AutismKB 2.0

Annotation Detail for NCAM1


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Basic Information Top
Gene Symbol:NCAM1 ( CD56,MSK39,NCAM )
Gene Full Name: neural cell adhesion molecule 1
Band: 11q23.2
Quick LinksEntrez ID:4684; OMIM: 116930; Uniprot ID:NCAM1_HUMAN; ENSEMBL ID: ENSG00000149294; HGNC ID: 7656
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04514Cell adhesion molecules (CAMs)
hsa05020Prion diseases
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200189FGF signaling pathway
No data
Pathway IDPathway Name
500079NCAM signaling for neurite out-growth
500087NCAM1 interactions
500100Signal transduction by L1
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1870Drug abuse
1934Cancer
1982Myopathy
1983Down syndrome
2045Bipolar disorder
2069Schizophrenia
Desease Name
bipolar disorder
affective disorder
PSYCH
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of NCAM1 mRNAdecreases expression 20406850
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NCAM1 mRNAaffects expression 16483693
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of NCAM1 mRNAaffects cotreatment|increases expression 18585445
D001151 Arsenic Arsenic affects the expression of NCAM1 mRNAaffects expression 18414638
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of NCAM1 mRNAaffects cotreatment|increases expression 18585445
D001374 Azacitidine Azacitidine results in increased expression of NCAM1 mRNAincreases expression 18037191
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NCAM1 mRNAdecreases expression 20713471
C053342 brevetoxin brevetoxin analog results in increased expression of NCAM1 mRNAincreases expression 14529743
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of NCAM1 mRNAdecreases expression 15336504
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NCAM1 mRNAaffects cotreatment|decreases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NCAM1 mRNAaffects expression 17484886
D003474 Curcumin Curcumin results in increased expression of NCAM1 protein modified formincreases expression 19161989
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NCAM1 mRNAaffects cotreatment|decreases expression 20360939
D004958 Estradiol Estradiol results in decreased expression of NCAM1 mRNAdecreases expression 14664709
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of NCAM1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NCAM1 mRNAdecreases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of NCAM1 mRNAdecreases expression 18035473
D005492 Folic Acid Folic Acid affects the expression of NCAM1 mRNAaffects expression 16361273
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of NCAM1 mRNAdecreases expression 20713471
D009020 Morphine Morphine results in decreased expression of NCAM1 protein modified formdecreases expression 15673448
D005996 Nitroglycerin Nitroglycerin results in increased expression of NCAM1 mRNAincreases expression 12102619
D013629 Tamoxifen Tamoxifen affects the expression of NCAM1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of NCAM1 mRNAaffects expression 16962184
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NCAM1 mRNAdecreases expression 19465110
D014635 Valproic Acid Valproic Acid results in increased expression of NCAM1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.8111752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.818875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7919490988
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D058186 Acute Kidney Injury Folic Acid 4.1917003819 16316344 16595132
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.7720464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 6.7711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7714692618
MESH:D000236 Adenoma Benzo(a)pyrene 15.336695378
MESH:D000236 Adenoma Diethylnitrosamine 15.3310737359 6695378
MESH:D000236 Adenoma Folic Acid 15.3316963246
MESH:D000236 Adenoma Methylcholanthrene 15.336695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.5519052882 17620307 19061943 16434500 18056438 17162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.5516835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.0617306315
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.0711874814
MESH:D019973 Alcohol-Related Disorders Curcumin 4.9317887948
MESH:D000544 Alzheimer Disease Curcumin 4.5115590663
MESH:D000544 Alzheimer Disease Folic Acid 4.5117116317
MESH:D000550 Amblyopia Valproic Acid 5.0817688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.4517497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9219183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8318414634 16835338 16251483 12569548
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5715885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7016807698
MESH:D050197 Atherosclerosis Arsenic 10.6112928151 19371607
MESH:D050197 Atherosclerosis Curcumin 10.6118704882
MESH:D050197 Atherosclerosis Methylcholanthrene 10.6111922910
MESH:D001321 Autistic Disorder Folic Acid 2.3721388746
MESH:D001321 Autistic Disorder Valproic Acid 2.3718177632 15238991 18940202 18316065 16609825 17507914 19460635 20603192 18985861 17157402 18396377 18558336 19232924 17688650 18775368
MESH:D001327 Autoimmune Diseases Curcumin 4.3419761891
MESH:D001714 Bipolar Disorder Valproic Acid 3.0020046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.7015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.708888407
MESH:D002545 Brain Ischemia Curcumin 10.1316770732
MESH:D002545 Brain Ischemia Morphine 10.1319211983
MESH:D001932 Brain Neoplasms Curcumin 3.8017596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.6217474063 20146248
MESH:D001943 Breast Neoplasms Curcumin 4.6218593918 18462866 16243823 19250217
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.6217474063
MESH:D001943 Breast Neoplasms Estradiol 4.6217289903 14630087 19861407 18497071 16675129 17018787 17261762 12948864
MESH:D001943 Breast Neoplasms Folic Acid 4.6216777985
MESH:D001943 Breast Neoplasms Methylcholanthrene 4.6217474063
MESH:D001943 Breast Neoplasms Tamoxifen 4.6220065188 15668708 19487384 19011961 20859285 19059307 17242785 19084267 19115204 16273361 17049068 19244106 17261762 16202921 18984771 15565566 20390343 18815881 19200415 18855134 20005174 19142967 19066611 19189210 19103187 19221464 19289846 18629630 21152245 19155303 16873071 17893378 19410462 20544844 18821012 18351453 19288272 20135344 18997820 11161223 21138602 19189212 18425577 17440819 16818667
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6310355542 16227642 16124888 15673190 3786805 18705752 16011737 15700767 16050911 15721981 16097048 16192424
MESH:D002277 Carcinoma Curcumin 13.3318593918
MESH:D002277 Carcinoma Methylcholanthrene 13.3310545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.3316835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5117687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3519066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.0716705839
MESH:D006528 Carcinoma, Hepatocellular Arsenic 11.0717306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.0718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.0721159647 17162532 19822196 20214788 17428255 16935385 18785209 20101231 19052882 17978847 18971187 16328049 18210153 19208518 20084675 18691550 16540662 16502159 18056438 19383236 20512989 17761372 20935162 19919837 19701751 16878318 16779866 20514400 18665156 18393292 10737359 18788625 11831363 19107877 19335982 10672840 19394651 16288022 19519916 17138121 3581430 17173139 16830150 18494052 20524982 19171122 20007298 16681979 19418558 20727157 3084413 20432363 19539802 17055752 16698587 16569478 16807293 18506893 18978308
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.0716924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.0716924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9318414057
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.3618922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.3620419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.3618462866
MESH:D002295 Carcinoma, Transitional Cell Arsenic 9.0618640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.0617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 7.3915738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Folic Acid 7.3916755160
MESH:D002340 Carotid Artery Diseases Arsenic 4.1816973168 18022660
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.206135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.207505956 17174075 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.2018566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 15.2016192471
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6520734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.8919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.7611677210 17681005 17110522 16919318 15861022 16105132 17333356
MESH:D002971 Cleft Lip Folic Acid 3.9021254359
MESH:D002972 Cleft Palate Folic Acid 5.898946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8916354765 15340226 12621046 8697196 15668235
MESH:D003092 Colitis Curcumin 4.0316804969 18200517 16782535
MESH:D003103 Coloboma Curcumin 4.4118809619
MESH:D003110 Colonic Neoplasms Curcumin 2.4816340194 19359593
MESH:D015179 Colorectal Neoplasms Azacitidine 3.0819934284
MESH:D015179 Colorectal Neoplasms Folic Acid 3.0816985020 17087956 17245555 16963246 17116713
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9317141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.7518497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4315322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.438888407 16575769 17688650
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2119031437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 9.9818403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.9820387270
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 9.9816886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.9817107852
MESH:D003928 Diabetic Nephropathies Curcumin 14.2818204486
MESH:D003928 Diabetic Nephropathies Estradiol 14.2819279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.2819279558
MESH:D003967 Diarrhea Morphine 4.382540324
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.5321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.5316227642 15998439 17522070 19336974 21278145 16177239 4309450 10092053 9327722 11566570 6884620 3732212 7440962 19085960 7179309 15027814 2869522 15968718 10915739 6623471 7120509 3786805
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.5319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.5320420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.531733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D004381 Duodenal Ulcer Curcumin 3.9017351913
MESH:D004421 Dystonia Valproic Acid 3.911851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.4612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.4619031437
MESH:D016889 Endometrial Neoplasms Estradiol 11.9818566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Folic Acid 11.9817301261
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.9820544844 19155303 17893378 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.899294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.0017275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.773922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.466426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.157750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.913659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9716302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9716530937
MESH:D017889 Exfoliation Syndrome Folic Acid 5.3416504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.9212631006 16045604 12795759 16239168 19224547 17595544 15959796 61145
MESH:D005234 Fatty Liver Curcumin 28.9219297423
MESH:D005234 Fatty Liver Diethylnitrosamine 28.9221071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.9215345470
MESH:D005234 Fatty Liver Tamoxifen 28.9214986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 28.9219224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7416575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.988888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0319069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.7914633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 13.9518705752
MESH:D005355 Fibrosis Curcumin 13.9518705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.9520067830
MESH:D005534 Foot Diseases Arsenic 5.416392382
MESH:D005756 Gastritis Folic Acid 4.9417171786
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.5418462866
MESH:D005901 Glaucoma Folic Acid 4.9316504073
MESH:D005909 Glioblastoma Curcumin 3.3817596214
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006261 Headache Nitroglycerin 5.0411554966 11284996
MESH:D006258 Head and Neck Neoplasms Curcumin 3.5518462866 18829502
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.7520471113
MESH:D006330 Heart Defects, Congenital Folic Acid 10.7516524890 17286298
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.7511294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4519110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7415340226 16120746 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8917701891
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D006679 HIV Seropositivity Folic Acid 5.3417209195
MESH:D019584 Hot Flashes Estradiol 3.6017088409
MESH:D006849 Hydrocephalus Valproic Acid 4.7117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8916354765 18606429 15340226 16959395 8697196
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D006937 Hypercholesterolemia Curcumin 3.9118704882
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.3716395265 16397167 16865747 16755160 16433478
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3217050553
MESH:D006973 Hypertension Arsenic 5.049931084 11953799 16076760
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D006987 Hypesthesia Arsenic 5.4116093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Atrazine 6.5712948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5717937319
MESH:D007249 Inflammation Curcumin 15.0318403477 16956363 17151092
MESH:D007249 Inflammation Diethylnitrosamine 15.0318785209
MESH:D007249 Inflammation Flavonoids 15.0317296493
MESH:D007249 Inflammation Tamoxifen 15.0319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.0312878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1518200517 18596194
MESH:D007333 Insulin Resistance Estradiol 2.8716393666 16627594
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 9.6510783313
MESH:D007414 Intestinal Neoplasms Curcumin 9.6510783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007642 Keratosis Arsenic 4.8416930632 12749816
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.0915369732
MESH:D007674 Kidney Diseases Estradiol 6.0915618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.6916705839
MESH:D007680 Kidney Neoplasms Estradiol 11.6915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.6918625569
MESH:D007889 Leiomyoma Curcumin 4.4318555241
MESH:D007938 Leukemia Azacitidine 6.5819148494
MESH:D007938 Leukemia Curcumin 6.5818462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.0716106398
MESH:D007951 Leukemia, Myeloid Azacitidine 4.4819077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.1318720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.1316294345 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.0519299654
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.7417339181
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 7.7416766008
MESH:D015458 Leukemia, T-Cell Curcumin 4.6116106398
MESH:D008064 Lipidoses Tamoxifen 3.0515342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3316239168 16943688 17157831 11408273 17174718 11903743 17334410 21278145 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.3318665156 18407596 20032147 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5317714472 17631135 17761835 16097048 16136751 16011737 15931870 10355542 12666154 15650968 17708605 15893842 17823541 18317297 14512876 18418968 15370692 18156304 12389079 16027843 15818738 17976157 17698563 12958196 16248980 14748882 12632514 12609069 15730626 12667390 12649538 15057751 18412020 12632512 18006644 20821823 14620537 18263696 18395914 16015684 18054572 18395095 12546737 17525996 17481882 17640975 17557913 17900296 16638106 15362042 12445418 18187930 15338365 15876570 17922224 18705752 17805973 18472332 15673190 18277467 18279442 12586293 18205269 18420326 15925388 17565644 12898905 18481824 18376398 16192424 17869086 14716833 17721639 18339082 18210741 17944888 18251166 16033810 14716496 17766677 18472094 18429990 13678700 12741479 14724832 11481614 15959796 16116963 15996030 15052691 15123356 12445421 18166357
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.5317355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.5318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5312878042
MESH:D008107 Liver Diseases Arsenic 12.1411134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 12.1417285989 16246199 15720792 15830285 16964402
MESH:D008107 Liver Diseases Curcumin 12.1416956363
MESH:D008107 Liver Diseases Diethylnitrosamine 12.1417034775
MESH:D008107 Liver Diseases Folic Acid 12.1416877991
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5614706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.037678174
MESH:D008113 Liver Neoplasms Arsenic 21.0316368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.0320195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.0319294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.0318754104 19294768 2862719 19499222 19090486 20501860 20405173 19254457 19996281 19638242 19426721 19812893 9163691 15175105 19690152 18648771 19850985 12112319 20434301 20118626 19256749 20452335 21047994 12771043 10737359 20137499 21071580 18977376 19551842 18978307 19427195 21278145 19833225 20101389 2422723 18644402 20583210 21167192 15885732 19073162 19642983 19255062 20492335 16942905
MESH:D008113 Liver Neoplasms Tamoxifen 21.0316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.0316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 17.652876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.6512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.6518308698 19004024 19126423 18544905 19519916 16267830 9362446 19009564 18282651 18079962 17854601 17174075 18253720 19539802 18093689 18775883 3124819 21159647 16842330 2563599 18164116 17942915
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 17.651399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.6512151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1117228818
MESH:D008175 Lung Neoplasms Arsenic 12.6819168569 17976673 17306315
MESH:D008175 Lung Neoplasms Azacitidine 12.6821224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.6818816296 6695378 20464547 20135361 17053015 20064080 18569708 20869020 18520028
MESH:D008175 Lung Neoplasms Curcumin 12.6819359593 18462866 16243823
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.686695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Methylcholanthrene 12.6815390079 11893704 20970405 7750092 16271038 6695378 16337739 1399818 9230183 21163286 20512841 10545420 17909032
MESH:D008175 Lung Neoplasms Tamoxifen 12.6818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.6819555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3017718048
MESH:D008223 Lymphoma Curcumin 3.4818462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.5416173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6119428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.6511408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.6511731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Estradiol 12.1419453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.1419453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.5416832597
MESH:D008545 Melanoma Curcumin 3.3718462866 17885582
MESH:D008545 Melanoma Tamoxifen 3.3712393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0315990972
MESH:D008569 Memory Disorders Curcumin 4.0117263510
MESH:D008654 Mesothelioma Atrazine 3.471916698
MESH:D008708 Methemoglobinemia Nitroglycerin 4.593537620
MESH:D008881 Migraine Disorders Valproic Acid 3.0818765137 18803445
MESH:D020326 Migraine without Aura Nitroglycerin 4.9814659530
MESH:D009006 Monosomy Azacitidine 5.9319299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0716381670
MESH:D009101 Multiple Myeloma Azacitidine 7.4019549372 18443271
MESH:D009101 Multiple Myeloma Curcumin 7.4019372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.7717962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.898888407
MESH:D009190 Myelodysplastic Syndromes Azacitidine 7.4518720364 19805378 17596541 17611569
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.4517596541
MESH:D009203 Myocardial Infarction Nitroglycerin 3.7214729435
MESH:D017202 Myocardial Ischemia Arsenic 8.6015371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.6012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1616810080
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.717678174 18551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.2218495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.539029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.5319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4719410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1011141357
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 10.3412497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.3419200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009421 Nervous System Malformations Estradiol 8.9716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9714600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.4818462866
MESH:D009436 Neural Tube Defects Arsenic 11.7516620997
MESH:D009436 Neural Tube Defects Folic Acid 11.7517438019
MESH:D009436 Neural Tube Defects Valproic Acid 11.758888407 16359493
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.2220387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.2317056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9720387270
MESH:D009503 Neutropenia Folic Acid 4.3616322990
MESH:D009765 Obesity Curcumin 2.7119297423
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3016049721
MESH:D010024 Osteoporosis Curcumin 3.3818719352
MESH:D010051 Ovarian Neoplasms Arsenic 7.7017306315
MESH:D010051 Ovarian Neoplasms Curcumin 7.7019020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 7.7019401270
MESH:D010146 Pain Morphine 4.0715275824 6776300 18699797 16273134 20225289 15215642
MESH:D010190 Pancreatic Neoplasms Curcumin 5.2419196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.2416540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010300 Parkinson Disease Atrazine 3.2217218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0316093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.846392382 15371236 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.422563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9611118676 11222880 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.9620603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7520887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.8916140617
MESH:D011471 Prostatic Neoplasms Azacitidine 1.8918324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Curcumin 1.8911398177 18769126 15129424 10851300 12497104 18226269 18156803
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011507 Proteinuria Arsenic 3.8621343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.1615861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.3911422049 12752131
MESH:D011656 Pulmonary Emphysema Curcumin 4.3919168576
MESH:D051437 Renal Insufficiency Folic Acid 4.6315728788
MESH:D015427 Reperfusion Injury Morphine 4.0619211983
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.8810666014 18379247
MESH:D012135 Respiratory Sounds Atrazine 4.3711874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0319155313
MESH:D012509 Sarcoma Curcumin 3.9818462866
MESH:D012559 Schizophrenia Folic Acid 3.8116641680
MESH:D012559 Schizophrenia Valproic Acid 3.8119110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 5.6018551238
MESH:D012640 Seizures Valproic Acid 5.6011044598 16876388 17978042 15475178 3137016 11738929 14763951 1511512
MESH:D018805 Sepsis Curcumin 3.9518389075
MESH:D012871 Skin Diseases Arsenic 5.2016702368 19834688 15952646 17453740 17548696 6392382 18709164 17050553 17938729 16759981 16353154
MESH:D012871 Skin Diseases Folic Acid 5.2018709164
MESH:D012878 Skin Neoplasms Arsenic 12.9817029826 17976673 16251483 17050553 15504454 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.9819755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.988532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.9816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.0616709447
MESH:D013088 Spermatocele Tamoxifen 11.0616709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.3416361298
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8919457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3912833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.372093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3718456281
MESH:D013274 Stomach Neoplasms Folic Acid 3.3717171786
MESH:D013276 Stomach Ulcer Curcumin 3.3616631530 19188055
MESH:D020521 Stroke Folic Acid 4.2116517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.877505956
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.0817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.373119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.1816049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 15.1817976673 18640142 19322015 19429237 11144890 17306315 15987713
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.1817053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 15.1818593936
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.188653321 17572228 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.498888407
MESH:D014565 Urogenital Neoplasms Curcumin 5.1118462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1710091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1514692618
MESH:D014652 Vascular Diseases Arsenic 4.5817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4014671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:05020 Prion diseases
REACT:6900 Signaling in Immune system
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018