AutismKB 2.0

Annotation Detail for ATF4


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Basic Information Top
Gene Symbol:ATF4 ( CREB-2,CREB2,TAXREB67,TXREB )
Gene Full Name: activating transcription factor 4 (tax-responsive enhancer element B67)
Band: 22q13.1
Quick LinksEntrez ID:468; OMIM: 604064; Uniprot ID:ATF4_HUMAN; ENSEMBL ID: ENSG00000128272; HGNC ID: 786
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04912GnRH signaling pathway
hsa04010MAPK signaling pathway
hsa04720Long-term potentiation
hsa04141Protein processing in endoplasmic reticulum
hsa04722Neurotrophin signaling pathway
hsa05215Prostate cancer
Pathway IDPathway Name
Diabetes pathways
Pathway IDPathway Name
200044Validated transcriptional targets of AP1 family members Fra1 and Fra2
Pathway IDPathway Name
P00006Apoptosis signaling pathway
Pathway IDPathway Name
500132PERK regulated gene expression
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
2045Bipolar disorder
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C106592 3,9-bis((ethylthio)methyl)-K-252a 3,9-bis((ethylthio)methyl)-K-252a results in increased expression of ATF4 mRNAincreases expression 15294995
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ATF4 mRNAdecreases expression 18648102
C105260 4-tert-octylphenol 4-tert-octylphenol results in decreased expression of ATF4 mRNAdecreases expression 17011747
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of ATF4 mRNAincreases expression 17011747
D000082 Acetaminophen Acetaminophen affects the expression of ATF4 mRNAaffects expression 17562736
15606129
D000082 Acetaminophen Acetaminophen results in increased expression of ATF4 mRNAincreases expression 11264010
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]decreases reaction|increases expression 15788408
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ATF4 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of ATF4 mRNAincreases expression 18305237
C015001 arsenite arsenite results in increased expression of ATF4 proteinincreases expression 18226606
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of ATF4 mRNAaffects expression 17331233
D001554 Benzene Benzene affects the expression of ATF4 mRNAaffects expression 15878777
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the activity of ATF4 proteinaffects activity 20624995
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ATF4 mRNAincreases expression 19150397
C006780 bisphenol A bisphenol A results in decreased expression of ATF4 mRNAdecreases expression 20678512
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in increased expression of ATF4 mRNAincreases expression 17553608
D002104 Cadmium Cadmium results in increased expression of ATF4 mRNAincreases expression 16759985
D002104 Cadmium Cadmium results in increased expression of ATF4 proteinincreases expression 16759985
D002104 Cadmium Cycloheximide inhibits the reaction [Cadmium results in increased expression of ATF4 protein]decreases reaction|increases expression 16759985
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of ATF4 mRNAincreases expression 16759985
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of ATF4 proteinincreases expression 16759985
D019256 Cadmium Chloride Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of ATF4 protein]decreases reaction|increases expression 16759985
D002211 Capsaicin Capsaicin results in increased expression of ATF4 proteinincreases expression 18533110
D002211 Capsaicin Cycloheximide inhibits the reaction [Capsaicin results in increased expression of ATF4 protein]decreases reaction|increases expression 18533110
D002392 Catechin Catechin results in increased expression of ATF4 mRNAincreases expression 15465739
C469298 CEP-11004 CEP-11004 results in increased expression of ATF4 mRNAincreases expression 15294995
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ATF4 mRNAaffects cotreatment|affects expression 17602206
D003513 Cycloheximide Cycloheximide inhibits the reaction [Capsaicin results in increased expression of ATF4 protein]decreases reaction|increases expression 18533110
D003513 Cycloheximide Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of ATF4 protein]decreases reaction|increases expression 16759985
D003513 Cycloheximide Cycloheximide inhibits the reaction [Cadmium results in increased expression of ATF4 protein]decreases reaction|increases expression 16759985
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ATF4 mRNAaffects cotreatment|affects expression 17602206
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of ATF4 mRNAincreases expression 17011747
D004317 Doxorubicin Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]decreases reaction|increases expression 16298333
D004317 Doxorubicin Doxorubicin results in decreased expression of ATF4 mRNAdecreases expression 16298333
D004958 Estradiol Estradiol affects the expression of ATF4 mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ATF4 mRNAincreases expression 19400957
16467188
17555576
16174780
17942748
D004997 Ethinyl Estradiol fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of ATF4 mRNA]decreases reaction|increases expression 16467188
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATF4 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ATF4 mRNAincreases expression 19400957
16174780
D005632 Fructose Fructose results in increased expression of ATF4 mRNAincreases expression 15150374
C070081 fulvestrant fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of ATF4 mRNA]decreases reaction|increases expression 16467188
C070081 fulvestrant fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ATF4 mRNA]decreases reaction|increases expression 16467188
D017313 Fenretinide Fenretinide results in increased expression of ATF4 mRNAincreases expression 17353921
16671099
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of ATF4 mRNAdecreases expression 12419474
C031927 hydroquinone hydroquinone results in increased expression of ATF4 mRNAincreases expression 15452088
D016627 Oxidopamine Oxidopamine results in increased expression of ATF4 mRNAincreases expression 12486162
D016627 Oxidopamine Oxidopamine results in increased expression of ATF4 proteinincreases expression 12486162
D008627 Mercuric Chloride Mercuric Chloride results in increased expression of ATF4 proteinincreases expression 16759985
D008628 Mercury Mercury results in increased expression of ATF4 proteinincreases expression 16759985
D008701 Methapyrilene Methapyrilene results in increased expression of ATF4 mRNAincreases expression 17450226
D015655 1-Methyl-4-phenylpyridinium 1-Methyl-4-phenylpyridinium results in increased expression of ATF4 proteinincreases expression 12486162
D016685 Mitomycin Mitomycin results in increased expression of ATF4 mRNAincreases expression 12760830
D009151 Mustard Gas Mustard Gas results in increased expression of ATF4 mRNAincreases expression 15674843
D009151 Mustard Gas Mustard Gas affects the expression of ATF4 mRNAaffects expression 15651846
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of ATF4 mRNAincreases expression 17616710
C055122 orlistat orlistat results in increased expression of ATF4 mRNAincreases expression 17283163
C006253 pirinixic acid pirinixic acid results in increased expression of ATF4 mRNAincreases expression 16985257
D011374 Progesterone Progesterone results in increased expression of ATF4 mRNAincreases expression 18037150
C031280 pyrazole pyrazole results in increased expression of ATF4 mRNAincreases expression 17945193
D012402 Rotenone Rotenone results in increased expression of ATF4 mRNAincreases expression 19233273
D012402 Rotenone Rotenone results in increased expression of ATF4 proteinincreases expression 19233273
D012402 Rotenone Rotenone results in increased expression of ATF4 proteinincreases expression 12486162
D012643 Selenium Selenium results in increased expression of ATF4 mRNAincreases expression 19244175
D012906 Smoke Smoke results in increased expression of ATF4 proteinincreases expression 18206657
C017947 sodium arsenite Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]decreases reaction|increases expression 15788408
C017947 sodium arsenite ATF4 protein affects the reaction [sodium arsenite results in increased expression of VEGFA mRNA]affects reaction|increases expression 15788408
C017947 sodium arsenite [sodium arsenite co-treated with ATF4 protein] results in increased expression of VEGFA mRNAaffects cotreatment|increases expression 15788408
C017947 sodium arsenite sodium arsenite promotes the reaction [ATF4 protein binds to VEGFA promoter]affects binding|increases reaction 15788408
C017947 sodium arsenite sodium arsenite results in increased expression of and results in increased activity of ATF4 proteinincreases activity|increases expression 15788408
C017947 sodium arsenite sodium arsenite results in increased expression of ATF4 mRNAincreases expression 12760830
C017947 sodium arsenite sodium arsenite results in increased expression of ATF4 mRNAincreases expression 16014739
C017947 sodium arsenite sodium arsenite results in increased expression of ATF4 proteinincreases expression 12606582
C016104 sodium bichromate sodium bichromate results in increased expression of ATF4 mRNAincreases expression 12760830
D013467 Sulindac Sulindac results in increased expression of ATF4 mRNAincreases expression 11906190
D013629 Tamoxifen Tamoxifen affects the expression of ATF4 mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen results in increased expression of ATF4 mRNAincreases expression 19400957
D013629 Tamoxifen Tamoxifen results in increased expression of ATF4 mRNAincreases expression 19400957
C534735 tetraarsenic tetrasulfide tetraarsenic tetrasulfide results in increased expression of ATF4 mRNAincreases expression 19208803
D013749 Tetrachlorodibenzodioxin fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ATF4 mRNA]decreases reaction|increases expression 16467188
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATF4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ATF4 mRNAincreases expression 16467188
17942748
D019284 Thapsigargin Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]decreases reaction|increases expression 16298333
D019284 Thapsigargin Thapsigargin results in increased expression of ATF4 mRNAincreases expression 17283163
16298333
D019284 Thapsigargin Thapsigargin results in increased expression of ATF4 proteinincreases expression 16298333
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 11.1314745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 11.1314745880
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 6.8618926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.8615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.0118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3817505938
MESH:D058186 Acute Kidney Injury Capsaicin 11.9618460982
MESH:D058186 Acute Kidney Injury Mercuric Chloride 11.9611274264
MESH:D058186 Acute Kidney Injury Sulindac 11.967897758
MESH:D055371 Acute Lung Injury pirinixic acid 2.6118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 14.8120127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 14.8117418594
MESH:D000230 Adenocarcinoma Estradiol 14.8111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 14.8114692618
MESH:D000230 Adenocarcinoma Fenretinide 14.8110697514
MESH:D000230 Adenocarcinoma Sulindac 14.8111910360
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 13.163712494
MESH:D000236 Adenoma Benzo(a)pyrene 13.166695378
MESH:D000236 Adenoma Diethylnitrosamine 13.1610737359 6695378
MESH:D000236 Adenoma Sulindac 13.1610223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.0616434500 17162532 19061943 18056438 17620307 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.0616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.0616835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.1119003578 12394442 11535846 17611924 16460482 11874996 15623613
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3316712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.0121441931
MESH:D000505 Alopecia Capsaicin 4.2817569567
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9515469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4611748828
MESH:D000741 Anemia, Aplastic Benzene 3.9311369114 14761424 17661222
MESH:D000799 Angioedema Acetaminophen 3.2810982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.3015885639
MESH:D001249 Asthma Mustard Gas 2.5210378619
MESH:D050197 Atherosclerosis Cadmium 3.3015687053
MESH:D001284 Atrophy fulvestrant 4.3211514358
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 4.2614699433
MESH:D001321 Autistic Disorder Acetaminophen 2.1518445737
MESH:D001321 Autistic Disorder Mercury 2.1517497416
MESH:D001327 Autoimmune Diseases Mercury 4.3316634805
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.451440618 11289319
MESH:D001768 Blister Mustard Gas 4.6019167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.1119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.1112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3915746008
MESH:D001855 Bone Marrow Diseases Benzene 4.6616183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.1314601052
MESH:D001862 Bone Resorption bisphenol A 3.3711985600
MESH:D001913 Bowen's Disease Sulindac 4.7911207687
MESH:D001919 Bradycardia Capsaicin 4.5018207255
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7717868700
MESH:D001930 Brain Injuries Progesterone 3.7215845082 15665606 15380490
MESH:D002545 Brain Ischemia Capsaicin 4.4219211983
MESH:D001932 Brain Neoplasms Doxorubicin 7.5117150277
MESH:D001932 Brain Neoplasms Fenretinide 7.5116187019
MESH:D001943 Breast Neoplasms Benzene 9.9811921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 9.9817474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 9.9817123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 9.9817474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 9.9815324884 17129689
MESH:D001943 Breast Neoplasms Doxorubicin 9.9816826403 15567936 18234424 17426702 16115903 16264153 15993339 15939500 15692762 16322301 17983394 18695136 18382427 16595493 15994142 15634643 11325840 16935488 17369602 19526202 16096432 15136595 18628466 15668708
MESH:D001943 Breast Neoplasms Estradiol 9.9812948864 17261762 16675129 17289903 17018787 14630087 19861407 18497071
MESH:D001943 Breast Neoplasms Fenretinide 9.9816601279
MESH:D001943 Breast Neoplasms fulvestrant 9.9818984771
MESH:D001943 Breast Neoplasms Progesterone 9.9815562024 16175315 17614352
MESH:D001943 Breast Neoplasms Sulindac 9.9816642371
MESH:D001943 Breast Neoplasms Tamoxifen 9.9819410462 17242785 20859285 16202921 17261762 16818667 16873071 17440819 19115204 18997820 19221464 19289846 19200415 18351453 21152245 18821012 20390343 19066611 19288272 18984771 19189210 19103187 21138602 19244106 18815881 16273361 19189212 19487384 17893378 18425577 19011961 19142967 20544844 20065188 18629630 18855134 19155303 19059307 15668708 17049068 19084267 20005174 15565566 20135344 11161223
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 9.9820435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.6015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.4117687719 10378619
MESH:D019121 Burkholderia Infections orlistat 6.0717874328
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9116111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.2416051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.3616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9619066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 17.497296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 17.493084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 17.4917173139 19107877 10672840 20214788 17978847 16328049 3084413 18978308 19335982 19383236 20084675 20101231 3581430 16502159 16288022 16569478 18785209 19208518 18210153 17162532 19701751 16698587 19171122 18788625 17055752 18494052 18506893 16878318 20935162 20727157 16807293 16540662 20514400 16935385 17428255 16830150 19052882 19919837 17138121 21159647 19539802 11831363 18393292 18971187 17761372 16779866 19394651 10737359 19822196 18665156 19519916 20512989 19418558 20007298 20432363 18691550 16681979 20524982 18056438
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 17.4915948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 17.4916234567 16023760 17876044 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 17.4916924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 17.4916270382 17159502
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 17.4917306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 17.4916924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.4317123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 5.587296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 5.5816201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 12.2417015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.2420419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 12.246189445
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 12.2416274795
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 12.2418572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.1317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0418850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.1517007740 17131338 16455267 17329180 16242529 16364871 17519947 16109756 17308081 15505089 17924179 16269455 16612575 16731534 15476868 18627295 17974986 16952015 17382496 16278810 15792986 16651473 15811867 17928571 17351982
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 5.4317334414 16243910
MESH:D002311 Cardiomyopathy, Dilated Mercury 5.4310334427
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.1216936243
MESH:D002386 Cataract Acetaminophen 2.2410977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 25.737505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 25.7320889678
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 25.7318226522
MESH:D002471 Cell Transformation, Neoplastic Cadmium 25.7317332340
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 25.7317174075 21159647 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 25.7318566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 25.7320056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 4.9216154183
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.7619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.7616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 10.9319486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 10.9317333356 17681005 17110522 16105132 15861022 11677210 16919318
MESH:D002779 Cholestasis pirinixic acid 10.9319176532
MESH:D002916 Chylothorax orlistat 6.0717003701
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8516354765 8697196 15668235 15340226 12621046
MESH:D003092 Colitis Selenium 3.2417936198
MESH:D003110 Colonic Neoplasms arsenite 3.7815037631
MESH:D003110 Colonic Neoplasms Sulindac 3.7812458338 12902858
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.3118802399 18259882
MESH:D015179 Colorectal Neoplasms Fenretinide 3.3117273769
MESH:D015179 Colorectal Neoplasms Sulindac 3.3110666051 18059344 11076880 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5917141729 14669216
MESH:D003327 Coronary Disease Fructose 4.1018504504
MESH:D003371 Cough Capsaicin 4.6110350223
MESH:D019465 Craniofacial Abnormalities Benzene 2.4615643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4620055451 10048152 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.0312952375 16002989
MESH:D003550 Cystic Fibrosis Acetylcysteine 3.9019747007
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8219031437
MESH:D003872 Dermatitis Benzene 4.2215902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 5.4411906362 18759878 14531868 8970840 2524372 11298694 8156756 12868966
MESH:D017449 Dermatitis, Allergic Contact Mercury 5.4416823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 2.982952479 3621924
MESH:D048909 Diabetes Complications orlistat 5.2719207292
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.0418603373
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.2120387270
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 6.2118603373
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.2117107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.2819279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.2819279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9517187935
MESH:D003930 Diabetic Retinopathy Sulindac 4.6512861449 17621415
MESH:D003967 Diarrhea orlistat 4.2020002075
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 18.659653073 1440618 18648102 9328219 6482804 8291058 18289764 6679447 11289319 9022650 18692083 7440962 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.6516485898 14986274 19923254 19739265 11743745 11834606 10774834 14725611 19370779 16227642 18713872 16781746 15619225 18071297 16177239 11461765 12392966 19416960 11739529 17522070 17562736 11421492 2444490 12958197 19085960 12540782 19420014 11287661 15968718 14550746 16109766 12705907 16081117 10915739 12594235 11529661 19164858 17906064 16393943 12153990 10663392
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 18.6511287661
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 18.6519107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 18.6517416283
MESH:D056486 Drug-Induced Liver Injury pyrazole 18.6512499123
MESH:D056486 Drug-Induced Liver Injury Selenium 18.6515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.6520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5319426721
MESH:D004362 Drug Toxicity Doxorubicin 6.7118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.7111462148
MESH:D004381 Duodenal Ulcer Capsaicin 4.1710671773 11535926
MESH:D004487 Edema Mustard Gas 8.5811402378 9260866 11428631 11428647
MESH:D004487 Edema pirinixic acid 8.5812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3315322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.2712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 12.2717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 12.2719031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.1416402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 14.6815700306 16804899
MESH:D016889 Endometrial Neoplasms Doxorubicin 14.6817359293
MESH:D016889 Endometrial Neoplasms Estradiol 14.6811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 14.6819155303 17893378 16202921 20544844
MESH:D004715 Endometriosis Progesterone 12.5416134523
MESH:D004715 Endometriosis Sulindac 12.5415652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 12.549294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.5918037988
MESH:D004890 Erythema Mustard Gas 4.609357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5516302075
MESH:D004935 Esophageal Diseases Capsaicin 5.1519566590
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 11.913581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.9120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 11.9116530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 11.9115547721 15547733 16510608 15150132 15264214 15878914 15623463 16805852 16704527
MESH:D004938 Esophageal Neoplasms Sulindac 11.9112235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.5911564622
MESH:D005234 Fatty Liver arsenite 24.2918296743
MESH:D005234 Fatty Liver Diethylnitrosamine 24.2920387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.2915345470
MESH:D005234 Fatty Liver Fructose 24.2918395287 18641190 19196556
MESH:D005234 Fatty Liver pirinixic acid 24.2920131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 24.2919224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.0216534752 16513791 16002989 15751030 16611131
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.0216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.456705139
MESH:D018221 Fibromatosis, Abdominal Sulindac 11.1014745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 11.1014745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 16.3319069698
MESH:D018222 Fibromatosis, Aggressive Sulindac 16.3319069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 16.3319069698
MESH:D005355 Fibrosis arsenite 11.8718296743
MESH:D005355 Fibrosis Fructose 11.8718504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 11.8720067830
MESH:D005414 Flatulence orlistat 6.0720002075
MESH:D005756 Gastritis Acetaminophen 3.1116983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.4811910360
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 10.9616452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 10.9616452187
MESH:D005909 Glioblastoma Capsaicin 9.9718405923
MESH:D005909 Glioblastoma Doxorubicin 9.9717150277
MESH:D005909 Glioblastoma Fenretinide 9.9716187019
MESH:D018149 Glucose Intolerance Fructose 4.8119165636
MESH:D006030 Glycosuria, Renal Mercuric Chloride 5.342918855
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.527505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0310696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.1415692506
MESH:D006356 Heartburn Capsaicin 5.1519566590
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.3820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.3811294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.0912587719 14766674 17888722 16879835 18674790 18006777 16330681 17875725 16244371 16495754 16707910 16244372 16144979
MESH:D006333 Heart Failure Doxorubicin 9.7017481944
MESH:D006333 Heart Failure pirinixic acid 9.7020558911
MESH:D006333 Heart Failure Selenium 9.7017162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.4115692506
MESH:D006402 Hematologic Diseases Benzene 4.1416183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 2.996705139
MESH:D006529 Hepatomegaly pirinixic acid 6.4716221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.4715340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.4615709030
MESH:D006689 Hodgkin Disease Doxorubicin 5.9418501091 17606976 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 5.9412676792
MESH:D019584 Hot Flashes Estradiol 3.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4816354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 6.5616870215
MESH:D006930 Hyperalgesia Capsaicin 6.5617043245 17434803
MESH:D006943 Hyperglycemia pirinixic acid 2.7020558911
MESH:D020138 Hyperhomocysteinemia Catechin 4.5017292331
MESH:D006946 Hyperinsulinism Fructose 4.4314757778 19008412 18360027 15752949 18563319
MESH:D006949 Hyperlipidemias Fructose 8.4015752949
MESH:D006949 Hyperlipidemias orlistat 8.4021332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 9.0315034207
MESH:D006965 Hyperplasia Diethylstilbestrol 9.0312960047 14722030
MESH:D006973 Hypertension Benzene 7.3917940673
MESH:D006973 Hypertension Fructose 7.3914633139 16843071 19008412 14573337 14568997
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.3918850075 18670907
MESH:D015228 Hypertriglyceridemia Fructose 4.5919342510 19799862
MESH:D007021 Hypospadias Diethylstilbestrol 9.4416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.4416945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8615869954
MESH:D007246 Infertility Diethylstilbestrol 3.8315036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.0617937319
MESH:D007248 Infertility, Male fulvestrant 9.0611514358
MESH:D007248 Infertility, Male sodium arsenite 9.0615346721 12646999
MESH:D007249 Inflammation Capsaicin 19.3816956363
MESH:D007249 Inflammation Diethylnitrosamine 19.3818785209
MESH:D007249 Inflammation Mustard Gas 19.3817524151 16001271 9260866 11428647 8975870 9357497 11428620 11428631 11402378
MESH:D007249 Inflammation Progesterone 19.3815869954
MESH:D007249 Inflammation Sulindac 19.383291741
MESH:D007249 Inflammation Tamoxifen 19.3819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 19.3812200463 12878042
MESH:D007251 Influenza, Human Selenium 3.6316624496
MESH:D007333 Insulin Resistance bisphenol A 19.2016393666
MESH:D007333 Insulin Resistance Estradiol 19.2016627594 16393666
MESH:D007333 Insulin Resistance Fructose 19.2019342510 18981581 14757778 14633139 19799862 18057795 17133782 18563319 14573337 19586609 19008412
MESH:D007333 Insulin Resistance orlistat 19.2017201808
MESH:D007333 Insulin Resistance pirinixic acid 19.2016306350
MESH:D007414 Intestinal Neoplasms Sulindac 4.1512663524 10213222 12584176 10223192 12628509 12351151
MESH:D007417 Intestinal Polyps Sulindac 4.4712394442 11245490
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.458074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8416580747
MESH:D007674 Kidney Diseases Acetaminophen 23.5915629191 12587719
MESH:D007674 Kidney Diseases Cadmium 23.5916226777 16962696 16322080
MESH:D007674 Kidney Diseases Cadmium Chloride 23.5916962696
MESH:D007674 Kidney Diseases Doxorubicin 23.5916775033 15699352 15369732
MESH:D007674 Kidney Diseases Estradiol 23.5915618244
MESH:D007674 Kidney Diseases Mercury 23.5917934191
MESH:D007674 Kidney Diseases sodium arsenite 23.5920008137
MESH:C531755 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules orlistat 6.0717185156
MESH:D007676 Kidney Failure, Chronic Doxorubicin 13.8616707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 13.8616518626
MESH:D007676 Kidney Failure, Chronic Selenium 13.8616518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.056582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 14.0514681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 14.0515610895
MESH:D007680 Kidney Neoplasms Tamoxifen 14.0518625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.5217184923
MESH:D007938 Leukemia Benzene 3.0917119257 14694614 15935818 18335105
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.5916085563
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive tetraarsenic tetrasulfide 4.6219208803
MESH:D007951 Leukemia, Myeloid Benzene 3.8217506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.5919478238
MESH:D007972 Leukoplakia, Oral Fenretinide 5.4816707609
MESH:D008064 Lipidoses Tamoxifen 2.7515342952 17567588
MESH:D008103 Liver Cirrhosis arsenite 9.3718296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 9.3718522880 18665156 19638242 20032147 18407596
MESH:D008103 Liver Cirrhosis orlistat 9.3717404856
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 7.299327722 15034207
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 7.2912468960
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 5.7516595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.7514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.7515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.7518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.7512878042
MESH:D008107 Liver Diseases Acetaminophen 7.9712969438 11587558 19014921 16610002 19460945 16611625 19784758 12587719
MESH:D008107 Liver Diseases Capsaicin 7.9716956363
MESH:D008107 Liver Diseases Diethylnitrosamine 7.9717034775
MESH:D008107 Liver Diseases Sulindac 7.9716867024 14986274
MESH:D017114 Liver Failure, Acute Acetaminophen 2.7517185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 29.0021137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 29.0017602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 29.0019996281 20452335 15175105 21278145 18648771 20137499 20583210 12112319 18977376 19690152 19255062 20492335 19254457 21047994 21167192 10737359 15885732 19812893 19294768 18644402 20101389 19426721 19073162 20405173 19090486 19638242 19850985 18754104 2862719 19256749 20501860 19499222 20434301 19833225 19551842 12771043 20118626 9163691 18978307 16942905 19642983 21071580 2422723 19427195
MESH:D008113 Liver Neoplasms Diethylstilbestrol 29.0016712894 15890375
MESH:D008113 Liver Neoplasms Methapyrilene 29.0015890375
MESH:D008113 Liver Neoplasms Mitomycin 29.0015113037
MESH:D008113 Liver Neoplasms pirinixic acid 29.0015890375 16377806 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 29.0015276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 29.0016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 29.0016984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.77598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Benzene 14.7712562636
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.7717942915 9362446 18093689 17854601 18544905 2563599 18775883 19519916 18079962 17174075 3124819 19126423 19009564 19004024 18282651 18164116 19539802 18253720 21159647 18308698 16842330 16267830
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 14.7717085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.7712151625
MESH:D008171 Lung Diseases Acetylcysteine 10.2412815614
MESH:D008171 Lung Diseases Mustard Gas 10.2418161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 10.2419095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.2414698565
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.4917365036
MESH:D008175 Lung Neoplasms arsenite 18.2616809336
MESH:D008175 Lung Neoplasms Benzene 18.2612562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 18.2620135361 18569708 6695378 18816296 20464547 20064080 17053015 20869020 18520028
MESH:D008175 Lung Neoplasms Diethylnitrosamine 18.266695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 18.266189445 17418594
MESH:D008175 Lung Neoplasms Mustard Gas 18.268781369 3148597
MESH:D008175 Lung Neoplasms Smoke 18.2611091918
MESH:D008175 Lung Neoplasms sodium arsenite 18.2616712894 17306315 19931552 15276417 17077188
MESH:D008175 Lung Neoplasms Sulindac 18.2619359593 15713900
MESH:D008175 Lung Neoplasms Tamoxifen 18.2618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 18.2619555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.5915166399
MESH:D008207 Lymphatic Metastasis orlistat 5.3518770866 20805790
MESH:D008223 Lymphoma Benzene 10.3117119257 17584886
MESH:D008223 Lymphoma Diethylstilbestrol 10.3115700306
MESH:D008223 Lymphoma Doxorubicin 10.3116098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.3317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.0215621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.9516002989
MESH:D015674 Mammary Neoplasms, Animal Benzene 8.2312562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.2319428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 22.7711921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 22.7715458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 22.7716891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 22.7710697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 22.7711408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 22.7715318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 22.7719196723 11731420 16827153 14580682 19196722
MESH:D020149 Manganese Poisoning Estradiol 10.7619453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.7619453300
MESH:D008545 Melanoma Doxorubicin 10.8116827129
MESH:D008545 Melanoma Fenretinide 10.8116270382
MESH:D008545 Melanoma orlistat 10.8120805790 18770866
MESH:D008545 Melanoma sodium arsenite 10.8116487513 19082730
MESH:D008545 Melanoma Sulindac 10.8116642371
MESH:D008545 Melanoma Tamoxifen 10.8119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0219513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 8.7716166281 16966607 18303189
MESH:D008654 Mesothelioma Doxorubicin 8.7717638057
MESH:D008654 Mesothelioma Selenium 8.7715107826
MESH:D024821 Metabolic Syndrome X Fructose 4.3617261469 17098227 16815490 18497449 19165636
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.0015792986
MESH:D009041 Motion Sickness Dextroamphetamine 4.951613127
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.3416381670
MESH:D009062 Mouth Neoplasms Fenretinide 7.3416274795
MESH:D052016 Mucositis Doxorubicin 4.2317415656
MESH:D009101 Multiple Myeloma Benzene 6.5317119195
MESH:D009101 Multiple Myeloma Capsaicin 6.5317505005
MESH:D009135 Muscular Diseases orlistat 8.9418430571
MESH:D009135 Muscular Diseases pirinixic acid 8.9416239165
MESH:D009164 Mycobacterium Infections orlistat 4.9321442799
MESH:D009203 Myocardial Infarction Doxorubicin 4.8419429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 4.8419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 6.8116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 6.8116411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 15.223581430
MESH:D009362 Neoplasm Metastasis Acetylcysteine 15.2214720322
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 15.229029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 15.2218259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 15.2219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3119410462
MESH:D009369 Neoplasms Benzo(a)pyrene 15.8511141357
MESH:D009369 Neoplasms Diethylstilbestrol 15.8515313581
MESH:D009369 Neoplasms Fenretinide 15.8515958647 17353921
MESH:D009369 Neoplasms orlistat 15.8518710210
MESH:D009369 Neoplasms pirinixic acid 15.8517405874
MESH:D009369 Neoplasms sodium arsenite 15.8511559025
MESH:D009374 Neoplasms, Experimental orlistat 7.8219381703
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.8220056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.4319196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic arsenite 13.9615738583
MESH:D009389 Neovascularization, Pathologic Estradiol 13.9617289903
MESH:D009389 Neovascularization, Pathologic orlistat 13.9617012255
MESH:D009401 Nephrosis Doxorubicin 4.2216636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.5315640375 16889571
MESH:D009410 Nerve Degeneration 1-Methyl-4-phenylpyridinium 7.6917433543
MESH:D009410 Nerve Degeneration Rotenone 7.6915790535 18619942 17356569
MESH:D009421 Nervous System Malformations bisphenol A 19.1216427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 19.1211399458
MESH:D009421 Nervous System Malformations Estradiol 19.1216427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 19.1214600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 14.286679447
MESH:D009436 Neural Tube Defects Acetylcysteine 14.2819446573
MESH:D009436 Neural Tube Defects Benzene 14.2815643154
MESH:D009436 Neural Tube Defects sodium arsenite 14.2812854658
MESH:D009447 Neuroblastoma Doxorubicin 2.9515555623
MESH:D019636 Neurodegenerative Diseases 1-Methyl-4-phenylpyridinium 21.5516353238
MESH:D019636 Neurodegenerative Diseases Acetaminophen 21.5518514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 21.5520387270
MESH:D019636 Neurodegenerative Diseases Oxidopamine 21.5518514411
MESH:D019636 Neurodegenerative Diseases Sulindac 21.5516850258 17266991
MESH:D020078 Neurogenic Inflammation Capsaicin 4.5717961222
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5520387270
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.1216303764
MESH:D009503 Neutropenia Mustard Gas 3.467688884 16761898
MESH:C541083 Non-alcoholic Fatty Liver Disease orlistat 5.0617404856
MESH:D009765 Obesity Capsaicin 9.3619056576
MESH:D009765 Obesity Fructose 9.3617707055 18585860
MESH:D009765 Obesity orlistat 9.3621438711 20002075 20540997 19046740 18773755 20518802 19207292 16938137 19461584 20599501 21442799 20065556
MESH:D009765 Obesity pirinixic acid 9.3620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 7.556482804 4026338
MESH:D009784 Occupational Diseases Benzene 7.5515935809 17479406 16737584 17178637 15612468 17119257 15576619 15727169 15913788
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.453988306
MESH:D012516 Osteosarcoma Doxorubicin 3.6615930896
MESH:D010049 Ovarian Diseases bisphenol A 4.4311985600
MESH:D010051 Ovarian Neoplasms Benzene 12.7412562636
MESH:D010051 Ovarian Neoplasms Estradiol 12.7419401270
MESH:D010051 Ovarian Neoplasms Fenretinide 12.7416133793
MESH:D010051 Ovarian Neoplasms Progesterone 12.7416525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 12.7417306315 15276417
MESH:D010146 Pain Acetaminophen 8.8616870215
MESH:D010146 Pain Capsaicin 8.8617043245 17434803 18987195 16996476 17084039 19081190
MESH:D010146 Pain Sulindac 8.863291741
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.5216540662
MESH:D010190 Pancreatic Neoplasms Fenretinide 10.5215580305
MESH:D010190 Pancreatic Neoplasms Mitomycin 10.5215113037
MESH:D010190 Pancreatic Neoplasms Sulindac 10.5216820089 11504793
MESH:D010195 Pancreatitis orlistat 4.3416938137 20065556
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 7.527296757
MESH:D010212 Papilloma Hydrogen Peroxide 7.5212065085
MESH:D010300 Parkinson Disease 1-Methyl-4-phenylpyridinium 5.2717433543
MESH:D010300 Parkinson Disease Rotenone 5.2718619942 11445065 16140633 11535288 16412576 19232380 18191903 19114014 15451049
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 4.9215893579 11771942
MESH:D020734 Parkinsonian Disorders Rotenone 3.5918197244 15927086 15795934 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6812520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 4.8315687053
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.906228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.5917983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.1316977796 15687265
MESH:D010954 Plasmacytoma Selenium 4.3215087411
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.3510923243
MESH:D010997 Pleural Neoplasms Doxorubicin 4.5917638057
MESH:D011041 Poisoning Mustard Gas 3.2915727166
MESH:D011085 Polycystic Ovary Syndrome orlistat 4.7917201808
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0318163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.082563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 13.0710548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 13.0717184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.0711399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.8920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.8920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6816740699
MESH:D011471 Prostatic Neoplasms Cadmium 2.6817075824
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.6815846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.6816868541 15897917 16888761 18437689 15749863 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 2.6816740699
MESH:D011471 Prostatic Neoplasms Fenretinide 2.6817024972
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6815067354
MESH:D011537 Pruritus Ethinyl Estradiol 7.6816919318 15861022
MESH:D011537 Pruritus Mustard Gas 7.6818058305
MESH:D011629 Puberty, Precocious bisphenol A 4.2310548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.0917365031 17322281 17975199 15814490
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.0910334151 17620002 17894541 17720292 17266442
MESH:D012035 Refsum Disease orlistat 5.5120871815
MESH:D000608 Renal Aminoacidurias Mercuric Chloride 5.532918855
MESH:D051437 Renal Insufficiency Doxorubicin 3.6817922066
MESH:D015427 Reperfusion Injury Capsaicin 5.8219211983 18460982
MESH:D015427 Reperfusion Injury pirinixic acid 5.8219058328
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.0212210543
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3118990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 7.703692021
MESH:D012162 Retinal Degeneration Fenretinide 7.7016303925
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6318045962
MESH:D012509 Sarcoma Doxorubicin 3.5117203757 15675481 17710206 16767912 15625365 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.7216326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.2317846226
MESH:D012871 Skin Diseases Mustard Gas 2.5512880345 15451306 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 18.6910029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 18.6915692506
MESH:D012878 Skin Neoplasms Fenretinide 18.6916467112
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 18.6912065085
MESH:D012878 Skin Neoplasms sodium arsenite 18.6918572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 18.6916192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.0215625365 17203757 16767912
MESH:D013088 Spermatocele Diethylstilbestrol 16.8516709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 16.8516709447
MESH:D013088 Spermatocele Tamoxifen 16.8516709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.0216503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.0219457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3612854658
MESH:D013274 Stomach Neoplasms Benzene 5.6112562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.612093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 5.6118456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 5.6117575124 12958204
MESH:D013274 Stomach Neoplasms orlistat 5.6119381703
MESH:D013276 Stomach Ulcer Acetylcysteine 3.5217918041
MESH:D019966 Substance-Related Disorders bisphenol A 3.4316045194 16684133
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.1617997062
MESH:D013733 Testicular Diseases pyrazole 4.266499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6815669648
MESH:D013953 Thymus Neoplasms Benzene 4.4010850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3312697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 9.511399818 3712494 6587162 6582329 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 9.517505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 9.5116010429 17909728
MESH:D013978 Tibial Fractures Estradiol 4.1219048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 20.278074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 20.2717053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 20.2716452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 20.2717653716
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 20.2716720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 20.2711723127 16452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 20.278653321 16712894 17572228
MESH:D014581 Urticaria Acetaminophen 2.4710982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 13.2016175088
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 13.2016154183
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.2011813266
MESH:D014591 Uterine Diseases bisphenol A 11.9314652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 11.9314652134
MESH:D014594 Uterine Neoplasms Benzene 18.6212562636
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 18.6216690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 18.6214692618
MESH:D014594 Uterine Neoplasms Sulindac 18.6218645019
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.8916513791 16002989
MESH:D014652 Vascular Diseases sodium arsenite 3.8717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0415869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.6816364871 17638931 17678736 17334414
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6815886252
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
KEGG:04912 GnRH signaling pathway
KEGG:04720 Long-term potentiation
KEGG:04010 MAPK signaling pathway
KEGG:04722 Neurotrophin signaling pathway
KEGG:05215 Prostate cancer
KEGG:04141 Protein processing in endoplasmic reticulum
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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