AutismKB 2.0

Annotation Detail for MYO5B


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Basic Information Top
Gene Symbol:MYO5B ( KIAA1119 )
Gene Full Name: myosin VB
Band: 18q
Quick LinksEntrez ID:4645; OMIM: 606540; Uniprot ID:MYO5B_HUMAN; ENSEMBL ID: ENSG00000167306; HGNC ID: 7603
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
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Related Diseases/Disorders Top
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Desease Name
Microvillus inclusion disease
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MYO5B mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MYO5B mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MYO5B mRNAdecreases expression 20106945
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of MYO5B mRNAaffects cotreatment|increases expression 17347304
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of MYO5B mRNAaffects cotreatment|increases expression 17347304
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of MYO5B mRNAincreases expression 17616710
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of MYO5B mRNAincreases expression 16221955
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MYO5B mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of MYO5B mRNAincreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MYO5B mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of MYO5B mRNAincreases expression 18301758
20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of MYO5B mRNA]increases expression|increases reaction 20059764
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 9.6518926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.656195326
MESH:D000138 Acidosis Ammonium Chloride 11.4418287403
MESH:D000138 Acidosis Ethanol 11.4411192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.0917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0916434500
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.6415451040 15451039
MESH:D000853 Anophthalmos Ethanol 5.0815513904
MESH:D001008 Anxiety Disorders Ethanol 4.1711141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D002056 Burns Ethanol 4.9116374292
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8216705839
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.8218788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.826705139 20935162 1701930 17173139 20007298
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Ethanol 3.5419332462
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.906135515
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D002971 Cleft Lip Ethanol 3.6815513904
MESH:D002972 Cleft Palate Ethanol 3.2515513904
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3315513904 15451040 15451039 11198716 19302082 10194807 11873399
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003967 Diarrhea marker/mechanism 18724368
OMIM:251850 DIARRHEA 2, WITH MICROVILLUS ATROPHY marker/mechanism
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.2618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Ethanol 4.2611566570
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D004487 Edema perfluorooctanoic acid 7.6717259670 12083418
MESH:D004487 Edema pirinixic acid 7.6712083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.1911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.6316530937
MESH:D004938 Esophageal Neoplasms Ethanol 7.6316704527
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.6316510608 16704527 15547733 15547721 15264214 15623463 15878914 15150132 16805852
MESH:D005234 Fatty Liver Ethanol 14.5616409862 18620774 19236843
MESH:D005234 Fatty Liver Fish Oils 14.5618620774
MESH:D005234 Fatty Liver pirinixic acid 14.5619236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.9817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.5816946407 15451040 10194807 15513904
MESH:D005756 Gastritis Ethanol 5.0115046732
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006529 Hepatomegaly perfluorooctanoic acid 16.123609246
MESH:D006529 Hepatomegaly Phenobarbital 16.1216109766
MESH:D006529 Hepatomegaly pirinixic acid 16.1219176532 16221962 19772884 18467677
MESH:D006930 Hyperalgesia Ethanol 8.7918783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 8.7912083418
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Fish Oils 4.9715752949
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.8211484837
MESH:D007249 Inflammation perfluorooctanoic acid 3.1512083418
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007410 Intestinal Diseases marker/mechanism 18724368
MESH:D007569 Jaw Abnormalities Ethanol 4.6115513904
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1516705839
MESH:D007859 Learning Disorders Ethanol 4.4715451040
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.518812269
MESH:D017880 Limb Deformities, Congenital Ethanol 3.9617676605
MESH:D008103 Liver Cirrhosis Ethanol 7.1915289165
MESH:D008103 Liver Cirrhosis Phenobarbital 7.1921047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.3818295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.5818166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5815474484
MESH:D008107 Liver Diseases Phenobarbital 2.2119363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.9117207112 17347304
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.997678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.9920195826 21137059
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 14.9918709148 14757943
MESH:D008113 Liver Neoplasms Phenobarbital 14.998742319 19812893 21047994 19073162 19482888 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 14.9915890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.352876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.3518308698 17172636 6150874 1399818 2563599
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5620135361 20464547 20869020 18569708 17053015 18816296 20064080 18520028 6695378
MESH:D008569 Memory Disorders Ethanol 4.4218411066 15451040
MESH:D008661 Metabolism, Inborn Errors marker/mechanism 18724368
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.1518551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1311141357
MESH:D009369 Neoplasms pirinixic acid 5.1317405874
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.219802331
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6216049721
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010190 Pancreatic Neoplasms Ethanol 5.6712384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.6716965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.802563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.6817132714
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012640 Seizures 2,6-dinitrotoluene 10.7018551238
MESH:D012640 Seizures Ethanol 10.709754883
MESH:D012640 Seizures Phenobarbital 10.703137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.5620155912 2093021
MESH:D013274 Stomach Neoplasms Ethanol 3.5618456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.5617575124 12958204
MESH:D013276 Stomach Ulcer Ethanol 3.739211565 9562338 17918041 16755016 11906479 17189318
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.459754883
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.211399818
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2117053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
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Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31408
    • No data
    Releated disease ID Related disease Name
    PA162355648microvillus inclusion disease
    Releated drug ID Related drug Name
    PA449014cisplatin
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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