AutismKB 2.0

Annotation Detail for MYH6


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Basic Information Top
Gene Symbol:MYH6 ( ASD3,CMD1EE,CMH14,MYHC,MYHCA,alpha-MHC )
Gene Full Name: myosin, heavy chain 6, cardiac muscle, alpha
Band: 14q11.2
Quick LinksEntrez ID:4624; OMIM: 160710; Uniprot ID:MYH6_HUMAN; ENSEMBL ID: ENSG00000197616; HGNC ID: 7576
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy
hsa05416Viral myocarditis
hsa04530Tight junction
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Muscle contraction
No data
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
P00016Cytoskeletal regulation by Rho GTPase
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Cardiac diseases
H00292Hypertrophic cardiomyopathy (HCM)
Desease IDDesease Name
2075Heart failure
No data
Desease Name
Electrocardiographic traits
Resting heart rate
Desease Name
Cardiomyopathy, familial hypertrophic, 14
Cardiomyopathy, dilated, 1EE
Atrial septal defect 3
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in decreased expression of MYH6 mRNAdecreases expression 17535870
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MYH6 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of MYH6 mRNAincreases expression 20458559
D016589 Astemizole Astemizole results in increased expression of MYH6 mRNAincreases expression 20221588
C006780 bisphenol A bisphenol A results in decreased expression of MYH6 mRNAdecreases expression 16474171
D004317 Doxorubicin Doxorubicin results in decreased expression of MYH6 proteindecreases expression 16109756
D004317 Doxorubicin HGF protein inhibits the reaction [Doxorubicin results in decreased expression of MYH6 protein]decreases expression|decreases reaction 16109756
C118667 dronedarone dronedarone results in decreased expression of MYH6 mRNAdecreases expression 17535870
D004958 Estradiol Estradiol results in decreased expression of MYH6 mRNAdecreases expression 16474171
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MYH6 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of MYH6 mRNAdecreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYH6 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of MYH6 mRNAdecreases expression 18035473
D005632 Fructose Fructose results in increased expression of MYH6 mRNAincreases expression 18192211
D005632 Fructose SIRT1 protein affects the reaction [Fructose results in increased expression of MYH6 mRNA]affects reaction|increases expression 18192211
C413355 GC 1 compound GC 1 compound results in increased expression of MYH6 mRNAincreases expression 11577024
D019833 Genistein Genistein results in decreased expression of MYH6 mRNAdecreases expression 16474171
C056599 icariin icariin results in increased expression of MYH6 mRNAincreases expression 16490167
15780198
D016686 Monocrotaline Monocrotaline results in decreased expression of MYH6 mRNAdecreases expression 16936438
C007350 nitrofen nitrofen results in increased expression of MYH6 mRNAincreases expression 16952587
D009638 Norepinephrine Norepinephrine results in decreased expression of MYH6 mRNAdecreases expression 17592507
D010656 Phenylephrine Phenylephrine results in decreased expression of MYH6 mRNAdecreases expression 17592507
15795322
15578571
11577024
D010656 Phenylephrine Prazosin inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA]decreases expression|decreases reaction 11577024
17592507
D010656 Phenylephrine THRA protein affects the reaction [Phenylephrine results in decreased expression of MYH6 protein]affects reaction|decreases expression 11577024
D010656 Phenylephrine Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA]decreases expression|decreases reaction 11577024
D010795 Phthalic Acids Phthalic Acids results in decreased expression of MYH6 mRNAdecreases expression 15728792
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in decreased expression of MYH6 mRNAdecreases expression 16474171
D011224 Prazosin Prazosin inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA]decreases expression|decreases reaction 11577024
17592507
C059514 resveratrol resveratrol results in increased expression of MYH6 mRNAincreases expression 18192211
C059514 resveratrol SIRT1 protein affects the reaction [resveratrol results in increased expression of MYH6 mRNA]affects reaction|increases expression 18192211
D014284 Triiodothyronine S100A6 protein inhibits the reaction [Triiodothyronine results in increased expression of MYH6 mRNA]decreases reaction|increases expression 15652358
D014284 Triiodothyronine Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA]decreases expression|decreases reaction 11577024
D014284 Triiodothyronine Triiodothyronine results in increased expression of MYH6 mRNAincreases expression 15652358
11577024
15578571
D013629 Tamoxifen Tamoxifen affects the expression of MYH6 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of MYH6 mRNAaffects expression 17872374
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYH6 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MYH6 mRNAdecreases expression 20130022
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MYH6 mRNAincreases expression 17942748
15328365
C025643 vinclozolin vinclozolin affects the expression of MYH6 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3414745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6414514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D058186 Acute Kidney Injury resveratrol 3.6616538975
MESH:D000230 Adenocarcinoma arsenic trioxide 12.9719825857 11798837
MESH:D000230 Adenocarcinoma Doxorubicin 12.9717418594
MESH:D000230 Adenocarcinoma Estradiol 12.9711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.9714692618
MESH:D000230 Adenocarcinoma Genistein 12.9711473722
MESH:D000236 Adenoma resveratrol 3.2015688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1716835633
MESH:D000419 Albuminuria Doxorubicin 4.3421441931
MESH:D000544 Alzheimer Disease icariin 4.7019782061 19858766
MESH:D000544 Alzheimer Disease resveratrol 4.7016183991 16162502
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000799 Angioedema Astemizole 5.452883202
MESH:D001008 Anxiety Disorders vinclozolin 3.4819015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 14.2318057881 18218290 20041841
MESH:D001145 Arrhythmias, Cardiac dronedarone 14.2318651412
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 14.2317460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.9415885639
MESH:D001169 Arthritis, Experimental resveratrol 6.9417115116
MESH:D050197 Atherosclerosis resveratrol 3.1516873680 17967414
MESH:D001281 Atrial Fibrillation Amiodarone 9.6919698954 18651412
MESH:D001281 Atrial Fibrillation dronedarone 9.6917804843
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.2220106747
MESH:D001321 Autistic Disorder Norepinephrine 3.398570775
MESH:D001778 Blood Coagulation Disorders Amiodarone 14.2819483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.2816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.2812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001847 Bone Diseases icariin 6.2018295595
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4914601052
MESH:D001862 Bone Resorption bisphenol A 3.6711985600
MESH:D001919 Bradycardia Phenylephrine 4.3315306635
MESH:D002545 Brain Ischemia icariin 10.0419303870
MESH:D002545 Brain Ischemia resveratrol 10.0417600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.6317150277
MESH:D001943 Breast Neoplasms bisphenol A 3.6317123778
MESH:D001943 Breast Neoplasms Doxorubicin 3.6317369602 16264153 16595493 18695136 17983394 16096432 15692762 15136595 18234424 19526202 16935488 18382427 15634643 18628466 15993339 15567936 15668708 15939500 15994142 17426702 16322301 11325840 16115903 16826403
MESH:D001943 Breast Neoplasms Estradiol 3.6317289903 17018787 12948864 16675129 17261762 18497071 19861407 14630087
MESH:D001943 Breast Neoplasms Genistein 3.6316873071 16541309 17200150
MESH:D001943 Breast Neoplasms resveratrol 3.6317651959 17534123 16393696
MESH:D001943 Breast Neoplasms Tamoxifen 3.6319487384 19189210 21152245 19084267 16273361 16202921 18821012 19189212 19066611 19142967 16818667 18629630 19288272 19221464 17242785 16873071 18997820 18815881 11161223 19115204 18984771 17893378 18351453 15668708 19244106 21138602 20065188 20544844 17261762 19410462 17049068 15565566 19289846 19011961 17440819 18855134 20135344 18425577 20390343 19103187 20859285 19200415 19059307 19155303 20005174
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6320435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1311589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6016051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3019066611
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 10.9414691202 15073043 16217749 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 10.9418059187 17876044 16234567 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.9416924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 10.9416924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 10.9416227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.9416924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.7817123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3816675471
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6619014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.0616201981 1485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9312490120
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.736189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.7316227395
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4317572228
MESH:D006332 Cardiomegaly Norepinephrine 10.9511179087
MESH:D006332 Cardiomegaly Phenylephrine 10.9517124262 11179087 16170337 15728586 17287366 11754973
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.9518850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3916455267 17519947 16952015 15505089 15792986 16269455 16612575 16651473 17924179 17329180 16278810 17351982 17382496 18627295 16242529 17974986 16364871 16731534 17007740 17308081 17131338 15476868 17928571 16109756 15811867
MESH:D002311 Cardiomyopathy, Dilated marker/mechanism
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.7415710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 5.7417334414 16243910
OMIM:192600 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 1 marker/mechanism
OMIM:613251 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 14 marker/mechanism
MESH:D024741 Cardiomyopathy, Hypertrophic, Familial marker/mechanism
MESH:D002318 Cardiovascular Diseases Genistein 7.0416332659
MESH:D002318 Cardiovascular Diseases resveratrol 7.0415458977
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8718974383
MESH:D002375 Catalepsy Norepinephrine 5.338216760
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.6318566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.7217681005 17333356 16919318 17110522 16105132 11677210 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.028697196 16354765 15340226 15668235 12621046
MESH:D003092 Colitis resveratrol 3.9216474422
MESH:D003110 Colonic Neoplasms Genistein 3.8017182828
MESH:D003110 Colonic Neoplasms resveratrol 3.8016338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.6820501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.6818802399 18259882
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 4.6815531428
MESH:D015179 Colorectal Neoplasms resveratrol 4.6816550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8817141729 14669216
MESH:D003327 Coronary Disease Fructose 8.3418504504
MESH:D003327 Coronary Disease resveratrol 8.3416507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8010525206
MESH:D019465 Craniofacial Abnormalities nitrofen 3.8011405365
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8010048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.1414966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9015213294
MESH:D003704 Dementia Polychlorinated Biphenyls 4.5116140633
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1519031437
MESH:D003921 Diabetes Mellitus, Experimental Fructose 8.2718603373
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 8.2716873680
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 6.9518603373
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.9516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.9517107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.0019279558
MESH:D003928 Diabetic Nephropathies resveratrol 14.0016286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.0019279558
MESH:D004244 Dizziness Astemizole 6.253105558
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.5615265979 18218290
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.5617416283
MESH:D056486 Drug-Induced Liver Injury Prazosin 8.5618071297
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.5620420201
MESH:D004362 Drug Toxicity Doxorubicin 7.6018602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.6011462148
MESH:D004487 Edema resveratrol 6.248985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6915322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.1912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 14.1917872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.1919031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.3816402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 16.6817359293
MESH:D016889 Endometrial Neoplasms Estradiol 16.6818566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 16.6811473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.6817893378 20544844 19155303 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8410568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9418037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6417923197
MESH:D004802 Eosinophilia Astemizole 4.601355641
MESH:D004827 Epilepsy Norepinephrine 4.19821787
MESH:D007172 Erectile Dysfunction icariin 5.2315329286 16281085
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.2612903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8611564622
MESH:D005234 Fatty Liver Amiodarone 22.6614986274
MESH:D005234 Fatty Liver arsenic trioxide 22.6615073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.6615345470
MESH:D005234 Fatty Liver Fructose 22.6618641190 18395287 19196556
MESH:D005234 Fatty Liver Tamoxifen 22.6614986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3214745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.7419069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.7419069698
MESH:D005355 Fibrosis Fructose 8.3518504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3520067830
MESH:D005499 Folliculitis Astemizole 5.701671328
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0616904648
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0916417039
MESH:D005909 Glioblastoma Doxorubicin 6.8917150277
MESH:D005909 Glioblastoma Genistein 6.8916598420
MESH:D018149 Glucose Intolerance Fructose 5.1319165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.3915692506
MESH:D006330 Heart Defects, Congenital nitrofen 6.6616080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6611294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.3416707910 16244372 14766674 16879835 18674790 17875725 17888722 16495754 16144979 18006777 16330681 16244371 12587719
MESH:D006333 Heart Failure Doxorubicin 3.2217481944
MESH:D006344 Heart Septal Defects, Atrial marker/mechanism
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7115692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006529 Hepatomegaly Amiodarone 7.8515265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.8512621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic nitrofen 3.8610370017 15088113 11685700 11329586 15707848 15764645 16292651 15793718 16080930 15136996 16473863 11584395 11588001 10693666 10898222 7760232 16863852 18958481 10646786 11076806 18280291 11057544 9476886 16490937 7576705 9473106 15756563 10370016 12746050 12505043 9575882 8863223 10541330 11409163 12547725 10359170 18280292 17245593 17270546 15185205 11051153 12021965 17618886 16720372 9859898 12194112 15578192 12407540 12904592 12759764 10898224 9698600 7520565
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D006561 Herpes Simplex resveratrol 3.9716876885
MESH:D006689 Hodgkin Disease Doxorubicin 3.2417606976 18501091 15147373
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8315340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Prazosin 4.7012727271
MESH:D006937 Hypercholesterolemia Amiodarone 8.698137927 9751232
MESH:D006937 Hypercholesterolemia resveratrol 8.6917188708
MESH:D006946 Hyperinsulinism Fructose 4.7218563319 14757778 15752949 19008412 18360027
MESH:D006949 Hyperlipidemias Fructose 9.0615752949
MESH:D006949 Hyperlipidemias resveratrol 9.0616873680
MESH:D006973 Hypertension Fructose 8.3516843071 14568997 14573337 19008412 14633139
MESH:D006973 Hypertension Phenylephrine 8.358949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.3518850075 18670907
MESH:D006976 Hypertension, Pulmonary Monocrotaline 5.3317042913 16936438 14726295
MESH:D015228 Hypertriglyceridemia Fructose 4.8919342510 19799862
MESH:D006984 Hypertrophy Phenylephrine 4.3618502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1217488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016569931 16945680
MESH:D007022 Hypotension Norepinephrine 4.806740701
MESH:D007037 Hypothyroidism Amiodarone 4.3117991464 18020914
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.4417600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2017937319
MESH:D007248 Infertility, Male vinclozolin 6.2016467254
MESH:D007249 Inflammation Flavonoids 11.0817296493
MESH:D007249 Inflammation resveratrol 11.0816366677
MESH:D007249 Inflammation Tamoxifen 11.0819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.0812200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.3316624496
MESH:D007333 Insulin Resistance bisphenol A 11.7516393666
MESH:D007333 Insulin Resistance Estradiol 11.7516393666 16627594
MESH:D007333 Insulin Resistance Fructose 11.7518563319 17133782 14757778 19008412 18057795 19799862 18981581 19342510 14573337 14633139 19586609
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1516580747
MESH:D007674 Kidney Diseases Doxorubicin 5.8015369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 5.8015618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.9616707910
MESH:D007680 Kidney Neoplasms Estradiol 6.8215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 6.8218625569
MESH:D007859 Learning Disorders icariin 5.1119782061
MESH:D007938 Leukemia arsenic trioxide 6.0915070760
MESH:D007938 Leukemia Genistein 6.0917468513 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9416085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6117077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.5719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1016467208 16968895 19850784 17050201 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.3417107899 19035177 19642359 19225113 16891316 12018890 9834237 11161223 15213294 16331271 17649720 15748426 15622746 16112521 12712474 17217047 16823087 16330433 19075265 16966277 17869043 15336539 17712046 12679006 11468182
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.3416087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1516882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5216417039
MESH:D017513 Lichen Nitidus Astemizole 6.252563723
MESH:D008064 Lipidoses Amiodarone 7.4217567588 15342952
MESH:D008064 Lipidoses Tamoxifen 7.4215342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.4516439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.4517823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.4518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4512878042
MESH:D008113 Liver Neoplasms arsenic trioxide 10.0514682389
MESH:D008113 Liver Neoplasms resveratrol 10.0519812893 19073162 20405173 19321006
MESH:D008113 Liver Neoplasms Tamoxifen 10.0516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.0516984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 13.1120377131
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 13.1117085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 13.111423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.1112151625
MESH:D008133 Long QT Syndrome Amiodarone 12.8217391786 11989578 15350150
MESH:D008133 Long QT Syndrome arsenic trioxide 12.8215213294
MESH:D008133 Long QT Syndrome Astemizole 12.8218472280 11989578
MESH:D008171 Lung Diseases Amiodarone 7.5112587719
MESH:D008171 Lung Diseases nitrofen 7.5116863852 17245593 9859898 9614859
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.2718516814
MESH:D008175 Lung Neoplasms arsenic trioxide 4.6411798837 19825857
MESH:D008175 Lung Neoplasms Doxorubicin 4.646189445 17418594
MESH:D008175 Lung Neoplasms Tamoxifen 4.6418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6411884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.3116098063
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1017088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.3117654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 8.3114749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3615621674
MESH:D008288 Malaria Astemizole 4.6016816845
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.3015688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 17.4115458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 17.4117203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 17.4114578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 17.418985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 17.4119196723 14580682 19196722 11731420 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.9419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.9419453300
MESH:D008545 Melanoma Doxorubicin 4.9616827129
MESH:D008545 Melanoma resveratrol 4.9617992120
MESH:D008545 Melanoma Tamoxifen 4.9612393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9715990972
MESH:D008569 Memory Disorders icariin 5.1019782061
MESH:D008654 Mesothelioma Doxorubicin 2.9817638057
MESH:D008659 Metabolic Diseases resveratrol 4.1917112576
MESH:D024821 Metabolic Syndrome X Fructose 4.6418497449 16815490 19165636 17098227 17261469
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3115792986
MESH:D052016 Mucositis Doxorubicin 4.5817415656
MESH:D009101 Multiple Myeloma arsenic trioxide 6.9314977855 19417148 19549372 11468182 15949261
MESH:D009101 Multiple Myeloma resveratrol 6.9316490592 14749477 17049120 17935668 16267019 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6617962980
MESH:D009181 Mycoses Amiodarone 4.6912754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0216105982 16882451
MESH:D009203 Myocardial Infarction Doxorubicin 9.1015857846 19429709
MESH:D009203 Myocardial Infarction Genistein 9.1017141266
MESH:D009203 Myocardial Infarction resveratrol 9.1016456233 17188708 17015251 16525036 17125593 16317513
MESH:D017202 Myocardial Ischemia resveratrol 8.4617015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.4612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.5016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.5017141266
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 13.5015642760
MESH:D009205 Myocarditis resveratrol 4.5517322642
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7616624393
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.5918259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.5919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009374 Neoplasms, Experimental resveratrol 3.808985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7919200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009401 Nephrosis Doxorubicin 4.5616899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8216889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 21.7811399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 21.7816427766 11399458
MESH:D009421 Nervous System Malformations Genistein 21.7816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.7814600291
MESH:D009436 Neural Tube Defects arsenic trioxide 2.9810525206
MESH:D009447 Neuroblastoma Doxorubicin 3.1615555623
MESH:D019636 Neurodegenerative Diseases resveratrol 3.6417652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.2017929310
MESH:D009759 Nystagmus, Pathologic Astemizole 6.256135121
MESH:D009765 Obesity Fructose 3.3718585860 17707055
MESH:D010024 Osteoporosis Genistein 7.3619401787
MESH:D010024 Osteoporosis icariin 7.3618236786 19747809
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.5016169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.5017513867
MESH:D012516 Osteosarcoma Doxorubicin 3.9515930896
MESH:D010049 Ovarian Diseases bisphenol A 4.7811985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.5119769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 7.5119401270
MESH:D010051 Ovarian Neoplasms Genistein 7.5119005980
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.4515580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9719927285
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3216702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9417983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9417638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 21.5210548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 21.5216679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 21.5211896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 21.5218042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.7218220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.9220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.9220887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4119131511
MESH:D011471 Prostatic Neoplasms bisphenol A 2.4116740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.4115749863 16868541 16888761 18437689 16729912 15897917
MESH:D011471 Prostatic Neoplasms Estradiol 2.4116740699
MESH:D011471 Prostatic Neoplasms Genistein 2.4115378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.4115721890
MESH:D011471 Prostatic Neoplasms resveratrol 2.4117636462 17718901 17804756 16731767 17675339 15767336
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4115067354
MESH:D011472 Prostatitis vinclozolin 4.7218629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.1016919318 15861022
MESH:D011629 Puberty, Precocious bisphenol A 4.5710548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7712832656 12490602 11597910
MESH:D051437 Renal Insufficiency Doxorubicin 4.0117922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3716325855
MESH:D015427 Reperfusion Injury resveratrol 3.1716314181 17058453 15827377 17520802 16317513
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 5.2210822083
MESH:D012509 Sarcoma Doxorubicin 3.8115625365 18313854 16767912 15675481 17710206 17203757
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.6116646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.6116326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5817846226
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8718724381
MESH:D012804 Sick Sinus Syndrome marker/mechanism 21378987
MESH:D012852 Sinusitis Phenylephrine 4.497327846
MESH:D012878 Skin Neoplasms Doxorubicin 8.9515692506
MESH:D012878 Skin Neoplasms resveratrol 8.958985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.9516192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3616767912 15625365 17203757
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8516709447
MESH:D013088 Spermatocele Tamoxifen 10.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8319457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013276 Stomach Ulcer Amiodarone 3.1318087811
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3016321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.7716684133 16045194
MESH:D013610 Tachycardia Amiodarone 10.4411238279
MESH:D013610 Tachycardia Norepinephrine 10.443261545
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9919225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Amiodarone 11.3419731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.3412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.8119014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.8117909728 16010429
MESH:D013971 Thyrotoxicosis Amiodarone 4.6519584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D014062 Tongue Neoplasms resveratrol 4.0316227395
MESH:D016171 Torsades de Pointes Amiodarone 16.1517467628 11989578
MESH:D016171 Torsades de Pointes arsenic trioxide 16.1515213294
MESH:D016171 Torsades de Pointes Astemizole 16.158256756 9583453
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.9011780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 7.9017653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.9017572228 8653321 16712894
MESH:D014581 Urticaria Astemizole 4.602568013 2147912 1683191 2565098 3134034 1976298 2568189 3080510 2885854 3097109 2883202 2859714
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.9217473185
MESH:D014591 Uterine Diseases bisphenol A 4.8014652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.8314692618
MESH:D014594 Uterine Neoplasms resveratrol 8.8317044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 9.6517638931 17334414 16364871 17678736
MESH:D018487 Ventricular Dysfunction, Left resveratrol 9.6517488730
MESH:D014717 Vertigo Astemizole 6.253105558
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
Pathway ID Pathway Name
KEGG:04260 Cardiac muscle contraction
KEGG:05414 Dilated cardiomyopathy
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:17044 Muscle contraction
KEGG:04530 Tight junction
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31373
    • No data
    Releated disease ID Related disease Name
    PA444368Heart Diseases
    PA444589Hypothyroidism
    Releated drug ID Related drug Name
    PA451156propylthiouracil
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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