AutismKB 2.0

Annotation Detail for NEDD4


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Basic Information Top
Gene Symbol:NEDD4 ( KIAA0093,MGC176705,NEDD4-1,RPF1 )
Gene Full Name: neural precursor cell expressed, developmentally down-regulated 4
Band: 15q21.3
Quick LinksEntrez ID:4734; OMIM: 602278; Uniprot ID:NEDD4_HUMAN; ENSEMBL ID: ENSG00000069869; HGNC ID: 7727
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa04120Ubiquitin mediated proteolysis
No data
Pathway IDPathway Name
200009ErbB4 signaling events
200161Signaling events mediated by VEGFR1 and VEGFR2
200052Presenilin action in Notch and Wnt signaling
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CANCER
Chronic lymphocytic leukemia
Desease Name
Keloid
Chronic lymphocytic leukemia
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NEDD4 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of NEDD4 mRNAincreases expression 20127859
D002118 Calcium Calcium affects the expression of NEDD4 mRNAaffects expression 15913539
D003024 Clozapine Clozapine results in decreased expression of NEDD4 mRNAdecreases expression 18797397
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of NEDD4 mRNAaffects expression 17555576
D005472 Fluorouracil NEDD4 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D006220 Haloperidol Haloperidol results in decreased expression of NEDD4 mRNAdecreases expression 18797397
C076029 olanzapine olanzapine results in decreased expression of NEDD4 mRNAdecreases expression 18797397
C076029 olanzapine olanzapine results in decreased expression of NEDD4 proteindecreases expression 18797397
C006253 pirinixic acid pirinixic acid results in decreased expression of NEDD4 mRNAdecreases expression 18445702
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3120127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.3114692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.3117638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000380 Agranulocytosis Clozapine 5.3114617031 16160616 12649775
MESH:D000740 Anemia Fluorouracil 3.9017963324 16511603 15504547
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Haloperidol 2.8419368416 18080171
MESH:D001321 Autistic Disorder olanzapine 2.8418685284 17069543
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1620146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.1615136595 16110121 16557594 16595493 18608205 19217205 18357371
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9916051944
MESH:D002277 Carcinoma Fluorouracil 3.7317121937
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1117045692 17088986 16332177 16799960 17971768 18930000
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1018695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8120419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8118986760 16757204 16280240 17066447
MESH:D002375 Catalepsy Haloperidol 5.1915215559 1977408
MESH:D002389 Catatonia olanzapine 6.5716772815 18071103
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2517110522 17681005 15861022 17333356 11677210 16919318 16105132
MESH:D002779 Cholestasis pirinixic acid 8.2519176532
MESH:D003072 Cognition Disorders Clozapine 5.2217123785
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2617016597 15001691 17172411 17725105 17169374 16510598 17287894 18772588 17018589 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0014970324 17695437 18288408 18509181 17016601 16331619 15289873 18383874 17594712 20501625 17255274 17401013 18949393 16524972 18448328 16303861 16391804 16282729 17094418 15148649 17454858 18802399
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.0620210726
MESH:D003704 Dementia Haloperidol 4.7811575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D002658 Developmental Disabilities olanzapine 4.8217069543
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 3.0116402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.8715331141
MESH:D050171 Dyslipidemias Clozapine 4.3316402076
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6416530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6416337965 16481741 15173087 16785472 17638652
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.2415345470
MESH:D005234 Fatty Liver pirinixic acid 8.2419236843 20131406
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5215102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006529 Hepatomegaly pirinixic acid 3.2519176532 19772884 16221962 18467677
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006948 Hyperkinesis Clozapine 5.1916046005
MESH:D006963 Hyperphagia olanzapine 6.5117933447
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007627 Keloid marker/mechanism 20711176
MESH:D007680 Kidney Neoplasms Fluorouracil 3.4816985049
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.3616316344
MESH:D008064 Lipidoses Clozapine 4.1017567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8120195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 7.8117045692 16603448 18383874 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 7.8120007298 16377806 15890375
MESH:D008133 Long QT Syndrome olanzapine 4.8820210726
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.516695378 18569708 20135361 20464547 20869020 17053015 20064080 18816296 18520028
MESH:D008175 Lung Neoplasms Fluorouracil 2.5115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D001523 Mental Disorders Clozapine 15.1816856516
MESH:D001523 Mental Disorders Haloperidol 15.1816856516
MESH:D001523 Mental Disorders olanzapine 15.1816856516
MESH:D008659 Metabolic Diseases olanzapine 5.6019142110
MESH:D024821 Metabolic Syndrome X Clozapine 4.5819142101
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.0616381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.0616757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009369 Neoplasms Benzo(a)pyrene 8.7611141357
MESH:D009369 Neoplasms Fluorouracil 8.7618239605 16928823 18600527
MESH:D009369 Neoplasms pirinixic acid 8.7617405874
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D009765 Obesity Clozapine 7.9219142110 18515891
MESH:D009765 Obesity olanzapine 7.9218515891
MESH:D009765 Obesity pirinixic acid 7.9220558911
MESH:D010024 Osteoporosis Calcium 3.9017882678
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7216500647 16929163 15113037 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1817292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.1819082440 18626508
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D011595 Psychomotor Agitation Haloperidol 12.7011575062
MESH:D011595 Psychomotor Agitation olanzapine 12.7018685284
MESH:D011618 Psychotic Disorders Clozapine 9.6415331141
MESH:D011618 Psychotic Disorders Haloperidol 9.6411575062
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1918286688 16160472 18722050 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012559 Schizophrenia Clozapine 6.0611763009 20168265 20521326 18806925 19369910 16141801 20452607 17667964 17726453 18855531 20107430 20521320 11151749 17123785 20580759
MESH:D012559 Schizophrenia Haloperidol 6.0619369910 20107430 1830565 18513383
MESH:D012559 Schizophrenia olanzapine 6.0620107430 17726453 20521326
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.462093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4617522103 17172411 16424979 18567086 18396642 19015929 16951190 19084572 17498489 15786421
MESH:D017180 Tachycardia, Ventricular Haloperidol 11.7620210726
MESH:D017180 Tachycardia, Ventricular olanzapine 11.7620210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2417053015
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0716803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D015430 Weight Gain Clozapine 10.9717502770 16141801 20107430 20564506 16402076 20521320
MESH:D015430 Weight Gain olanzapine 10.9717933447 19434072 20107430
MESH:D015431 Weight Loss Clozapine 5.3617933447
Pathway ID Pathway Name
KEGG:04144 Endocytosis
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31533
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    PA452347glucocorticoids
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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