AutismKB 2.0

Annotation Detail for NEFM


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Basic Information Top
Gene Symbol:NEFM ( NEF3,NF-M,NFM )
Gene Full Name: neurofilament, medium polypeptide
Band: 8p21.2
Quick LinksEntrez ID:4741; OMIM: 162250; Uniprot ID:NFM_HUMAN; ENSEMBL ID: ENSG00000104722; HGNC ID: 7734
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05014Amyotrophic lateral sclerosis (ALS)
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1982Myopathy
Desease Name
PSYCH
psychoses schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D020106 Acrylamide Acrylamide results in increased expression of NEFM mRNAincreases expression 10678756
D020106 Acrylamide Acrylamide results in increased expression of NEFM proteinincreases expression 10678756
D020106 Acrylamide Dexamethasone inhibits the reaction [Acrylamide results in increased expression of NEFM protein]decreases reaction|increases expression 10678756
D020106 Acrylamide Dexamethasone inhibits the reaction [NGF protein promotes the reaction [Acrylamide results in increased expression of NEFM protein]]decreases reaction|increases expression|increases reaction 10678756
D020106 Acrylamide K 252 inhibits the reaction [Acrylamide results in increased expression of NEFM protein]decreases reaction|increases expression 10678756
D020106 Acrylamide NGF protein promotes the reaction [Acrylamide results in increased expression of NEFM protein]increases expression|increases reaction 10678756
C103303 alitretinoin alitretinoin results in increased expression of NEFM proteinincreases expression 8892963
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NEFM mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of NEFM proteindecreases expression 18722528
D000643 Ammonium Chloride roscovitine inhibits the reaction [Ammonium Chloride results in decreased expression of NEFM protein]decreases expression|decreases reaction 18722528
D001151 Arsenic Arsenic metabolite affects the expression of NEFM mRNAaffects expression 17553662
D002246 Carbon Disulfide Carbon Disulfide results in decreased expression of NEFM proteindecreases expression 17120161
16474999
D002246 Carbon Disulfide Carbon Disulfide results in increased expression of NEFM mRNAincreases expression 17120161
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of NEFM mRNAincreases expression 18812211
D003474 Curcumin Curcumin results in increased expression of NEFM mRNAincreases expression 18299980
D003907 Dexamethasone Dexamethasone inhibits the reaction [Acrylamide results in increased expression of NEFM protein]decreases reaction|increases expression 10678756
D003907 Dexamethasone Dexamethasone inhibits the reaction [NGF protein promotes the reaction [Acrylamide results in increased expression of NEFM protein]]decreases reaction|increases expression|increases reaction 10678756
D003907 Dexamethasone Dexamethasone inhibits the reaction [NGF protein results in increased expression of NEFM protein]decreases reaction|increases expression 10678756
D003976 Diazinon Diazinon results in increased expression of NEFM mRNAincreases expression 18812211
17452286
D004026 Dieldrin Dieldrin results in increased expression of NEFM mRNAincreases expression 18812211
D005419 Flavonoids Flavonoids results in increased expression of NEFM mRNAincreases expression 18035473
C049985 K 252 K 252 inhibits the reaction [Acrylamide results in increased expression of NEFM protein]decreases reaction|increases expression 10678756
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of NEFM mRNAincreases expression 12057914
C014655 methamidophos methamidophos affects the expression of NEFM proteinaffects expression 15938848
D009532 Nickel Nickel affects the expression of NEFM mRNAaffects expression 18812211
C408604 PD 169316 PD 169316 results in increased expression of NEFM mRNAincreases expression 16424397
C104586 roscovitine roscovitine inhibits the reaction [Ammonium Chloride results in decreased expression of NEFM protein]decreases expression|decreases reaction 18722528
C104586 roscovitine roscovitine results in increased phosphorylation of NEFM proteinincreases phosphorylation 18722528
D014212 Tretinoin [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NEFM proteinaffects cotreatment|increases expression 17085092
D014212 Tretinoin Tretinoin results in increased expression of NEFM proteinincreases expression 16149052
D014212 Tretinoin Tretinoin results in increased expression of NEFM mRNAincreases expression 16424397
D014212 Tretinoin Tretinoin results in increased expression of NEFM proteinincreases expression 8892963
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.4418653653 11850527
MESH:D055371 Acute Lung Injury Nickel 9.4416166738
MESH:D018246 Adrenocortical Adenoma Arsenic 5.1817306315
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.0517119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.0516487989
MESH:D019973 Alcohol-Related Disorders Curcumin 5.0517887948
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000544 Alzheimer Disease Curcumin 2.6115590663
MESH:D020261 Arsenic Poisoning Arsenic 2.8516251483 12569548 16835338 18414634
MESH:D001169 Arthritis, Experimental Dexamethasone 7.4417659584
MESH:D001169 Arthritis, Experimental Tretinoin 7.4416412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.7016807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.7016292516
MESH:D001249 Asthma Tretinoin 2.3316456186
MESH:D050197 Atherosclerosis Arsenic 11.1819371607 12928151
MESH:D050197 Atherosclerosis Carbon Disulfide 11.1810367350 10658303
MESH:D050197 Atherosclerosis Curcumin 11.1818704882
MESH:D001327 Autoimmune Diseases Curcumin 4.4519761891
MESH:D001342 Autonomic Nervous System Diseases methamidophos 6.7411527224
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.5716197459 16206674
MESH:D002545 Brain Ischemia Curcumin 4.2916770732
MESH:D001932 Brain Neoplasms Curcumin 3.9017596214
MESH:D001943 Breast Neoplasms Acrylamide 2.9718183576 16253758
MESH:D001943 Breast Neoplasms alitretinoin 2.9716344269
MESH:D001943 Breast Neoplasms Curcumin 2.9716243823 19250217 18462866 18593918
MESH:D001943 Breast Neoplasms Dieldrin 2.9711859874 15770527
MESH:D001943 Breast Neoplasms Nickel 2.9715986119
MESH:D001943 Breast Neoplasms Tretinoin 2.9716443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5516813970
MESH:D002277 Carcinoma Curcumin 3.8018593918
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5715504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.1817306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.181917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9618414057
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.5815504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.5818462866
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.5816096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.0418640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.4215738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.2718022660 16973168
MESH:D002386 Cataract Tretinoin 3.0717460283
MESH:D002418 Cattle Diseases Acrylamide 5.4212510666
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002972 Cleft Palate Tretinoin 2.659407595
MESH:D003092 Colitis Curcumin 9.5116782535 16804969 18200517
MESH:D003092 Colitis Tretinoin 9.5117035595
MESH:D003103 Coloboma Curcumin 4.5118809619
MESH:D003110 Colonic Neoplasms Curcumin 4.0016340194 19359593
MESH:D003110 Colonic Neoplasms Dexamethasone 4.0015824018
MESH:D016510 Corneal Neovascularization Curcumin 4.8618497527
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.8117728286
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.819211117 17551590 9125849 16925845 9664655 10589399 9224671 9142499 8800419 14991402
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 7.3312438553
MESH:D017449 Dermatitis, Allergic Contact Nickel 7.3317100760 17244072 19470301
MESH:D003877 Dermatitis, Contact Nickel 4.592952479
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.6918403477
MESH:D003928 Diabetic Nephropathies Curcumin 3.9718204486
MESH:D003967 Diarrhea Dexamethasone 3.667237001
MESH:D004381 Duodenal Ulcer Curcumin 4.0117351913
MESH:D004417 Dyspnea Diazinon 4.7716487989
MESH:D004485 Eczema Dexamethasone 4.4212438553
MESH:D004487 Edema Dexamethasone 3.3619703484
MESH:D004489 Edema, Cardiac Tretinoin 4.4418230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0816569247
MESH:D019446 Endotoxemia Lipopolysaccharides 4.3615821434 15328337 17637181
MESH:D005124 Eye Abnormalities Tretinoin 3.5416938888 9664655
MESH:D005234 Fatty Liver Curcumin 3.6619297423
MESH:D005334 Fever Lipopolysaccharides 3.979205823 11852909
MESH:D005355 Fibrosis Curcumin 8.8718705752
MESH:D005355 Fibrosis Tretinoin 8.8717994277
MESH:D005517 Foodborne Diseases methamidophos 7.1111527224
MESH:D005534 Foot Diseases Arsenic 5.536392382
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.6518462866
MESH:D005909 Glioblastoma Curcumin 7.1917596214
MESH:D005909 Glioblastoma Tretinoin 7.1917312396
MESH:D006258 Head and Neck Neoplasms Curcumin 7.7918829502 18462866
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.7916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.879664655 14991402
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.3416366002
MESH:D006505 Hepatitis Diazinon 4.5316487989
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.0017701891
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.057520565
MESH:D015658 HIV Infections Nickel 3.7917263646
MESH:D006930 Hyperalgesia Tretinoin 3.1816870215
MESH:D006937 Hypercholesterolemia Curcumin 4.0118704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.4217050553
MESH:D006973 Hypertension Arsenic 5.5516076760 11953799 9931084
MESH:D006973 Hypertension Dexamethasone 5.5517042910
MESH:D006987 Hypesthesia Arsenic 5.5316093927
MESH:D007247 Infertility, Female Acrylamide 10.8011020651
MESH:D007247 Infertility, Female Dieldrin 10.8010630421
MESH:D007248 Infertility, Male Acrylamide 11.6312507653 15355880 11020651 15749267
MESH:D007248 Infertility, Male Diazinon 11.6312948887 16466525
MESH:D007248 Infertility, Male methamidophos 11.6310828210
MESH:D007249 Inflammation Curcumin 15.6818403477 16956363 17151092
MESH:D007249 Inflammation Dexamethasone 15.6811099482 8960868
MESH:D007249 Inflammation Flavonoids 15.6817296493
MESH:D007249 Inflammation Lipopolysaccharides 15.6817255318 12878042 17963957 17237260 9205823
MESH:D007249 Inflammation Nickel 15.6816166738
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1918200517 18596194
MESH:D007410 Intestinal Diseases Tretinoin 3.7317994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.1810783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.5917255318
MESH:D007569 Jaw Abnormalities Tretinoin 3.8617551590 15992940
MESH:D007642 Keratosis Arsenic 4.9512749816 16930632
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.6016144296
MESH:D007889 Leiomyoma Curcumin 4.5318555241
MESH:D007938 Leukemia Curcumin 10.6518462866
MESH:D007938 Leukemia roscovitine 10.6516275999
MESH:D007938 Leukemia Tretinoin 10.6517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.1616106398
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6616482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0717596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.6617339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.6617339181 9834237 12679006 17217047 19075265 16331271 17361223 16766008 17294898 19225113 17107899 19035177 16823087 16140955 16788101 16935935 19642359 17368321 17649720 15748426 17506722 19029980 17712046 17301526 16891316
MESH:D015458 Leukemia, T-Cell Curcumin 4.7216106398
MESH:D007970 Leukopenia Lipopolysaccharides 4.6615821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.279224671
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 5.0018705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 5.0016718785
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 5.0012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0018397230 16248980
MESH:D008107 Liver Diseases Arsenic 6.7311134558
MESH:D008107 Liver Diseases Chlorpyrifos 6.7315991261
MESH:D008107 Liver Diseases Curcumin 6.7316956363
MESH:D008113 Liver Neoplasms Arsenic 5.1116368122
MESH:D008113 Liver Neoplasms Dieldrin 5.119539021 8742319
MESH:D055370 Lung Injury Lipopolysaccharides 3.9721114838
MESH:D008175 Lung Neoplasms alitretinoin 4.9316413115
MESH:D008175 Lung Neoplasms Arsenic 4.9317306315 19168569 17976673
MESH:D008175 Lung Neoplasms Curcumin 4.9316243823 19359593 18462866
MESH:D008175 Lung Neoplasms Dexamethasone 4.9315824018 11195469
MESH:D008223 Lymphoma Curcumin 3.5518462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.6516173963
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma Curcumin 3.4617885582 18462866
MESH:D008545 Melanoma Tretinoin 3.4616752155
MESH:D008569 Memory Disorders Curcumin 4.1117263510
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D009101 Multiple Myeloma Curcumin 7.4819372569
MESH:D009101 Multiple Myeloma Dexamethasone 7.4815744524 15867202 16118317
MESH:D018908 Muscle Weakness methamidophos 6.7417849254
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.8817962980
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.459809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.4517596541
MESH:D017202 Myocardial Ischemia Arsenic 3.9515371236
MESH:D009361 Neoplasm Invasiveness Curcumin 4.3318495463
MESH:D009369 Neoplasms alitretinoin 8.4216946489
MESH:D009369 Neoplasms Dieldrin 8.428820588
MESH:D009369 Neoplasms Tretinoin 8.4216594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.5012497104
MESH:D009410 Nerve Degeneration Acrylamide 4.6611264303 12387366 12387367
MESH:D009422 Nervous System Diseases Acrylamide 16.2112164553 12507653
MESH:D009422 Nervous System Diseases Carbon Disulfide 16.2110669001
MESH:D009422 Nervous System Diseases methamidophos 16.212238440 15938848
MESH:D009421 Nervous System Malformations Tretinoin 3.749125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.6018462866
MESH:D009436 Neural Tube Defects Arsenic 7.3316620997
MESH:D009436 Neural Tube Defects Tretinoin 7.339142499
MESH:D020078 Neurogenic Inflammation Arsenic 4.3317056641
MESH:D020258 Neurotoxicity Syndromes Carbon Disulfide 8.9015315294
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 8.9015081274
MESH:D009765 Obesity Curcumin 2.7419297423
MESH:D010024 Osteoporosis Curcumin 3.4418719352
MESH:D010051 Ovarian Neoplasms Arsenic 7.9217306315
MESH:D010051 Ovarian Neoplasms Curcumin 7.9219020741 18462866
MESH:D010051 Ovarian Neoplasms Tretinoin 7.9216936753
MESH:D010146 Pain Tretinoin 2.8716870215
MESH:D010190 Pancreatic Neoplasms Curcumin 5.3919401701 19196508 17440100
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.3915976015
MESH:D010300 Parkinson Disease Dieldrin 3.5117291500 16809432 16112328 11181820 11445065
MESH:D020734 Parkinsonian Disorders Carbon Disulfide 5.5915019297
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 16.7011510240
MESH:D010523 Peripheral Nervous System Diseases Arsenic 16.7016093927
MESH:D010523 Peripheral Nervous System Diseases methamidophos 16.7010447555 2170085 7654138
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.956392382 16905509 15371236
MESH:D011014 Pneumonia Lipopolysaccharides 4.5212224865 11605937
MESH:D011041 Poisoning Diazinon 9.4817603234
MESH:D011041 Poisoning methamidophos 9.4816119251 17849254
MESH:D011115 Polyneuropathies methamidophos 6.047654138
MESH:D017499 Porokeratosis alitretinoin 5.9816144296
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5221297632
MESH:D011471 Prostatic Neoplasms Arsenic 2.9516140617
MESH:D011471 Prostatic Neoplasms Curcumin 2.9510851300 12497104 11398177 18156803 18769126 15129424 18226269
MESH:D011471 Prostatic Neoplasms roscovitine 2.9516140939
MESH:D011507 Proteinuria Arsenic 9.1421343184
MESH:D011507 Proteinuria Tretinoin 9.1416636307
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.4919168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 9.1710666014 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 9.1711700416 18379247
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7010835634
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.6011874814 16611668 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.8616611668 17119214
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0616283617 16116481
MESH:D012509 Sarcoma Curcumin 4.0818462866
MESH:D012512 Sarcoma, Ewing's roscovitine 5.7416230394
MESH:D018805 Sepsis Curcumin 4.0418389075
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.066418539
MESH:D012871 Skin Diseases Arsenic 2.7419834688 16702368 16759981 17453740 16353154 15952646 17050553 18709164 6392382 17548696 17938729
MESH:D012878 Skin Neoplasms Arsenic 5.8515504454 17050553 17029826 16251483 19538983 17976673
MESH:D012878 Skin Neoplasms Tretinoin 5.8516467112
MESH:D013272 Stomach Diseases Dexamethasone 4.2915472012
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013276 Stomach Ulcer Curcumin 7.4019188055 16631530
MESH:D013276 Stomach Ulcer Dexamethasone 7.4015138204
MESH:D013733 Testicular Diseases Acrylamide 5.1915864552
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.1215821434
MESH:D013964 Thyroid Neoplasms Tretinoin 2.9916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7516051514
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.3717306315 11144890 15987713 19429237 19322015 17976673 18640142
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.3718593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.2318462866
MESH:D014570 Urologic Diseases Diazinon 5.2516487989
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.5816752155
MESH:D014605 Uveitis Dexamethasone 4.791336536
MESH:D014652 Vascular Diseases Arsenic 4.7017056641
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
Pathway ID Pathway Name
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162397442
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA451257risperidone
    PA452233antipsychotics
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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