AutismKB 2.0

Annotation Detail for MYH9


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MYH9 ( DFNA17,EPSTS,FTNS,MGC104539,MHA,NMHC-II-A,NMMHCA )
Gene Full Name: myosin, heavy chain 9, non-muscle
Band: 22q12.3
Quick LinksEntrez ID:4627; OMIM: 160775; Uniprot ID:MYH9_HUMAN; ENSEMBL ID: ENSG00000100345; HGNC ID: 7579
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05416Viral myocarditis
hsa04530Tight junction
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Axon guidance
No data
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
P00016Cytoskeletal regulation by Rho GTPase
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00233Macrothrombocytopenia
Circulatory system diseases
Hematologic diseases
Desease IDDesease Name
2032Kidney disease
2114Thrombocytopenia
2207Deafness
No data
Desease Name
Optic disc size (rim)
End-stage renal disease (non-diabetic)
Desease Name
Epstein syndrome
May-Hegglin anomaly
Fechtner syndrome
Sebastian syndrome
Deafness, autosomal dominant 17
Macrothrombocytopenia and progressive sensorineural deafness
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MYH9 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MYH9 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of MYH9 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MYH9 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MYH9 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MYH9 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of MYH9 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of MYH9 mRNAincreases expression 20106945
C056933 fumonisin B1 fumonisin B1 results in increased expression of MYH9 mRNAincreases expression 16221962
C006253 pirinixic acid pirinixic acid results in decreased expression of MYH9 mRNAdecreases expression 16221962
17426115
D012643 Selenium Selenium results in increased expression of MYH9 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MYH9 mRNAdecreases expression 16054898
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MYH9 proteindecreases expression 16548065
D013876 Thiophenes Thiophenes analog promotes the reaction [Tretinoin results in increased expression of MYH9 mRNA]increases expression|increases reaction 16140955
D014212 Tretinoin Thiophenes analog promotes the reaction [Tretinoin results in increased expression of MYH9 mRNA]increases expression|increases reaction 16140955
D014212 Tretinoin Tretinoin results in increased expression of MYH9 mRNAincreases expression 16140955
C025643 vinclozolin vinclozolin affects the expression of MYH9 mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of MYH9 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9015322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3020127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.3011473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.653712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.656695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.0716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.0716835633
MESH:D000505 Alopecia Tretinoin 3.6415955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6619015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.0916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3516456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.4416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0811289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.4519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.4512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.4516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9217474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 1.9216675129 17289903 18497071 17261762 17018787 19861407 12948864 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9216443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6416813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8216097048 15700767 16050911 15721981 10355542 16227642 3786805 15673190 16011737 18705752 16124888 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2216168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.4516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.453581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.453084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.4518788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.4516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.451917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.697296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5920419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5916051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 7.2810977129
MESH:D002386 Cataract Tretinoin 7.2817460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 21.306135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 21.307505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 21.3020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 21.3012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 21.3018566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.509022650 19486331
MESH:D002779 Cholestasis Cyclosporine 13.5019486331
MESH:D002779 Cholestasis pirinixic acid 13.5019176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2216461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8012621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.809407595
MESH:D003092 Colitis Selenium 9.6417936198
MESH:D003092 Colitis Tretinoin 9.6417035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4515322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4510589399 8800419 17551590 14991402 16925845 9142499 9664655 9224671 9125849 9211117
MESH:D003456 Cryptorchidism vinclozolin 4.3814966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0618551238
OMIM:603622 DEAFNESS, AUTOSOMAL DOMINANT 17 marker/mechanism
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.848156756 2524372 12868966 11298694 14531868 8970840 18759878 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.522952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 18.8418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 18.8418692083 11289319 1440618 7440962 16192314 18648102 18289764 8291058 9653073 6482804 9022650 6679447 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.8412392966 19085960 11529661 14986274 18713872 12958197 16393943 11461765 16781746 12594235 10663392 19164858 19370779 11421492 15619225 19416960 16485898 16109766 10774834 10915739 14550746 16227642 11743745 11287661 19420014 18071297 14725611 17522070 11739529 17906064 17562736 16081117 12153990 2444490 12540782 12705907 16177239 15968718 11834606 19739265 19923254
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 18.8415968718 16227642 11566570 7440962 19085960 6884620 15027814 17522070 16177239 21278145 3732212 10915739 7120509 7179309 6623471 2869522 19336974 9327722 3786805 4309450 10092053 15998439
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 18.8416221962
MESH:D056486 Drug-Induced Liver Injury Selenium 18.8415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.8420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.1615322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.1618230668
MESH:D016889 Endometrial Neoplasms Estradiol 7.4711473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 7.4716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:C535507 Epstein syndrome marker/mechanism 11590545
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.223581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.2216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.9011564622
MESH:D005124 Eye Abnormalities Tretinoin 8.909664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.2216045604 12795759 61145 12631006 16239168 19224547 17595544 15959796
MESH:D005234 Fatty Liver Cyclosporine 13.2219224547
MESH:D005234 Fatty Liver pirinixic acid 13.2219236843 20131406
MESH:C537078 Fechtner syndrome marker/mechanism 11590545
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.086705139
MESH:D005355 Fibrosis Carbon Tetrachloride 21.5218705752
MESH:D005355 Fibrosis Cyclosporine 21.5212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 21.5220067830
MESH:D005355 Fibrosis Tretinoin 21.5217994277
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3616417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D005909 Glioblastoma Tretinoin 3.0217312396
MESH:D005923 Glomerulosclerosis, Focal Segmental marker/mechanism 18794856
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.077505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2216084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.1720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.1710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.179664655 14991402
MESH:D006333 Heart Failure pirinixic acid 7.0120558911
MESH:D006333 Heart Failure Selenium 7.0117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.356705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.3519110552 19900420
MESH:D006529 Hepatomegaly fumonisin B1 14.7516221962
MESH:D006529 Hepatomegaly pirinixic acid 14.7518467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.7515340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D019584 Hot Flashes Estradiol 3.8117088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.118697196 18606429 16959395 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 7.7016870215
MESH:D006930 Hyperalgesia Tretinoin 7.7016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5816899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6116778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9815034207
MESH:D006973 Hypertension Cyclosporine 4.9810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1315338365
MESH:D006977 Hypertension, Renal marker/mechanism 18794856
MESH:D007248 Infertility, Male vinclozolin 3.0616467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8712200463 12878042
MESH:D007251 Influenza, Human Selenium 4.2616624496
MESH:D007333 Insulin Resistance Estradiol 7.2616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.2616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.8117994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.089022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.0316580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.0315992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Acetaminophen 10.0712587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.078314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 10.0715618244
MESH:D007676 Kidney Failure, Chronic marker/mechanism 18794854 18794856
MESH:D007676 Kidney Failure, Chronic Selenium 3.9116518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.9416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.946582329
MESH:D007680 Kidney Neoplasms Cyclosporine 17.9412371664
MESH:D007680 Kidney Neoplasms Estradiol 17.9415610895
MESH:D007938 Leukemia Tretinoin 2.7817143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7316932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0819850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Thiophenes 8.2916140954 16140955
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.2912679006 17217047 17649720 16788101 17301526 19642359 16935935 17339181 16891316 19075265 16140955 9834237 19225113 16823087 19029980 19035177 17506722 17107899 17712046 17368321 16331271 17361223 17294898 15748426 16766008
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7816417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.339224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8211903743 16221502 16943688 16239168 11408273 17174718 17334410 21278145 17157831
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.219327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.7614716833 14512876 15996030 15370692 12958196 18279442 18156304 18251166 16011737 15931870 15959796 17481882 18481824 18376398 12445421 15673190 12667390 16248980 15123356 14716496 12632512 17708605 14724832 18210741 18418968 17869086 17900296 15925388 15650968 15338365 15893842 12649538 16097048 12546737 16192424 17761835 17631135 15818738 15052691 13678700 17565644 12632514 17766677 12389079 18277467 16638106 16033810 17922224 20821823 17698563 17976157 18412020 18420326 15730626 15876570 18054572 17944888 17557913 15362042 12898905 18395095 18395914 18472332 17721639 16027843 10355542 14748882 16136751 18166357 17805973 18263696 18205269 17525996 17714472 18705752 12445418 16116963 18472094 12741479 18006644 18339082 12666154 18187930 17823541 18317297 14620537 15057751 16015684 18429990 12586293 12609069 11481614 17640975
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.7614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.7615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.7612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.7618397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 3.9216611625 19460945 19014921 12587719 19784758 16610002 12969438 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9217285989 15830285 15720792 16964402 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5014706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.347678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.3421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.3419294768
MESH:D008113 Liver Neoplasms pirinixic acid 14.3416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.3416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.242876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.243712494 6587162 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.2412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.2412151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.1920464547 20135361 18569708 6695378 18520028 20064080 17053015 20869020 18816296
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.1911884234 19555203
OMIM:600208 MACROTHROMBOCYTOPENIA AND PROGRESSIVE SENSORINEURAL DEAFNESS marker/mechanism
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.0817203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.0815318939
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:C536037 May-Hegglin anomaly marker/mechanism 11590545
MESH:D008527 Medulloblastoma Tretinoin 2.7917453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008591 Meningomyelocele Tretinoin 4.4716940565
MESH:D008654 Mesothelioma Selenium 2.8015107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2116381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0917596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3216411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.917678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.483581430
MESH:D009369 Neoplasms Benzo(a)pyrene 8.2711141357
MESH:D009369 Neoplasms pirinixic acid 8.2717405874
MESH:D009369 Neoplasms Tretinoin 8.2716946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 16.5511399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.5514600291
MESH:D009421 Nervous System Malformations Tretinoin 16.559125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.296679447
MESH:D009436 Neural Tube Defects Tretinoin 7.299142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9716049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.976482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.083988306
MESH:D010051 Ovarian Neoplasms Estradiol 4.8319401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8316936753
MESH:D010146 Pain Acetaminophen 6.6616870215
MESH:D010146 Pain Tretinoin 6.6616870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4715976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.527296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.536228378
MESH:D010954 Plasmacytoma Selenium 4.9515087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6611399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.6618220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.9818220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1017292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.1016740699
MESH:D011472 Prostatitis vinclozolin 4.9818629315
MESH:D011507 Proteinuria Tretinoin 3.6416636307
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011625 Pterygium Tretinoin 4.8416723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.393692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1316116481 16283617
MESH:C537531 Sebastian syndrome marker/mechanism 11590545
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5518551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.4610029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.4616192470
MESH:D012878 Skin Neoplasms Tretinoin 9.4616467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3520155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.3517261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.206582329 3712494 1399818 7505956 6587162
MESH:D013964 Thyroid Neoplasms Tretinoin 7.2017045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.8116051514
MESH:D014376 Tuberculosis Tretinoin 3.2416040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.3216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.328074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.3217053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3710091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6716752155
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D014820 Vitiligo Tretinoin 4.0916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D009396 Wilms Tumor Tretinoin 3.9916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04810 Regulation of actin cytoskeleton
KEGG:04530 Tight junction
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31377
    • No data
    Releated disease ID Related disease Name
    PA444289Glomerulosclerosis, Focal Segmental
    PA443736Cleft Lip
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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