AutismKB 2.0

Annotation Detail for NDUFV3


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Basic Information Top
Gene Symbol:NDUFV3 ( CI-10k,CI-9KD )
Gene Full Name: NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa
Band: 21q22.3
Quick LinksEntrez ID:4731; OMIM: 602184; Uniprot ID:NDUV3_HUMAN; ENSEMBL ID: ENSG00000160194; HGNC ID: 7719
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
Pathway IDPathway Name
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncou
Pathway IDPathway Name
200194FOXA1 transcription factor network
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
cognitive trait
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NDUFV3 mRNAaffects expression 21346803
D000638 Amiodarone Amiodarone affects the expression of NDUFV3 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NDUFV3 mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of NDUFV3 mRNAaffects expression 19483382
D002994 Clofibrate Clofibrate affects the expression of NDUFV3 mRNAaffects expression 19483382
D005001 Ethionine Ethionine affects the expression of NDUFV3 mRNAaffects expression 19483382
D005419 Flavonoids Flavonoids results in increased expression of NDUFV3 mRNAincreases expression 18035473
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of NDUFV3 mRNAincreases expression 17616710
D009853 Omeprazole Omeprazole affects the expression of NDUFV3 mRNAaffects expression 19483382
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NDUFV3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid affects the expression of NDUFV3 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of NDUFV3 mRNAaffects expression 19483382
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NDUFV3 mRNAincreases expression 20399798
D013853 Thioacetamide Thioacetamide affects the expression of NDUFV3 mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8818218290 18057881 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 3.9619698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 60.6619483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 60.6619483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 60.6619483382
MESH:D001778 Blood Coagulation Disorders Ethionine 60.6619483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 60.6619483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 60.6619483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 60.6619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 60.6612125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 60.6619483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8416705839
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 4.841701930
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 4.8417997003
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4116120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9219225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2018974383
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 3.581399818
MESH:D002637 Chest Pain Omeprazole 5.2415447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7916835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.7918291259
MESH:D002779 Cholestasis pirinixic acid 2.8819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.138697196 15340226 15668235 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.2015265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2020420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 9.2012963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.4215991576 21218061 17151854 16613094
MESH:D050171 Dyslipidemias Clofibrate 4.1216707586
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7915264214 15547721 16510608 16805852 15623463 15150132 15547733 15878914 16704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005218 Fat Necrosis Thioacetamide 5.8516456712
MESH:D005234 Fatty Liver Amiodarone 13.7114986274
MESH:D005234 Fatty Liver Clofibrate 13.7119224547
MESH:D005234 Fatty Liver pirinixic acid 13.7119236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.6518665440 17276928 15929193
MESH:D006505 Hepatitis Thioacetamide 4.3116456712
MESH:D006529 Hepatomegaly Amiodarone 15.0515265979
MESH:D006529 Hepatomegaly pirinixic acid 15.0519772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.0515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 16959395 8697196 18606429 16354765
MESH:D006937 Hypercholesterolemia Amiodarone 3.959751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318670907 18850075
MESH:D007037 Hypothyroidism Amiodarone 11.9618020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 11.9618031379 8137927
MESH:D007249 Inflammation Flavonoids 5.1317296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1312878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.0416705839
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.1619248655
MESH:D008064 Lipidoses Amiodarone 3.5715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5212878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.5218263696 18606216 18416461 17292413 16098781 15158331 11172339 17355460 12175628 15288472 10677585 16126171 15465738 18032466 15334695 16248980 11481614 15474484 16097051 17629604 14739098 15095483 15075984 15716488 15078482 16343077 16511523 18031379 17050028 11682029 12557150 12891558 12679928 18458672 18615449 18295389 18395095 15316131 15362042 18380797 15288473 12085344 12531686 16489207 17127702
MESH:D008107 Liver Diseases Thioacetamide 2.7218374380 16337175 15158337
MESH:D017114 Liver Failure, Acute Thioacetamide 4.3915633222 17276928 15313186 12479984
MESH:D008113 Liver Neoplasms pirinixic acid 4.3416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1512151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6417391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.4312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.6118516814
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009181 Mycoses Amiodarone 5.0412754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9718551238
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 5.049802331
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5012819281 16049721
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111896295 11118676 11399792 11222880
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8811597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5818551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2018724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013272 Stomach Diseases Omeprazole 4.7318545984
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3217575124 12958204
MESH:D013276 Stomach Ulcer Amiodarone 7.8518087811
MESH:D013276 Stomach Ulcer Omeprazole 7.8515991576 18237397 10750652 17977527 11906479 16755016
MESH:D013610 Tachycardia Amiodarone 4.3811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2819225199
MESH:D013959 Thyroid Diseases Amiodarone 12.5119731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.5112697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.7415710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.9619584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.3111989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4310091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05016 Huntington's disease
KEGG:01100 Metabolic pathways
KEGG:00190 Oxidative phosphorylation
KEGG:05012 Parkinson's disease
REACT:6305 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00157 - NADH Dietary supplement;Micronutrient
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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