016569247
MESH:D004715 Endometriosis Indomethacin 7.4115652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.419294722 10568697
MESH:D019446 Endotoxemia Indomethacin 8.7518509659
MESH:D019446 Endotoxemia Lipopolysaccharides 8.7515328337 15821434 17637181
MESH:D004751 Enteritis Indomethacin 4.1616328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.4217980183
MESH:D004802 Eosinophilia Indomethacin 3.5011298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.553659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.293922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.5720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.066401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.697750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.453659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5316302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 8.8620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 8.8616530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 8.8615173087 16481741 16337965 16785472 17638652
MESH:D004938 Esophageal Neoplasms Indomethacin 8.8611005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.5711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.2012795759 61145 12631006 16239168 15959796 19224547 17595544 16045604
MESH:D005234 Fatty Liver Cyclosporine 19.2019224547
MESH:D005234 Fatty Liver Diethylnitrosamine 19.2021071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.2015345470
MESH:D005234 Fatty Liver pirinixic acid 19.2020131406 19236843
MESH:D005264 Femoral Fractures zoledronic acid 5.2516234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9011858732
MESH:D005334 Fever Indomethacin 7.6911852909 10431976 17627676
MESH:D005334 Fever Lipopolysaccharides 7.699205823 11852909
MESH:D005354 Fibrosarcoma Indomethacin 4.3210962813
MESH:D005355 Fibrosis Carbon Tetrachloride 21.8318705752
MESH:D005355 Fibrosis Cyclosporine 21.8312639820 12168785
MESH:D005355 Fibrosis Indomethacin 21.8317994277
MESH:D005355 Fibrosis Quercetin 21.8319474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 21.8320067830
MESH:D005499 Folliculitis Indomethacin 4.5811298111
MESH:D005534 Foot Diseases Arsenic 4.976392382
MESH:D005756 Gastritis Acetaminophen 9.2016983495
MESH:D005756 Gastritis Indomethacin 9.2015046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.3616973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.7116417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.1016452187
MESH:D005871 Giant Lymph Node Hyperplasia Thalidomide 5.7212701121
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.648708960
MESH:D005909 Glioblastoma Ethylnitrosourea 9.8116436596
MESH:D005909 Glioblastoma Indomethacin 9.8112870263
MESH:D005909 Glioblastoma Quercetin 9.8119804834
MESH:D005910 Glioma Ethylnitrosourea 15.8216651633 16357521 18412241
MESH:D005910 Glioma Fluorouracil 15.8216145905
MESH:D005910 Glioma Indomethacin 15.8218371953 16487511
MESH:D005910 Glioma Quercetin 15.8217643826
MESH:D005910 Glioma Thalidomide 15.8216327979
MESH:D005911 Gliosis Paraquat 4.5811124998
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.8211849393
MESH:D018149 Glucose Intolerance sodium arsenate 4.5519446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0110696789
MESH:D006073 Gout Indomethacin 4.7811248219
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.6515162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Indomethacin 6.6515482327
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 13.3311294989
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 13.3316080930
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 13.3320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 13.3310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.1720558911
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 4.5713678655
MESH:D006402 Hematologic Diseases Benzene 4.1216183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8515720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.8816366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8211000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.0515633222
MESH:D006505 Hepatitis Carbon Tetrachloride 3.0519900420 19110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.1415135802
MESH:D006529 Hepatomegaly perfluorooctanoic acid 16.123609246
MESH:D006529 Hepatomegaly Phenobarbital 16.1216109766
MESH:D006529 Hepatomegaly pirinixic acid 16.1219176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.1215340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 5.4716490937 16863852
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 5.477520565
MESH:D006689 Hodgkin Disease sodium arsenite 2.6812676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4616959395 16354765 18606429 8697196 15340226
MESH:D006930 Hyperalgesia Acetaminophen 14.9716870215
MESH:D006930 Hyperalgesia Indomethacin 14.9712727271
MESH:D006930 Hyperalgesia perfluorooctanoic acid 14.9712083418
MESH:D006930 Hyperalgesia zoledronic acid 14.9716769263
MESH:D034321 Hyperamylasemia Indomethacin 5.1317883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.9616899240
MESH:D006934 Hypercalcemia bortezomib 9.7218089816
MESH:D006934 Hypercalcemia zoledronic acid 9.7218089816 19622757
MESH:D006940 Hyperemia Indomethacin 4.4312524144
MESH:D006943 Hyperglycemia kaempferol 12.9018262572
MESH:D006943 Hyperglycemia pirinixic acid 12.9020558911
MESH:D006943 Hyperglycemia Quercetin 12.9011834736 18262572
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 3.9517050553
MESH:D006949 Hyperlipidemias Indomethacin 3.6417546600
MESH:D006973 Hypertension Arsenic 17.2711953799 9931084 16076760
MESH:D006973 Hypertension Benzene 17.2717940673
MESH:D006973 Hypertension Cyclosporine 17.2710903974
MESH:D006973 Hypertension Dexamethasone 17.2717042910
MESH:D006973 Hypertension Quercetin 17.2718356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 17.2718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5315338365
MESH:D006987 Hypesthesia Arsenic 4.9716093927
MESH:D006996 Hypocalcemia zoledronic acid 5.6112669777
MESH:D007021 Hypospadias Ethinyl Estradiol 3.2516569931 16945680
MESH:D007077 Ileal Diseases Indomethacin 4.4418306037 10574470
MESH:D007079 Ileitis Indomethacin 4.7816133968 10647630 10651667
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.7816133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 16.9017937319
MESH:D007248 Infertility, Male Paraquat 16.904850670
MESH:D007248 Infertility, Male sodium arsenite 16.9012646999 15346721
MESH:D007248 Infertility, Male Sulfasalazine 16.9010689203
MESH:D007248 Infertility, Male vinclozolin 16.9016467254
MESH:D007249 Inflammation Dexamethasone 19.2011099482 8960868
MESH:D007249 Inflammation Diethylnitrosamine 19.2018785209
MESH:D007249 Inflammation Indomethacin 19.203291741 12568917 7812673
MESH:D007249 Inflammation Lipopolysaccharides 19.2012878042 17237260 17255318 9205823 17963957
MESH:D007249 Inflammation perfluorooctanoic acid 19.2012083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 19.2012878042 12200463
MESH:D007249 Inflammation Thalidomide 19.2016134734
MESH:D015212 Inflammatory Bowel Diseases Sulfasalazine 4.4215339030
MESH:D007251 Influenza, Human Quercetin 3.9216624496
MESH:D007333 Insulin Resistance pirinixic acid 2.2416306350
MESH:D007410 Intestinal Diseases Indomethacin 3.7718236018 15831440 17994277 17329856 11855677 15610444 11686837 11713966 10210152
MESH:D019586 Intracranial Hypertension Indomethacin 4.7815241188
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.1017255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8216580747
MESH:D007579 Jejunal Diseases Indomethacin 4.4410574470 16133968 18306037
MESH:D007627 Keloid Quercetin 4.3917086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8515604871
MESH:D007642 Keratosis Arsenic 4.4116930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 15.2815629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 15.2818776723 10903974 8314463
MESH:D007674 Kidney Diseases Indomethacin 15.2817190690
MESH:D007674 Kidney Diseases Quercetin 15.2816962696
MESH:D007674 Kidney Diseases sodium arsenite 15.2820008137
MESH:D007680 Kidney Neoplasms Cyclosporine 9.8212371664
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 9.8217379185
MESH:D007680 Kidney Neoplasms Fluorouracil 9.8216985049
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.4410320625 12228301 11703811
MESH:D007898 Leishmaniasis, Visceral Thalidomide 3.9016514283
MESH:D007938 Leukemia Azacitidine 12.4919148494
MESH:D007938 Leukemia Benzene 12.4917119257 14694614 18335105 15935818
MESH:D007938 Leukemia kaempferol 12.4917468513
MESH:D007938 Leukemia Quercetin 12.4917468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell bortezomib 8.7718089816
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 8.7718089816
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.4910785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid Azacitidine 8.3119077051
MESH:D007951 Leukemia, Myeloid Benzene 8.3117506065
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 10.2317596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute Benzene 10.2319478238
MESH:D015470 Leukemia, Myeloid, Acute bortezomib 10.2320471514
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 10.2318360721
MESH:D015470 Leukemia, Myeloid, Acute Thalidomide 10.2318720364
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.6619299654
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.1617339181
MESH:D007964 Leukocytosis Indomethacin 4.7816537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.1317980183
MESH:D007970 Leukopenia Lipopolysaccharides 4.1215821434
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 11.038812269
MESH:D007984 Leydig Cell Tumor vinclozolin 11.0316417039
MESH:D017880 Limb Deformities, Congenital Thalidomide 4.0310473037
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.1311479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 12.9817157831 16943688 16221502 11903743 17174718 11408273 16239168 17334410 21278145
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 12.9818665156 18407596 18522880 19638242 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 12.9821047994
MESH:D008103 Liver Cirrhosis Thalidomide 12.9817174718 16943688
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 16.0417823541 17631135 14512876 16192424 15370692 18339082 12546737 17565644 12445418 12741479 17922224 15362042 16015684 15057751 17481882 12667390 18395914 17976157 17714472 12958196 14748882 12445421 18054572 18277467 16638106 20821823 15818738 18418968 17557913 14724832 18472332 15123356 17698563 18395095 12389079 12586293 17869086 12649538 18006644 11481614 14620537 14716833 15931870 16011737 15925388 15996030 18412020 16097048 12898905 17640975 18376398 16136751 18251166 17900296 14716496 17525996 12666154 18429990 17708605 18156304 18210741 12632512 15338365 16027843 13678700 17944888 17761835 17721639 18279442 18420326 18205269 15650968 10355542 16116963 15673190 18705752 15730626 15893842 12632514 17766677 17805973 18472094 16248980 16033810 18481824 18263696 12609069 18166357 18317297 15876570 15959796 18187930 15052691
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 16.0416718785
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 16.0415474484
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 16.0418194892
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 16.0412878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 16.0415474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 16.0412741479
MESH:D008106 Liver Cirrhosis, Experimental Sulfasalazine 16.0415633128
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 16.0412878042
MESH:D008106 Liver Cirrhosis, Experimental Thalidomide 16.0415465738
MESH:D008107 Liver Diseases Acetaminophen 10.5012969438 16611625 19014921 12587719 19460945 11587558 19784758 16610002
MESH:D008107 Liver Diseases Arsenic 10.5011134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 10.5017285989 15720792 16246199 15830285 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 10.5017034775
MESH:D008107 Liver Diseases Phenobarbital 10.5019363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.7416871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.7414706259 16899240
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 44.7918644402 16835634
MESH:D008113 Liver Neoplasms Arsenic 44.7916368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 44.7921137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 44.7919389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 44.7919294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 44.7915885732 19812893 20118626 19294768 20501860 19638242 20101389 18754104 18648771 18644402 19254457 18977376 18978307 19499222 15175105 12112319 19255062 19426721 12771043 20452335 2862719 19690152 19073162 21278145 19996281 20405173 20137499 20583210 19850985 2422723 10737359 21071580 19551842 21167192 19642983 19427195 16942905 20492335 19090486 21047994 20434301 19833225 9163691 19256749
MESH:D008113 Liver Neoplasms Fenofibrate 44.7918978307
MESH:D008113 Liver Neoplasms Fluorouracil 44.7915113037 17045692 16603448 18383874
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 44.7914757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 44.7919812893 8742319 19482888 19073162 15975961 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 44.7920007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 44.7918980244
MESH:D008113 Liver Neoplasms sodium arsenite 44.7915276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 44.7916984957
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 35.3618544905
MESH:D008114 Liver Neoplasms, Experimental Benzene 35.3612562636
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 35.3618164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 35.3612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 35.369362446 18544905 17942915 18775883 18093689 19539802 3124819 19009564 19519916 16267830 2563599 18079962 18164116 21159647 16842330 17174075 18253720 19004024 17854601 18308698 18282651 19126423
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 35.3618775883 18253720
MESH:D008114 Liver Neoplasms, Experimental kojic acid 35.3618544905
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 35.3618308698 6150874 1399818 2563599 17172636
MESH:D008114 Liver Neoplasms, Experimental Quercetin 35.3619519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 35.3612151625
MESH:D008171 Lung Diseases Ascorbic Acid 6.3916863852
MESH:D008171 Lung Diseases sodium arsenite 6.3919095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.2214698565
MESH:D055370 Lung Injury Asbestos, Crocidolite 7.4517365036
MESH:D055370 Lung Injury Lipopolysaccharides 7.4521114838
MESH:D008175 Lung Neoplasms Arsenic 23.2417306315 19168569 17976673
MESH:D008175 Lung Neoplasms Ascorbic Acid 23.2416401635
MESH:D008175 Lung Neoplasms Azacitidine 23.2421224363
MESH:D008175 Lung Neoplasms Benzene 23.2412562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 23.2420869020 20464547 20064080 18816296 17053015 18569708 18520028 20135361 6695378
MESH:D008175 Lung Neoplasms Dexamethasone 23.2415824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 23.2421163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Ethylnitrosourea 23.246695378 16271038 17703301 16019985
MESH:D008175 Lung Neoplasms Fluorouracil 23.2415246190
MESH:D008175 Lung Neoplasms Indomethacin 23.2411053908 11497255 16537180
MESH:D008175 Lung Neoplasms Quercetin 23.2416280456
MESH:D008175 Lung Neoplasms sodium arsenite 23.2416712894 19931552 17306315 17077188 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 23.2419555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.2215086387
MESH:D008223 Lymphoma Benzene 10.4417584886 17119257
MESH:D008223 Lymphoma bortezomib 10.4416098063
MESH:D008223 Lymphoma Ethylnitrosourea 10.4415790496
MESH:D016393 Lymphoma, B-Cell bortezomib 4.7916675587
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.4915375218
MESH:D015674 Mammary Neoplasms, Animal Benzene 3.8712562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 11.3011921183
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 11.3010767621 10838139 18041768
MESH:D008325 Mammary Neoplasms, Experimental methyleugenol 11.3011921183
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 11.3017312309
MESH:D008527 Medulloblastoma bortezomib 3.9719213072
MESH:D008545 Melanoma sodium arsenite 3.3616487513 19082730
MESH:D008545 Melanoma Thalidomide 3.3616098027 17089043 12829675
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0119513568
MESH:D008579 Meningioma Ethylnitrosourea 5.4017943659
MESH:D008654 Mesothelioma Asbestos, Crocidolite 5.8116166281 16966607 18303189
MESH:D008654 Mesothelioma zoledronic acid 5.8116675582
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2016801185
MESH:D008881 Migraine Disorders Indomethacin 3.2611903285
MESH:D009006 Monosomy Azacitidine 5.4919299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 11.8216381670
MESH:D009062 Mouth Neoplasms Fluorouracil 11.8218986760 16757204
MESH:D009062 Mouth Neoplasms Indomethacin 11.8212636206
MESH:D009101 Multiple Myeloma Azacitidine 27.5918443271 19549372
MESH:D009101 Multiple Myeloma Benzene 27.5917119195
MESH:D009101 Multiple Myeloma bortezomib 27.5919372569 19112817 19112201
MESH:D009101 Multiple Myeloma Dexamethasone 27.5915867202 15744524 16118317
MESH:D009101 Multiple Myeloma fluvastatin 27.5916996129
MESH:D009101 Multiple Myeloma Thalidomide 27.5919112201 19372569 17168659 15939924 15867202 19112817 15741222 15920492 16445831 15744524
MESH:D009101 Multiple Myeloma zoledronic acid 27.5918089719 19621390 16996129
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 6.1013678655
MESH:D009135 Muscular Diseases pirinixic acid 2.9516239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.3418186108
MESH:D009190 Myelodysplastic Syndromes Azacitidine 10.5818720364 17596541 19805378 17611569
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 10.589809623
MESH:D009190 Myelodysplastic Syndromes Thalidomide 10.5818720364
MESH:D009203 Myocardial Infarction pirinixic acid 4.8219151258
MESH:D009203 Myocardial Infarction Quercetin 4.8219595682
MESH:D017202 Myocardial Ischemia Arsenic 7.4715371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.4712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 6.9516411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 6.9519207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9017484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.159029167 3581430
MESH:D009362 Neoplasm Metastasis Indomethacin 8.1511239499 16537180 11053908
MESH:D009362 Neoplasm Metastasis zoledronic acid 8.1519139120 17312309 15867366
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 15.708820588
MESH:D009369 Neoplasms Benzo(a)pyrene 15.7011141357
MESH:D009369 Neoplasms Fluorouracil 15.7018600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 15.7017405874
MESH:D009369 Neoplasms Quercetin 15.7015185748
MESH:D009369 Neoplasms sodium arsenite 15.7011559025
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 12.1916707424
MESH:D009374 Neoplasms, Experimental Indomethacin 12.1915625704 10663608
MESH:D009374 Neoplasms, Experimental sodium arsenite 12.1920056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8018481113 19348381
MESH:D009410 Nerve Degeneration Paraquat 3.2716893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.1214600291
MESH:D009421 Nervous System Malformations Thalidomide 8.1216859833
MESH:D009436 Neural Tube Defects Arsenic 14.1916620997
MESH:D009436 Neural Tube Defects Benzene 14.1915643154
MESH:D009436 Neural Tube Defects sodium arsenate 14.1911749123 19446573 10525206 18186108
MESH:D009436 Neural Tube Defects sodium arsenite 14.1912854658
MESH:D009442 Neurilemmoma Ethylnitrosourea 4.8416651423 16003739 17160924
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.3418514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 11.3420387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 11.3412349958
MESH:D020078 Neurogenic Inflammation Arsenic 8.9217056641
MESH:D020078 Neurogenic Inflammation Quercetin 8.9217929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5320387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.0316436463
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.399802331
MESH:D009765 Obesity Ascorbic Acid 4.1517217161
MESH:D009765 Obesity pirinixic acid 4.1520558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.586374098
MESH:D009784 Occupational Diseases Benzene 3.6817119257 15727169 17178637 15913788 15576619 15935809 17479406 15612468 16737584
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.4017160924
MESH:D010003 Osteoarthritis Indomethacin 3.307009135
MESH:D010014 Osteolysis zoledronic acid 4.8015867366
MESH:D010018 Osteomalacia Phenobarbital 3.7917016548
MESH:D010024 Osteoporosis kaempferol 6.7216756079
MESH:D010024 Osteoporosis zoledronic acid 6.7217882678
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.6919495926
MESH:D010051 Ovarian Neoplasms Arsenic 19.5617306315
MESH:D010051 Ovarian Neoplasms Benzene 19.5612562636
MESH:D010051 Ovarian Neoplasms CD 437 19.5617474084
MESH:D010051 Ovarian Neoplasms Luteolin 19.5619005980
MESH:D010051 Ovarian Neoplasms Quercetin 19.5619005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 19.5615276417 17306315
MESH:D010051 Ovarian Neoplasms Thalidomide 19.5616288038
MESH:D010146 Pain Acetaminophen 8.7116870215
MESH:D010146 Pain Indomethacin 8.7113679232 3291741 17627676 17440234
MESH:D010146 Pain zoledronic acid 8.7116475674
MESH:D010149 Pain, Postoperative Indomethacin 4.1018702446 12538197
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.3316540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 10.3316500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 10.3316965848
MESH:D010190 Pancreatic Neoplasms Quercetin 10.3316965848
MESH:D010195 Pancreatitis Indomethacin 3.4015028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1611578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.1316537180
MESH:D010291 Paresis Thalidomide 5.729200351
MESH:D010300 Parkinson Disease Eugenol 5.2717329831
MESH:D010300 Parkinson Disease Paraquat 5.2715451049 12911755 16510128 11445065 11124998 15824117 16140633 11181820
MESH:D010302 Parkinson Disease, Secondary Paraquat 3.8716190885
MESH:D020734 Parkinsonian Disorders Indomethacin 3.6212349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.1311903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6612520081
MESH:D010437 Peptic Ulcer Indomethacin 4.5711148446
MESH:D010518 Periodontitis Indomethacin 4.3317225004
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.6416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.416392382 15371236 16905509
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.3310923243
MESH:D011014 Pneumonia Lipopolysaccharides 9.2211605937 12224865
MESH:D011014 Pneumonia Paraquat 9.2212504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0118163543
MESH:D011230 Precancerous Conditions Cyclosporine 17.8912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 17.892563599
MESH:D011230 Precancerous Conditions Phenobarbital 17.892563599
MESH:D011230 Precancerous Conditions Quercetin 17.8919056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 6.8121297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thalidomide 6.8117031469
MESH:D047928 Premature Birth Indomethacin 4.5617000239
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 13.0017132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.0011222880 11399792 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 13.0018042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.3618220299
MESH:D011471 Prostatic Neoplasms AGN 194204 2.6716000583
MESH:D011471 Prostatic Neoplasms Arsenic 2.6716140617
MESH:D011471 Prostatic Neoplasms Azacitidine 2.6718324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6717292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6718626508 19082440
MESH:D011471 Prostatic Neoplasms Quercetin 2.6714715546 17292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6716039940
MESH:D011471 Prostatic Neoplasms Thalidomide 2.6716729912
MESH:D011471 Prostatic Neoplasms zoledronic acid 2.6712438248 19103299
MESH:D011472 Prostatitis vinclozolin 4.3618629315
MESH:D011507 Proteinuria Arsenic 7.7321343184
MESH:D011507 Proteinuria Indomethacin 7.7311849393
MESH:D011536 Prurigo Thalidomide 5.7212755975
MESH:D011537 Pruritus Ethinyl Estradiol 2.7416919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 3.9112752131
MESH:D011565 Psoriasis Cyclosporine 2.0016882103
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 4.7514606601
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.0517975199 17365031 15814490 17322281
MESH:D011658 Pulmonary Fibrosis Paraquat 5.0517997886 16324872
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5215538739 18286688 18722050 16160472
MESH:D015427 Reperfusion Injury pirinixic acid 2.0819058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 7.5118379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 7.5111700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.3410835634
MESH:D012135 Respiratory Sounds Paraquat 3.5011874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2918990726
MESH:D012162 Retinal Degeneration Paraquat 3.4316458197
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.1216849425
MESH:D012512 Sarcoma, Ewing's zoledronic acid 4.3916121404
MESH:D012554 Schistosomiasis japonica Quercetin 4.9616862918
MESH:D019873 Schnitzler Syndrome Thalidomide 5.3616096327
MESH:D012640 Seizures Phenobarbital 2.313137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.256407741
MESH:D012871 Skin Diseases marker/mechanism 16835338
MESH:D012871 Skin Diseases Arsenic 4.7017050553 19834688 16759981 17548696 17938729 6392382 16353154 18709164 16702368 15952646 17453740
MESH:D012871 Skin Diseases Ascorbic Acid 4.7018709164
MESH:D012878 Skin Neoplasms Arsenic 14.6917976673 16251483 17029826 19538983 17050553 15504454
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 14.6919755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 14.6918572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 14.698532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.6916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.3616709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3412854658
MESH:D013272 Stomach Diseases Dexamethasone 8.4715472012
MESH:D013272 Stomach Diseases Indomethacin 8.4710215738 15038085 10192188 17207306 10486359 17160473 18209964 15472012 18545984 16184426 16113693 16280098 17638125
MESH:D013274 Stomach Neoplasms Benzene 5.5512562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.552093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 5.5518456281
MESH:D013274 Stomach Neoplasms Fluorouracil 5.5519084572 17522103 17498489 16424979 15786421 18396642 19015929 18567086 16951190 17172411
MESH:D013274 Stomach Neoplasms Indomethacin 5.5515609394
MESH:D013276 Stomach Ulcer Ascorbic Acid 17.2118726076
MESH:D013276 Stomach Ulcer Dexamethasone 17.2115138204
MESH:D013276 Stomach Ulcer Eugenol 17.2118543354
MESH:D013276 Stomach Ulcer Indomethacin 17.2111729361 12077510 16252198 16150113 14567935 17918041 18299717 15138204 17654042 17135157 12787963 16397915 16169175 18543354 12500499 16755016 18237397 17895592 18087811 17977527 18193104 10750652 12498302 16631530 11595415 18431645 18181030 17627676 17657623 15104355 15255614 10878458 16934674 10423059 11523592 11595431 11145282 1323529 18726076 11906479 12467913 18209962
MESH:D013276 Stomach Ulcer Thalidomide 17.2115138204
MESH:D020521 Stroke Ascorbic Acid 3.8316517955 16403987
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.6615821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.0911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6715669648
MESH:D013953 Thymus Neoplasms Benzene 10.2910850423
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 10.2915790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 9.487505956
MESH:D013964 Thyroid Neoplasms Indomethacin 9.4814736730 11352223 18791128
MESH:D013964 Thyroid Neoplasms Phenobarbital 9.481399818
MESH:D014062 Tongue Neoplasms Fluorouracil 3.4916280240
MESH:D014456 Ulcer Indomethacin 4.3217380554 10574470
MESH:D001749 Urinary Bladder Neoplasms Arsenic 13.0319429237 19322015 18640142 17976673 15987713 11144890 17306315
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 13.0317053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 13.0316720286
MESH:D001749 Urinary Bladder Neoplasms Quercetin 13.0316720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 13.0311723127 16712894 16452187 17306315
MESH:D014581 Urticaria Acetaminophen 2.4510982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 7.8216803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 7.8211813266
MESH:D014594 Uterine Neoplasms Benzene 7.7612562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.7614692618
MESH:D014605 Uveitis Cyclosporine 9.821336536
MESH:D014605 Uveitis Dexamethasone 9.821336536
MESH:D014652 Vascular Diseases Arsenic 16.9317056641
MESH:D014652 Vascular Diseases sodium arsenite 16.9317056641
MESH:D014652 Vascular Diseases Thalidomide 16.9315741222
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0214671159 15869587
MESH:D014839 Vomiting Indomethacin 4.1611897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6615886252
MESH:D014985 Xerophthalmia Cyclosporine 3.8517120751
Pathway ID Pathway Name
KEGG:04110 Cell cycle
KEGG:04010 MAPK signaling pathway
KEGG:04115 p53 signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28511
    • No data
    Releated disease ID Related disease Name
    PA152238066Mental Retardation, X-Linked
    PA445742Stomach Neoplasms
    Releated drug ID Related drug Name
    PA449957ibuprofen
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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