AutismKB 2.0

Annotation Detail for ZFHX3


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Basic Information Top
Gene Symbol:ZFHX3 ( ATBF1,ATBT,ZNF927 )
Gene Full Name: zinc finger homeobox 3
Band: 16q22.2-q22.3
Quick LinksEntrez ID:463; OMIM: 104155; Uniprot ID:ZFHX3_HUMAN; ENSEMBL ID: ENSG00000140836; HGNC ID: 777
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200130C-MYB transcription factor network
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1843Metastasis to lymph nodes
1944Breast cancer
2000Multiple malignancy
1841Stomach cancer
2022Liver cancer
Desease Name
Atrial Fibrillation
CARDIOVASCULAR
IMMUNE
kawasaki disease
Desease Name
Kawasaki disease
Atrial fibrillation
Desease Name
Prostate cancer, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of ZFHX3 mRNAdecreases expression 20406850
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ZFHX3 mRNAdecreases expression 18648102
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of ZFHX3 mRNAdecreases expression 17023530
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ZFHX3 mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZFHX3 mRNAdecreases expression 19150397
D003474 Curcumin Curcumin results in decreased expression of ZFHX3 mRNAdecreases expression 17198877
D004041 Dietary Fats Dietary Fats results in decreased expression of ZFHX3 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of ZFHX3 mRNAdecreases expression 18042831
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ZFHX3 mRNAincreases expression 19465110
D014212 Tretinoin Tretinoin results in increased expression of ZFHX3 mRNAincreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 11752688 15322242
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220464547 20127859
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.913712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.916695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.3517887948
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000544 Alzheimer Disease Curcumin 2.6515590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.8516807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.8516292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D050197 Atherosclerosis Curcumin 3.4118704882
MESH:D001281 Atrial Fibrillation marker/mechanism 19597492 19597491
MESH:D001327 Autoimmune Diseases Curcumin 4.7119761891
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.5216197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D002545 Brain Ischemia Curcumin 4.5716770732
MESH:D001932 Brain Neoplasms Curcumin 4.1017596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3820146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 2.3816243823 19250217 18593918 18462866
MESH:D001943 Breast Neoplasms Dietary Fats 2.3820435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3820435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3816166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002277 Carcinoma Curcumin 8.7518593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.7516835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.717296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.711917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0318414057
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8220419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.8218462866
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.8216096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18670907 18850075
MESH:D002386 Cataract Tretinoin 3.1917460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.856135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.857505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.8520889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.279022650 19486331
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9812621046 15340226 15668235 16354765 8697196
MESH:D002972 Cleft Palate Tretinoin 5.989407595
MESH:D003092 Colitis Curcumin 10.3718200517 16804969 16782535
MESH:D003092 Colitis Tretinoin 10.3717035595
MESH:D003103 Coloboma Curcumin 4.7218809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5316340194 19359593
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 5.1118497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.499142499 9224671 16925845 14991402 10589399 8800419 9664655 9125849 9211117 17551590
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0114531868 18759878 2524372 12868966 11906362 8156756 11298694 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.672952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.5318403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5317107852
MESH:D003928 Diabetic Nephropathies Curcumin 4.1618204486
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.4318289764 11289319 18692083 18648102 6482804 7440962 9022650 9328219 8291058 16192314 1440618 9653073 6679447
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004381 Duodenal Ulcer Curcumin 4.2517351913
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.8518230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.8518230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.413581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.2611564622
MESH:D005124 Eye Abnormalities Tretinoin 9.2616938888 9664655
MESH:D005234 Fatty Liver Curcumin 8.6219297423
MESH:D005234 Fatty Liver Dietary Fats 8.6219551842 19004024 18296743 17967931
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Curcumin 23.0918705752
MESH:D005355 Fibrosis Dietary Fats 23.0918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 23.0920067830
MESH:D005355 Fibrosis Tretinoin 23.0917994277
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.9118462866
MESH:D005909 Glioblastoma Curcumin 7.6517596214
MESH:D005909 Glioblastoma Tretinoin 7.6517312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Curcumin 8.2718829502 18462866
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.5720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.5711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 11.579664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 16120746 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.2617701891
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 15340226 16354765 18606429 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.3516870215
MESH:D006937 Hypercholesterolemia Curcumin 9.8118704882
MESH:D006937 Hypercholesterolemia Dietary Fats 9.8121332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007249 Inflammation Curcumin 8.8317151092 18403477 16956363
MESH:D007249 Inflammation Dietary Fats 8.8320412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.8312878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2718596194 18200517
MESH:D007333 Insulin Resistance Dietary Fats 3.2111836018 18457598
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.3810783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.5116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.5115992940 17551590
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.8416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.846582329
MESH:D007889 Leiomyoma Curcumin 4.7618555241
MESH:D007938 Leukemia Curcumin 6.7518462866
MESH:D007938 Leukemia Tretinoin 6.7517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.3816106398
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8716482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1017596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2619035177 16891316 16331271 17712046 16140955 16788101 17217047 19075265 17368321 17301526 15748426 12679006 9834237 17107899 16766008 19029980 17294898 19225113 17339181 17361223 17649720 16823087 16935935 17506722 19642359
MESH:D015458 Leukemia, T-Cell Curcumin 4.9616106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9618296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.6118705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.6118397230 16248980
MESH:D008107 Liver Diseases Curcumin 2.6516956363
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.697678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.6921137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.376135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.376587162 598648 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3712151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5118520028 20135361 17053015 18816296 20464547 18569708 6695378 20064080 20869020
MESH:D008175 Lung Neoplasms Curcumin 3.5119359593 18462866 16243823
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5119555203 11884234
MESH:D008223 Lymphoma Curcumin 3.7118462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.9116173963
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Curcumin 3.5618462866 17885582
MESH:D008545 Melanoma Tretinoin 3.5616752155
MESH:D008569 Memory Disorders Curcumin 4.3517263510
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009101 Multiple Myeloma Curcumin 3.6319372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.1617962980
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.107678174 18551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.5718495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2511141357
MESH:D009369 Neoplasms Tretinoin 5.2516946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.8012497104
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1814600291
MESH:D009421 Nervous System Malformations Tretinoin 10.189125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.9018462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.596679447
MESH:D009436 Neural Tube Defects Tretinoin 7.599142499
MESH:D009765 Obesity Curcumin 4.9019297423
MESH:D009765 Obesity Dietary Fats 4.9018674790 20518802 17217161 21332399 19632207 18457598 16723640 11836018 20132043
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.4316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.434026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010024 Osteoporosis Curcumin 3.5718719352
MESH:D010051 Ovarian Neoplasms Curcumin 5.1818462866 19020741
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1816936753
MESH:D010146 Pain Tretinoin 3.0416870215
MESH:D010190 Pancreatic Neoplasms Curcumin 5.6219401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6215976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms marker/mechanism 16637072 17013881
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2917292933
MESH:D011471 Prostatic Neoplasms Curcumin 3.2918156803 11398177 15129424 10851300 12497104 18769126 18226269
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.6919168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2118379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816116481 16283617
MESH:D012509 Sarcoma Curcumin 4.2818462866
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6418551238
MESH:D018805 Sepsis Curcumin 4.2218389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.8216192470
MESH:D012878 Skin Neoplasms Tretinoin 9.8216467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.382093021 20155912
MESH:D013274 Stomach Neoplasms Tretinoin 2.3817261132
MESH:D013276 Stomach Ulcer Curcumin 3.6619188055 16631530
OMIM:601367 STROKE, ISCHEMIC marker/mechanism 19597491
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.571399818 6582329 3712494 7505956 6587162
MESH:D013964 Thyroid Neoplasms Tretinoin 7.5716026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.4416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.448074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.4417053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 12.4418593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.5018462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5610091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162409676
    • No data
    Releated disease ID Related disease Name
    PA443459Atrial Fibrillation
    PA444977Mucocutaneous Lymph Node Syndrome
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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