AutismKB 2.0

Annotation Detail for NDN


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Basic Information Top
Gene Symbol:NDN ( HsT16328,PWCR )
Gene Full Name: necdin homolog (mouse)
Band: 15q11.2
Quick LinksEntrez ID:4692; OMIM: 602117; Uniprot ID:NECD_HUMAN; ENSEMBL ID: ENSG00000182636; HGNC ID: 7675
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200103p75(NTR)-mediated signaling
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1818Systemic scleroderma
No data
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Desease Name
Prader-Willi syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NDN mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of NDN mRNAdecreases expression 20106945
C014347 decitabine decitabine inhibits the reaction [tobacco tar results in decreased expression of NDN mRNA]decreases expression|decreases reaction 19559774
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of NDN mRNAdecreases expression 17005392
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NDN mRNAdecreases expression 17557909
D009151 Mustard Gas Mustard Gas results in increased expression of NDN mRNAincreases expression 15674843
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NDN mRNAaffects binding|decreases expression|increases activity 19710929
C024746 tobacco tar decitabine inhibits the reaction [tobacco tar results in decreased expression of NDN mRNA]decreases expression|decreases reaction 19559774
C024746 tobacco tar tobacco tar results in decreased expression of NDN mRNAdecreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000686 Amyloidosis Diethylstilbestrol 4.7615469931
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001249 Asthma Mustard Gas 2.7710378619
MESH:D001768 Blister Mustard Gas 5.5019167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms decitabine 2.4118320071 19208741
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.4115324884 17129689
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.3517687719 10378619
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0818705752 3786805 15700767 10355542 15673190 16050911 16227642 16011737 15721981 16124888 16097048 16192424
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.2618788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 3.2616924424 15948411
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6519215824
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.5412371664
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 7.5419559774
MESH:D002779 Cholestasis Cyclosporine 14.3819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.3816919318 11677210 17681005 15861022 16105132 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 14.3819176532
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.8412952375 16002989
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0919336974 2869522 3732212 17522070 19085960 6884620 15968718 7440962 11566570 7179309 3786805 10915739 10092053 16227642 15998439 9327722 15027814 21278145 6623471 4309450 16177239 7120509
MESH:D004487 Edema Mustard Gas 7.699260866 11428631 11428647 11402378
MESH:D004487 Edema pirinixic acid 7.6912083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4919294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.0316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.6116804899 15700306
MESH:D004890 Erythema Mustard Gas 5.509357497
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.8561145 12631006 15959796 12795759 16239168 17595544 19224547 16045604
MESH:D005234 Fatty Liver Cyclosporine 20.8519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.8515345470
MESH:D005234 Fatty Liver pirinixic acid 20.8520131406 19236843
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7916513791 16534752 15751030 16611131 16002989
MESH:D005355 Fibrosis Carbon Tetrachloride 9.7118705752
MESH:D005355 Fibrosis Cyclosporine 9.7112639820 12168785
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.2816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006258 Head and Neck Neoplasms decitabine 3.6419215824
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 19176532 19772884 18467677
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.7414722030 12960047
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007021 Hypospadias Diethylstilbestrol 12.2916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 12.2916945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.6415036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male decitabine 7.2317581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.2317937319
MESH:D007249 Inflammation Mustard Gas 2.8911402378 9260866 16001271 17524151 11428631 8975870 11428647 9357497 11428620
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.468314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 8.1312371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.1315003126 16762066 14681315
MESH:D007859 Learning Disorders Diethylstilbestrol 4.3717184923
MESH:D007938 Leukemia decitabine 3.1818980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.2418454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4117679729 19387464 18460780 19010910 18704418 18206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.8418055864
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9211903743 16239168 16943688 17174718 11408273 16221502 17157831 21278145 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3817525996 17698563 17766677 16248980 16011737 17721639 15057751 15925388 18481824 17761835 16116963 16638106 12632512 15818738 15876570 18205269 20821823 18006644 17976157 14620537 18156304 17922224 12958196 18279442 18395095 14716496 15650968 12649538 18429990 15730626 18317297 15338365 12667390 12898905 15893842 12445418 14716833 13678700 16192424 18210741 17900296 12546737 18263696 17557913 12586293 14512876 16027843 15370692 17944888 12666154 18705752 17823541 18420326 17869086 16033810 18376398 15123356 18472094 14724832 15673190 12741479 15931870 18472332 18251166 17565644 16136751 18187930 17714472 15052691 17708605 17631135 12632514 15362042 17805973 18166357 18412020 12445421 18054572 18339082 12389079 18418968 18395914 16015684 17481882 16097048 10355542 17640975 15996030 12609069 14748882 18277467 15959796 11481614
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3815474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1316246199 15720792 15830285 17285989 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9214706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9219294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.9216712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 7.9216377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7515583823 12014681
MESH:D008171 Lung Diseases Mustard Gas 3.6018161513 18702808
MESH:D008175 Lung Neoplasms Mustard Gas 2.173148597 8781369
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.4915166399
MESH:D008223 Lymphoma decitabine 8.2919470736
MESH:D008223 Lymphoma Diethylstilbestrol 8.2915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.8916002989
MESH:D008545 Melanoma decitabine 2.2716505122 17785578
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009101 Multiple Myeloma decitabine 3.5118172295
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5119157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms decitabine 8.9417925555 19470736 19116145
MESH:D009369 Neoplasms Diethylstilbestrol 8.9415313581
MESH:D009369 Neoplasms pirinixic acid 8.9417405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D009421 Nervous System Malformations Diethylstilbestrol 4.4211399458
MESH:D009503 Neutropenia Mustard Gas 4.2316761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010051 Ovarian Neoplasms decitabine 2.7119259094 19331143
MESH:D010190 Pancreatic Neoplasms decitabine 2.8419294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.5514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.9815687265 16977796
MESH:D011041 Poisoning Mustard Gas 4.0615727166
MESH:D011218 Prader-Willi Syndrome marker/mechanism
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.4517184923
MESH:D055728 Primary Myelofibrosis decitabine 5.0317616702
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.5315046698 17136230 15846301
MESH:D011537 Pruritus Ethinyl Estradiol 10.6816919318 15861022
MESH:D011537 Pruritus Mustard Gas 10.6818058305
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0017266442 10334151 17894541 17720292 17620002
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012208 Rhabdomyosarcoma decitabine 4.6619155313
MESH:D012871 Skin Diseases Mustard Gas 2.7615451306 12880345 16961503
MESH:D013088 Spermatocele Diethylstilbestrol 13.0016709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0016709447
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013964 Thyroid Neoplasms decitabine 3.5117967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.6217616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.6216452187 16712894 17306315
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.2616175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.5514652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 10.4315809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.4314692618
MESH:D014604 Uveal Neoplasms decitabine 5.2917785578
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.7416513791 16002989
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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