AutismKB 2.0

Annotation Detail for NDUFA4


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Basic Information Top
Gene Symbol:NDUFA4 ( CI-9k,CI-MLRQ,FLJ27440,MGC104422,MGC126843,MGC126845,MLRQ )
Gene Full Name: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa
Band: 7p21.3
Quick LinksEntrez ID:4697; OMIM: 603833; Uniprot ID:NDUA4_HUMAN; ENSEMBL ID: ENSG00000189043; HGNC ID: 7687
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
Pathway IDPathway Name
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncou
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NDUFA4 mRNAdecreases expression 18648102
C006632 arsenic trioxide arsenic trioxide results in increased expression of NDUFA4 mRNAincreases expression 20458559
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of NDUFA4 mRNAaffects cotreatment|increases expression 18313992
D010634 Phenobarbital Phenobarbital results in increased expression of NDUFA4 mRNAincreases expression 12082028
D011794 Quercetin Quercetin results in decreased expression of NDUFA4 mRNAdecreases expression 15309432
D012402 Rotenone Rotenone results in increased expression of NDUFA4 mRNAincreases expression 18191903
D012643 Selenium Selenium results in decreased expression of NDUFA4 mRNAdecreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of NDUFA4 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NDUFA4 mRNAincreases expression 20399798
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of NDUFA4 mRNAaffects cotreatment|increases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.106195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1015322242 11752688 14514962
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.049612607
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3219825857 11798837
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.843712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.8917620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.4117084956
MESH:D001260 Ataxia Telangiectasia Quercetin 5.2115336622
MESH:D001327 Autoimmune Diseases Quercetin 4.6219761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.5416206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Quercetin 2.1118628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1120435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002105 Cadmium Poisoning Quercetin 5.8116962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.803581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8016217749 15553829 14691202 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.8020007298 17173139 1701930 20935162 6705139
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.8019519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.1717234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D006332 Cardiomegaly Quercetin 7.0919794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0918670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.877505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.474080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.2719486331 9022650
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9715894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1616354765 15340226 15668235 12621046 8697196
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D003110 Colonic Neoplasms Quercetin 2.4415741050 11134977 19056647 16640504 17148506 17191121 19440933
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6520501625
MESH:D015179 Colorectal Neoplasms Quercetin 2.6518095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5115322242 10048152 20055451
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0112868966 14531868 18759878 11906362 2524372 8970840 8156756 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9316285004
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8719496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.367440962 16192314 8291058 1440618 9328219 18289764 11289319 18692083 9653073 9022650 6679447 6482804 18648102
MESH:D056486 Drug-Induced Liver Injury Selenium 9.3615131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.3615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3620420201
MESH:D004362 Drug Toxicity Lamivudine 14.6215040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 14.6211462148
MESH:D004362 Drug Toxicity Zidovudine 14.6215040536
MESH:D004421 Dystonia Phenobarbital 4.191851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.323659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.143922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.696401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.263659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.603581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6012903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver arsenic trioxide 8.7215073043
MESH:D005234 Fatty Liver Zidovudine 8.7218299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Quercetin 9.4919474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.4920067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005909 Glioblastoma Quercetin 3.5019804834
MESH:D005910 Glioma Quercetin 3.1117643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006402 Hematologic Diseases Zidovudine 4.9012579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006509 Hepatitis B Lamivudine 5.2717703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.2715309715 16476009 15274664 15631357 12044531
MESH:D006529 Hepatomegaly Phenobarbital 9.1716109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1716120746 15340226 12621046
MESH:D015658 HIV Infections Lamivudine 7.3320032539 9296927 17530837 11141242
MESH:D015658 HIV Infections Zidovudine 7.3317358032 11698656 11141242 11363243 20032539
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3118606429 15340226 16959395 8697196 16354765
MESH:D006943 Hyperglycemia Quercetin 4.1918262572 11834736
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Quercetin 5.4218356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4218670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007251 Influenza, Human Quercetin 11.9716624496
MESH:D007251 Influenza, Human Selenium 11.9716624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.3814714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.289022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007627 Keloid Quercetin 5.1717086741
MESH:D007674 Kidney Diseases Quercetin 3.1916962696
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.146582329
MESH:D007680 Kidney Neoplasms Zidovudine 8.1412579204
MESH:D007938 Leukemia arsenic trioxide 6.7415070760
MESH:D007938 Leukemia Quercetin 6.7417468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 10.4217077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 10.4220370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616968895 20471514 16467208 17050201 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3217107899 19225113 19035177 12018890 9834237 19075265 16823087 16330433 16891316 17217047 19642359 17869043 17712046 11161223 17649720 15336539 11468182 12679006 12712474 15748426 15213294 16331271 16112521 15622746 16966277
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9821047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.4912741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4912878042
MESH:D008107 Liver Diseases Phenobarbital 2.2019363144
MESH:D008113 Liver Neoplasms arsenic trioxide 11.2114682389
MESH:D008113 Liver Neoplasms Phenobarbital 11.2119812893 8742319 15975961 19482888 19073162 21047994
MESH:D008113 Liver Neoplasms Quercetin 11.2118980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 19.771399818 598648 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 19.7720377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 19.776150874 18308698 17172636 2563599 1399818
MESH:D008114 Liver Neoplasms, Experimental Quercetin 19.7719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.7712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0311798837 19825857
MESH:D008175 Lung Neoplasms Quercetin 5.0316280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0311884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 5.0318800350
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2414737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8615318939
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.1017358032
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2219417148 14977855 19549372 15949261 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316882451 16105982
MESH:D009203 Myocardial Infarction Quercetin 3.0519595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.9219207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7117484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms Quercetin 2.8715185748
MESH:D009410 Nerve Degeneration Rotenone 4.0117356569 18619942 15790535
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.616679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6110525206
MESH:D020078 Neurogenic Inflammation Quercetin 4.5517929310
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.584026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010018 Osteomalacia Phenobarbital 4.6017016548
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4019495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1719769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Quercetin 5.1719005980
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.9915580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.9916965848
MESH:D010190 Pancreatic Neoplasms Quercetin 8.9916965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010300 Parkinson Disease Rotenone 3.0315451049 18619942 19114014 18191903 11535288 16140633 11445065 19232380 16412576
MESH:D020734 Parkinsonian Disorders Rotenone 4.2415927086 18197244 15795934 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Phenobarbital 9.762563599
MESH:D011230 Precancerous Conditions Quercetin 9.7619056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311222880 11896295 11118676 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6119131511
MESH:D011471 Prostatic Neoplasms Quercetin 2.6117292933 14715546
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6118760546
MESH:D019310 Pseudolymphoma Phenobarbital 4.7612752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012206 Rhabdomyolysis Lamivudine 5.779296927
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.8116862918
MESH:D012640 Seizures Phenobarbital 2.803137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.066407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.7417007042
MESH:D013274 Stomach Neoplasms Zidovudine 2.7417696246
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.746587162 6582329 3712494 7505956 1399818
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.7419014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.741399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.738074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.7311780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.7316720314
MESH:D014625 Vaginal Neoplasms Zidovudine 4.9712579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05016 Huntington's disease
KEGG:01100 Metabolic pathways
KEGG:00190 Oxidative phosphorylation
KEGG:05012 Parkinson's disease
REACT:6305 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00157 - NADH Dietary supplement;Micronutrient
No data
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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