AutismKB 2.0

Annotation Detail for RERE


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Basic Information Top
Gene Symbol:RERE ( ARG,ARP,ATN1L,DNB1,FLJ38775,KIAA0458 )
Gene Full Name: arginine-glutamic acid dipeptide (RE) repeats
Band: 1p36.23
Quick LinksEntrez ID:473; OMIM: 605226; Uniprot ID:RERE_HUMAN; ENSEMBL ID: ENSG00000142599; HGNC ID: 9965
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RERE mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RERE mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of RERE mRNAincreases expression 15761015
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RERE mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of RERE mRNAdecreases expression 16174780
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RERE mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of RERE mRNAdecreases expression 16174780
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RERE mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of RERE mRNAincreases expression 18301758
C025462 sulindac sulfide sulindac sulfide results in decreased expression of RERE mRNAdecreases expression 12734198
D013629 Tamoxifen Tamoxifen affects the expression of RERE mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RERE mRNAaffects cotreatment|increases expression 17942748
C025643 vinclozolin vinclozolin affects the expression of RERE mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of RERE mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4419825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4414692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000544 Alzheimer Disease sulindac sulfide 3.1218759972
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001008 Anxiety Disorders vinclozolin 3.8019015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.5216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.5219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.5212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9419244106 19289846 16873071 19142967 19066611 18425577 21152245 19084267 19410462 18351453 16818667 16202921 17440819 18855134 19189212 19103187 19221464 20005174 17049068 11161223 18815881 19115204 16273361 15668708 20390343 20135344 18997820 19011961 17242785 18984771 17893378 19155303 19288272 18629630 18821012 20065188 21138602 19059307 20544844 19487384 19189210 17261762 20859285 19200415 15565566
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7516705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7516217749 14691202 11135700 15073043 15553829
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7516924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.5112391285
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.906135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2511677210 17110522 16919318 16105132 15861022 17333356 17681005
MESH:D002779 Cholestasis pirinixic acid 8.2519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815668235 8697196 16354765 15340226 12621046
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.5814966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.8718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1716202921 17893378 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3512903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver arsenic trioxide 20.5415073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.5415345470
MESH:D005234 Fatty Liver pirinixic acid 20.5419236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 20.5419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6216417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly pirinixic acid 9.1419176532 18467677 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1415340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 15340226 16959395 18606429 16354765
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1017937319
MESH:D007248 Infertility, Male vinclozolin 7.1016467254
MESH:D007249 Inflammation Tamoxifen 5.2119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2112878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9716705839
MESH:D007680 Kidney Neoplasms Tamoxifen 7.9718625569
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1620471514 16467208 19850784 17050201 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3415336539 17649720 16330433 15622746 15748426 17869043 17107899 16966277 11468182 19225113 19075265 12679006 19035177 11161223 17712046 12018890 19642359 16823087 16331271 17217047 12712474 16112521 9834237 15213294 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0216417039
MESH:D008064 Lipidoses Tamoxifen 3.3017567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.977678174
MESH:D008113 Liver Neoplasms arsenic trioxide 14.9714682389
MESH:D008113 Liver Neoplasms pirinixic acid 14.9720007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 14.9716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.9716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.512876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.5120377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.4919825857 11798837
MESH:D008175 Lung Neoplasms Tamoxifen 3.4918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4911884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7419196723 14580682 16827153 19196722 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2519549372 11468182 19417148 14977855 15949261
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.157678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219196722 19189210 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2410525206
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6216049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4619769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4611896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.4618042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.2218220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1919131511
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1915067354
MESH:D011472 Prostatitis vinclozolin 5.2218629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6718551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7316049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.7312973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.7316712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.5014692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 10.5018645019
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34332
    • No data
    Releated disease ID Related disease Name
    PA446047Vitiligo
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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