AutismKB 2.0

Annotation Detail for NEDD8


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NEDD8 ( FLJ43224,MGC104393,MGC125896,MGC125897,Nedd-8 )
Gene Full Name: neural precursor cell expressed, developmentally down-regulated 8
Band: 14q12
Quick LinksEntrez ID:4738; OMIM: 603171; Uniprot ID:NEDD8_HUMAN; ENSEMBL ID: ENSG00000129559; HGNC ID: 7732
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200175p53 pathway
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
1976Squamous cell cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NEDD8 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NEDD8 mRNAdecreases expression 18648102
C014949 acetylhydrazine acetylhydrazine results in decreased expression of NEDD8 mRNAdecreases expression 15282401
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of NEDD8 proteinincreases expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of NEDD8 proteindecreases expression 19364129
C020711 beryllium sulfate beryllium sulfate results in increased expression of NEDD8 mRNAincreases expression 16314022
D002995 Clofibric Acid Clofibric Acid affects the expression of NEDD8 mRNAaffects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NEDD8 mRNAincreases expression 17942748
16174780
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEDD8 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NEDD8 mRNAincreases expression 16174780
D008713 Methimazole Methimazole results in decreased expression of NEDD8 mRNAdecreases expression 17403546
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of NEDD8 mRNAincreases expression 17616710
C494474 perchlorate perchlorate results in decreased expression of NEDD8 mRNAdecreases expression 17403546
D011441 Propylthiouracil Propylthiouracil results in decreased expression of NEDD8 mRNAdecreases expression 17403546
D011794 Quercetin Quercetin results in increased expression of NEDD8 proteinincreases expression 17292933
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of NEDD8 mRNAaffects cotreatment|increases expression 19244175
D013974 Thyroxine Thyroxine affects the expression of NEDD8 mRNAaffects expression 17403546
D013974 Thyroxine Thyroxine results in increased expression of NEDD8 mRNAincreases expression 17399805
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEDD8 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NEDD8 mRNAincreases expression 18796159
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of NEDD8 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of NEDD8 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8411752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.2711798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2714692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.743712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.2217084956
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D001260 Ataxia Telangiectasia Quercetin 4.9715336622
MESH:D001327 Autoimmune Diseases Quercetin 4.3919761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0211289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.3316206674
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 15.3319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001943 Breast Neoplasms Quercetin 2.1318628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1320435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3111589617
MESH:D002105 Cadmium Poisoning Quercetin 5.5516962696
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9216050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.5716705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.577296757 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.5716217749 15073043 14691202 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.5719519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.9417234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8719014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.667296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1012490120
MESH:D006332 Cardiomegaly Quercetin 11.4819794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 11.4818670907 16120746 18850075
MESH:D006332 Cardiomegaly Thyroxine 11.4818093424
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.616135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.617505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.8119486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8117110522 16919318 17681005 16105132 15861022 17333356 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0915340226 12621046 8697196 15668235 16354765
MESH:D003092 Colitis Selenium 3.7717936198
MESH:D003110 Colonic Neoplasms Quercetin 2.4219056647 15741050 17191121 17148506 11134977 19440933 16640504
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6120501625
MESH:D015179 Colorectal Neoplasms Quercetin 2.6118095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7610048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.7619769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0018551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0815213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7911298694 14531868 8970840 12868966 2524372 11906362 8156756 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.472952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.7119496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.9218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.9218289764 9653073 18692083 9022650 16192314 18648102 8291058 1440618 6482804 6679447 11289319 9328219 7440962
MESH:D056486 Drug-Induced Liver Injury Selenium 8.9215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:C538011 Eales disease Vitamin E 4.709068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0010568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.293581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.2912903497
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.2916704527 15547721 15878914 15547733 16510608 16805852 15264214 15623463 15150132
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver arsenic trioxide 7.6815073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.6815345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.026705139
MESH:D005355 Fibrosis Quercetin 8.7219474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2416904648
MESH:D005909 Glioblastoma Quercetin 3.3819804834
MESH:D005910 Glioma Quercetin 3.0417643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 11.427505956
MESH:D006042 Goiter perchlorate 11.4218801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5310048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.5316080930
MESH:D006333 Heart Failure Selenium 3.0617162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.506705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8816120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6916490937 16863852
MESH:D019584 Hot Flashes Vitamin E 3.9714716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0518606429 15340226 16959395 16354765 8697196
MESH:D006943 Hyperglycemia Quercetin 4.0118262572 11834736
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9215034207
MESH:D006973 Hypertension Quercetin 5.2018356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2018670907 18850075
MESH:D006980 Hyperthyroidism Methimazole 5.6014678291
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016945680 16569931
MESH:D007037 Hypothyroidism Methimazole 11.9118031379
MESH:D007037 Hypothyroidism Propylthiouracil 11.918137927 18031379
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4717937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8412200463 12878042
MESH:D007251 Influenza, Human Quercetin 18.6416624496
MESH:D007251 Influenza, Human Selenium 18.6416624496
MESH:D007251 Influenza, Human Vitamin E 18.6416624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.028074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007627 Keloid Quercetin 4.9417086741
MESH:D007674 Kidney Diseases Quercetin 6.2616962696
MESH:D007674 Kidney Diseases Vitamin E 6.2612488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8716518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.3016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.306582329
MESH:D007938 Leukemia arsenic trioxide 6.4515070760
MESH:D007938 Leukemia Quercetin 6.4517468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1319850784 17050201 16467208 20471514 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2015336539 11161223 17712046 16331271 19075265 17869043 12018890 15622746 15213294 19225113 9834237 15748426 17107899 16966277 17217047 16330433 11468182 12679006 17649720 16891316 12712474 16112521 16823087 19035177 19642359
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3416882451
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.189327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.5112741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5116169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.177678174
MESH:D008113 Liver Neoplasms arsenic trioxide 14.1714682389
MESH:D008113 Liver Neoplasms Clofibric Acid 14.1717602206
MESH:D008113 Liver Neoplasms Quercetin 14.1718980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.1716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 18.512876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 18.513712494 6587162 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 18.5120377131
MESH:D008114 Liver Neoplasms, Experimental Quercetin 18.5119519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.5112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3315213294
MESH:D008171 Lung Diseases Vitamin E 3.1616863852
MESH:D008175 Lung Neoplasms arsenic trioxide 4.8411798837 19825857
MESH:D008175 Lung Neoplasms Quercetin 4.8416280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8411884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 4.8411062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7515318939
MESH:D008654 Mesothelioma Selenium 2.7815107826
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0919549372 19417148 11468182 15949261 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1316105982 16882451
MESH:D009203 Myocardial Infarction Quercetin 2.9819595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.7819207477
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.857678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9416624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.463581430
MESH:D009369 Neoplasms Quercetin 2.7815185748
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.206679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.2010525206
MESH:D020078 Neurogenic Inflammation Quercetin 4.3417929310
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.8216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.824026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.023988306
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.2019495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9919769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Quercetin 4.9919005980
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4115580305
MESH:D010190 Pancreatic Neoplasms Quercetin 5.4116965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.477296757
MESH:D010235 Paraganglioma arsenic trioxide 4.1419927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.476228378
MESH:D010954 Plasmacytoma Selenium 4.8915087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Quercetin 3.9619056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1811118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6419131511
MESH:D011471 Prostatic Neoplasms Quercetin 2.6417292933 14715546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6415084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.363692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9416646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.5516862918
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5218551238
MESH:D012871 Skin Diseases Vitamin E 2.4418709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9416709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.6517007042
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.6517575124 12958204
MESH:D020521 Stroke Vitamin E 3.5016517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.3812697716
MESH:D013959 Thyroid Diseases Thyroxine 12.3819910387
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.966587162 6582329 7505956 1399818 3712494
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.9619014326
MESH:D013964 Thyroid Neoplasms Propylthiouracil 11.9615710170
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9515213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.8816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.888074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.8812973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Quercetin 11.8816720314
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved