AutismKB 2.0

Annotation Detail for SERPINC1


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Basic Information Top
Gene Symbol:SERPINC1 ( AT3,ATIII,MGC22579 )
Gene Full Name: serpin peptidase inhibitor, clade C (antithrombin), member 1
Band: 1q25.1
Quick LinksEntrez ID:462; OMIM: 107300; Uniprot ID:ANT3_HUMAN; ENSEMBL ID: ENSG00000117601; HGNC ID: 775
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Hemostasis
Pathway IDPathway Name
200021Glypican 1 network
Pathway IDPathway Name
P00011Blood coagulation
Pathway IDPathway Name
500303Common Pathway
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00223Inherited thrombophilia
Desease IDDesease Name
1706Thrombophilia
1760CNS lymphoma
1831Prostate cancer
2032Kidney disease
2120Rabies
Desease Name
Thrombosis
Venous Thrombosis
CARDIOVASCULAR
severe childhood thrombosis
defective heparin binding associated
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of SERPINC1 mRNAdecreases expression 17547211
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SERPINC1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SERPINC1 mRNAaffects expression 21346803
C041594 4-nonylphenol 4-nonylphenol affects the expression of SERPINC1 mRNAaffects expression 15792627
D000082 Acetaminophen Acetaminophen results in decreased expression of SERPINC1 proteindecreases expression 16687475
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SERPINC1 proteinaffects expression 20106945
D000965 Antimony Antimony results in decreased expression of SERPINC1 mRNAdecreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in decreased expression of SERPINC1 mRNAdecreases expression 17547211
D002104 Cadmium Cadmium results in decreased expression of SERPINC1 mRNAdecreases expression 17547211
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of SERPINC1 mRNAdecreases expression 17547211
D002857 Chromium Chromium results in decreased expression of SERPINC1 mRNAdecreases expression 17547211
D016572 Cyclosporine Cyclosporine results in decreased expression of SERPINC1 mRNAdecreases expression 20106945
C023635 dienogest [Ethinyl Estradiol co-treated with dienogest] results in decreased activity of SERPINC1 proteinaffects cotreatment|decreases activity 15288212
C418365 estradiol, norethindrone drug combination estradiol, norethindrone drug combination results in decreased expression of SERPINC1 proteindecreases expression 14561536
C454300 estradiol valerate-dienogest [Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in decreased activity of SERPINC1 proteinaffects cotreatment|decreases activity 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol binds to Norethindrone] which results in decreased expression of SERPINC1 proteinaffects binding|decreases expression 14561536
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with dienogest] results in decreased activity of SERPINC1 proteinaffects cotreatment|decreases activity 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in decreased activity of SERPINC1 proteinaffects cotreatment|decreases activity 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of SERPINC1 proteinaffects cotreatment|decreases activity 11994571
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of SERPINC1 proteinaffects cotreatment|decreases expression 12618251
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased activity of SERPINC1 proteinaffects cotreatment|decreases activity 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of SERPINC1 proteinaffects cotreatment|decreases expression 14981370
12618251
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with norgestimate] results in decreased expression of SERPINC1 proteinaffects cotreatment|decreases expression 12618251
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased activity of SERPINC1 proteindecreases activity 17374706
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in decreased activity of SERPINC1 proteindecreases activity 11994571
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in decreased expression of SERPINC1 proteindecreases expression 14981370
12618251
10928463
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in increased expression of SERPINC1 proteinincreases expression 15318540
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of SERPINC1 proteinaffects cotreatment|decreases activity 11994571
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of SERPINC1 proteinaffects cotreatment|decreases expression 12618251
D008628 Mercury Mercury results in decreased expression of SERPINC1 mRNAdecreases expression 17547211
D008767 Methylmercury Compounds Methylmercury Compounds results in decreased expression of SERPINC1 mRNAdecreases expression 16966085
C022838 nickel chloride nickel chloride results in decreased expression of SERPINC1 mRNAdecreases expression 17547211
D009640 Norethindrone [Ethinyl Estradiol binds to Norethindrone] which results in decreased expression of SERPINC1 proteinaffects binding|decreases expression 14561536
C017576 norgestimate [Ethinyl Estradiol co-treated with norgestimate] results in decreased expression of SERPINC1 proteinaffects cotreatment|decreases expression 12618251
D016912 Levonorgestrel [Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased activity of SERPINC1 proteinaffects cotreatment|decreases activity 15288212
D016912 Levonorgestrel [Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of SERPINC1 proteinaffects cotreatment|decreases expression 12618251
14981370
D011192 Potassium Dichromate Potassium Dichromate results in decreased expression of SERPINC1 mRNAdecreases expression 17547211
C009277 sodium arsenate sodium arsenate results in decreased expression of SERPINC1 mRNAdecreases expression 16882884
C017947 sodium arsenite sodium arsenite affects the expression of SERPINC1 mRNAaffects expression 17450228
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 11.5517505938
MESH:D000152 Acne Vulgaris norgestimate 11.5517505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7614692618
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6717306315 16712894
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D020152 Antithrombin III Deficiency marker/mechanism
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5315885639
MESH:D050197 Atherosclerosis Cadmium 3.5115687053
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Mercury 2.1417497416
MESH:D001327 Autoimmune Diseases Mercury 4.6516634805
MESH:D001943 Breast Neoplasms Chromium 3.5215986119
MESH:D001991 Bronchitis Antimony 5.908768112
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.4516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.4516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.453084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.4521507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.4515276417 16507464 17306315
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3218572023
MESH:D002311 Cardiomyopathy, Dilated Antimony 6.2810334427
MESH:D002311 Cardiomyopathy, Dilated Mercury 6.2810334427
MESH:D002386 Cataract Acetaminophen 2.4510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.786135515
MESH:D002471 Cell Transformation, Neoplastic Cadmium 14.7817332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.7812371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.7819524636 20056578
MESH:D002779 Cholestasis Cyclosporine 12.6619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.6617333356 15861022 17110522 11677210 16919318 16105132 17681005
MESH:D002779 Cholestasis Levonorgestrel 12.6615861022
MESH:D019465 Craniofacial Abnormalities sodium arsenate 2.7110525206
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.1418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.1418551238
MESH:D003704 Dementia Methylmercury Compounds 4.7916140633
MESH:D017449 Dermatitis, Allergic Contact Mercury 7.0016823706
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 7.0016823706
MESH:D004283 Dog Diseases Antimony 5.4312019027
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.4312153990 11287661 19420014 12705907 12594235 16393943 19416960 16485898 12540782 17906064 11739529 2444490 18713872 16177239 11743745 19923254 11461765 12958197 19164858 10915739 10663392 19085960 11529661 17522070 15619225 16109766 19739265 14725611 14550746 15968718 11421492 18071297 19370779 16081117 16227642 11834606 17562736 12392966 10774834 16781746 14986274
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 8.4318186108
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9712538720
MESH:D005234 Fatty Liver Cyclosporine 6.9019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 6.9015345470
MESH:D005355 Fibrosis Cyclosporine 2.9212168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.4416983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D018149 Glucose Intolerance sodium arsenate 4.8719446573
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006689 Hodgkin Disease sodium arsenite 2.9712676792
MESH:D006930 Hyperalgesia Acetaminophen 2.5216870215
MESH:D006973 Hypertension Cyclosporine 2.0110903974
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1417937319
MESH:D007248 Infertility, Male sodium arsenite 6.1412646999 15346721
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007674 Kidney Diseases Acetaminophen 31.7112587719 15629191
MESH:D007674 Kidney Diseases Cadmium 31.7116962696 16226777 16322080
MESH:D007674 Kidney Diseases Cadmium Chloride 31.7116962696
MESH:D007674 Kidney Diseases Chromium 31.7117934191
MESH:D007674 Kidney Diseases Cyclosporine 31.7118776723 8314463 10903974
MESH:D007674 Kidney Diseases Mercury 31.7117934191
MESH:D007674 Kidney Diseases Potassium Dichromate 31.7119665454
MESH:D007674 Kidney Diseases sodium arsenite 31.7120008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.3016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.3016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.3012371664
MESH:D007896 Leishmaniasis Antimony 4.6212019027 15220340 21182181 10953559 21063981
MESH:D016773 Leishmaniasis, Cutaneous Antimony 4.4811475954 8889330 19141829
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.2610651420 9643325 10881086 11370249 7854095
MESH:D007898 Leishmaniasis, Visceral Antimony 8.168142506 7854095 20495762 11105143 1899875 7554475 7875148
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 8.1612707265
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 4.379834237
MESH:D008107 Liver Diseases Acetaminophen 1.5819014921 19784758 16610002 16611625 11587558 12969438 12587719 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 6.987678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 6.9815890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms sodium arsenite 6.9815276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.502876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.508603461
MESH:D008171 Lung Diseases sodium arsenite 3.0219095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.4714755239
MESH:D008175 Lung Neoplasms sodium arsenite 2.4717077188 17306315 15276417 19931552 16712894
MESH:D008545 Melanoma sodium arsenite 2.0016487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008569 Memory Disorders Methylmercury Compounds 4.6918436314
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D009069 Movement Disorders Methylmercury Compounds 5.1118436314
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.6518186108
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.5818551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.5818551238 7678174
MESH:D009369 Neoplasms sodium arsenite 2.3911559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4420056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0919348381 18481113
MESH:D009436 Neural Tube Defects sodium arsenate 7.1511749123 18186108 19446573 10525206
MESH:D009436 Neural Tube Defects sodium arsenite 7.1512854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6918514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.2316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.2316049721
MESH:D010024 Osteoporosis Levonorgestrel 4.5212665316
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.3717306315 15276417
MESH:D010146 Pain Acetaminophen 2.2116870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010409 Penile Diseases Antimony 5.509643325
MESH:D010493 Pericarditis Antimony 5.8820465667
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.1515687053
MESH:D011085 Polycystic Ovary Syndrome ethinyl estradiol-desogestrel combination 5.4017105841
MESH:D011230 Precancerous Conditions Cyclosporine 3.0312371664
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 4.7518436314
MESH:D011471 Prostatic Neoplasms Cadmium 3.6517075824
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.6516039940
MESH:D011537 Pruritus Ethinyl Estradiol 9.2415861022 16919318
MESH:D011537 Pruritus Levonorgestrel 9.2415861022
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D012640 Seizures 2,4-dinitrotoluene 5.3618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.3618551238
MESH:D012878 Skin Neoplasms sodium arsenite 2.5918572023 19524636
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7116709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6212854658
MESH:D019851 Thrombophilia Ethinyl Estradiol 17.2511994571
MESH:D019851 Thrombophilia ethinyl estradiol-desogestrel combination 17.2511994571
MESH:D019851 Thrombophilia Gestodene 17.2511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 8.9115669648
MESH:D013927 Thrombosis Gestodene 8.9115669648
MESH:D014352 Trypanosomiasis Antimony 5.7015220340
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.7816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.7816049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.7811723127 16712894 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.2210091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.2210091137
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.5711813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0814692618
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2017056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 16.7415869587 14671159
MESH:D020246 Venous Thrombosis ethinyl estradiol-desogestrel combination 16.7415869587
MESH:D020246 Venous Thrombosis Levonorgestrel 16.7415869587
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35026
    • No data
    No data
    Releated drug ID Related drug Name
    PA450635nitric oxide
    PA165290929norelgestromin/ethinyl estradiol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00407 potentiator Ardeparin Anticoagulants;Fibrinolytic Agents
    DB00569 potentiator Fondaparinux sodium Anticoagulants;Antithrombotics
    DB01109 potentiator Heparin Anticoagulants;Heparins
    DB01225 agonist Enoxaparin Anticoagulants;Fibrinolytic Agents;Heparins
    DB02944 - Alpha-D-Mannose
    DB03665 - Heparin Pentasaccharide
    DB04464 - N-Formylmethionine
    DB06271 activator Sulodexide Antithrombotic Agents
    DB06779 potentiator Dalteparin Anticoagulants;Antithrombotics;Heparins
    DB06822 potentiator Tinzaparin Anticoagulants;Antithrombotics
    DB08813 potentiator Nadroparin Anticoagulants;Antithrombotics
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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