AutismKB 2.0

Annotation Detail for MYO7A


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Basic Information Top
Gene Symbol:MYO7A ( DFNA11,DFNB2,MYOVIIA,MYU7A,NSRD2,USH1B )
Gene Full Name: myosin VIIA
Band: 11q13.5
Quick LinksEntrez ID:4647; OMIM: 276903; Uniprot ID:MYO7A_HUMAN; ENSEMBL ID: ENSG00000137474; HGNC ID: 7606
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2207Deafness
Desease Name
VISION
usher syndrome
hearing loss, sensorineural nonsyndromic
No data
Desease Name
Usher syndrome, type 1B
Deafness, autosomal recessive 2, neurosensory
Deafness, autosomal dominant 11, neurosensory
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of MYO7A mRNAincreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MYO7A mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MYO7A mRNAaffects expression 16483693
D001194 Asbestos Asbestos affects the expression of MYO7A mRNAaffects expression 17297452
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of MYO7A mRNAincreases expression 14729362
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MYO7A mRNAincreases expression 17606305
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of MYO7A geneincreases mutagenesis 15965244
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of MYO7A mRNAdecreases expression 20713471
C006253 pirinixic acid pirinixic acid results in decreased expression of MYO7A mRNAdecreases expression 17426115
C020806 tetrabromobisphenol A tetrabromobisphenol A affects the expression of MYO7A mRNAaffects expression 18976794
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MYO7A mRNAincreases expression 19933214
D014212 Tretinoin Tretinoin results in increased expression of MYO7A proteinincreases expression 17331193
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma Ethylnitrosourea 7.466695378
MESH:D000236 Adenoma Methylcholanthrene 7.466695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4215885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3716456186
MESH:D050197 Atherosclerosis Asbestos 7.5218795166
MESH:D050197 Atherosclerosis Methylcholanthrene 7.5211922910
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.9319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.9312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.9316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001927 Brain Diseases Ethylnitrosourea 4.9814991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.3916651633 18412241 15144691 16357521 16436596
MESH:D001943 Breast Neoplasms Methylcholanthrene 1.9217474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7416813970
MESH:D002277 Carcinoma Methylcholanthrene 8.6310545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.6316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0516705839
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.051917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3216051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 16120746 18670907
MESH:D002386 Cataract Tretinoin 3.1517460283
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 7.5316003739
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.5316192471
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.1617160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0117110522 16105132 17333356 11677210 15861022 17681005 16919318
MESH:D002779 Cholestasis pirinixic acid 8.0119176532
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9012621046 8697196 16354765 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 5.909407595
MESH:D003092 Colitis Tretinoin 3.8417035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4815322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4817551590 9142499 16925845 8800419 10589399 14991402 9211117 9664655 9125849 9224671
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1518551238
OMIM:601317 DEAFNESS, AUTOSOMAL DOMINANT 11 marker/mechanism
OMIM:600060 DEAFNESS, AUTOSOMAL RECESSIVE 2 marker/mechanism
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.7918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.1618357618
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.5318230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.5318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.1116938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.9115345470
MESH:D005234 Fatty Liver pirinixic acid 7.9120131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.0910962813 14633661
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0920067830
MESH:D005355 Fibrosis Tretinoin 9.0917994277
MESH:D005909 Glioblastoma Ethylnitrosourea 7.6516436596
MESH:D005909 Glioblastoma Tretinoin 7.6517312396
MESH:D005910 Glioma Ethylnitrosourea 3.5316651633 16357521 18412241
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.729664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.7316221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216959395 15340226 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Tretinoin 3.3016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.3017551590 15992940
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.0216705839
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 8.0217379185
MESH:D007938 Leukemia Tretinoin 2.8217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8116482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0919850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2217217047 19035177 17107899 17649720 17368321 17506722 16935935 17294898 17301526 9834237 15748426 16891316 16331271 17361223 17339181 17712046 16140955 16788101 16766008 16823087 19225113 19642359 19075265 19029980 12679006
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.389224671
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4616248980 18397230
MESH:D008113 Liver Neoplasms pirinixic acid 4.3715890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3716984957
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 6.22598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2212151625
MESH:D008175 Lung Neoplasms Asbestos 5.0712111688
MESH:D008175 Lung Neoplasms Ethylnitrosourea 5.0717703301 16019985 16271038 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 5.0720512841 7750092 6695378 16337739 11893704 9230183 17909032 20970405 21163286 1399818 10545420 16271038 15390079
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0719555203 11884234
MESH:D008223 Lymphoma Ethylnitrosourea 4.0215790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.1915375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.5818041768 10767621 10838139
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008579 Meningioma Ethylnitrosourea 6.1617943659
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D008654 Mesothelioma Asbestos 4.1218709470 16564556 18310086 16319530 16919927
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0118551238
MESH:D009369 Neoplasms pirinixic acid 5.0817405874
MESH:D009369 Neoplasms Tretinoin 5.0816946489 16594593
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.5416707424
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.9414600291
MESH:D009421 Nervous System Malformations Tretinoin 9.949125849
MESH:D009436 Neural Tube Defects Tretinoin 3.129142499
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.5716651423 16003739 17160924
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5316049721 12819281
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.1617160924
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3716936753
MESH:D010146 Pain Tretinoin 2.9916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411222880 11399792 11118676 11896295
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2216283617 16116481
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6018551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.718532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7116192470
MESH:D012878 Skin Neoplasms Tretinoin 9.7116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.3115790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1117045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.8916051514
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3216049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4710091137
MESH:D052245 Usher Syndromes marker/mechanism 15965244
OMIM:276900 USHER SYNDROME, TYPE I marker/mechanism
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7816752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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