AutismKB 2.0

Annotation Detail for NACA


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Basic Information Top
Gene Symbol:NACA ( MGC117224,NACA1 )
Gene Full Name: nascent polypeptide-associated complex alpha subunit
Band: 12q23-q24.1
Quick LinksEntrez ID:4666; OMIM: 601234; Uniprot ID:NACA_HUMAN; ENSEMBL ID: ENSG00000196531; HGNC ID: 7629
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1983Down syndrome
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of NACA mRNAdecreases expression 12958071
C006632 arsenic trioxide arsenic trioxide results in increased expression of NACA mRNAincreases expression 20458559
C099555 CD 437 CD 437 results in decreased expression of NACA mRNAdecreases expression 12958071
D016572 Cyclosporine Cyclosporine results in increased expression of NACA mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NACA mRNAincreases expression 17606305
C037219 quinoline quinoline analog results in decreased expression of NACA proteindecreases expression 18645022
D012402 Rotenone Rotenone results in increased expression of NACA mRNAincreases expression 19013527
D012643 Selenium Selenium results in decreased expression of NACA mRNAdecreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of NACA mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4411798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4414692618
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8816206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.6915553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular quinoline 3.69598648
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6612371664
MESH:D002779 Cholestasis Cyclosporine 8.2819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2817110522 11677210 16105132 17333356 17681005 15861022 16919318
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0115894690
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9616285004
MESH:D056486 Drug-Induced Liver Injury Selenium 4.2215131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.2215131321
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3512903497
MESH:D005234 Fatty Liver arsenic trioxide 14.3015073043
MESH:D005234 Fatty Liver Cyclosporine 14.3019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.3015345470
MESH:D005355 Fibrosis Cyclosporine 3.4012168785 12639820
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006333 Heart Failure Selenium 3.1917162251
MESH:D006390 Hemangioendothelioma quinoline 6.22598648
MESH:D006394 Hemangiosarcoma quinoline 5.20598648
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007251 Influenza, Human Selenium 4.5116624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.4014714311
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4418776723 10903974 8314463
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9012371664
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 17050201 16968895 19850784 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.349834237 15336539 16891316 12018890 19642359 17869043 19035177 17217047 15748426 12679006 12712474 17649720 19075265 19225113 17712046 11161223 16331271 15622746 16112521 16966277 15213294 16823087 11468182 16330433 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4014682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8520377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8719825857 11798837
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2814737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8815318939
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2515949261 19417148 14977855 11468182 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009362 Neoplasm Metastasis quinoline 4.11598648
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D009410 Nerve Degeneration Rotenone 4.0415790535 18619942 17356569
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2410525206
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.4112452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms CD 437 5.4117474084
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010300 Parkinson Disease Rotenone 3.0415451049 18619942 11535288 16140633 19114014 16412576 11445065 19232380 18191903
MESH:D020734 Parkinsonian Disorders Rotenone 4.2715795934 18197244 15927086 15574749
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2919131511
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2918760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.7212973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.7216720286
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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