AutismKB 2.0

Annotation Detail for NAGLU


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Basic Information Top
Gene Symbol:NAGLU ( MPS-IIIB,MPS3B,NAG,UFHSD )
Gene Full Name: N-acetylglucosaminidase, alpha
Band: 17q21.2
Quick LinksEntrez ID:4669; OMIM: 609701; Uniprot ID:ANAG_HUMAN; ENSEMBL ID: ENSG00000108784; HGNC ID: 7632
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04142Lysosome
hsa00531Glycosaminoglycan degradation
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Lysosomal storage diseases
H00130Mucopolysaccharidosis type III (MPS3)
Genetic disorders
Desease IDDesease Name
2027Connective tissue disease
No data
No data
Desease Name
Sanfilippo syndrome, type B
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NAGLU mRNAdecreases expression 18648102
D012643 Selenium Selenium results in increased expression of NAGLU mRNAincreases expression 19244175
D014212 Tretinoin Tretinoin results in increased expression of NAGLU mRNAincreases expression 17138961
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.983712494
MESH:D000505 Alopecia Tretinoin 3.9815955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.3216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3416292516
MESH:D001249 Asthma Tretinoin 2.4416456186
MESH:D001471 Barrett Esophagus Tretinoin 4.9916935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.8911289319 1440618
MESH:D001778 Blood Coagulation Disorders Tretinoin 4.0916197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2316873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.3316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 6.0316168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.167296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.161917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.847296757
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3816096774 16051514
MESH:D002386 Cataract Tretinoin 3.3217460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.057505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.3316129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.479022650 19486331
MESH:D002822 Choriocarcinoma Tretinoin 6.0316461808
MESH:D002972 Cleft Palate Tretinoin 2.819407595
MESH:D003092 Colitis Selenium 11.7617936198
MESH:D003092 Colitis Tretinoin 11.7617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 9125849 8800419 9211117 17551590 9664655 16925845 9142499 14991402 9224671
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.4411906362 18759878 2524372 12868966 11298694 8156756 14531868 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.023621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.2618692083 9653073 6679447 18648102 16192314 7440962 8291058 9022650 11289319 9328219 1440618 18289764 6482804
MESH:D056486 Drug-Induced Liver Injury Selenium 4.2615131321
MESH:D004489 Edema, Cardiac Tretinoin 5.3318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3716569247
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.193581430
MESH:D005124 Eye Abnormalities Tretinoin 3.909664655 16938888
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.896705139
MESH:D005355 Fibrosis Tretinoin 4.1617994277
MESH:D005909 Glioblastoma Tretinoin 3.2717312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.577505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 6.0316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0914991402 9664655
MESH:D006333 Heart Failure Selenium 3.3217162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.106705139
MESH:D006930 Hyperalgesia Tretinoin 3.5716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.2216778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5915034207
MESH:D007251 Influenza, Human Selenium 5.0616624496
MESH:D007410 Intestinal Diseases Tretinoin 4.4217994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.899022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 4.3917551590 15992940
MESH:D007676 Kidney Failure, Chronic Selenium 4.3716518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.356582329
MESH:D007938 Leukemia Tretinoin 2.9517143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.1816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1317596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.4217506722 17712046 19225113 19642359 16331271 17361223 17217047 16788101 17301526 17649720 16766008 16823087 17368321 17294898 19029980 17339181 12679006 19035177 16935935 9834237 15748426 17107899 19075265 16140955 16891316
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.629224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.78598648 3712494 1399818 6587162
MESH:D008325 Mammary Neoplasms, Experimental Selenium 3.0215318939
MESH:D008527 Medulloblastoma Tretinoin 2.9217453147
MESH:D008545 Melanoma Tretinoin 1.9916752155
MESH:D008591 Meningomyelocele Tretinoin 5.0816940565
MESH:D008654 Mesothelioma Selenium 2.9315107826
MESH:D009084 Mucopolysaccharidosis III marker/mechanism
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.3017596541
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.613581430
MESH:D009369 Neoplasms Tretinoin 2.5916946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.369125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 8.136679447
MESH:D009436 Neural Tube Defects Tretinoin 8.139142499
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.874026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.893988306
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4516936753
MESH:D010146 Pain Tretinoin 3.2816870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5815976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.137296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.346228378
MESH:D010954 Plasmacytoma Selenium 5.7615087411
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011507 Proteinuria Tretinoin 4.1316636307
MESH:D011625 Pterygium Tretinoin 5.5416723453
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.703692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.6316283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7816467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.291399818 6582329 6587162 7505956 3712494
MESH:D013964 Thyroid Neoplasms Tretinoin 8.2917045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.2416051514
MESH:D014376 Tuberculosis Tretinoin 3.4716040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.418074119
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.1216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.4816752155
MESH:D014820 Vitiligo Tretinoin 4.6416761959
MESH:D009396 Wilms Tumor Tretinoin 4.3916287080
Pathway ID Pathway Name
KEGG:00531 Glycosaminoglycan degradation
KEGG:04142 Lysosome
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00141 activator N-Acetyl-D-glucosamine Dietary supplement;Micronutrient
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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