AutismKB 2.0

Annotation Detail for MYO9B


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Basic Information Top
Gene Symbol:MYO9B ( CELIAC4,MYR5 )
Gene Full Name: myosin IXB
Band: 19p13.11
Quick LinksEntrez ID:4650; OMIM: 602129; Uniprot ID:B0I1T6_HUMAN; ENSEMBL ID: ENSG00000099331; HGNC ID: 7609
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
No data
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1807Autoimmune disease
1998Enteritis
2069Schizophrenia
2094Ulcerative colitis
2146Lupus erythematosus
2171Celiac disease
2220Dermatitis
Desease Name
IMMUNE
Crohn's disease ulcerative colitis
celiac disease lupus erythematosus rheumatoid arthritis
No data
Desease Name
Celiac disease, susceptibility to, 4
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MYO9B mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of MYO9B mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of MYO9B mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MYO9B mRNAaffects expression 16483693
C032036 bromobenzene bromobenzene results in decreased expression of MYO9B mRNAdecreases expression 15056800
C056516 exemestane exemestane results in increased expression of MYO9B mRNAincreases expression 17254854
D005996 Nitroglycerin Nitroglycerin results in decreased expression of MYO9B mRNAdecreases expression 12102619
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MYO9B mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms exemestane 2.6116002280 17892469 17952589
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.6120435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.9116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002446 Celiac Disease marker/mechanism
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.936135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915668235 8697196 12621046 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.5118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.5117562736 11461765 12392966 14986274 12594235 12705907 19164858 16081117 14550746 14725611 16177239 16227642 11529661 10663392 19420014 16781746 16485898 11421492 18713872 18071297 12540782 12958197 11743745 17522070 11739529 11834606 15968718 12153990 19923254 11287661 2444490 10915739 16393943 19739265 19370779 16109766 19085960 19416960 10774834 17906064 15619225
MESH:D056486 Drug-Induced Liver Injury bromobenzene 9.5112628495 10092053
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.5120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006261 Headache Nitroglycerin 5.5611554966 11284996
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216354765 15340226 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1816705839
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6719460945 16610002 12969438 16611625 19784758 11587558 12587719 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.637678174
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.202876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2012151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008708 Methemoglobinemia Nitroglycerin 4.993537620
MESH:D020326 Migraine without Aura Nitroglycerin 5.4114659530
MESH:D009203 Myocardial Infarction Nitroglycerin 3.8714729435
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2018551238 7678174
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311222880 11896295 11399792 11118676
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6918551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3716049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
REACT:11044 Signaling by Rho GTPases
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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