AutismKB 2.0

Annotation Detail for MYOC


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Basic Information Top
Gene Symbol:MYOC ( GLC1A,GPOA,JOAG,JOAG1,TIGR,myocilin )
Gene Full Name: myocilin, trabecular meshwork inducible glucocorticoid response
Band: 1q24.3
Quick LinksEntrez ID:4653; OMIM: 601652; Uniprot ID:MYOC_HUMAN; ENSEMBL ID: ENSG00000034971; HGNC ID: 7610
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1808Eye disease
1872Chronic simple glaucoma
2060Glaucoma
2178Retinal disease
Desease Name
glaucoma, primary open-angle
VISION
glaucoma
Myopia
primary open-angle glaucoma
No data
Desease Name
Glaucoma, early-onset, digenic
Glaucoma 1A, primary open angle, juvenile-onset
Glaucoma 1A, primary open angle, recessive
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MYOC mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MYOC mRNAaffects expression 16483693
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of MYOC geneincreases mutagenesis 16495775
D014212 Tretinoin Tretinoin results in decreased expression of MYOC mRNAdecreases expression 18230668
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1918287403
MESH:D000236 Adenoma Ethylnitrosourea 3.926695378
MESH:D000505 Alopecia Tretinoin 3.9415955085
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.3016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.9116935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 4.0316197459 16206674
MESH:D001927 Brain Diseases Ethylnitrosourea 5.2814991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.6815144691 16436596 16357521 16651633 18412241
MESH:D001943 Breast Neoplasms Tretinoin 2.2316873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.2216813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.8816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.013084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.011917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716096774 16051514
MESH:D002386 Cataract Acetaminophen 7.9210977129
MESH:D002386 Cataract Tretinoin 7.9217460283
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.9816003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.7117160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.2216129372
MESH:D002822 Choriocarcinoma Tretinoin 5.8816461808
MESH:D002972 Cleft Palate Tretinoin 2.809407595
MESH:D003092 Colitis Tretinoin 4.2617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8316925845 14991402 9142499 8800419 17551590 9664655 10589399 9224671 9125849 9211117
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6711739529 17906064 19923254 11287661 19164858 16227642 12540782 19416960 12392966 18071297 2444490 11461765 10774834 10915739 16081117 17522070 15619225 14550746 19085960 11421492 12594235 16781746 17562736 14725611 11529661 11834606 16393943 12153990 10663392 12705907 16109766 15968718 19370779 14986274 19420014 19739265 16485898 12958197 16177239 18713872 11743745
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.7118357618
MESH:D004489 Edema, Cardiac Tretinoin 5.1918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3516569247
MESH:D005124 Eye Abnormalities Tretinoin 3.8716938888 9664655
MESH:D005355 Fibrosis Tretinoin 4.0717994277
MESH:D005756 Gastritis Acetaminophen 4.4016983495
OMIM:137750 GLAUCOMA 1, OPEN ANGLE, A marker/mechanism
MESH:D005909 Glioblastoma Ethylnitrosourea 8.2316436596
MESH:D005909 Glioblastoma Tretinoin 8.2317312396
MESH:D005910 Glioma Ethylnitrosourea 3.6216357521 16651633 18412241
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.8816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0714991402 9664655
MESH:D006930 Hyperalgesia Acetaminophen 8.7216870215
MESH:D006930 Hyperalgesia Tretinoin 8.7216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.1316778211
MESH:D007410 Intestinal Diseases Tretinoin 4.3317994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.3317551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.4015629191 12587719
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.2717379185
MESH:D007938 Leukemia Tretinoin 2.9317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.1216482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1219850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.399834237 17649720 16935935 19075265 19225113 16823087 17217047 17294898 17301526 19642359 17368321 17361223 15748426 12679006 16766008 16788101 19029980 17712046 16331271 17107899 19035177 17339181 16140955 16891316 17506722
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.589224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.7019460945 11587558 19014921 16610002 12969438 12587719 19784758 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6316871587 17185352
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.636695378 16019985 17703301 16271038
MESH:D008223 Lymphoma Ethylnitrosourea 4.2215790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.6115375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.7418041768 10767621 10838139
MESH:D008527 Medulloblastoma Tretinoin 2.9117453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008579 Meningioma Ethylnitrosourea 6.7117943659
MESH:D008591 Meningomyelocele Tretinoin 4.9916940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2817596541
MESH:D009369 Neoplasms Tretinoin 2.5716594593 16946489
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.9616707424
MESH:D009421 Nervous System Malformations Tretinoin 4.289125849
MESH:D009436 Neural Tube Defects Tretinoin 3.299142499
MESH:D009442 Neurilemmoma Ethylnitrosourea 6.0516003739 16651423 17160924
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.7117160924
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4416936753
MESH:D010146 Pain Acetaminophen 7.7516870215
MESH:D010146 Pain Tretinoin 7.7516870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5715976015
MESH:D011507 Proteinuria Tretinoin 4.0716636307
MESH:D011625 Pterygium Tretinoin 5.4216723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5616116481 16283617
MESH:D012878 Skin Neoplasms Tretinoin 2.7616467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.7915790496
MESH:D013964 Thyroid Neoplasms Tretinoin 3.3316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1816051514
MESH:D014376 Tuberculosis Tretinoin 3.4516040207
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0716129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.3316752155
MESH:D014820 Vitiligo Tretinoin 4.5616761959
MESH:D009396 Wilms Tumor Tretinoin 4.3416287080
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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