AutismKB 2.0

Annotation Detail for NDUFB2


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Basic Information Top
Gene Symbol:NDUFB2 ( AGGG,CI-AGGG,MGC70788 )
Gene Full Name: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
Band: 7q34
Quick LinksEntrez ID:4708; OMIM: 603838; Uniprot ID:NDUB2_HUMAN; ENSEMBL ID: ENSG00000090266; HGNC ID: 7697
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
Pathway IDPathway Name
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncou
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of NDUFB2 mRNAaffects expression 18343893
D000082 Acetaminophen Acetaminophen affects the expression of NDUFB2 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of NDUFB2 mRNAdecreases expression 19422848
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of NDUFB2 mRNAdecreases expression 15336504
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NDUFB2 mRNAaffects cotreatment|increases expression 17942748
D017313 Fenretinide Fenretinide affects the expression of NDUFB2 mRNAaffects expression 16570282
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of NDUFB2 mRNAaffects cotreatment|increases expression 17183730
D017239 Paclitaxel NDUFB2 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
D012402 Rotenone Rotenone results in increased expression of NDUFB2 mRNAincreases expression 18191903
D012643 Selenium Selenium results in decreased expression of NDUFB2 mRNAdecreases expression 19244175
C021751 tanshinone tanshinone results in increased expression of NDUFB2 mRNAincreases expression 15849732
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of NDUFB2 mRNAaffects expression 18343893
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NDUFB2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NDUFB2 mRNAincreases expression 20399798
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of NDUFB2 mRNAaffects cotreatment|increases expression 17183730
D014747 Vinblastine NDUFB2 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5914514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.598875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9819490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D000230 Adenocarcinoma arsenic trioxide 7.2619825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.2614692618
MESH:D000230 Adenocarcinoma Fenretinide 7.2610697514
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000550 Amblyopia Valproic Acid 5.3317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6217497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518985861 19232924 18558336 18940202 17507914 16609825 15238991 18396377 18316065 19460635 18177632 18775368 20603192 17688650 17157402
MESH:D001714 Bipolar Disorder Valproic Acid 3.1017594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.1416206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.1315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.138888407
MESH:D001859 Bone Neoplasms Paclitaxel 4.6315867366
MESH:D001932 Brain Neoplasms Fenretinide 4.4016187019
MESH:D001943 Breast Neoplasms Fenretinide 2.0916601279
MESH:D001943 Breast Neoplasms Paclitaxel 2.0918223236 16244791 16115903 18323546 18234424 15136595 11325840 16273361
MESH:D001943 Breast Neoplasms tanshinone 2.0919885617 15849732
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3911589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.713084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7115073043 16217749 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 6.7117159502 16270382
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 6.7116313753
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9719014326
MESH:D002292 Carcinoma, Renal Cell Vinblastine 3.801485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1712490120
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 3.1916274795
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3916120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.5616154183
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9117333356 17681005 17110522 16919318 11677210 16105132 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1215668235 8697196 12621046 15340226 16354765
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.9320501625
MESH:D015179 Colorectal Neoplasms Fenretinide 4.9317273769
MESH:D015179 Colorectal Neoplasms Paclitaxel 4.9318802399
MESH:D015179 Colorectal Neoplasms Vinblastine 4.9318802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8015322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.8016575769 8888407 17688650
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1515213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0912958197 16485898 19923254 19420014 11421492 19370779 19416960 11743745 14725611 19164858 16081117 16393943 16781746 12705907 16109766 11739529 17522070 10663392 16227642 18713872 10915739 12153990 11834606 14550746 11461765 12540782 14986274 12594235 19739265 18071297 11287661 12392966 19085960 11529661 15968718 17562736 16177239 10774834 2444490 17906064 15619225
MESH:D056486 Drug-Induced Liver Injury Selenium 9.0915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.091733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004421 Dystonia Valproic Acid 4.111851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.2317275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.013922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.636254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.377750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.153659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.8012903497
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.8016481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver arsenic trioxide 13.4615073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.4615345470
MESH:D005234 Fatty Liver Valproic Acid 13.4619224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.9816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.198888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3316904648
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005909 Glioblastoma Fenretinide 3.9216187019
MESH:D005910 Glioma tanshinone 4.0416955220
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 7.0711294989
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0711294989 10048152
MESH:D006333 Heart Failure Selenium 3.1117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9615340226 12621046 16120746
MESH:D006689 Hodgkin Disease Vinblastine 4.0818180244 18501091
MESH:D006849 Hydrocephalus Valproic Acid 4.9517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.148697196 16354765 18606429 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7016612254
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 5.2919662366
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8812200463 12878042
MESH:D007251 Influenza, Human Selenium 4.2916624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2315629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007938 Leukemia arsenic trioxide 2.8615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8512560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8119077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9416467208 20471514 19850784 17050201 16968895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9416294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2517217047 12712474 15336539 11468182 16331271 19075265 15748426 16112521 17869043 16891316 16330433 9834237 19225113 17712046 11161223 17107899 16966277 15213294 12679006 19642359 15622746 12018890 17649720 19035177 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4216882451
MESH:D007972 Leukoplakia, Oral Fenretinide 6.1416707609
MESH:D008080 Liposarcoma Paclitaxel 4.8817353645
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6412587719 16611625 19784758 19014921 11587558 12969438 16610002 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2916871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 4.5014682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5016984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.9120377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3915213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3617228818
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3111798837 19825857
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3119555203 11884234
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.1314749477
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 6.5010697514
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.5015318939
MESH:D008545 Melanoma Fenretinide 5.4816270382
MESH:D008545 Melanoma Paclitaxel 5.4812040289 12025231 16342250
MESH:D008545 Melanoma Vinblastine 5.4816809738 16432458 15577320 16248763 12374674 18505091 18176117 17761969 15577323 18332650
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D008881 Migraine Disorders Valproic Acid 3.2318803445 18765137
MESH:D009062 Mouth Neoplasms Fenretinide 4.3616274795
MESH:D009101 Multiple Myeloma arsenic trioxide 7.6315949261 19417148 14977855 19549372 11468182
MESH:D009101 Multiple Myeloma Paclitaxel 7.6314749477
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.088888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.5216105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.5217596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0216624393
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.2715867366
MESH:D009369 Neoplasms Fenretinide 3.3217353921 15958647
MESH:D009410 Nerve Degeneration Rotenone 3.9218619942 17356569 15790535
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.4410525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.4416359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.7616303764
MESH:D009503 Neutropenia Vinblastine 4.6317378895
MESH:D010014 Osteolysis Paclitaxel 5.0615867366
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.1919769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Fenretinide 8.1916133793
MESH:D010051 Ovarian Neoplasms Paclitaxel 8.1911161223
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.6715580305
MESH:D010190 Pancreatic Neoplasms Fenretinide 5.6715580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010235 Paraganglioma arsenic trioxide 4.2219927285
MESH:D010300 Parkinson Disease Rotenone 2.9919114014 18619942 15451049 16412576 11535288 18191903 11445065 19232380 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 4.1315795934 15574749 15927086 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7411896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.7420603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7719131511
MESH:D011471 Prostatic Neoplasms Fenretinide 2.7717024972
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.7716356831 17172428 16729912 17136230
MESH:D011537 Pruritus Ethinyl Estradiol 3.3915861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.6411422049 12752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012162 Retinal Degeneration Fenretinide 4.4416303925
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2319155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0216646077
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures Valproic Acid 2.7717978042 3137016 15475178 1511512 11738929 11044598 16876388 14763951
MESH:D012878 Skin Neoplasms Fenretinide 9.6916467112
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.698532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.6916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6412833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.7117007042
MESH:D013274 Stomach Neoplasms Paclitaxel 2.7118396642 18506536
MESH:D024801 Tauopathies Paclitaxel 4.8916930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1319014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0415213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.3317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.603119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.5212973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 5.5216720286
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.718888407
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 4.6116154183
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D014625 Vaginal Neoplasms Vinblastine 5.1215577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05016 Huntington's disease
KEGG:01100 Metabolic pathways
KEGG:00190 Oxidative phosphorylation
KEGG:05012 Parkinson's disease
REACT:6305 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00157 - NADH Dietary supplement;Micronutrient
No data
No data
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Simple Query:


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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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