AutismKB 2.0

Annotation Detail for NAB1


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Basic Information Top
Gene Symbol:NAB1 ( - )
Gene Full Name: NGFI-A binding protein 1 (EGR1 binding protein 1)
Band: 2q32.2
Quick LinksEntrez ID:4664; OMIM: 600800; Uniprot ID:NAB1_HUMAN; ENSEMBL ID: ENSG00000138386; HGNC ID: 7626
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C021296 2-ethoxyethanol 2-ethoxyethanol results in increased expression of NAB1 mRNAincreases expression 19643169
D000082 Acetaminophen Acetaminophen affects the expression of NAB1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NAB1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NAB1 mRNAdecreases expression 20018196
D002945 Cisplatin NAB1 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D007545 Isoproterenol [Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB1 mRNAaffects cotreatment|increases expression 10710348
C005219 methyl cellosolve methyl cellosolve results in increased expression of NAB1 mRNAincreases expression 19643169
D009151 Mustard Gas Mustard Gas results in increased expression of NAB1 mRNAincreases expression 15674843
D010634 Phenobarbital Phenobarbital results in increased expression of NAB1 mRNAincreases expression 12082028
D010656 Phenylephrine [Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB1 mRNAaffects cotreatment|increases expression 10710348
C006253 pirinixic acid pirinixic acid results in increased expression of NAB1 mRNAincreases expression 18301758
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of NAB1 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen Tamoxifen affects the expression of NAB1 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of NAB1 mRNAaffects cotreatment|increases expression 19059307
D019772 Topotecan NAB1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
C025643 vinclozolin vinclozolin affects the expression of NAB1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6114745880
MESH:D000014 Abnormalities, Drug-Induced 2-ethoxyethanol 14.927151721 6499823 6499796 6499820 6499812
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 14.926499812 3652986 6474471
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 14.926195326
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D058186 Acute Kidney Injury Cisplatin 3.9915814532 12690470 17670903
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Cisplatin 2.7617638652 11798837
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.2917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.2916434500
MESH:D000419 Albuminuria Raloxifene 4.6317451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5515800139
MESH:D000748 Anemia, Macrocytic methyl cellosolve 6.413699323
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6619015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1417460149
MESH:D053627 Asthenozoospermia 2-ethoxyethanol 12.776499823 10689203 6499807
MESH:D053627 Asthenozoospermia methyl cellosolve 12.773987992
MESH:D001249 Asthma Mustard Gas 2.7210378619
MESH:D001259 Ataxia 2-ethoxyethanol 5.497151721
MESH:D001284 Atrophy 2-ethoxyethanol 11.5315850284 6499799
MESH:D001284 Atrophy methyl cellosolve 11.532626667 6705890 3699323
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D053713 Azoospermia 2-ethoxyethanol 5.626492198 6499807
MESH:D001724 Birth Weight 2-ethoxyethanol 6.582884743 6499823
MESH:D001768 Blister Mustard Gas 5.2119167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1719483382
MESH:D001836 Body Weight Changes 2-ethoxyethanol 5.777151721 6499796
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.9514601052
MESH:D001919 Bradycardia Isoproterenol 11.136740701
MESH:D001919 Bradycardia Phenylephrine 11.1315306635
MESH:D001930 Brain Injuries Raloxifene 4.5216580743
MESH:D001943 Breast Neoplasms Cisplatin 2.0319526202 18382427
MESH:D001943 Breast Neoplasms Raloxifene 2.0317893378 17261762 15572757 17242785 16912660 17049068 15758505 17595753 15775269 17952589 17440819 16837676
MESH:D001943 Breast Neoplasms Tamoxifen 2.0317440819 18855134 18997820 20135344 16873071 19189212 19084267 19115204 18821012 19103187 16273361 16202921 19200415 18351453 17049068 18984771 17242785 17893378 17261762 11161223 19059307 18815881 20859285 19221464 19011961 20544844 20065188 19142967 19410462 20005174 20390343 15565566 19288272 19155303 18425577 19189210 19487384 18629630 16818667 15668708 19066611 19289846 21152245 21138602 19244106
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0417687719 10378619
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5519066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.623084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.6217982673
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.6217173139 20007298 1701930 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6216924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0416685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.836189445 17066447 18337622
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.5917572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.5917572228
MESH:D006332 Cardiomegaly Isoproterenol 7.5911179087 7544033
MESH:D006332 Cardiomegaly Phenylephrine 7.5917124262 17287366 15728586 16170337 11754973 11179087
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4615775269
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.7420889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.294080065
MESH:D002764 Cholecystitis 2-ethoxyethanol 13.866499794
MESH:D002764 Cholecystitis methyl cellosolve 13.866499794
MESH:D002779 Cholestasis pirinixic acid 2.8519176532
MESH:D003072 Cognition Disorders Raloxifene 4.6615800139
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D000013 Congenital Abnormalities methyl cellosolve 4.846499821 12530607
MESH:D003456 Cryptorchidism vinclozolin 4.3814966744
MESH:D003643 Death 2-ethoxyethanol 6.036499796
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1917474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003928 Diabetic Nephropathies Raloxifene 9.1215920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.1219279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.5910774834 16109766 11743745 19085960 10663392 17906064 19164858 11421492 12153990 17522070 15619225 12392966 19739265 19370779 19923254 16485898 18713872 17562736 11739529 12958197 11529661 16177239 12594235 16393943 2444490 15968718 14550746 11287661 19420014 12705907 12540782 14986274 19416960 18071297 16781746 10915739 11461765 16081117 14725611 16227642 11834606
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Cisplatin 3.8815033597 12649298 19839026 12231392
MESH:D004421 Dystonia Phenobarbital 4.041851702
MESH:D004487 Edema Mustard Gas 11.7311428647 9260866 11402378 11428631
MESH:D004487 Edema pirinixic acid 11.7312083418
MESH:D004487 Edema Raloxifene 11.7315860553
MESH:D020964 Embryo Loss 2-ethoxyethanol 6.586499796
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.3615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0619155303 17893378 16202921 20544844
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.153659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.9311558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.576401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.297750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.073659116
MESH:D004890 Erythema Mustard Gas 5.219357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6520426865
MESH:D004938 Esophageal Neoplasms Cisplatin 4.6515464296 17638652 15173087 16481741 16785472
MESH:D005234 Fatty Liver pirinixic acid 13.3219236843 20131406
MESH:D005234 Fatty Liver Raloxifene 13.3217473493
MESH:D005234 Fatty Liver Tamoxifen 13.3214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2516709447
MESH:D005313 Fetal Death 2-ethoxyethanol 5.427151721 2884743 6499820 6499823 7198755
MESH:D005317 Fetal Growth Retardation 2-ethoxyethanol 5.456499796
MESH:D005327 Fetal Resorption 2-ethoxyethanol 12.886499820 6499812
MESH:D005327 Fetal Resorption methyl cellosolve 12.886499821 3987992 6499812 6474471
MESH:D020567 Fetal Weight 2-ethoxyethanol 13.862884743 7151721 6499820
MESH:D020567 Fetal Weight methyl cellosolve 13.866499821 6499812 6474471
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2319069698
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.523652986
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3616417039
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.7315102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.3219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.4415464296
MESH:D006331 Heart Diseases Raloxifene 3.5511110106
MESH:D006333 Heart Failure Isoproterenol 7.4318097624
MESH:D006333 Heart Failure pirinixic acid 7.4320558911
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.836499821
MESH:D006402 Hematologic Diseases 2-ethoxyethanol 5.4220172899 10514026
MESH:D006461 Hemolysis 2-ethoxyethanol 12.5517874071 19051582
MESH:D006461 Hemolysis methyl cellosolve 12.5517874071
MESH:D006529 Hepatomegaly Phenobarbital 8.6216109766
MESH:D006529 Hepatomegaly pirinixic acid 8.6216221962 18467677 19772884 19176532
MESH:D006689 Hodgkin Disease Cisplatin 3.6216170182 16200630
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006973 Hypertension Phenylephrine 5.698949925 12717712
MESH:D006973 Hypertension Raloxifene 5.6915787275 17577099
MESH:D006984 Hypertrophy Isoproterenol 11.1012791704
MESH:D006984 Hypertrophy Phenylephrine 11.1018502941 12791704
MESH:D007022 Hypotension Isoproterenol 4.836740701
MESH:D007247 Infertility, Female 2-ethoxyethanol 5.266499823
MESH:D007248 Infertility, Male 2-ethoxyethanol 11.716499823
MESH:D007248 Infertility, Male methyl cellosolve 11.713987992
MESH:D007248 Infertility, Male vinclozolin 11.7116467254
MESH:D007249 Inflammation Mustard Gas 5.2811402378 9260866 11428631 11428620 9357497 8975870 16001271 17524151 11428647
MESH:D007249 Inflammation Tamoxifen 5.2819457130
MESH:D007333 Insulin Resistance pirinixic acid 2.6516306350
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.2015464296
MESH:D007674 Kidney Diseases Acetaminophen 6.1815629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 6.1819839026 12649298 15190930 18289764 12231392
MESH:D007680 Kidney Neoplasms Tamoxifen 3.0718625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.8611231351
MESH:D007889 Leiomyoma Raloxifene 4.5316973256
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7816417039
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 4.526499821
MESH:D008064 Lipidoses Tamoxifen 3.1715342952 17567588
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9121047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3318564211
MESH:D008107 Liver Diseases Acetaminophen 3.9519014921 19784758 11587558 19460945 16610002 12969438 16611625 12587719
MESH:D008107 Liver Diseases Phenobarbital 3.9519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 7.4719812893 19482888 8742319 21047994 19073162 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 7.4720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 7.4716684651
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.7218308698 17172636 6150874 1399818 2563599
MESH:D008171 Lung Diseases Mustard Gas 3.4718702808 18161513
MESH:D008175 Lung Neoplasms Cisplatin 3.5911798837 6189445 17225452
MESH:D008175 Lung Neoplasms Mustard Gas 3.598781369 3148597
MESH:D008175 Lung Neoplasms Tamoxifen 3.5918625569
MESH:D008231 Lymphopenia methyl cellosolve 5.833699323
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6411731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.6119453300
MESH:D008545 Melanoma Cisplatin 3.4918505091 16248763 12374674 16809738 12393984 15577323 18176117 11135225 16432458 17761969 18332650 17023156 12883367
MESH:D008545 Melanoma Tamoxifen 3.4912393984 19393235
MESH:D018328 Melanoma, Amelanotic Cisplatin 11.6815990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 11.6815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008654 Mesothelioma Cisplatin 3.2517638057
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.6215863610
MESH:D009101 Multiple Myeloma Raloxifene 3.4616497877
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009203 Myocardial Infarction Isoproterenol 6.0816584858 16697266 19172585 16538859 19595682 17052832 15740881
MESH:D009203 Myocardial Infarction pirinixic acid 6.0819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5317484760
MESH:D009232 Myxoma Raloxifene 5.6216343187
MESH:D009336 Necrosis 2-ethoxyethanol 5.3920172899
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms Cisplatin 5.1516773208
MESH:D009369 Neoplasms pirinixic acid 5.1517405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0619189210 19196722 19200415
MESH:D009395 Nephritis, Interstitial Cisplatin 4.5515464296
MESH:D009447 Neuroblastoma Cisplatin 7.408761367
MESH:D009447 Neuroblastoma Topotecan 7.4015176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.758761367
MESH:D009503 Neutropenia Mustard Gas 4.0016761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009845 Oligospermia 2-ethoxyethanol 11.5520172899
MESH:D009845 Oligospermia methyl cellosolve 11.553987992
MESH:D010018 Osteomalacia Phenobarbital 4.4117016548
MESH:D010024 Osteoporosis Raloxifene 3.4117882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2617823083 15579764 17893378 15758505
MESH:D010051 Ovarian Neoplasms Cisplatin 2.8817225452 19769630 15464296 6897625
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.5019003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.5016965848
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.3415464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.4117638057
MESH:D011041 Poisoning Mustard Gas 3.8315727166
MESH:D011230 Precancerous Conditions Phenobarbital 3.652563599
MESH:D011297 Prenatal Exposure Delayed Effects 2-ethoxyethanol 16.962884743 6499817 7198755
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 16.967974496 12530607 6499817
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 16.9618220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.9818220299
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3616220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3615067354
MESH:D011472 Prostatitis vinclozolin 4.9818629315
MESH:D011537 Pruritus Mustard Gas 4.1418058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.5612752131
MESH:D011654 Pulmonary Edema Isoproterenol 5.3110903255
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9417266442 10334151 17894541 17620002 17720292
MESH:D011693 Purpura Raloxifene 5.6215770314
MESH:D051437 Renal Insufficiency Cisplatin 4.4515464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.4614601052
MESH:D012640 Seizures Phenobarbital 2.713137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.876407741
MESH:D012852 Sinusitis Phenylephrine 4.757327846
MESH:D012871 Skin Diseases Mustard Gas 2.7216961503 12880345 15451306
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.4115464296
MESH:D013088 Spermatocele Tamoxifen 4.3516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0919457130
MESH:D013274 Stomach Neoplasms Cisplatin 2.3315958060 17522103 18396642
MESH:D013276 Stomach Ulcer 2-ethoxyethanol 4.416499799
MESH:D020521 Stroke Raloxifene 3.8416837676
MESH:D013733 Testicular Diseases 2-ethoxyethanol 11.2410514026 6499806 10048760
MESH:D013733 Testicular Diseases methyl cellosolve 11.246499806
MESH:D013736 Testicular Neoplasms Cisplatin 4.6615464296 17225452
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.071399818
MESH:D013978 Tibial Fractures Raloxifene 5.2719048282
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.5115464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.5117572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.5116712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.2316803524
MESH:D014625 Vaginal Neoplasms Cisplatin 4.6515577323
MESH:D054556 Venous Thromboembolism Raloxifene 5.2716837676
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 5.1618097624
MESH:D020257 Ventricular Remodeling Isoproterenol 5.7418097624
MESH:D014839 Vomiting Cisplatin 4.7811897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.6216343187
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31431
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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