AutismKB 2.0

Annotation Detail for MYH11


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Basic Information Top
Gene Symbol:MYH11 ( AAT4,DKFZp686D10126,DKFZp686D19237,FAA4,FLJ35232,MGC126726,MGC32963,SMHC,SMMHC )
Gene Full Name: myosin, heavy chain 11, smooth muscle
Band: 16p13.11
Quick LinksEntrez ID:4629; OMIM: 160745; Uniprot ID:MYH11_HUMAN; ENSEMBL ID: ENSG00000133392; HGNC ID: 7569
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa05416Viral myocarditis
hsa04530Tight junction
Pathway IDPathway Name
Axon guidance
Muscle contraction
No data
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
P00016Cytoskeletal regulation by Rho GTPase
P00031Inflammation mediated by chemokine and cytokine signaling pathway
Pathway IDPathway Name
500191Smooth Muscle Contraction
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1806Arteriopathy
2051Leukemia
2053Colon cancer
2259Hereditary disease
No data
No data
Desease Name
Aortic aneurysm, familial thoracic 4
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of MYH11 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MYH11 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in increased expression of MYH11 mRNAincreases expression 12075121
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MYH11 mRNAaffects expression 17484886
D003345 Corticosterone Corticosterone results in increased expression of MYH11 mRNAincreases expression 15755911
D004041 Dietary Fats Dietary Fats results in increased expression of MYH11 mRNAincreases expression 18042831
C041786 palm oil palm oil results in increased expression of MYH11 mRNAincreases expression 18042831
C017947 sodium arsenite sodium arsenite results in increased expression of MYH11 mRNAincreases expression 20308225
C004648 testosterone enanthate testosterone enanthate affects the expression of MYH11 mRNAaffects expression 17440010
D014212 Tretinoin Tretinoin results in increased expression of MYH11 mRNAincreases expression 17069765
D014212 Tretinoin Tretinoin results in increased expression of MYH11 proteinincreases expression 17069765
C025643 vinclozolin vinclozolin affects the expression of MYH11 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1216712894 17306315
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D001008 Anxiety Disorders vinclozolin 3.7519015723
MESH:C537784 Aortic aneurysm, familial thoracic 4 marker/mechanism
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9318057881 18218290 20041841
MESH:D001161 Arteriosclerosis Dietary Fats 4.0615238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.1616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001281 Atrial Fibrillation Amiodarone 4.0119698954 18651412
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.7219483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.7216197459 16206674
MESH:D001862 Bone Resorption bisphenol A 4.0011985600
MESH:D001943 Breast Neoplasms bisphenol A 1.9417123778
MESH:D001943 Breast Neoplasms Dietary Fats 1.9420435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9416443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9510355542 16124888 3786805 16050911 15673190 16192424 15700767 16097048 16227642 16011737 15721981 18705752
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7318788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.7317306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.731917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.1817123778
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8118572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8116096774 16051514
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9319225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2818974383
MESH:D002386 Cataract Tretinoin 3.1717460283
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.0820056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tretinoin 2.729407595
MESH:D003092 Colitis Tretinoin 3.8817035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.829142499 17551590 8800419 9224671 14991402 9211117 9664655 16925845 9125849 10589399
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.1618218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.1619085960 21278145 15968718 7179309 16177239 7120509 4309450 15998439 16227642 3786805 3732212 2869522 17522070 6884620 10915739 19336974 9327722 11566570 7440962 15027814 6623471 10092053
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004489 Edema, Cardiac Tretinoin 4.6818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1916569247
MESH:D005124 Eye Abnormalities Tretinoin 3.6816938888 9664655
MESH:D005234 Fatty Liver Amiodarone 14.0314986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.0319224547 15959796 16239168 12795759 16045604 61145 12631006 17595544
MESH:D005234 Fatty Liver Dietary Fats 14.0319551842 19004024 18296743 17967931
MESH:D005355 Fibrosis Carbon Tetrachloride 15.9018705752
MESH:D005355 Fibrosis Dietary Fats 15.9018296743
MESH:D005355 Fibrosis Tretinoin 15.9017994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8716452187
MESH:D005909 Glioblastoma Tretinoin 3.0917312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9614991402 9664655
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly Amiodarone 3.9215265979
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.9617440010
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D006930 Hyperalgesia Tretinoin 3.3216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006937 Hypercholesterolemia Amiodarone 9.648137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 9.6421332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007037 Hypothyroidism Amiodarone 4.6918020914 17991464
MESH:D007248 Infertility, Male sodium arsenite 7.1512646999 15346721
MESH:D007248 Infertility, Male vinclozolin 7.1516467254
MESH:D007249 Inflammation Dietary Fats 2.4920412841
MESH:D007333 Insulin Resistance bisphenol A 7.7816393666
MESH:D007333 Insulin Resistance Dietary Fats 7.7818457598 11836018
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0415992940 17551590
MESH:D007674 Kidney Diseases sodium arsenite 2.8720008137
MESH:D007938 Leukemia Tretinoin 2.8317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1017596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2417368321 17712046 16331271 9834237 19642359 16891316 17339181 17649720 17217047 19035177 16766008 19075265 12679006 16823087 19029980 17294898 15748426 16788101 17506722 17361223 17301526 17107899 19225113 16140955 16935935
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008064 Lipidoses Amiodarone 3.6115342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.8711408273 21278145 16943688 17334410 16239168 17174718 11903743 17157831 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 6.8718296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5318418968 18472332 12667390 16116963 17525996 18395914 11481614 14748882 18187930 17698563 17900296 18054572 18339082 17823541 18205269 17565644 16097048 18263696 13678700 15370692 14716833 15730626 18166357 17714472 17721639 16136751 10355542 17869086 15818738 15931870 18481824 18277467 12586293 12445418 17766677 15650968 17631135 12666154 15362042 14620537 17708605 18472094 17761835 16248980 20821823 12632514 15052691 16638106 18156304 12389079 18395095 15925388 12741479 15959796 18429990 17922224 12609069 18251166 18420326 18317297 15057751 15338365 18705752 16015684 16027843 15673190 12958196 15893842 12632512 12546737 12445421 12649538 17640975 18210741 17944888 14716496 16033810 14512876 15996030 12898905 14724832 18412020 15876570 18006644 16192424 17481882 18279442 17805973 15123356 18376398 17976157 17557913 16011737
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5316248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1116246199 15720792 16964402 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8214706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.7919294768
MESH:D008113 Liver Neoplasms sodium arsenite 4.7915276417 16712894
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6915583823 12014681
MESH:D008133 Long QT Syndrome Amiodarone 3.6911989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 7.8212587719
MESH:D008171 Lung Diseases sodium arsenite 7.8219095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.7018516814
MESH:D008175 Lung Neoplasms sodium arsenite 1.8917306315 19931552 15276417 17077188 16712894
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 3.7112807724
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma sodium arsenite 3.4119082730 16487513
MESH:D008545 Melanoma Tretinoin 3.4116752155
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D009181 Mycoses Amiodarone 5.1212754197 17974566
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1517596541
MESH:D009369 Neoplasms sodium arsenite 5.3211559025
MESH:D009369 Neoplasms Tretinoin 5.3216594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009421 Nervous System Malformations bisphenol A 10.3411399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 10.349125849
MESH:D009436 Neural Tube Defects sodium arsenite 7.6112854658
MESH:D009436 Neural Tube Defects Tretinoin 7.619142499
MESH:D009765 Obesity Dietary Fats 2.3117217161 18674790 21332399 20132043 19632207 20518802 18457598 16723640 11836018
MESH:D010049 Ovarian Diseases bisphenol A 5.1811985600
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.0117306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0116936753
MESH:D010146 Pain Tretinoin 3.0216870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.4210548101
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.4218220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3520887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3116740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3116039940
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D011629 Puberty, Precocious bisphenol A 4.9810548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9012490602 12832656 11597910
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516116481 16283617
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2818724381
MESH:D012878 Skin Neoplasms sodium arsenite 6.0019524636 18572023
MESH:D012878 Skin Neoplasms Tretinoin 6.0016467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013276 Stomach Ulcer Amiodarone 3.4518087811
MESH:D019966 Substance-Related Disorders bisphenol A 4.1816045194 16684133
MESH:D013610 Tachycardia Amiodarone 4.4511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3519225199
MESH:D013959 Thyroid Diseases Amiodarone 4.9819731979
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1316026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 5.0418020914 19584973
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D016171 Torsades de Pointes Amiodarone 4.3811989578 17467628
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5511723127 16452187 16712894 17306315
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.8511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.8516129372
MESH:D014591 Uterine Diseases bisphenol A 5.2314652134
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
Pathway ID Pathway Name
REACT:18266 Axon guidance
REACT:17044 Muscle contraction
KEGG:04530 Tight junction
KEGG:04270 Vascular smooth muscle contraction
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03431 - Adenosine-5'-Diphosphate
DB04444 - Tetrafluoroaluminate Ion
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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