AutismKB 2.0

Annotation Detail for MYH10


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Basic Information Top
Gene Symbol:MYH10 ( MGC134913,MGC134914,NMMHCB )
Gene Full Name: myosin, heavy chain 10, non-muscle
Band: 17p13.1
Quick LinksEntrez ID:4628; OMIM: 160776; Uniprot ID:MYH10_HUMAN; ENSEMBL ID: ENSG00000133026; HGNC ID: 7568
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05416Viral myocarditis
hsa04530Tight junction
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Axon guidance
No data
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
P00016Cytoskeletal regulation by Rho GTPase
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1817Respiratory failure
1934Cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MYH10 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of MYH10 mRNAdecreases expression 17942131
D006710 Homocysteine Homocysteine results in decreased expression of MYH10 mRNAdecreases expression 17326132
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MYH10 mRNAaffects expression 16483693
D001151 Arsenic MYH10 mRNA results in increased susceptibility to Arsenicincreases response to substance 17976673
C006632 arsenic trioxide arsenic trioxide results in increased expression of MYH10 mRNAincreases expression 20458559
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MYH10 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MYH10 mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MYH10 mRNAdecreases expression 17942131
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of MYH10 mRNAdecreases expression 17942131
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MYH10 mRNAaffects expression 17484886
D003520 Cyclophosphamide MYH10 protein affects the susceptibility to Cyclophosphamideaffects response to substance 16217747
D016572 Cyclosporine Cyclosporine results in decreased expression of MYH10 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of MYH10 mRNAdecreases expression 17942131
D004041 Dietary Fats Dietary Fats results in increased expression of MYH10 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MYH10 mRNAaffects cotreatment|increases expression 18164116
D004054 Diethylstilbestrol Diethylstilbestrol inhibits the reaction [MYH10 protein binds to MYH10 protein]affects binding|decreases reaction 16901965
D004958 Estradiol Estradiol affects the localization of and results in increased expression of and results in increased phosphorylation of and affects the activity of MYH10 proteinaffects activity|affects localization|increases expression|increases phosphorylation 16901965
D004958 Estradiol Estradiol inhibits the reaction [MYH10 protein binds to MYH10 protein]affects binding|decreases reaction 16901965
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in increased expression of MYH10 protein]decreases reaction|increases expression 16901965
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of MYH10 protein]decreases reaction|increases phosphorylation 16901965
D004958 Estradiol Tamoxifen inhibits the reaction [Estradiol results in increased expression of MYH10 protein]decreases reaction|increases expression 16901965
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of MYH10 mRNAdecreases expression 17557909
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in increased expression of MYH10 protein]decreases reaction|increases expression 16901965
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of MYH10 protein]decreases reaction|increases phosphorylation 16901965
C051890 irinotecan irinotecan analog results in decreased expression of MYH10 mRNAdecreases expression 18927307
D007657 Ketone Bodies Ketone Bodies results in increased expression of MYH10 mRNAincreases expression 16807920
C029938 nickel sulfate nickel sulfate results in decreased expression of MYH10 mRNAdecreases expression 16780908
D010126 Ozone Ozone results in decreased expression of MYH10 mRNAdecreases expression 17095637
C041786 palm oil palm oil results in increased expression of MYH10 mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MYH10 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of MYH10 mRNAdecreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of MYH10 mRNA]decreases expression|increases reaction 17950772
C025462 sulindac sulfide sulindac sulfide results in increased expression of MYH10 mRNAincreases expression 12734198
D013629 Tamoxifen Tamoxifen inhibits the reaction [Estradiol results in increased expression of MYH10 protein]decreases reaction|increases expression 16901965
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D055371 Acute Lung Injury nickel sulfate 8.5511954676 12718980 16100012 19131640
MESH:D055371 Acute Lung Injury pirinixic acid 8.5518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 9.7419825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.7420127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.7411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.7414692618
MESH:D000236 Adenoma Benzo(a)pyrene 10.576695378
MESH:D000236 Adenoma beta-Naphthoflavone 10.5719389873
MESH:D000236 Adenoma Diethylnitrosamine 10.5710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.4518056438 17620307 17162532 16434500 19052882 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.4516434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.0217306315
MESH:D000544 Alzheimer Disease Ozone 4.4215513908
MESH:D000544 Alzheimer Disease sulindac sulfide 4.4218759972
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3015469931
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8819183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8116251483 12569548 18414634 16835338
MESH:D001161 Arteriosclerosis Cyclophosphamide 15.9715014928
MESH:D001161 Arteriosclerosis Dietary Fats 15.9715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 15.9711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5515885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5115570426
MESH:D001249 Asthma Ozone 2.5817854713 16373670
MESH:D050197 Atherosclerosis Arsenic 3.1419371607 12928151
MESH:D001284 Atrophy fulvestrant 4.6611514358
MESH:D001321 Autistic Disorder Acetaminophen 2.2318445737
MESH:D001321 Autistic Disorder Homocysteine 2.2320468076 16297937
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.4216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.4219483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.5820146248 17474063
MESH:D001943 Breast Neoplasms Cyclophosphamide 4.5817020986 11325840 15136595 17388661 16978400 18234424 18323546 12006526 15093573
MESH:D001943 Breast Neoplasms Dietary Fats 4.5820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.5817474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 4.5817129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 4.5814630087 17018787 12948864 17261762 17289903 19861407 18497071 16675129
MESH:D001943 Breast Neoplasms fulvestrant 4.5818984771
MESH:D001943 Breast Neoplasms Tamoxifen 4.5816202921 19189212 19011961 19288272 11161223 19200415 18855134 18425577 15668708 17893378 19084267 16873071 18984771 20859285 19142967 19289846 20135344 18821012 19103187 17440819 19115204 17049068 19155303 19410462 18629630 19487384 18351453 16273361 20005174 18997820 20544844 19066611 21152245 17261762 20390343 19244106 19189210 16818667 17242785 19221464 20065188 18815881 19059307 15565566 21138602
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5319059883 15516495 17626835 16777450 14754758 18417511 18315731
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1511589617
MESH:D002100 Cachexia Ozone 4.5516183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5916011737 16227642 3786805 16124888 16050911 15721981 10355542 16097048 16192424 15700767 18705752 15673190
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4915504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.303084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 19.3016507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 19.3014691202 15553829 16217749 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.3018788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 19.3019701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 19.3016502159 21159647 18506893 18056438 19052882 18494052 16878318 20524982 19539802 20432363 18210153 19519916 19919837 18393292 19701751 19107877 20727157 19383236 16328049 16807293 16540662 17761372 17055752 3581430 20512989 20101231 18788625 19394651 20214788 10737359 16935385 20084675 17138121 17428255 16569478 17162532 3084413 18665156 19208518 20007298 16698587 19822196 10672840 18971187 20514400 20935162 16288022 18785209 17978847 16779866 18978308 16681979 17173139 19418558 16830150 18691550 19171122 11831363 19335982
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 19.3016924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.3016924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 19.3016924424
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.7016152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.3812391285
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6819014326
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.4516201981
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9512490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.5318922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5320419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 8.9518640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.9517572228
MESH:D002318 Cardiovascular Diseases Arsenic 3.3217938729 15738583 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.1518022660 16973168
MESH:D002386 Cataract Acetaminophen 2.4710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.4012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.4017174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.4018566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5219052882
MESH:D002779 Cholestasis Cyclosporine 12.5319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.5317681005 15861022 16105132 17110522 17333356 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 12.5319176532
MESH:D003110 Colonic Neoplasms irinotecan 2.5617287894 17725105
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6320501625
MESH:D015179 Colorectal Neoplasms irinotecan 2.6318259882 16303861 16391804 17159606 18509181 15273666 17454858
MESH:D003324 Coronary Artery Disease Homocysteine 3.6916379339
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8710525206
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3712952375 16002989
MESH:D003556 Cystitis Cyclophosphamide 4.7912913760 16651033 15276878 18710439 15643279 17010015 16614059 16989017 10700343 18483878 12388444 18295254 18433785 12161096 18372110 16413132 10498854 17979934 18093676 11948286
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9215213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.4916823706 11298694 16780908
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.9115331540 11751995 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1618772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1520387270
MESH:D003928 Diabetic Nephropathies Estradiol 8.3019279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.3019279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.8612958197 18071297 17522070 11739529 19739265 12153990 16081117 12594235 12705907 17906064 11421492 10774834 15968718 11529661 19370779 10663392 19416960 11287661 16485898 19164858 16177239 15619225 16781746 2444490 17562736 18713872 14725611 19923254 16393943 19420014 16109766 10915739 11461765 12540782 16227642 14550746 11834606 11743745 14986274 19085960 12392966
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.8611566570 21278145 6623471 4309450 7440962 17522070 7179309 19085960 7120509 15968718 3732212 9327722 3786805 16177239 19336974 10915739 15998439 2869522 16227642 10092053 15027814 6884620
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.8619107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D050171 Dyslipidemias Dietary Fats 3.3218367378
MESH:D004487 Edema pirinixic acid 2.3112083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.3312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.3319031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.5016402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 11.7615700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 11.7618566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.7620544844 16202921 19155303 17893378
MESH:D004802 Eosinophilia Cyclophosphamide 4.0311006010
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.2712903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2716530937
MESH:D017889 Exfoliation Syndrome Homocysteine 5.5116504073
MESH:D005234 Fatty Liver arsenic trioxide 40.3715073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 40.3715959796 16239168 12795759 17595544 12631006 61145 19224547 16045604
MESH:D005234 Fatty Liver Cyclosporine 40.3719224547
MESH:D005234 Fatty Liver Dietary Fats 40.3718296743 19551842 17967931 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 40.3720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 40.3715345470
MESH:D005234 Fatty Liver pirinixic acid 40.3719236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 40.3714986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.8315751030 16513791 16534752 16611131 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.8316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005355 Fibrosis Carbon Tetrachloride 13.6918705752
MESH:D005355 Fibrosis Cyclosporine 13.6912639820 12168785
MESH:D005355 Fibrosis Dietary Fats 13.6918296743
MESH:D005534 Foot Diseases Arsenic 5.376392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0816904648
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D005901 Glaucoma Homocysteine 5.1116504073
MESH:D018316 Gliosarcoma Cyclophosphamide 5.3211389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.8516376943 11014644 15172196
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7320471113
MESH:D006330 Heart Defects, Congenital Homocysteine 6.7319638421
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.1011918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.3414986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4119900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 2.8119176532 18467677 16221962 19772884
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.6316135485 17606976
MESH:D019584 Hot Flashes Estradiol 3.5617088409
MESH:D006930 Hyperalgesia Acetaminophen 2.5516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3416899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4221332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.5418234410 17292331 17369066
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2917050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.4421332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2512960047 14722030
MESH:D006973 Hypertension Arsenic 5.0616076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 5.0610903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9015338365
MESH:D006987 Hypesthesia Arsenic 5.3716093927
MESH:D007021 Hypospadias Diethylstilbestrol 10.6116002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.6116569931 16945680
MESH:D007154 Immune System Diseases Cyclophosphamide 5.1416076520
MESH:D007246 Infertility Diethylstilbestrol 4.1715036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Cyclophosphamide 10.667193160 16517039
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.6617937319
MESH:D007248 Infertility, Male fulvestrant 10.6611514358
MESH:D007249 Inflammation Dietary Fats 7.7720412841
MESH:D007249 Inflammation Diethylnitrosamine 7.7718785209
MESH:D007249 Inflammation Tamoxifen 7.7719457130
MESH:D007333 Insulin Resistance Dietary Fats 11.5818457598 11836018
MESH:D007333 Insulin Resistance Estradiol 11.5816627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.5816306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007642 Keratosis Arsenic 4.8012749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 9.3415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.348314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.3415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 16.4912371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 16.4915003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 16.4915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 16.4918625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8717184923
MESH:D007938 Leukemia arsenic trioxide 6.2915070760
MESH:D007938 Leukemia Cyclophosphamide 6.2910602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4217658394 18587576 18172266 17296974 17008537 17802794
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.1514633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 8.1510373061
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.5919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1120471514 16467208 16968895 17050201 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.3717339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.3715213294 12018890 16891316 11161223 15336539 17649720 16112521 16823087 17107899 16966277 9834237 17869043 12712474 15748426 11468182 12679006 19075265 16331271 19642359 19225113 19035177 15622746 16330433 17217047 17712046
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1716882451
MESH:D007970 Leukopenia Cyclophosphamide 4.7711830472 10052129
MESH:D008064 Lipidoses Tamoxifen 3.0215342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.4117334410 16943688 17174718 16239168 21278145 11408273 16221502 17157831 11903743
MESH:D008103 Liver Cirrhosis Dietary Fats 10.4118296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.4119638242 18407596 18665156 20032147 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.7417714472 12958196 18251166 17944888 18277467 10355542 12741479 17565644 16136751 12389079 12546737 16097048 18210741 15052691 17557913 17640975 16248980 16192424 14748882 12666154 16015684 12632512 18395914 15925388 12649538 17631135 17869086 20821823 18339082 17823541 18412020 11481614 17761835 14716496 12898905 16033810 15996030 18166357 17708605 15876570 15730626 12445421 17481882 18317297 15673190 17900296 15123356 14512876 15338365 16116963 15931870 12667390 16638106 17525996 17805973 14620537 12586293 18205269 12632514 13678700 18472332 18187930 17922224 18420326 15362042 18418968 18472094 15057751 18054572 18481824 18376398 18705752 15818738 12609069 12445418 18395095 18429990 18156304 16027843 17976157 15650968 18006644 16011737 14716833 17766677 18263696 15370692 17698563 15893842 15959796 18279442 17721639 14724832
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.7414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.7418564211
MESH:D008107 Liver Diseases Acetaminophen 8.9711587558 19460945 16610002 19014921 19784758 12969438 12587719 16611625
MESH:D008107 Liver Diseases Arsenic 8.9711134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.9715830285 16246199 16964402 17285989 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 8.9717034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.8517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.8516899240 14706259
MESH:D008113 Liver Neoplasms Arsenic 28.7616368122
MESH:D008113 Liver Neoplasms arsenic trioxide 28.7614682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 28.7621137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 28.7621295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 28.7619294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 28.7615885732 12771043 2862719 15175105 19427195 20137499 10737359 19499222 21047994 20101389 9163691 19255062 20452335 19426721 19256749 18644402 19551842 19690152 20492335 20583210 18978307 12112319 16942905 19850985 20118626 19638242 20405173 21167192 20501860 19294768 19833225 21278145 19090486 19996281 19642983 18977376 2422723 20434301 19073162 19254457 21071580 18648771 19812893 18754104
MESH:D008113 Liver Neoplasms Diethylstilbestrol 28.7615890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 28.7616377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 28.7616684651
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 13.1920377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 13.1918164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.1912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.1919519916 18282651 9362446 18308698 18253720 19009564 18079962 19539802 18164116 16267830 18544905 16842330 19126423 18775883 21159647 17854601 17174075 2563599 18093689 17942915 19004024 3124819
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2115213294
MESH:D008171 Lung Diseases Ozone 3.2519066396 8266340
MESH:D055370 Lung Injury Ozone 3.6620417186
MESH:D008175 Lung Neoplasms Arsenic 8.2417306315 19168569 17976673
MESH:D008175 Lung Neoplasms arsenic trioxide 8.2411798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.2420464547 20869020 18816296 17053015 18569708 18520028 6695378 20064080 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.2420970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Ozone 8.248597069 7614698
MESH:D008175 Lung Neoplasms Tamoxifen 8.2418625569
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9615166399
MESH:D008223 Lymphoma Cyclophosphamide 7.4412854902
MESH:D008223 Lymphoma Diethylstilbestrol 7.4415700306
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.4216675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.0111911406
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3216002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.5717203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.5711731420 14580682 19196723 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.0019453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.0019453300
MESH:D008545 Melanoma Tamoxifen 1.8619393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 10.2019513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 10.2016388313
MESH:D008591 Meningomyelocele Homocysteine 5.3516602021
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D008679 Metaplasia Ozone 4.9110496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0416381670
MESH:D052016 Mucositis irinotecan 4.8217159606
MESH:D009101 Multiple Myeloma arsenic trioxide 2.9714977855 19549372 15949261 19417148 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0316105982 16882451
MESH:D009203 Myocardial Infarction Homocysteine 5.7317412321
MESH:D009203 Myocardial Infarction pirinixic acid 5.7319151258
MESH:D017202 Myocardial Ischemia Arsenic 3.8315371236
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.7716411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7816624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.113581430 9029167
MESH:D009362 Neoplasm Metastasis irinotecan 9.1118259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.1119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 11.1111141357
MESH:D009369 Neoplasms Cyclophosphamide 11.1118854779
MESH:D009369 Neoplasms Diethylstilbestrol 11.1115313581
MESH:D009369 Neoplasms pirinixic acid 11.1117405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1219348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 9.1911399458
MESH:D009421 Nervous System Malformations Estradiol 9.1916427766 11399458
MESH:D009436 Neural Tube Defects Arsenic 7.0416620997
MESH:D009436 Neural Tube Defects arsenic trioxide 7.0410525206
MESH:D009447 Neuroblastoma Cyclophosphamide 6.9715176712 16115947 8761367
MESH:D009447 Neuroblastoma irinotecan 6.978761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6620387270
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 10.8912837982 8761367
MESH:D017599 Neuroectodermal Tumors irinotecan 10.898761367
MESH:D020078 Neurogenic Inflammation Arsenic 4.2017056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D009503 Neutropenia Cyclophosphamide 4.158291058
MESH:D009765 Obesity Dietary Fats 4.2711836018 21332399 20518802 20132043 17217161 18457598 16723640 19632207 18674790
MESH:D009765 Obesity pirinixic acid 4.2720558911
MESH:D009845 Oligospermia Cyclophosphamide 4.5216517039
MESH:D010051 Ovarian Neoplasms Arsenic 7.5717306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.5712452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 7.5719401270
MESH:D010146 Pain Acetaminophen 6.3416870215
MESH:D010146 Pain Cyclophosphamide 6.3412161096 18093676
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.3115580305
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 8.3111332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.3116540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9819927285
MESH:D010300 Parkinson Disease Homocysteine 3.5016275827
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9916093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.8016905509 6392382 15371236
MESH:D010538 Peritonitis Ozone 3.9416369182
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4815687265 16977796
MESH:D011014 Pneumonia Ozone 4.2018007984 18929643 18381685
MESH:D011230 Precancerous Conditions Cyclosporine 8.4112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.412563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.7021297632
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 3.9217184923
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7120887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.0716140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0719131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.0717136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0715046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0715067354
MESH:D011507 Proteinuria Arsenic 3.8321343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.1215861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.2116636934
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7816646077
MESH:D012559 Schizophrenia Homocysteine 3.0816641680
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.6416636934
MESH:D012871 Skin Diseases Arsenic 2.7016353154 16759981 19834688 17938729 18709164 17453740 17548696 16702368 6392382 15952646 17050553
MESH:D012878 Skin Neoplasms Arsenic 5.5317050553 19538983 17976673 15504454 16251483 17029826
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5310029692 19755658
MESH:D013088 Spermatocele Diethylstilbestrol 19.0116709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 19.0116709447
MESH:D013088 Spermatocele Tamoxifen 19.0116709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.3216517039
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8519457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.5717007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.5720155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5718456281
MESH:D013274 Stomach Neoplasms irinotecan 4.5715723263
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.8612837982
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.7119014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.717505956
MESH:D013978 Tibial Fractures Estradiol 4.4919048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7715213294
MESH:D001749 Urinary Bladder Neoplasms Arsenic 18.9211144890 17306315 19322015 18640142 17976673 15987713 19429237
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 18.9211780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 18.9217053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 18.9214692829
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 18.9216712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 18.9216712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.8716175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9814652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 15.0715809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 15.0714692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 15.0718645019
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2516002989 16513791
MESH:D014652 Vascular Diseases Arsenic 4.5417056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.5816723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04810 Regulation of actin cytoskeleton
KEGG:04530 Tight junction
KEGG:05416 Viral myocarditis
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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