AutismKB 2.0

Annotation Detail for PPP1R12B


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Basic Information Top
Gene Symbol:PPP1R12B ( FLJ40942,MGC131980,MGC87886,MYPT2 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 12B
Band: 1q32.1
Quick LinksEntrez ID:4660; OMIM: 603768; Uniprot ID:MYPT2_HUMAN; ENSEMBL ID: ENSG00000077157; HGNC ID: 7619
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PPP1R12B mRNAdecreases expression 20064835
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of PPP1R12B mRNAdecreases expression 17490981
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PPP1R12B mRNAaffects binding|decreases expression|increases activity 19710929
D013629 Tamoxifen Tamoxifen affects the expression of PPP1R12B mRNAaffects expression 14699072
D014810 Vitamin E Vitamin E results in increased expression of PPP1R12B mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0517474063 20146248
MESH:D001943 Breast Neoplasms Tamoxifen 2.0515668708 16202921 20390343 20135344 19289846 19115204 16873071 19084267 18425577 17893378 19103187 19066611 19200415 19059307 17261762 17242785 18997820 18815881 19487384 19189212 19410462 20065188 17049068 11161223 18984771 19189210 19011961 16818667 21152245 19221464 17440819 20544844 18821012 18351453 19288272 19244106 20859285 15565566 20005174 19142967 21138602 16273361 18855134 19155303 18629630
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.4116050911
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8516924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9617572228
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8019279558
MESH:C538011 Eales disease Vitamin E 5.329068938
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.9819031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2620544844 17893378 16202921 19155303
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver pirinixic acid 8.9420131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 8.9419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.2320471113
MESH:D006330 Heart Defects, Congenital Vitamin E 7.2316080930
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4819772884 16221962 18467677 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8016863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.5814716179
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007249 Inflammation Tamoxifen 2.5119457130
MESH:D007251 Influenza, Human Vitamin E 4.8316624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007674 Kidney Diseases Vitamin E 2.9812488133
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3518625569
MESH:D008064 Lipidoses Tamoxifen 3.4015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.6518564211
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.6516169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.0321137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 8.0320007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 8.0316684651
MESH:D008171 Lung Diseases Vitamin E 3.4016863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6018520028 18569708 20064080 17053015 18816296 20464547 20135361 20869020 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 3.6018625569
MESH:D008175 Lung Neoplasms Vitamin E 3.6011062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8319196723 19196722 16827153 14580682 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 5.1619453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3311141357
MESH:D009369 Neoplasms pirinixic acid 5.3317405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119189210 19196722 19200415
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4717292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4715067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.4715084515
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012871 Skin Diseases Vitamin E 2.5118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5119755658 10029692
MESH:D013088 Spermatocele Tamoxifen 4.9016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.8116517955
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3817053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.388653321 17572228 16712894
Pathway ID Pathway Name
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33618
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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