AutismKB 2.0

Annotation Detail for MYO1C


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Basic Information Top
Gene Symbol:MYO1C ( FLJ23903,MMI-beta,MMIb,NMI,myr2 )
Gene Full Name: myosin IC
Band: 17p13.3
Quick LinksEntrez ID:4641; OMIM: 606538; Uniprot ID:MYO1C_HUMAN; ENSEMBL ID: ENSG00000197879; HGNC ID: 7597
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of MYO1C mRNAincreases expression 20713471
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MYO1C mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MYO1C mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MYO1C mRNAincreases expression 16644059
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MYO1C mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MYO1C mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYO1C mRNAaffects cotreatment|increases expression 17942748
C056933 fumonisin B1 fumonisin B1 results in increased expression of MYO1C mRNAincreases expression 16221962
C006253 pirinixic acid pirinixic acid results in decreased expression of MYO1C mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of MYO1C mRNAincreases expression 18301758
D013629 Tamoxifen Tamoxifen affects the expression of MYO1C mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYO1C mRNAaffects cotreatment|increases expression 17942748
C025643 vinclozolin vinclozolin affects the expression of MYO1C mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 1.9511921183
MESH:D001943 Breast Neoplasms Tamoxifen 1.9518815881 19487384 19084267 20390343 19155303 17049068 18629630 19410462 18855134 19244106 16202921 17242785 19142967 21152245 15565566 16273361 19011961 17261762 15668708 18425577 20544844 19059307 19221464 18984771 17893378 16818667 19189210 11161223 20859285 19289846 19288272 19200415 19189212 20065188 19115204 18821012 20135344 16873071 19066611 21138602 17440819 18997820 18351453 19103187 20005174
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9916192424 16227642 16124888 15700767 18705752 15673190 16050911 15721981 3786805 16097048 16011737 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7118788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7116924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 16120746 18670907
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.1717681005 17333356 16105132 17110522 16919318 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 8.1719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1612621046 8697196 15668235 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6319279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.3921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.3911566570 4309450 7179309 7440962 10092053 10915739 6884620 6623471 7120509 15998439 3732212 21278145 15027814 17522070 19336974 9327722 2869522 16227642 16177239 3786805 19085960 15968718
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 9.3916221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.6212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.6219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1520544844 16202921 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.2312631006 16239168 12795759 61145 17595544 16045604 15959796 19224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.2315345470
MESH:D005234 Fatty Liver pirinixic acid 20.2320131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 20.2319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 9.3318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3320067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919900420 19110552
MESH:D006529 Hepatomegaly fumonisin B1 15.7916221962
MESH:D006529 Hepatomegaly pirinixic acid 15.7916221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.7915340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 15340226 16354765 16959395 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0317937319
MESH:D007248 Infertility, Male vinclozolin 7.0316467254
MESH:D007249 Inflammation Tamoxifen 5.1619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1612200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8716705839
MESH:D007680 Kidney Neoplasms Tamoxifen 7.8718625569
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008064 Lipidoses Tamoxifen 3.2717567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8916221502 11903743 11408273 17174718 16943688 21278145 17157831 16239168 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0616097048 15370692 17900296 18472332 16033810 12546737 16192424 12649538 12586293 17805973 12632512 17698563 17976157 14724832 18339082 15673190 18376398 17481882 12609069 14512876 18395095 11481614 18418968 12666154 12667390 14620537 17565644 16015684 17525996 14716496 17640975 15057751 12741479 20821823 12445421 12632514 18420326 17944888 18187930 12898905 15876570 17869086 18251166 12389079 16027843 18166357 15996030 17761835 15893842 17922224 18429990 14748882 15362042 15931870 15052691 17823541 15123356 15925388 15959796 12445418 15650968 18472094 14716833 18481824 18263696 16638106 17766677 18277467 12958196 15338365 16116963 18705752 17721639 18412020 17714472 17708605 10355542 18395914 18156304 18210741 18279442 18054572 13678700 15818738 18317297 18006644 18205269 17557913 16011737 16248980 17631135 16136751 15730626
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.0618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0612878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1216964402 17285989 15720792 15830285 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8514706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.1619294768
MESH:D008113 Liver Neoplasms pirinixic acid 11.1615890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 11.1616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1616984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1012151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.2918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2911884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 6.7011921183
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.7014580682 19196722 11731420 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.8119453300
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5916049721 12819281
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2911118676 11896295 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.2919015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1215067354
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6418551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4616709447
MESH:D013088 Spermatocele Tamoxifen 12.4616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2819457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2316049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.238653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018