AutismKB 2.0

Annotation Detail for MYH4


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Basic Information Top
Gene Symbol:MYH4 ( MYH2B,MyHC-2B,MyHC-IIb )
Gene Full Name: myosin, heavy chain 4, skeletal muscle
Band: 17p13.1
Quick LinksEntrez ID:4622; OMIM: 160742; Uniprot ID:MYH4_HUMAN; ENSEMBL ID: ENSG00000141048; HGNC ID: 7574
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05416Viral myocarditis
hsa04530Tight junction
No data
No data
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
P00016Cytoskeletal regulation by Rho GTPase
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA]decreases reaction|increases expression 19657059
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MYH4 mRNAaffects expression 16483693
C487049 BXL628 BXL628 results in decreased expression of MYH4 mRNAdecreases expression 16003237
D018021 Lithium Chloride Lithium Chloride promotes the reaction [IGF1 protein results in increased expression of MYH4 mRNA]increases expression|increases reaction 19657059
C006253 pirinixic acid pirinixic acid results in increased expression of MYH4 mRNAincreases expression 12832660
C009687 wortmannin wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA]decreases reaction|increases expression 19657059
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D005234 Fatty Liver pirinixic acid 3.0919236843 20131406
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4119176532 18467677 19772884 16221962
MESH:D006869 Hydronephrosis Lithium Chloride 6.5419797860
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 3.9412970779
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9120007298 15890375 16377806
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 3.4516211241
MESH:D011141 Polyuria Lithium Chloride 6.4619692487
MESH:D011470 Prostatic Hyperplasia BXL628 6.9815572423 16957418
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
Pathway ID Pathway Name
KEGG:04530 Tight junction
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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