AutismKB 2.0

Annotation Detail for MYO6


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Basic Information Top
Gene Symbol:MYO6 ( DFNA22,DFNB37,KIAA0389 )
Gene Full Name: myosin VI
Band: 6q14.1
Quick LinksEntrez ID:4646; OMIM: 600970; Uniprot ID:MYO6_HUMAN; ENSEMBL ID: ENSG00000196586; HGNC ID: 7605
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Synaptic Transmission
Membrane Trafficking
Pathway IDPathway Name
200155Stabilization and expansion of the E-cadherin adherens junction
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
Pathway IDPathway Name
500171Trafficking of AMPA receptors
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
2207Deafness
No data
No data
Desease Name
Deafness, autosomal recessive 37
Deafness, autosomal dominant 22
Deafness, sensorineural, with hypertrophic cardiomyopathy
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of MYO6 mRNAincreases expression 17258074
C053541 bicalutamide bicalutamide results in increased expression of MYO6 mRNAincreases expression 15790403
16631469
D003010 Clorgyline Clorgyline results in increased expression of MYO6 mRNAincreases expression 19691856
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of MYO6 geneincreases mutagenesis 17329413
D005472 Fluorouracil MYO6 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D008727 Methotrexate MYO6 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of MYO6 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of MYO6 mRNAdecreases expression 19244175
D014635 Valproic Acid Valproic Acid results in increased expression of MYO6 mRNAincreases expression 19101580
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of MYO6 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of MYO6 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 9.7912039119
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.798875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D000230 Adenocarcinoma arsenic trioxide 4.6619825857 11798837
MESH:D000230 Adenocarcinoma Fluorouracil 4.6617638652
MESH:D000236 Adenoma Ethylnitrosourea 3.836695378
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D000740 Anemia Fluorouracil 3.9017963324 16511603 15504547
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1417286800
MESH:D001321 Autistic Disorder Valproic Acid 1.9917507914 18396377 15238991 18940202 18985861 17157402 18316065 18775368 20603192 19460635 18558336 16609825 19232924 17688650 18177632
MESH:D001714 Bipolar Disorder Valproic Acid 3.1717594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8816206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.528888407
MESH:D001927 Brain Diseases Ethylnitrosourea 5.0714991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.4818412241 16436596 16651633 16357521 15144691
MESH:D001943 Breast Neoplasms Fluorouracil 2.5519217205 18357371 16557594 15136595 16110121 16595493 18608205
MESH:D001943 Breast Neoplasms Methotrexate 2.5516978400
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9916051944
MESH:D002277 Carcinoma Fluorouracil 3.7317121937
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.2315073043 16217749 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.2316799960 16332177 18930000 17971768 17088986 17045692
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1018695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5418986760 17066447 16280240 16757204
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.8616003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.3017160924
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2617725105 17169374 16510598 18772588 15001691 17287894 17016597 16340194 17172411 17018589
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5920501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5920501625 17016601 17401013 14970324 17695437 16391804 18802399 17255274 16303861 18288408 18509181 17094418 16282729 18448328 18383874 15289873 17454858 18949393 15148649 17594712 16524972 16331619
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.6310525206
MESH:D019465 Craniofacial Abnormalities Methotrexate 5.639562676 12039119
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.638888407 16575769 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.6319769572
MESH:D003550 Cystic Fibrosis Methotrexate 4.4319747007
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
OMIM:606346 DEAFNESS, AUTOSOMAL DOMINANT 22;DFNA22 DEAFNESS, AUTOSOMAL DOMINANT 22, WITH HYPERTROPHIC CARDIOMYOPATHY, marker/mechanism
OMIM:607821 DEAFNESS, AUTOSOMAL RECESSIVE 37 marker/mechanism
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003882 Dermatomyositis Methotrexate 5.3620191521
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1815131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.181733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.3018357618
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.413659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0318234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.777562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7512903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7516785472 16337965 16481741 15173087 17638652
MESH:D005234 Fatty Liver arsenic trioxide 8.6115073043
MESH:D005234 Fatty Liver Valproic Acid 8.6119224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.378888407 18558336
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005909 Glioblastoma Ethylnitrosourea 3.9516436596
MESH:D005910 Glioma Ethylnitrosourea 6.5816357521 18412241 16651633
MESH:D005910 Glioma Fluorouracil 6.5816145905
MESH:D006086 Graft vs Host Disease Methotrexate 5.4116518429
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5218337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0816080930
MESH:D006333 Heart Failure Selenium 3.1917162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D007251 Influenza, Human Selenium 12.0416624496
MESH:D007251 Influenza, Human Vitamin E 12.0416624496
MESH:D007674 Kidney Diseases Vitamin E 2.9112488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 8.4117379185
MESH:D007680 Kidney Neoplasms Fluorouracil 8.4116985049
MESH:D007805 Language Development Disorders Methotrexate 5.329562676
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0119850784 17050201 16467208 16968895 20471514
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0117596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3416966277 17107899 17869043 19642359 19225113 17649720 12679006 17712046 16331271 16823087 15622746 11468182 15748426 19035177 11161223 19075265 16330433 16891316 15336539 9834237 16112521 12712474 15213294 12018890 17217047
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008103 Liver Cirrhosis Methotrexate 3.8014986274
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008113 Liver Neoplasms arsenic trioxide 4.9414682389
MESH:D008113 Liver Neoplasms Fluorouracil 4.9416603448 18383874 17045692 15113037
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8520377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D017563 Lung Diseases, Interstitial Methotrexate 12.5518516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 12.5517228818
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0911798837 19825857
MESH:D008175 Lung Neoplasms Ethylnitrosourea 5.0916271038 17703301 16019985 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 5.0915246190
MESH:D008175 Lung Neoplasms Vitamin E 5.0911062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D008223 Lymphoma Ethylnitrosourea 8.5815790496
MESH:D008223 Lymphoma Methotrexate 8.5817352296
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.3115375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 6.7910767621 10838139 18041768
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.7915318939
MESH:D008579 Meningioma Ethylnitrosourea 6.3017943659
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D008881 Migraine Disorders Valproic Acid 3.3318765137 18803445
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7916757204 18986760
MESH:D052016 Mucositis Methotrexate 5.5717488658
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2519549372 19417148 15949261 14977855 11468182
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.7816105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.7817596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009369 Neoplasms Fluorouracil 2.7018239605 18600527 16928823
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.6616707424
MESH:D009436 Neural Tube Defects arsenic trioxide 7.7510525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.7516359493 8888407
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.7017160924 16003739 16651423
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.3017160924
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4619769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5715580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.5716929163 19003803 16500647 15113037
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1120603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8919131511
MESH:D011471 Prostatic Neoplasms bicalutamide 1.8915638997 18487222 19240160 19011039 17914592
MESH:D011471 Prostatic Neoplasms Clorgyline 1.8919691856
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8918626508 19082440
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8915084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.8612752131 11422049
MESH:D011565 Psoriasis Methotrexate 3.4917410198
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1916160472 18286688 18722050 15538739
MESH:D051437 Renal Insufficiency Methotrexate 4.9717352296
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8714763951 15475178 16876388 3137016 11738929 1511512 17978042 11044598
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5717007042
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5716951190 18396642 15786421 17522103 19015929 16424979 19084572 17498489 18567086 17172411
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D013576 Syndactyly Methotrexate 5.279562676
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.4515790496
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5511780464 20435036 12845720 12973940
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0716803524
Pathway ID Pathway Name
REACT:11123 Membrane Trafficking
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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